rxTest({ # Dual lhs/param values (Issue #135) test_that("Two defined variables", { mod1 <- rxode2({ k <- k + 3 km <- km + 4 }) expect_equal(mod1$lhs, c("k", "km")) expect_equal(mod1$params, c("k", "km")) expect_equal(as.vector(rxSolve(mod1, et(0), params = c(k = 3, km = 4), returnType = "matrix")), as.double(c(0, 6, 8))) }) test_that("Two defined variables with ini", { mod1 <- rxode2({ k <- 3 k <- k + 3 km <- 4 km <- km + 4 }) expect_equal(mod1$lhs, c("k", "km")) expect_equal(mod1$params, c("k", "km")) expect_equal(rxInits(mod1), c(k = 3, km = 4)) expect_equal(as.vector(rxSolve(mod1, et(0), returnType = "matrix")), as.double(c(0, 6, 8))) }) test_that("lhs/params changes", { mod4 <- rxode2({ j <- k + m k <- j + 3 }) expect_equal(mod4$lhs, c("j", "k")) expect_equal(mod4$params, c("k", "m")) }) test_that("one variable/param", { mod1 <- rxode2({ k <- k + 3 }) expect_equal(mod1$lhs, "k") expect_equal(mod1$params, "k") }) test_that("Sc is not lhs", { tmp <- rxode2({ Sc <- L^2 * ((g * e) / (g + e)) * (1 + (km * L / v)) d / dt(L) <- ((1 / (3 * L^2))) * (((v / g) * Sc) - km * L^3) }) expect_false(any(tmp$params == "Sc")) }) test_that("Last item of last line still counts", { mod4 <- rxode2({ j <- k k <- j + 3 }) expect_equal(mod4$lhs, c("j", "k")) expect_equal(mod4$params, "k") mod4 <- rxode2({ j <- k + 4 k <- j + 3 }) expect_equal(mod4$lhs, c("j", "k")) expect_equal(mod4$params, "k") }) test_that("Make sure CL is correctly identified as hidden lhs not a dual", { mod2 <- rxode2({ C2 <- centr / V2 C3 ~ peri / V3 CL ~ TCL * exp(eta.Cl) d / dt(depot) ~ -KA * depot d / dt(centr) ~ KA * depot - CL * C2 - Q * C2 + Q * C3 d / dt(peri) ~ Q * C2 - Q * C3 d / dt(eff) <- Kin - Kout * (1 - C2 / (EC50 + C2)) * eff eff(0) <- 1000 e1 <- err1 e2 <- err2 resp <- eff + e1 pk <- C2 * exp(e2) }) expect_false(any("CL" == mod2$params)) expect_false(any("CL" == mod2$lhs)) }) test_that("newind variables not identified as dual parameters", { ode.1c <- rxode2({ V <- 20 Cl <- 1 fc <- 1 C2 <- center / V ni <- newind ni2 <- NEWIND d / dt(center) ~ -Cl * C2 f(center) <- fc }) expect_equal(ode.1c$params, c("V", "Cl", "fc")) expect_equal(ode.1c$lhs, c("C2", "ni", "ni2")) }) test_that("suppressed assignments give correct variables", { mod1 <- rxode2({ k ~ k + 3 km ~ km + 4 ret <- k + km }) expect_equal(mod1$lhs, "ret") expect_equal(mod1$params, c("k", "km")) expect_equal(rxSolve(mod1, c(k = 1, km = 2), et(0))$ret, as.double(10)) }) test_that("a=NA gives correct variables", { mod1 <- rxode2("a=NA;\nb=2;\nc=a+b") expect_equal(mod1$params, "b") expect_equal(mod1$lhs, c("a", "c")) mod1 <- rxode2("a=2;\nb=NA;\nc=a+b") expect_equal(mod1$params, "a") expect_equal(mod1$lhs, c("b", "c")) mod1 <- rxode2("a~NA;\nb~2;\nc=a+b") expect_equal(mod1$params, character(0)) expect_equal(mod1$lhs, "c") mod1 <- rxode2("a~2;\nb~NA;\nc=a+b") expect_equal(mod1$params, character(0)) expect_equal(mod1$lhs, "c") }) test_that("dual order lhs mixed with non dual-order gives right order", { m <- rxode2({ param(THETA[1], THETA[2], THETA[3], THETA[4], Nominal) rx_yj_ ~ 162 rx_lambda_ ~ 1 rx_hi_ ~ 1 rx_low_ ~ 0 rx_expr_0 ~ exp(THETA[2]) rx_expr_1 ~ exp(THETA[3]) rx_expr_2 ~ exp(THETA[1]) rx_pred_ = linCmtA(rx__PTR__, t, 2, 1, 1, -1, 1, rx_expr_0, rx_expr_1, 0, 0, 0, 0, rx_expr_2) rx_r_ = Rx_pow_di(THETA[4], 2) tka = THETA[1] tcl = THETA[2] tv = THETA[3] add.sd = THETA[4] ka = rx_expr_2 cl = rx_expr_0 v = rx_expr_1 Nominal = Nominal tad = tad() dosenum = dosenum() cmt(rxLinCmt) dvid(3) }) expect_equal(m$lhs, c("rx_pred_", "rx_r_", "tka", "tcl", "tv", "add.sd", "ka", "cl", "v", "Nominal", "tad", "dosenum")) theo_sd2 <- nlmixr2data::theo_sd theo_sd2$Nominal <- 300 s <- rxSolve(m, theo_sd2, c(`THETA[1]` = 0.440455057067531, `THETA[2]` = 0.962169566880609, `THETA[3]` = 3.49144561224211, `THETA[4]` = 1.39422305101919), addCov=FALSE) expect_true(all(s$Nominal == 300)) expect_false(any(s$rx_pred_ == 300)) }) })