library(survival) options(na.action=na.exclude) options(contrasts=c('contr.treatment', 'contr.poly')) #ensure constrast type # # Tests from the appendix of Therneau and Grambsch # Data set 1 + exact method test1 <- data.frame(time= c(9, 3,1,1,6,6,8), status=c(1,NA,1,0,1,1,0), x= c(0, 2,1,1,1,0,0)) byhand7 <- function(beta) { r <- exp(beta) loglik <- 2*(beta - log(3*r + 3)) u <- 2/(r+1) imat <- 2*r/(r+1)^2 haz <- c(1/(3*r+3), 2/(r+3), 0, 1 ) ties <- c(1,1,2,2,3,4) wt <- c(r,r,r,1,1,1) mart <- c(1,0,1,1,0,1) - wt* (cumsum(haz))[ties] #martingale residual list(loglik=loglik, u=u, imat=imat, mart=mart) } aeq <- function(x,y) all.equal(as.vector(x), as.vector(y)) fit0 <-coxph(Surv(time, status) ~x, test1, iter=0, method='exact') truth0 <- byhand7(0) aeq(truth0$loglik, fit0$loglik[1]) aeq(1/truth0$imat, fit0$var) aeq(truth0$mart, fit0$resid[c(2:6,1)]) fit1 <- coxph(Surv(time, status) ~x, test1, iter=1, method='exact') aeq(fit1$coef, truth0$u*fit0$var) truth1 <- byhand7(fit1$coef) aeq(fit1$loglik[2], truth1$loglik) aeq(1/truth1$imat, fit1$var) aeq(truth1$mart, resid(fit1)[c(3:7,1)]) # Beta is infinite for this model, so we will get a warning message fit2 <- coxph(Surv(time, status) ~x, test1, method='exact') aeq(resid(fit2)[-2], c(0, 2/3, -1/3, -4/3, 1, 0)) #values from the book # # Now a multivariate case: start/stop data uses a different C routine # zz <- rep(0, nrow(lung)) fit1 <- coxph(Surv(time, status) ~ age + ph.ecog + sex, lung, method="exact") fit2 <- coxph(Surv(zz, time, status) ~ age + ph.ecog + sex, lung, method="exact") aeq(fit1$loglik, fit2$loglik) aeq(fit1$var, fit2$var) aeq(fit1$score, fit2$score) aeq(fit1$resid, fit2$resid)