if (!.Call(`_rxode2_isIntel`)) { ## system("rm -v ~/src/rxode2/src/*.so ~/src/rxode2/src/*.o ~/src/rxode2parse/src/*.so ~/src/rxode2parse/src/*.o ~/src/rxode2random/src/*.so ~/src/rxode2random/src/*.o");devtools::install("~/src/rxode2parse", dep=FALSE); devtools::install("~/src/rxode2random", dep=FALSE); devtools::load_all();rxClean();#devtools::test() ## devtools::load_all() d <- nlmixr2data::nmtest # internally rxode2 treats lag time evids differently than # non-lagged events # 2 different models to test then f <- rxode2({ cl <- 1.1 v <- 20 ka <- 1.5 d/dt(depot) <- -ka*depot d/dt(central) <- ka*depot - (cl/v)*central f(central) <- bioav if (mode == 1) rate(central) <- rat2 if (mode == 2) dur(central) <- dur2 cp <- central/(v/1000) }) fl <- rxode2({ cl <- 1.1 v <- 20 ka <- 1.5 d/dt(depot) <- -ka*depot d/dt(central) <- ka*depot - (cl/v)*central lag(central) <- lagt f(central) <- bioav if (mode == 1) rate(central) <- rat2 if (mode == 2) dur(central) <- dur2 cp <- central/(v/1000) }) library(ggplot2) solveEqual <- function(id, plot = p, meth="liblsoda", modifyData = c("none", "dur", "rate"), addlKeepsCov = TRUE, addlDropSs=TRUE, ss2cancelAllPending=FALSE) { noLag <- all(d[d$id == id & d$evid != 0,]$lagt == 0) hasRate <- any(d[d$id == id & d$evid != 0,]$rate != 0) hasModeledRate <- any(d[d$id == id & d$evid != 0,]$mode == 1) hasModeledDur <- any(d[d$id == id & d$evid != 0, ]$mode == 2) hasChangedF <- any(d[d$id == id & d$evid != 0, ]$bioav != 1) modifyData <- match.arg(modifyData) d <- d[d$id == id,] rate <- unlist(as.vector(d[d$evid != 0, "rate"])) ii0 <- all(d$ii == 0) oneRate <- (length(rate) == 1L) dose1 <- all(d[d$evid != 0, ]$cmt == 1) if (!addlDropSs) { if (any(d$ss == 2)) { return() } } if (modifyData == "rate" && hasRate && !hasModeledRate && !hasModeledDur && oneRate && !ii0 && !dose1) { if (p) message("modified rate to be modeled") rate <- d[d$evid != 0, "rate", drop=FALSE] rate <- rate$rate if (length(rate) == 1) { d$rat2 <- rate d$rate <- ifelse(d$rate==0, 0, -1) d$mode <- 1 } ## print(etTrans(d, f, addlDropSs=addlDropSs)) } else if (modifyData == "dur" && hasRate && !hasModeledRate && !hasModeledDur && !hasChangedF && oneRate && !ii0 && !dose1) { if (p) message("modified dur to be modeled") rate <- as.numeric(d[d$evid != 0, "rate"]) amt <- as.numeric(d[d$evid != 0, "amt"]) if (length(rate) == 1) { d$dur2 <- amt/rate d$rate <- ifelse(d$rate==0, 0, -2) d$mode <- 2 assign(".d", d, envir=globalenv()) } } else if (any(modifyData == c("dur", "rate"))) { if (p) { message("skipping because cannot be modified") print(list(modifyData=modifyData, noLag=noLag, hasRate=hasRate, hasModeledRate=hasModeledRate, hasModeledDur= hasModeledDur, hasChangedF=hasChangedF)) } return(invisible()) } if (plot) { print(ggplot(d, aes(time, cp)) + geom_point(col="red") + rxode2::rxTheme() + ggtitle(paste0("id=", id))) ## print(etTrans(d, fl)) s1 <- rxSolve(fl, d, method=meth, addlKeepsCov = addlKeepsCov, addlDropSs=addlDropSs, ss2cancelAllPending=ss2cancelAllPending) if (!noLag) { print(plot(s1, cp) + geom_point(data=d, aes(x=time, y=cp), col="red") + ggtitle(paste0("id=", id, "(lag)"))) } else { message("================================================== ") message("f without lag") message("================================================== ") s2 <- rxSolve(f, d, method=meth, addlKeepsCov = addlKeepsCov, addlDropSs=addlDropSs, ss2cancelAllPending=ss2cancelAllPending) return(plot(s1, cp) + geom_point(data=d, aes(x=time, y=cp), col="red") + geom_line(data=s2, aes(x=time, y=cp), col="blue", alpha=0.5, linewidth=2) + ggtitle(paste0("id=", id, "(nolag)"))) } ## print(etTrans(d, fl)) } else { sub <- 0 if (id %in% c(410, 411, 409, 415, 709, 510, 610)) { sub <- 24 } if (id %in% c(809, 909, 1009)) { sub <- 48 } if (id %in% 825) { sub <- 96 } if (noLag) { test_that(paste0("nmtest id:", id, " no alag; method: ", meth, "; modifyData:", modifyData, "; addlDropSs: ", addlDropSs), { s1 <- rxSolve(f, d, method=meth, addlKeepsCov = addlKeepsCov, addlDropSs=addlDropSs) expect_equal(s1$cp[s1$time >= sub], d[d$id == id & d$evid == 0 & d$time >= sub,]$cp, tolerance = 0.1) }) } test_that(paste0("nmtest id:", id, " alag; method: ", meth, "; modifyData:", modifyData,"; addlDropSs: ", addlDropSs), { s1 <- rxSolve(fl, d, method=meth, addlKeepsCov = addlKeepsCov, addlDropSs=addlDropSs) expect_equal(s1$cp[s1$time >= sub], d[d$id == id & d$evid == 0 & d$time >= sub,]$cp, tolerance = 0.1) }) } } p <- TRUE id <- unique(d$id) p <- FALSE lapply(id, function(i) { meths <- c("liblsoda", "lsoda", "dop853") modDat <- c("none", "rate", "dur") for (meth in meths) { for (modifyData in modDat) { for (addlDropSs in c(TRUE, FALSE)) { solveEqual(i, meth=meth, modifyData=modifyData, addlDropSs=addlDropSs) } } } }) ## invisible(lapply(unique(d$id), function(i){message(i);solveEqual(i);Sys.sleep(1)})) ## need to check id=25 type for infusions too (static, modeled) need ## to check for steady state when the infusion is still going at the ## time of steady-state release ## Need to check steady state infusion as well as infusions where ii=dur with lag times ## modeled equivalents of 425, 525 }