library(survival) aeq <- function(x,y, ...) all.equal(as.vector(x), as.vector(y), ...) # # Test the multi-state version of the CI curve # tdata <- data.frame(id=c(1,1,1,1, 2,2,2, 3,3, 4,4,4,4, 5, 6, 6), time1=c(0, 10,20,30, 0, 5, 15, 0, 20, 0, 6,18,34, 0, 0,15), time2=c(10,20,30,40, 5, 15,25, 20, 22, 6,18,34,50,10,15,20), status=c(1,1,1,1, 1,1,1, 1,0, 1,1,1,0,0,1,0), event= letters[c(1,2,3,4, 2,4,3, 2,2, 3,1,2,2,1, 1,1)], wt = c(2,2,2,2, 1,1,1, 3,3, 1,1,1,1, 2, 1,1), stringsAsFactors=TRUE) tdata$stat2 <- factor(tdata$status * as.numeric(tdata$event), labels=c("censor", levels(tdata$event))) fit <- survfit(Surv(time1, time2, stat2) ~1, id=id, weight=wt, tdata, influence=TRUE) # The exact figures for testci2. # The subject data of id, weight, (transition time, transition) #1: 2 (10, 0->a) (20, a->b) (30, b->c) (40, c->d) no data after 40=censored #2: 1 ( 5, 0->b) (15, b->d) (25, d->c) no data after 25 implies censored then #3: 3 (20, 0->b) (22, censor) #4: 1 ( 6, 0->c) (18, c->a) (34, a->b) (50, censor) #5: 2 (10, censor) #6: 1 (15, 0->a) (20, censor) # Each line below follows a subject through time as a (state, rdist weight) pair # using the redistribute to the right algorithm. # RDR algorithm: at each censoring (or last fu) a subject's weight is put into # a "pool" for that state and their weight goes to zero. The pool is # dynamically shared between all members of the state proportional to their # original case weight, when someone leaves they take their portion of the # pool to the new state. # Table of case weights and state, blank is weight of zero # time 5 6 10 15 18 20 25 30 34 40 50 # ----------------------------------------------------------------------- # id, wt # 1, 2 - - a a a b b c c d # 2, 1 b b b d d d c # 3, 3 - - - - - b # 4, 1 - c c c a a a a b b b # 5, 2 - - - # 6, 1 - - - a a a # Pool weights # 10 10+ 15 18 20 20+ 22+ 25 25+ 30 34 40 40+ # - 0 2 3/2 3/2 0 # a 0 0 1/2 1/2 1/4 5/4 5/4 5/4 5/4 5/4 # b 0 0 0 0 7/4 7/4 19/4 19/4 19/4 5/4 5/4 5/4 # c 0 0 0 0 0 1 23/4 23/4 # d 0 0 0 0 0 23/4 31/4 # fit$pstate for time i and state j = total weight at that time/state in the # above table (original weight + redistrib), divided by 10. # time 5 6 10 15 18 20 25 30 34 40 50 truth <- matrix(c(0, 0, 2, 3, 4, 2, 1, 1, 0, 0, 0, 1, 1, 1, 0, 0, 5, 2, 0, 1, 1, 1, 0, 1, 1, 1, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 1, 1, 1, 0, 0, 0, 2, 0) + c(0, 0, 0, .5, .5, 1/4, 5/4, 5/4, 0, 0, 0, 0, 0, 0, 0, 0, 7/4, 19/4, 0, 5/4, 5/4, 5/4, 0, 0, 0, 0, 0, 0, 0, 23/4, 23/4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23/4, 31/4), ncol=4) truth <- truth[c(1:6, 6:11),]/10 #the explicit censor at 22 #dimnames(truth) <- list(c(5, 6, 10, 15, 18, 20, 25, 30, 34, 40, 50), # c('a', 'b', 'c', 'd') aeq(truth, fit$pstate[,2:5]) # Test the dfbetas # It was a big surprise, but the epsilon where a finite difference approx to # the derivative is most accurate is around 1e-7 = approx sqrt(precision). # Smaller eps makes the approximate derivative worse. # There is a now a formal test in mstate.R, not approximate. # compute the per observation influence first n <- nrow(tdata) U <- array(0, dim=c(n, dim(fit$pstate))) eps <- sqrt(.Machine$double.eps) n <- nrow(tdata) for (i in 1:n) { twt <- tdata$wt twt[i] <- twt[i] + eps tfit <- survfit(Surv(time1, time2, stat2) ~ 1, id=id, tdata, weight=twt) U[i,,] <- (tfit$pstate - fit$pstate)/eps #finite difference approx } dfbeta <- rowsum(tdata$wt*matrix(U,nrow=n), tdata$id) # per subject dfbeta <- array(dfbeta, dim=c(6,12,5)) aeq(dfbeta, fit$influence, tolerance= eps*10) aeq(fit$std.err, sqrt(apply(fit$influence.pstate^2, 2:3, sum))) if (FALSE) { # a plot of the data that helped during creation of the example plot(c(0,50), c(1,6), type='n', xlab='time', ylab='subject') with(tdata, segments(time1, id, time2, id)) with(tdata, text(time2, id, as.numeric(stat2)-1, cex=1.5, col=2)) } if (FALSE) { # The following lines test out 4 error messages in the routine # # Gap in follow-up time, id 2 survfit(Surv(c(0,5,9,0,5,0), c(5,9,12, 4, 6, 3), factor(c(0,0,1,1,0,2))) ~1, id=c(1,1,1,2,2,3)) # mismatched weights survfit(Surv(c(0,5,9,0,5,0), c(5,9,12, 5, 6, 3), factor(c(0,0,1,1,0,2))) ~1, id=c(1,1,1,2,2,3), weights=c(1,1,2,1,1,4)) # in two groups at once survfit(Surv(c(0,5,9,0,5,0), c(5,9,12, 5, 6, 3), factor(c(0,0,1,1,0,2))) ~ c(1,1,2,1,1,2), id=c(1,1,1,2,2,3)) # state change that isn't a state change (went from 1 to 1) survfit(Surv(c(0,5,9,0,5,0), c(5,9,12, 5, 6, 3), factor(c(0,1,1,1,0,2))) ~1, id=c(1,1,1,2,2,3)) } # Check the start.time option # # Later work showed this test has to be false. At time 0 everyone starts in # state (s0), but by time 20 many have shifted to another. fit2 picks up at # the right place, but because there is no istate varaible, fit2x starts # everyone in (s0) at time 20. There is no way for survfit to know. if (FALSE) { fit2 <- survfit(Surv(time1, time2, stat2) ~1, id=id, weight=wt, tdata, start.time=20) data2 <- subset(tdata, time2>= 20) fit2x <- survfit(Surv(time1, time2, stat2) ~1, id=id, weight=wt, data2) ii <- names(fit2)[!(names(fit2) %in% c("call", "start.time"))] all.equal(unclass(fit2)[ii], unclass(fit2x)[ii]) }