R version 4.4.0 RC (2024-04-16 r86458 ucrt) -- "Puppy Cup"
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> library(survival)
> aeq <- function(x, y) all.equal(as.vector(x), as.vector(y))
> # 
> # Compute the hazard functions for a multi-state Cox model
> #
> coxhaz <- function(y, id, risk, wt, expm=TRUE) {
+     # y should be a multi-state survival
+     if (!inherits(y, "Surv") || attr(y, "type") != "mcounting")
+         stop("invalid response")
+ 
+     n <- nrow(y)
+     if (missing(id) || length(id) !=n) stop("invalid id")
+      
+     if (missing(wt)) wt <- rep(1.0, n)
+     else if (length(wt) !=n || any(wt <=0)) stop("invalid wt")
+ 
+     # get the current state, and the list of transtions
+     #  transitions to censor don't count
+     mcheck <- survcheck(y~1, id= id)
+     states <- mcheck$states
+     nstate <- length(states)
+     istate <- mcheck$istate
+ 
+     event <- y[,3] > 0
+     temp <- attr(y, 'states')[y[event,3]]
+     tmat <- table(y[event,2], from=istate[event], to=temp)
+     tmat2 <- tapply(wt[event], list(y[event,2], from=mcheck$istate[event],
+                                     to=temp), sum)
+     tmat2 <- ifelse(is.na(tmat2), 0, tmat2)
+ 
+ 
+     # Hazards can be done one at a time.  For each of them the risk
+     #  weight vector for the subjects can be different.
+     # First organize the material as a 2 dim matrix
+     temp <- apply(tmat, 2:3, sum)  # count of transtions
+     keep <- which(temp>0)
+     from <- states[row(temp)[keep]] 
+     hlab <- outer(match(rownames(temp), states), 
+                   match(colnames(temp), states), paste, sep=':')[keep]
+     nhaz <- length(keep)
+     nevent <- matrix(tmat2, nrow(tmat2))[,keep]
+     dtime <- sort(unique(y[event,2]))
+     ntime <- length(dtime)
+     dimnames(nevent) <- list(NULL, hlab)
+     aindex <- cbind(as.numeric(substring(hlab,1,1)), 
+                     as.numeric(substring(hlab,3,3)))
+ 
+     if (missing(risk)) risk <- matrix(1, nrow=n, ncol=nhaz)
+     if (!is.matrix(risk) || nrow(risk) != n || ncol(risk) != nhaz)
+         stop("invalid risk matrix")
+     risk <- risk * wt
+ 
+     # get the weighted at risk at each time
+     wtrisk <- matrix(, length(dtime), nhaz)
+     statematch <- outer(istate, from, function(x, y) x==y)
+     risk <- ifelse(statematch, risk, 0)
+     for (i in 1:ntime) {
+         atrisk <- (y[,1]< dtime[i] & y[,2] >= dtime[i])
+         wtrisk[i,] <- colSums(risk[atrisk,, drop=FALSE]) 
+     }
+ 
+     haz <- nevent/ifelse(wtrisk==0, 1, wtrisk)   # avoid 0/0
+     chaz<- apply(haz, 2, cumsum)
+     
+     # compute the probability in state, with p(0)= 1,0, ..
+     pstate <- matrix(0, ntime+1, nstate)
+     pstate[1,1] <- 1
+     for (i in 1:ntime) {
+         tmat <- matrix(0, nstate, nstate)
+         tmat[aindex] <- haz[i,]
+         if (expm) {
+             diag(tmat) <- -rowSums(tmat)
+             pstate[i+1,] <- pstate[i,] %*% as.matrix(Matrix::expm(tmat))
+         } else {  
+             diag(tmat) <- 1-rowSums(tmat)
+             pstate[i+1,] <- pstate[i,] %*% tmat
+         }
+     }
+ 
+     list(time=dtime, nrisk=wtrisk, nevent=nevent,
+          haz=haz, cumhaz=chaz, states=states, pstate= pstate[-1,])
+ }
> 
> mtest <- data.frame(id= c(1, 1, 1,  2,  3,  4, 4, 4,  5, 5),
+                     t1= c(0, 4, 9,  0,  2,  0, 2, 8,  1, 3),
+                     t2= c(4, 9, 10, 5,  9,  2, 8, 9,  3, 11),
+                     state= c(1, 2,  1, 2,  3,  1, 3, 0,  2,  0),
+                     x = c(0, 0,  0, 1,  1,  0, 0, 0,  2,  2))
> mtest$state <- factor(mtest$state, 0:3, c("censor", "a", "b", "c"))
> 
> # True results
> #
> #time       at risk               events
> #         entry  a   b  c        
> #
> #2        1245                   4 -> a
> #3        1235   4               5 -> b
> #4        123    4   5           1 -> a
> #5         23    14  5           2 -> b, exits
> #8         3     14  5           4 -> c
> #9         3     1   5  4        1->b, 3->c & exit, 4 censored
> #10                  15          1->a, exit
> #11                   5          censor
> 
> # with all coefficients =0 
> check1 <- with(mtest, coxhaz(Surv(t1, t2, state), id))
> fit1 <- survfit(Surv(t1, t2, state) ~1, mtest, id=id)
> aeq(check1$cumhaz, fit1$cumhaz[match(check1$time, fit1$time),])
[1] TRUE
> 
> dummy <- data.frame(x=1:2)
> cox0 <-  coxph(Surv(t1, t2, state) ~x, iter=0, mtest, id=id)
> cfit0 <- survfit(cox0, newdata=dummy)
> indx <- match(check1$time, cfit0$time)
> aeq(check1$cumhaz, cfit0$cumhaz[indx,1,])
[1] TRUE
> aeq(check1$cumhaz, cfit0$cumhaz[indx,2,])
[1] TRUE
> aeq(check1$pstate, cfit0$pstate[indx,1,])
[1] TRUE
> 
> # a fixed coefficient
> mfit <- coxph(Surv(t1, t2, state) ~x, iter=0, mtest, id=id,
+               init= log(1:6))
> msurv <- survfit(mfit, newdata=list(x=0:1))
> mrisk <- exp(outer(mtest$x, log(1:6), '*'))  # hazards for each transition
> check2 <- with(mtest, coxhaz(Surv(t1, t2, state), id=id, risk=mrisk))
> aeq(check2$cumhaz, msurv$cumhaz[indx,1,])
[1] TRUE
> aeq(check2$pstate, msurv$pstate[indx,1,])
[1] TRUE
> 
> # a different predicted x multiplies the risk weights
> #  now use exp(x - target) as the risk score
> mrisk2 <- mrisk %*% diag(1/(1:6))
> check2b <- with(mtest, coxhaz(Surv(t1, t2, state), id=id, risk=mrisk2))
> aeq(check2b$cumhaz, msurv$cumhaz[indx,2,]) 
[1] TRUE
> aeq(check2b$pstate, msurv$pstate[indx,2,])
[1] TRUE
> 
> # since pstate depends only on the hazards and p(0), if the hazards are
> #  right I don't have to check pstate for every subcase
> 
> if (FALSE) {
+     # this graph is very useful
+     temp <- survcheck(Surv(t1, t2, state) ~1, mtest, id=id)
+     plot(c(0,11), c(1,5.1), type='n', xlab="Time", ylab= "Subject")
+     with(mtest, segments(t1+.1, id, t2, id, col=as.numeric(temp$istate)))
+     event <- subset(mtest, state!='censor')
+     text(event$t2, event$id+.2, as.character(event$state))
+ }
>          
> 
> # slight change, add a few censored subjects
> #  all the events happen on even numbered days
> test2 <- data.frame(id= c(1, 1, 1,  2,  3,  4, 4, 4,  5, 5,
+                           6, 7, 8,  9),
+                     t1= c(0, 8, 18,  0,  4,  0, 4, 16,  2, 6,
+                           0, 0, 7,  8),
+                     t2= c(8, 18, 20, 10,  18,  4, 16, 18,  6, 22,
+                           5, 10,  10, 15),
+                     state= c(1, 2,  1, 2,  3,  1, 3, 0,  2,  0,0,0,0,0),
+                     x = c(0, 0,  0, 1,  1,  0, 0, 0,  2,  2, 1, 1, 2, 0))
> test2$state <- factor(test2$state, 0:3, c("censor", "a", "b", "c"))
> 
> if (FALSE) {
+     # this graph is very useful when debugging
+     temp <- survcheck(Surv(t1, t2, state) ~1, test2, id=id)
+     plot(c(0,22), c(1,9.1), type='n', xlab="Time", ylab= "Subject")
+     with(test2, segments(t1+.1, id, t2, id, col=as.numeric(temp$istate)))
+     event <- subset(test2, state!='censor')
+     text(event$t2, event$id+.2, as.character(event$state))
+ }
> 
> # s0 to a, cumhaz of 1/6 (t=4) + 1/5 (t=8)
> #  b to a, cumhaz of 1/2 at 20
> # s0 to b, cumhaz of 1/5 at 6, +1/5 at 10
> #  a to b, cumhaz of 1/1 at 18
> # s0 to c, cumhaz of 1/1 at 18
> #  a to c, cumhaz of 1/2 at 16
> time2 <-     c(4,5,6,8,10,15,16,18,20, 22)
> chaz2 <- matrix(0, nrow= length(time2), ncol=6,
+             dimnames=list(time2, c("1:2", "1:3", "1:3", "2:3", "1:4", "2:4")))
> chaz2['4',1] <- 1/6; chaz2['8',1] <- 1/5
> chaz2['20',2] <- 1/2
> chaz2['6', 3] <- 1/5; chaz2['10', 3] <- 1/5
> chaz2['18',4:5] <- 1
> chaz2['16', 6] <- 1/2
> chaz2 <- apply(chaz2, 2, cumsum)
>  
> 
> cox3 <- coxph(Surv(t1, t2, state) ~x, id=id, test2, iter=0)  # no weights
> csurv3 <- survfit(cox3, newdata=data.frame(x=0:1), time0=FALSE)
> aeq(csurv3$time, time2)
[1] TRUE
> aeq(csurv3$cumhaz[,1,], chaz2)
[1] TRUE
> aeq(csurv3$cumhaz[,2,], chaz2)
[1] TRUE
> check3 <- with(test2, coxhaz(Surv(t1, t2, state), id=id))
> indx3 <- match(check3$time, csurv3$time)
> aeq(check3$cumhaz, chaz2[indx3,])  # a check on the coxhaz function above
[1] TRUE
> aeq(check3$pstate, csurv3$pstate[indx3,1,])
[1] TRUE
> 
> cox4 <- coxph(Surv(t1,t2, state) ~ x, id=id, test2, 
+                      init=log(1:6), iter=0)
> csurv4 <- survfit(cox4, newdata=data.frame(x=0:1), time0= FALSE)
> mrisk4 <- exp(outer(test2$x, log(1:6), '*'))  # hazards for each transition
> check4 <- with(test2, coxhaz(Surv(t1, t2, state), id=id, risk=mrisk4))
> aeq(check4$cumhaz, csurv4$cumhaz[indx3,1,])
[1] TRUE
> aeq(check4$pstate, csurv4$pstate[indx3,1,])
[1] TRUE
> aeq(csurv4$cumhaz[,2,], csurv4$cumhaz[,1,] %*% diag(1:6))
[1] TRUE
> 
> 
> # Check the stype=1 option
> csurv4b <- survfit(cox4, newdata= data.frame(x=0:1), stype=1)
> check4b <- with(test2, coxhaz(Surv(t1, t2, state), id=id, risk=mrisk4, 
+                               expm=FALSE))
> aeq(check4b$cumhaz, csurv4b$cumhaz[indx3,1,])
[1] TRUE
> aeq(check4b$pstate, csurv4b$pstate[indx3,1,])
[1] TRUE
> 
> proc.time()
   user  system elapsed 
   0.95    0.17    1.06