test_that("et import rate=-2", { d <- data.frame(id = c(1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1), time = c(0, 2, 12.5, 24.5, 37, 48, 60.5, 72.5, 85.3, 96.5, 108.5, 112.5), amt = c(25, 0, 3.5, 3.5, 3.5, 3.5, 3.5, 3.5, 3.5, 3.5, 3.5, 0), rate = c(-2, 0, -2, -2, -2, -2, -2, -2, -2, -2, -2, 0)) d2 <- as.data.frame(et(d)) expect_equal(d2$rate, c(-2, NA_real_, -2, -2, -2, -2, -2, -2, -2, -2, -2, NA_real_)) }) for (radi in c(1, 2)) { forderForceBase(switch(radi, TRUE, FALSE )) radix <- switch(radi, "base::order", "data.table::forder" ) # context(sprintf("Test event Table et(...) sort:%s", radix)) et <- et() test_that("Empty event table check", { ## expect_s3_class(et$env,"rxHidden") expect_equal(et$nobs, 0L) expect_equal(et$ndose, 0L) expect_equal(et$get.EventTable(), NULL) expect_equal(et$get.dosing(), NULL) expect_equal(et$get.sampling(), NULL) }) et <- et(1:10) test_that("10 sample items", { expect_equal(et$nobs, 10L) expect_equal(et$ndose, 0L) expect_s3_class(et$get.EventTable(), "data.frame") expect_true(is(et, "rxEt")) expect_false(et$show["id"]) expect_false(et$show["cmt"]) expect_equal(et$get.dosing(), NULL) expect_equal(length(et$get.sampling()$time), 10) }) et <- et(1:10, "matt") test_that("compartment check", { expect_equal(et$nobs, 10L) expect_equal(et$ndose, 0L) expect_s3_class(et$get.EventTable(), "data.frame") expect_true(is(et, "rxEt")) expect_false(et$show["id"]) expect_true(et$show["cmt"]) expect_equal(et$get.dosing(), NULL) expect_equal(length(et$get.sampling()$time), 10) }) et <- et(1:10, cmt = 1) test_that("compartment check", { expect_equal(et$nobs, 10L) expect_equal(et$ndose, 0L) expect_s3_class(et$get.EventTable(), "data.frame") expect_true(is(et, "rxEt")) expect_false(et$show["id"]) expect_true(et$show["cmt"]) expect_equal(et$get.dosing(), NULL) expect_equal(length(et$get.sampling()$time), 10) expect_true(all(et$cmt == 1L)) }) et1 <- et(1:10, id = 1:10) test_that("Observation only table check", { expect_equal(et1$nobs, 100L) expect_equal(et1$ndose, 0L) expect_s3_class(et1$get.EventTable(), "data.frame") expect_true(is(et1, "rxEt")) expect_true(et1$show["id"]) expect_false(et1$show["cmt"]) expect_equal(et1$get.dosing(), NULL) expect_equal(length(et1$get.sampling()$time), 100) }) ## now resize down et2 <- et1 %>% et(id = -(2:10)) test_that("compartment check", { expect_equal(et2$nobs, 10L) expect_equal(et2$ndose, 0L) expect_s3_class(et2$get.EventTable(), "data.frame") expect_true(is(et, "rxEt")) expect_true(et2$show["id"]) expect_false(et2$show["cmt"]) expect_equal(et2$get.dosing(), NULL) expect_equal(length(et2$get.sampling()$time), 10) }) ## now resize back up et3 <- et2 %>% et(id = 1:10) test_that("Using simulate with et without windows will warn", { f1 <- as.data.frame(et3) f2 <- suppressWarnings({ as.data.frame(simulate(et3)) }) expect_equal(f1$time, f2$time) expect_warning(simulate(et3)) }) eti <- et(amt = 10) %>% et(id = 2:3) eti1 <- et(amt = 10, id = 3:4) eti2 <- et(amt = 10, id = 3) eti3 <- et(10, id = 3:4) eti4 <- et(10, id = 3) eti5 <- et(10) %>% et(id = 2:3) eti6 <- et(amt = 10) %>% et(id = 2) eti7 <- et(10) %>% et(id = 2) eti8 <- et(10, id = 1) eti9 <- et(10) %>% et(id = 1) eti10 <- et(amt = 10, id = 1) eti11 <- et(amt = 10) %>% et(id = 1) ## Now look at windows eti12 <- et(list(c(10, 11)), id = 1) eti13 <- et(list(c(10, 11))) %>% et(id = 1) eti14 <- et(list(c(10, 11)), amt = 10, id = 1) eti15 <- et(list(c(10, 11)), amt = 10) %>% et(id = 1) eti16 <- et(list(c(10, 11)), id = 2) eti17 <- et(list(c(10, 11))) %>% et(id = 2) eti18 <- et(list(c(10, 11)), amt = 10, id = 2) eti19 <- et(list(c(10, 11)), amt = 10) %>% et(id = 2) eti20 <- et(list(c(10, 11)), id = 2:3) eti21 <- et(list(c(10, 11))) %>% et(id = 2:3) eti22 <- et(list(c(10, 11)), amt = 10, id = 2:3) eti23 <- et(list(c(10, 11)), amt = 10) %>% et(id = 2:3) ## Now do it with dosing/sampling windows test_that("Make sure that et only has IDs 2 and 3.", { expect_equal(eti$id, 2:3) expect_equal(eti1$id, 3:4) expect_equal(eti2$id, 3) expect_equal(eti3$id, 3:4) expect_equal(eti4$id, 3) expect_equal(eti5$id, 2:3) expect_equal(eti6$id, 2) expect_equal(eti7$id, 2) expect_equal(eti8$id, 1) expect_true(eti8$env$show["id"]) expect_equal(eti9$id, 1) expect_true(eti9$env$show["id"]) expect_equal(eti10$id, 1) expect_true(eti10$env$show["id"]) expect_equal(eti11$id, 1) expect_true(eti11$env$show["id"]) expect_equal(eti12$id, 1) expect_true(eti12$env$show["id"]) expect_equal(eti13$id, 1) expect_true(eti13$env$show["id"]) expect_equal(eti14$id, 1) expect_true(eti14$env$show["id"]) expect_equal(eti15$id, 1) expect_true(eti15$env$show["id"]) expect_equal(eti16$id, 2) expect_true(eti16$env$show["id"]) expect_equal(eti17$id, 2) expect_true(eti17$env$show["id"]) expect_equal(eti18$id, 2) expect_true(eti18$env$show["id"]) expect_equal(eti19$id, 2) expect_true(eti19$env$show["id"]) expect_equal(eti20$id, 2:3) expect_true(eti20$env$show["id"]) expect_equal(eti21$id, 2:3) expect_true(eti21$env$show["id"]) expect_equal(eti22$id, 2:3) expect_true(eti22$env$show["id"]) expect_equal(eti23$id, 2:3) expect_true(eti23$env$show["id"]) }) test_that("Observation only table check", { expect_equal(et1$nobs, 100L) expect_equal(et1$ndose, 0L) expect_s3_class(et1$get.EventTable(), "data.frame") expect_true(is(et1, "rxEt")) expect_true(et1$show["id"]) expect_false(et1$show["cmt"]) expect_equal(et1$get.dosing(), NULL) expect_equal(length(et1$get.sampling()$time), 100) }) ## Check adding different units of time, rate, amt work test_that("units tests", { skip_if_not_installed("units") ## Make sure units are right. et3 <- et3 %>% units::set_units(mg) e <- et(amount.units = "mg", time_units = "hr") %>% add.sampling(seq(0, 24, by = 3)) %>% add.dosing(1, 3) %>% et(rate = 3, amt = 2, time = 120) e2 <- e %>% et(amt = units::set_units(0.0003, "lb"), time = 0.5) expect_equal(e2$amt[e2$time == units::set_units(0.5, hr)], units::set_units(units::set_units(0.0003, lb), mg)) e2 <- e %>% et(units::set_units(30, min)) expect_true(any(e2$time == units::set_units(0.5, hr))) e2 <- e %>% et(time = 0.25, rate = units::set_units(30, ug / min), amt = units::set_units(4, ug)) tmp <- e2[e2$time == units::set_units(0.25, hr), ] expect_equal(units::set_units(1.8, mg / h), tmp$rate) expect_equal(units::set_units(0.004, mg), tmp$amt) e2 <- e %>% et(time = 0.25, ii = units::set_units(30, min), amt = 4, addl = 4) expect_equal(e2$ii[e2$time == units::set_units(0.25, hr)], units::set_units(0.5, hr)) ## Check importing wrong different ii and time units as well as different rate units work. e <- et(amount.units = "mg", time_units = "hr") %>% add.sampling(seq(0, 24, by = 3)) %>% add.dosing(1, 3) %>% et(rate = 3, amt = 2, time = 120) etDf <- as.data.frame(e) etDf$rate <- units::set_units(etDf$rate, ug / s) etDf$ii <- units::set_units(etDf$ii, min) et <- et() et$import.EventTable(etDf) expect_equal(et$ii, e$ii) expect_equal(et$rate, e$rate) }) test_that("seq works with wait", { e1 <- et(amt = 100, ii = 24, addl = 6) e2 <- et(amt = 200, ii = 24, addl = 6) e3 <- seq(e1, e2, e1) e4 <- seq(e1, wait = 72, e2, wait = 72, e1) %>% as.data.frame() expect_equal(structure(list( time = c(0, 216, 432), amt = c(100, 200, 100), ii = c(24, 24, 24), addl = c(6L, 6L, 6L), evid = c(1L, 1L, 1L) ), class = "data.frame", row.names = c(NA, -3L) ), e4) e5 <- etSeq(e1, wait = 72, e2, wait = 72, e1, waitII = "+ii") %>% as.data.frame() expect_equal(structure(list( time = c(0, 240, 480), amt = c(100, 200, 100), ii = c(24, 24, 24), addl = c(6L, 6L, 6L), evid = c(1L, 1L, 1L) ), class = "data.frame", row.names = c(NA, -3L) ), e5) e1 <- et(amt = 500) e2 <- et(amt = 250, ii = 24, addl = 4) expect_equal( structure(list( time = c(0, 24), amt = c(500, 250), ii = c(0, 24), addl = c(0L, 4L), evid = c(1L, 1L) ), class = "data.frame", row.names = c(NA, -2L) ), c(e1, e2) %>% as.data.frame() ) expect_equal( structure(list( time = c(0, 120, 144), amt = c(250, 500, 250), ii = c(24, 0, 24), addl = c(4L, 0L, 4L), evid = c(1L, 1L, 1L) ), class = "data.frame", row.names = c(NA, -3L) ), c(e2, e1, e2) %>% as.data.frame() ) e3 <- et(amt = 200) expect_warning(c(e1, e3)) e4 <- suppressWarnings(c(e1, e3) %>% as.data.frame()) expect_equal( structure(list( time = c(0, 24), amt = c(500, 200), ii = c(0, 0), addl = c(0L, 0L), evid = c(1L, 1L) ), class = "data.frame", row.names = c(NA, -2L) ), e4 ) e4 <- suppressWarnings(c(e1, e3, ii = 12) %>% as.data.frame()) expect_equal( structure(list( time = c(0, 12), amt = c(500, 200), ii = c(0, 0), addl = c(0L, 0L), evid = c(1L, 1L) ), class = "data.frame", row.names = c(NA, -2L) ), e4 ) e1 <- et(amt = 100, ii = 24, addl = 6) %>% et(seq(0, 2 * 168, by = 0.1)) e2 <- c(e1, e1, samples = "use") expect_equal(range(e2$time), c(0, 672)) ## combine without changing, use rbind e1 <- et(amt = 100, ii = 24, addl = 6, ID = 1:5) e2 <- et(amt = 50, ii = 12, addl = 13, ID = 1:3) e3 <- et(amt = 200, ii = 24, addl = 2, ID = 1:2) e4 <- rbind(e1, e2, e3) expect_equal( e4 %>% dplyr::select(id, time, amt, ii, addl) %>% as.data.frame(), structure(list( id = c(1L, 1L, 1L, 2L, 2L, 2L, 3L, 3L, 4L, 5L), time = c(0, 0, 0, 0, 0, 0, 0, 0, 0, 0), amt = c(100, 50, 200, 100, 50, 200, 100, 50, 100, 100), ii = c(24, 12, 24, 24, 12, 24, 24, 12, 24, 24), addl = c(6L, 13L, 2L, 6L, 13L, 2L, 6L, 13L, 6L, 6L) ), class = "data.frame", row.names = c(NA, -10L) ) ) e4 <- rbind(e1, e2, e3, id = "unique") expect_equal( e4 %>% dplyr::select(id, time, amt, ii, addl) %>% as.data.frame(), structure(list( id = 1:10, time = c(0, 0, 0, 0, 0, 0, 0, 0, 0, 0), amt = c(100, 100, 100, 100, 100, 50, 50, 50, 200, 200), ii = c(24, 24, 24, 24, 24, 12, 12, 12, 24, 24), addl = c(6L, 6L, 6L, 6L, 6L, 13L, 13L, 13L, 2L, 2L) ), class = "data.frame", row.names = c(NA, -10L) ) ) }) ## FIXME test windows and dur test_that("no ii throws an error with addl", { expect_error(et(c(11, 13), amt = 10, addl = 3)) }) ## Test Windows et <- et(list( c(0, 1), c(1, 4), c(4, 8), c(8, 12), c(12, 24) )) %>% et(amt = 10) %>% et(c(11, 13), amt = 10, addl = 3, ii = 12) test_that("Using simulate with et works and gives a different data frame", { et2 <- as.data.frame(simulate(et)) et1 <- as.data.frame(et) expect_false(all(et1$time == et2$time)) et3 <- as.data.frame(et) expect_true(all(et1$time == et3$time)) et$simulate() et3 <- as.data.frame(et) expect_false(all(et1$time == et3$time)) }) test_that("Low/High middle tests; i.e windows", { et2 <- et[which(!is.na(et$low)), ] expect_true(et$show["low"]) expect_true(et$show["high"]) expect_true(all(et2$time < et2$high)) expect_true(all(et2$time > et2$low)) }) et <- et(list( c(0, 1), c(1, 4), c(4, 8), c(8, 12), c(12, 24) ), cmt = 1) %>% et(amt = 10) %>% et(c(11, 13), amt = 10, addl = 3, ii = 12) test_that("Low/High middle tests; i.e windows", { et2 <- et[which(!is.na(et$low)), ] expect_true(et$show["low"]) expect_true(et$show["high"]) expect_true(all(et2$time < et2$high)) expect_true(all(et2$time > et2$low)) }) test_that("Window Errors", { expect_error(et(list(c(1, 0)))) expect_error(et(list(c(0, 1, 2)))) }) test_that("until is inclusive", { expect_equal(et(amt = 1, time = 50, until = 57.5, ii = 1.5)$addl, 5) expect_equal(et(amt = 1, time = 50, until = 57.49999, ii = 1.5)$addl, 4) expect_equal(et(amt = 1, time = 50, until = 57.50001, ii = 1.5)$addl, 5) }) test_that("et expected errors", { expect_error(et(list(c(2, 1), c(3, 4)), amt = 3)) expect_error(et(list(c(1, 2), 3, c(1, 2, 3)), amt = 3)) expect_error(et(list(c(1, 2), 3, TRUE), amt = 3)) }) test_that("et steady state constant infusion", { expect_error(et(amt = 0, rate = 10, ii = 0, ss = 2)) expect_error(et(amt = 0, rate = 10, ii = 2, ss = 1)) expect_error(et(amt = 0, rate = -2, ii = 0, ss = 1)) expect_error(et(rate = 10, ii = 0, ss = 2)) expect_error(et(rate = 10, ii = 2, ss = 1)) expect_error(et(rate = -2, ii = 0, ss = 1)) t1 <- et(amt = 0, rate = 10, ii = 0, ss = 1) %>% as.data.frame() t2 <- et(rate = 10, ii = 0, ss = 1) %>% as.data.frame() expect_equal(t1, t2) t1 <- et(amt = 0, rate = -1, ii = 0, ss = 1) %>% as.data.frame() t2 <- et(rate = -1, ii = 0, ss = 1) %>% as.data.frame() expect_equal(t1, t2) }) test_that("et addl expand", { ev <- et(amt = 3, ii = 24, until = 120) tmp <- etExpand(ev) expect_equal(ev$amt, 3) expect_equal(tmp$time, c(0, 24, 48, 72, 96, 120)) ev$expand() expect_equal(ev$time, c(0, 24, 48, 72, 96, 120)) }) ev2 <- et(amt = 3, ii = 24, until = 120) %>% et(amt = 3, rate = 7) test_that("data.frame conversion", { tmp <- data.frame(ev2) expect_equal(names(tmp), c("time", "amt", "rate", "ii", "addl", "evid")) expect_false(inherits(tmp$rate, "rxRateDur")) expect_false(inherits(tmp$evid, "rxEvid")) }) test_that("tibble conversion", { tmp <- tibble::as_tibble(ev2) expect_equal(names(tmp), c("time", "amt", "rate", "ii", "addl", "evid")) expect_false(inherits(tmp$rate, "rxRateDur")) expect_false(inherits(tmp$evid, "rxEvid")) }) } test_that("seq() args work; see #97", { et1 <- et() %>% add.sampling(seq(0, 24, by = 3)) et2 <- et(from = 0, to = 24, by = 3) expect_equal(et1$time, et2$time) }) test_that("errors", { expect_error(et(ii = 12, dosing.interval = 14)) expect_error(et(dose = 4, amt = 3)) expect_error(et(cmt = 1, dosing.to = 3)) expect_error(et(cmt = 1, dose.to = 3)) expect_error(et(cmt = 1, state = 3)) expect_error(et(amt.units = "mg", dose.units = "mg")) expect_error(et(time.units = "mg", timeUnits = "mg")) expect_error(et(time = 4, start.time = 5)) expect_error(et(nbr.doses = 4, nbrDoses = 5)) expect_error(et(dur = 4, duration = 5)) }) test_that("dose=0 is OK; see #192", { ev1 <- et(amt = 0, time = 10) ev2 <- eventTable() ev2$add.dosing(dose = 0, start.time = 10) expect_equal(as.data.frame(ev1), as.data.frame(ev2)) }) test_that("Issue #236 math in to/from", { expect_error(et(from = 0, to = 168 * 2 * 6, length.out = 168 * 2 * 6 + 1), NA) }) test_that("Issue #257 numeric cmt vectorized", { ds4 <- c(1, 2, 3, 4) rate <- c(1.5, 2.5, 3.5, 4.5) expect_error(et() %>% et(amt = ds4, rate = rate, cmt = 4), NA) }) test_that("etRep #313", { skip_if_not_installed("units") sch1 <- et(timeUnits = "hr") %>% et(amt = 100, ii = 24, until = units::set_units(2, "days")) toto <- rep(sch1, times = 10, wait = units::set_units(19, "days")) expect_equal(toto$time, seq(0, by = 504, length.out = 10)) sch1 <- et(timeUnits = "hr") %>% et(amt = 100, ii = 24, until = units::set_units(2, "days")) %>% etExpand() toto1 <- etExpand(toto) expect_warning(toto <- rep(sch1, times = 10, wait = units::set_units(19, "days"))) }) test_that("'by' and 'length.out'", { expect_error(et(0, 3, by = 0.5, length.out = 3)) }) test_that("'amt' and 'time' have different values", { expect_error(et(amt = c(1, 2), time = c(1, 3, 4))) }) test_that("'time' with invalid list", { expect_error(et(time = list(1, 2, 3))) }) test_that("'is' for rxode2 event tables are 'rxEt'", { ev <- et() expect_true(is(ev, "rxEt")) }) test_that("can use 'evid=0' with time entries", { expect_error(et(amt = 10, cmt = 1, time = 0, evid = 1, id = 1) %>% et(time = c(0, 10, 20), evid = 0), NA) }) test_that("extra doses are not added (nlmixr2/rxode2et#2)", { foo <- et(amt=10, id=1:2) %>% et(time=1, id=2:3) expect_equal( foo$id[!is.na(foo$amt)], 1:2 ) }) test_that("event table id, (rxode2et#4)", { expect_error(et(amt = 10, time = 0, evid = 1, id = 1:5) %>% et(amt = 100, time = 0, evid = 1, id = 6:10) %>% et(amt = 1000, time = 0, evid = 1, id = 11), NA) }) test_that("event table non-zero time", { expect_warning(et(amt=1.153846, ii=24*7*6, until=24*7*6*2) %>% et(amt=1.153846, time=24*7*6*(2+8), ii=24*7*8, until=24*7), "until") }) test_that("event table cmt needs to be evaluated #16", { dosing_df <- data.frame( DOSE = c(0.1, 0.5), CMT = c("A", "B"), TIME = c(0, 0) ) samp_t <- c(0, 0.1, 0.5, 1, 2) # The below should work... but does not sub_df <- dosing_df[1, , drop = T] expect_error(et( amt = sub_df$DOSE, cmt = sub_df$CMT, time = sub_df$TIME, evid = 1, id = 1:5 ) %>% add.sampling(time = samp_t), NA) }) test_that("toTrialDuration works", { trialEnd = 2 ev <- et(data.frame(id = rep(1:2, 3), time = c(13, 14, 13.5, 14.5, 15.3, 16.5))) res <- toTrialDuration(ev, trialEnd = trialEnd, interval = 0.5) expect_setequal(res$time, c(13, 13.5, 14, 14.5, 15, 14, 14.5, 15, 15.5, 16)) }) test_that("Ad issue #23", { cmti <- "Ad" dose_nmol <- 3 dosing <- et(time = 0, amt = dose_nmol, cmt = cmti) expect_equal(dosing$cmt, "Ad") dosing <- et(time = 0, amt = dose_nmol, cmt = cmtj) expect_equal(dosing$cmt, "cmtj") }) test_that("test import with NA time", { e <- et() expect_warning(e$importEventTable(data.frame( ID = "A", TIME = c(738.9333333, NA), CMT = c("depot", "central"), AMT = c(300, NA), EVID = c(1, 0), DOSE = 300, COVAR = 1 ))) }) test_that("another import", { e <- et() expect_warning(e$importEventTable(data.frame(ID = c("A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A131", "A132", "A132", "A132", "A132", "A132", "A132", "A132", "A132", "A132", "A132", "A132", "A132", "A132", "A132", "A132", "A132", "A132", "A132", "A132", "A132", "A132", "A132", "A132", "A132", "A132", "A132", "A132", "A132", "A132", "A132", "A132", "A132", "A132", "A132", "A132", "A132", "A132", "A132", "A132", "A132", "A133", "A133", "A133", "A133", "A133", "A133", "A133", "A133", "A133", "A133", "A133", "A133", "A133", "A133", "A133", "A133", "A133", "A133", "A133", "A133", "A133", "A133", "A133", "A133", "A133", "A133", "A133", "A133", "A133", "A133", "A133", "A133", "A133", "A133", "A133", "A133", "A133", "A133", "A133", "A134", "A134", "A134", "A134", "A134", "A134", "A134", "A134", "A134", "A134", "A134", "A135", "A135", "A135", "A135", "A135", "A135", "A135", "A135", "A135", "A135", "A135", "A135", "A135", "A135", "A135", "A135", "A135", "A135", "A135", "A135", "A135", "A135", "A135", "A135", "A135", "A135", "A135", "A135", "A135", "A135", "A135"), TIME = c(0, 0, 1.3, 1.883333333, 2.766666667, 4.85, 6.883333333, 7.816666667, 23.81666667, 47.81666667, 71.81666667, 95.81666667, 166.2, 166.2, 190.2, 214.2, 238.2, 262.2, 332.3333333, 332.3333333, 332.95, 333.5333333, 334.5333333, 336.5333333, 338.5333333, 339.45, 355.45, 379.45, 403.45, 427.45, 504.3166667, 504.3166667, 528.3166667, 552.3166667, 576.3166667, 672.3166667, 696.3166667, 720.3166667, 744.3166667, 840.3166667, 864.3166667, 888.3166667, 909.5333333, 909.5333333, 910.3666667, 910.8166667, 911.7, 913.45, 915.4, 917, 1009.783333, 1009.783333, 1012.3, 1034.3, 1058.3, 1082.3, 1178.3, 1202.3, 1226.3, 1250.3, 2016.1, 2016.1, 2040.1, 2064.1, 2088.1, 2184.1, 2208.1, 2232.1, 2256.1, 2352.1, 2376.1, 2400.1, 2424.1, 2522.1, 2522.1, 2522.45, 2544.45, 2568.45, 2592.45, 2688.45, 2712.45, 2736.45, 2760.45, 2856.45, 2880.45, 2904.45, 2928.45, 3025.8, 3025.8, 3028.266667, 3050.266667, 3074.266667, 3098.266667, 3194.266667, 3218.266667, 3242.266667, 3266.266667, 0, 0, 0.85, 24.35, 48.35, 72.35, 96.35, 336.35, 360.35, 384.35, 408.35, 432.35, 500.7, 500.7, 503.0166667, 525.0166667, 549.0166667, 573.0166667, 597.0166667, 666.1333333, 666.1333333, 666.9833333, 667.4833333, 668.4833333, 669.9833333, 672.0333333, 673.7, 689.7, 713.7, 737.7, 761.7, 833.7, 881.7, 905.7, 1001.7, 1025.7, 1049.7, 1082.816667, 1082.816667, 1085.7, 0, 0, 1.616666667, 2.033333333, 2.866666667, 4.866666667, 6.283333333, 24.28333333, 170.2833333, 170.2833333, 194.2833333, 218.2833333, 242.2833333, 261.6833333, 333.1666667, 357.1666667, 381.1666667, 405.1666667, 429.1666667, 505.35, 505.35, 508.3333333, 530.3333333, 554.3333333, 578.3333333, 595.4, 595.4, 596.9333333, 666.9333333, 690.9333333, 714.9333333, 738.9333333, NA, NA, NA, NA, NA, NA, NA, 0, 0, 1.133333333, 1.716666667, 2.633333333, 4.416666667, 6.216666667, 24.21666667, 48.21666667, 72.21666667, 96.21666667, 0, 0, 0.9666666667, 1.466666667, 2.266666667, 4.35, 6.016666667, 24.01666667, 48.01666667, 168.0166667, 192.0166667, 216.0166667, 240.0166667, 264.0166667, 336.0166667, 360.0166667, 384.0166667, 408.0166667, 432.0166667, 503.3, 503.3, 505.9, 527.9, 551.9, 575.9, 599.9, 1175.566667, 1175.566667, 1178, 1200, 1224 ), CMT = c("central", "depot", "central", "central", "central", "central", "central", "central", "depot", "depot", "depot", "depot", "central", "depot", "depot", "depot", "depot", "depot", "central", "depot", "central", "central", "central", "central", "central", "central", "depot", "depot", "depot", "depot", "central", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "central", "depot", "central", "central", "central", "central", "central", "central", "central", "depot", "central", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "central", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "central", "depot", "central", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "central", "depot", "central", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "central", "depot", "central", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "central", "depot", "central", "depot", "depot", "depot", "depot", "central", "depot", "central", "central", "central", "central", "central", "central", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "central", "depot", "central", "central", "depot", "central", "central", "central", "central", "central", "depot", "central", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "central", "depot", "central", "depot", "depot", "depot", "central", "depot", "central", "depot", "depot", "depot", "depot", "central", "central", "central", "central", "central", "central", "central", "central", "depot", "central", "central", "central", "central", "central", "depot", "depot", "depot", "depot", "central", "depot", "central", "central", "central", "central", "central", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "depot", "central", "depot", "central", "depot", "depot", "depot", "depot", "central", "depot", "central", "depot", "depot"), AMT = c(NA, 400, NA, NA, NA, NA, NA, NA, 400, 400, 400, 400, NA, 400, 400, 400, 400, 400, NA, 400, NA, NA, NA, NA, NA, NA, 400, 400, 400, 400, NA, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, NA, 400, NA, NA, NA, NA, NA, NA, NA, 400, NA, 400, 400, 400, 400, 400, 400, 400, NA, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, NA, 400, NA, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, NA, 400, NA, 400, 400, 400, 400, 400, 400, 400, NA, 500, NA, 500, 500, 500, 500, 450, 450, 450, 450, 450, NA, 450, NA, 450, 450, 450, 450, NA, 450, NA, NA, NA, NA, NA, NA, 450, 450, 450, 450, 450, 450, 450, 450, 450, 450, NA, 450, NA, NA, 350, NA, NA, NA, NA, NA, 350, NA, 300, 300, 300, 300, 300, 300, 300, 300, 300, 300, NA, 300, NA, 300, 300, 300, NA, 300, NA, 300, 300, 300, 300, NA, NA, NA, NA, NA, NA, NA, NA, 350, NA, NA, NA, NA, NA, 350, 350, 350, 350, NA, 400, NA, NA, NA, NA, NA, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, NA, 400, NA, 400, 400, 400, 400, NA, 400, NA, 400, 400), DOSE = c(0, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 0, 500, 500, 500, 500, 500, 500, 450, 450, 450, 450, 450, 450, 450, 450, 450, 450, 450, 450, 450, 450, 450, 450, 450, 450, 450, 450, 450, 450, 450, 450, 450, 450, 450, 450, 450, 450, 450, 450, 450, 0, 350, 350, 350, 350, 350, 350, 350, 350, 300, 300, 300, 300, 300, 300, 300, 300, 300, 300, 300, 300, 300, 300, 300, 300, 300, 300, 300, 300, 300, 300, 300, 300, 300, 300, 300, 300, 300, 300, 0, 350, 350, 350, 350, 350, 350, 350, 350, 350, 350, 0, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400, 400), EVID = c(0, 1, 0, 0, 0, 0, 0, 0, 1, 1, 1, 1, 0, 1, 1, 1, 1, 1, 0, 1, 0, 0, 0, 0, 0, 0, 1, 1, 1, 1, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 1, 1, 1, 1, 1, 1, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 0, 1, 1, 1, 1, 1, 1, 1, 0, 1, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 0, 1, 1, 1, 1, 0, 1, 0, 0, 0, 0, 0, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 0, 0, 1, 0, 0, 0, 0, 0, 1, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 0, 1, 1, 1, 0, 1, 0, 1, 1, 1, 1, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 1, 1, 1, 1, 0, 1, 0, 0, 0, 0, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 0, 1, 1, 1, 1, 0, 1, 0, 1, 1), COVAR = c(1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 1, 1, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 1, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 1, 1, 1, 1, 1, 1, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0) ))) })