library(survival) # Strata by covariate interactions, a case pointed out in early 2011 # by Frank Harrell, which as it turns out had never been computed # correctly by any version of the package. Which shows how often this # case arises in practice. # aeq <- function(x, y, ...) all.equal(as.vector(x), as.vector(y)) fit1 <- coxph(Surv(time, status) ~ wt.loss + age*strata(sex) + strata(ph.ecog), data=lung) tdata <- data.frame(wt.loss=c(10,5,0,10, 15,20,25), age =c(50,60,50,60,70,40,21), sex =c(1,1,2,2,1,1,1), ph.ecog=c(0,0,1,1,2,2,2)) surv1 <- survfit(fit1, newdata=tdata) fit2 <- coxph(Surv(time, status) ~ wt.loss + age + I(age*0), data=lung, init=fit1$coef, iter=0, subset=(sex==1 & ph.ecog==0)) fit2$var <- fit1$var surv2 <- survfit(fit2, newdata=list(wt.loss=c(10,5), age=c(50,60))) s1 <- surv1[1:2] aeq(s1$surv, surv2$surv) #first a vector, second a matrix aeq(s1$std.err, surv2$std.err) aeq(s1[1]$time, surv2$time) aeq(s1[1]$n.event, surv2$n.event) fit3 <- coxph(Surv(time, status) ~ wt.loss + age + I(age*1), data=lung, init=fit1$coef, iter=0, subset=(sex==2 & ph.ecog==1)) fit3$var <- fit1$var surv3 <- survfit(fit3, newdata=list(wt.loss=c(0,10), age=c(50,60))) aeq(surv1[3:4]$surv, surv3$surv) aeq(surv1[3:4]$std, surv3$std) fit4 <- coxph(Surv(time, status) ~ wt.loss + age + I(age*0), data=lung, init=fit1$coef, iter=0, subset=(sex==1 & ph.ecog==2)) fit4$var <- fit1$var surv4 <- survfit(fit4, newdata=list(wt.loss=c(15,20,25), age=c(70,40,21))) aeq(surv1[5:7]$surv, surv4$surv) aeq(surv1[5:7]$std.err, surv4$std.err) aeq(surv1[5]$n.risk, surv4$n.risk)