test_that("functions that use data.table still return a data frame", { class_expected <- "data.frame" # counting_process() x <- data.frame( stratum = c(rep(1, 10), rep(2, 6)), treatment = rep(c(1, 1, 0, 0), 4), tte = 1:16, event = rep(c(0, 1), 8) ) expect_identical(class(counting_process(x, arm = 1)), c("counting_process", class_expected)) # cut_data_by_date() x <- sim_pw_surv(n = 20) expect_identical(class(cut_data_by_date(x, 5)), c("tte_data", class_expected)) # early_zero_weight() x <- sim_pw_surv(n = 200) x <- cut_data_by_event(x, 125) x <- counting_process(x, arm = "experimental") expect_identical(class(early_zero_weight(x, early_period = 2)), class_expected) # fh_weight() expect_identical(class(fh_weight()), c("counting_process", class_expected)) # mb_weight() x <- sim_pw_surv() x <- cut_data_by_event(x, 125) x <- counting_process(x, arm = "experimental") expect_identical(class(mb_weight(x)), class_expected) # sim_fixed_n() expect_identical(class(sim_fixed_n(n_sim = 1)), class_expected) # sim_pw_surv() expect_identical(class(sim_pw_surv(n = 1)), class_expected) # to_sim_pw_surv() output <- to_sim_pw_surv() expect_identical(class(output$fail_rate), class_expected) expect_identical(class(output$dropout_rate), class_expected) }) # simtrial functions accept any object that inherits "data.frame", eg tibble # and data.table. These tests ensure that data.table-enabled functions make a # copy instead of modifying the input object by reference test_that("functions that use data.table do not modify input data table", { skip_if_not_installed("gsDesign2") # confirm that tests can detect a data table that is modified by reference modify_by_reference <- function(x) { data.table::setDT(x) data.table::set(x, i = 1L, j = "second", value = 2) return(x[]) } x <- data.table::data.table(first = 1) x_original <- data.table::copy(x) y <- modify_by_reference(x) expect_identical(x, y) expect_false(identical(x, x_original)) # counting_process() x <- data.table::data.table( stratum = c(rep(1, 10), rep(2, 6)), treatment = rep(c(1, 1, 0, 0), 4), tte = 1:16, event = rep(c(0, 1), 8) ) x_original <- data.table::copy(x) counting_process(x, arm = 1) expect_identical(x, x_original) # cut_data_by_date() x <- sim_pw_surv(n = 20) data.table::setDT(x) x_original <- data.table::copy(x) cut_data_by_date(x, 5) expect_identical(x, x_original) # early_zero_weight() x <- sim_pw_surv(n = 200) x <- cut_data_by_event(x, 125) x <- counting_process(x, arm = "experimental") data.table::setDT(x) x_original <- data.table::copy(x) early_zero_weight(x, early_period = 2) expect_identical(x, x_original) # stratified # Example 2: Stratified n <- 500 # Two strata stratum <- c("Biomarker-positive", "Biomarker-negative") prevalence_ratio <- c(0.6, 0.4) # Enrollment rate enroll_rate <- gsDesign2::define_enroll_rate( stratum = rep(stratum, each = 2), duration = c(2, 10, 2, 10), rate = c(c(1, 4) * prevalence_ratio[1], c(1, 4) * prevalence_ratio[2]) ) enroll_rate$rate <- enroll_rate$rate * n / sum(enroll_rate$duration * enroll_rate$rate) # Failure rate med_pos <- 10 # Median of the biomarker positive population med_neg <- 8 # Median of the biomarker negative population hr_pos <- c(1, 0.7) # Hazard ratio of the biomarker positive population hr_neg <- c(1, 0.8) # Hazard ratio of the biomarker negative population fail_rate <- gsDesign2::define_fail_rate( stratum = rep(stratum, each = 2), duration = c(3, 1000, 4, 1000), fail_rate = c(log(2) / c(med_pos, med_pos, med_neg, med_neg)), hr = c(hr_pos, hr_neg), dropout_rate = 0.01 ) # Simulate data temp <- to_sim_pw_surv(fail_rate) # Convert the failure rate set.seed(2023) x <- sim_pw_surv( n = n, # Sample size # Stratified design with prevalence ratio of 6:4 stratum = data.frame(stratum = stratum, p = prevalence_ratio), # Randomization ratio block = c("control", "control", "experimental", "experimental"), enroll_rate = enroll_rate, # Enrollment rate fail_rate = temp$fail_rate, # Failure rate dropout_rate = temp$dropout_rate # Dropout rate ) x <- cut_data_by_event(x, 125) x <- counting_process(x, arm = "experimental") data.table::setDT(x) x_original <- data.table::copy(x) data.table::setDT(fail_rate) fail_rate_original <- data.table::copy(fail_rate) early_zero_weight(x, early_period = 2, fail_rate = fail_rate) expect_identical(x, x_original) expect_identical(fail_rate, fail_rate_original) # fh_weight() x <- sim_pw_surv() x <- cut_data_by_event(x, 125) x <- counting_process(x, arm = "experimental") data.table::setDT(x) x_original <- data.table::copy(x) fh_weight(x) expect_identical(x, x_original) # get_analysis_date() x <- sim_pw_surv(n = 5) data.table::setDT(x) x_original <- data.table::copy(x) get_analysis_date(x, planned_calendar_time = 1) expect_identical(x, x_original) # get_cut_date_by_event() x <- sim_pw_surv(n = 5) data.table::setDT(x) x_original <- data.table::copy(x) get_cut_date_by_event(x, event = 1) expect_identical(x, x_original) # mb_weight() x <- sim_pw_surv() x <- cut_data_by_event(x, 125) x <- counting_process(x, arm = "experimental") data.table::setDT(x) x_original <- data.table::copy(x) mb_weight(x) expect_identical(x, x_original) # rpwexp_enroll() enroll_rate <- data.table::data.table( rate = c(5, 15, 30), duration = c(100, 200, 100) ) data.table::setDT(enroll_rate) enroll_rate_original <- data.table::copy(enroll_rate) rpwexp_enroll(n = 10, enroll_rate = enroll_rate) expect_identical(enroll_rate, enroll_rate_original) # sim_fixed_n() stratum <- data.table::data.table(stratum = "All", p = 1) enroll_rate <- data.table::data.table(duration = c(2, 2, 10), rate = c(3, 6, 9)) fail_rate <- data.table::data.table( stratum = "All", duration = c(3, 100), fail_rate = log(2) / c(9, 18), hr = c(0.9, 0.6), dropout_rate = rep(0.001, 2) ) data.table::setDT(stratum) stratum_original <- data.table::copy(stratum) data.table::setDT(enroll_rate) enroll_rate_original <- data.table::copy(enroll_rate) data.table::setDT(fail_rate) fail_rate_original <- data.table::copy(fail_rate) sim_fixed_n( n_sim = 1, stratum = stratum, enroll_rate = enroll_rate, fail_rate = fail_rate ) expect_identical(stratum, stratum_original) expect_identical(enroll_rate, enroll_rate_original) expect_identical(fail_rate, fail_rate_original) # sim_pw_surv() stratum <- data.table::data.table(stratum = "All", p = 1) enroll_rate <- data.table::data.table(rate = 9, duration = 1) fail_rate <- data.table::data.table( stratum = rep("All", 4), period = rep(1:2, 2), treatment = c(rep("control", 2), rep("experimental", 2)), duration = rep(c(3, 1), 2), rate = log(2) / c(9, 9, 9, 18) ) dropout_rate <- data.table::data.table( stratum = rep("All", 2), period = rep(1, 2), treatment = c("control", "experimental"), duration = rep(100, 2), rate = rep(0.001, 2) ) data.table::setDT(stratum) stratum_original <- data.table::copy(stratum) data.table::setDT(enroll_rate) enroll_rate_original <- data.table::copy(enroll_rate) data.table::setDT(fail_rate) fail_rate_original <- data.table::copy(fail_rate) data.table::setDT(dropout_rate) dropout_rate_original <- data.table::copy(dropout_rate) sim_pw_surv( n = 1, stratum = stratum, enroll_rate = enroll_rate, fail_rate = fail_rate, dropout_rate = dropout_rate ) expect_identical(stratum, stratum_original) expect_identical(enroll_rate, enroll_rate_original) expect_identical(fail_rate, fail_rate_original) expect_identical(dropout_rate, dropout_rate_original) # to_sim_pw_surv() fail_rate <- data.table::data.table( stratum = "All", duration = c(3, 100), fail_rate = log(2) / c(9, 18), hr = c(0.9, 0.6), dropout_rate = rep(0.001, 2) ) data.table::setDT(fail_rate) fail_rate_original <- data.table::copy(fail_rate) to_sim_pw_surv(fail_rate = fail_rate) expect_identical(fail_rate, fail_rate_original) })