# A short test on coxph.detail, to ensure that the computed hazard is # equal to the theoretical value library(survival) aeq <- function(a,b) all.equal(as.vector(a), as.vector(b)) # taken from book4.R test2 <- data.frame(start=c(1, 2, 5, 2, 1, 7, 3, 4, 8, 8), stop =c(2, 3, 6, 7, 8, 9, 9, 9,14,17), event=c(1, 1, 1, 1, 1, 1, 1, 0, 0, 0), x =c(1, 0, 0, 1, 0, 1, 1, 1, 0, 0) ) byhand <- function(beta, newx=0) { r <- exp(beta) loglik <- 4*beta - (log(r+1) + log(r+2) + 2*log(3*r+2) + 2*log(3*r+1) + log(2*r +2)) u <- 1/(r+1) + 1/(3*r+1) + 2*(1/(3*r+2) + 1/(2*r+2)) - ( r/(r+2) +3*r/(3*r+2) + 3*r/(3*r+1)) imat <- r*(1/(r+1)^2 + 2/(r+2)^2 + 6/(3*r+2)^2 + 6/(3*r+1)^2 + 6/(3*r+2)^2 + 4/(2*r +2)^2) hazard <-c( 1/(r+1), 1/(r+2), 1/(3*r+2), 1/(3*r+1), 1/(3*r+1), 1/(3*r+2), 1/(2*r +2) ) # The matrix of weights, one row per obs, one col per time # deaths at 2,3,6,7,8,9 wtmat <- matrix(c(1,0,0,0,1, 0, 0,0,0,0, 0,1,0,1,1, 0, 0,0,0,0, 0,0,1,1,1, 0, 1,1,0,0, 0,0,0,1,1, 0, 1,1,0,0, 0,0,0,0,1, 1, 1,1,0,0, 0,0,0,0,0, 1, 1,1,1,1, 0,0,0,0,0,.5,.5,1,1,1), ncol=7) wtmat <- diag(c(r,1,1,r,1,r,r,r,1,1)) %*% wtmat x <- c(1,0,0,1,0,1,1,1,0,0) status <- c(1,1,1,1,1,1,1,0,0,0) xbar <- colSums(wtmat*x)/ colSums(wtmat) n <- length(x) # Table of sums for score and Schoenfeld resids hazmat <- wtmat %*% diag(hazard) #each subject's hazard over time dM <- -hazmat #Expected part for (i in 1:5) dM[i,i] <- dM[i,i] +1 #observed dM[6:7,6:7] <- dM[6:7,6:7] +.5 # observed mart <- rowSums(dM) # Table of sums for score and Schoenfeld resids # Looks like the last table of appendix E.2.1 of the book resid <- dM * outer(x, xbar, '-') score <- rowSums(resid) scho <- colSums(resid) # We need to add the ties back up (they are symmetric) scho[6:7] <- rep(mean(scho[6:7]), 2) list(loglik=loglik, u=u, imat=imat, xbar=xbar, haz=hazard* exp(beta*newx), mart=mart, score=score, rmat=resid, scho=scho) } # The actual coefficient of the fit is close to zero. Using a larger # number pushes the test harder, but it should still work without # the init and iter arguments, i.e., for any coefficient. fit1 <- coxph(Surv(start, stop, event) ~x, test2,init=-1, iter=0) temp <- coxph.detail(fit1) temp2 <- byhand(fit1$coef, fit1$means) aeq(temp$haz, c(temp2$haz[1:5], sum(temp2$haz[6:7])))