R version 4.4.0 beta (2024-04-15 r86425 ucrt) -- "Puppy Cup" Copyright (C) 2024 The R Foundation for Statistical Computing Platform: x86_64-w64-mingw32/x64 R is free software and comes with ABSOLUTELY NO WARRANTY. You are welcome to redistribute it under certain conditions. Type 'license()' or 'licence()' for distribution details. R is a collaborative project with many contributors. Type 'contributors()' for more information and 'citation()' on how to cite R or R packages in publications. Type 'demo()' for some demos, 'help()' for on-line help, or 'help.start()' for an HTML browser interface to help. Type 'q()' to quit R. > options(na.action=na.exclude) # preserve missings > options(contrasts=c('contr.treatment', 'contr.poly')) #ensure constrast type > library(survival) > > # Tests using the rats data > # > # (Female rats, from Mantel et al, Cancer Research 37, > # 3863-3868, November 77) > > rfit <- coxph(Surv(time,status) ~ rx + frailty(litter), rats, + method='breslow', subset= (sex=='f')) > rfit Call: coxph(formula = Surv(time, status) ~ rx + frailty(litter), data = rats, subset = (sex == "f"), method = "breslow") coef se(coef) se2 Chisq DF p rx 0.906 0.323 0.319 7.882 1.0 0.005 frailty(litter) 16.888 13.8 0.253 Iterations: 6 outer, 25 Newton-Raphson Variance of random effect= 0.474 I-likelihood = -181.1 Degrees of freedom for terms= 1.0 13.9 Likelihood ratio test=36.3 on 14.8 df, p=0.001 n= 150, number of events= 40 > > rfit$iter [1] 6 25 > rfit$df [1] 0.975943 13.854864 > rfit$history[[1]] $theta [1] 0.4742849 $done c.loglik TRUE $history theta loglik c.loglik [1,] 0.0000000 -181.8451 -181.8451 [2,] 1.0000000 -168.3683 -181.5458 [3,] 0.5000000 -173.3117 -181.0788 [4,] 0.3090061 -175.9446 -181.1490 [5,] 0.4645720 -173.7590 -181.0775 [6,] 0.4736210 -173.6431 -181.0773 $c.loglik [1] -181.0773 > > rfit1 <- coxph(Surv(time,status) ~ rx + frailty(litter, theta=1), rats, + method='breslow', subset=(sex=="f")) > rfit1 Call: coxph(formula = Surv(time, status) ~ rx + frailty(litter, theta = 1), data = rats, subset = (sex == "f"), method = "breslow") coef se(coef) se2 Chisq DF p rx 0.918 0.327 0.321 7.851 1.0 0.0051 frailty(litter, theta = 1 27.245 22.7 0.2324 Iterations: 1 outer, 6 Newton-Raphson Variance of random effect= 1 I-likelihood = -181.5 Degrees of freedom for terms= 1.0 22.7 Likelihood ratio test=50.7 on 23.7 df, p=0.001 n= 150, number of events= 40 > > rfit2 <- coxph(Surv(time,status) ~ frailty(litter), rats, subset=(sex=='f')) > rfit2 Call: coxph(formula = Surv(time, status) ~ frailty(litter), data = rats, subset = (sex == "f")) coef se(coef) se2 Chisq DF p frailty(litter) 18 14.6 0.24 Iterations: 6 outer, 22 Newton-Raphson Variance of random effect= 0.504 I-likelihood = -184.8 Degrees of freedom for terms= 14.6 Likelihood ratio test=30 on 14.6 df, p=0.01 n= 150, number of events= 40 > > proc.time() user system elapsed 1.00 0.07 1.06