rxTest({
  test_that("Issue RxODE#410", {
    mod <- rxode2("cmt(EFFECT);\nd/dt(EFFECT)=0;\nd/dt(rx__sens_EFFECT_BY_ETA_1___)=0;\nrx_yj_~2;\nrx_lambda_~1;\nrx_hi_~1;\nrx_low_~0;\nrx_expr_0~exp(THETA[4]);\nrx_expr_1~ETA[1]+THETA[3];\nrx_expr_2~SEX==\"F\";\nrx_expr_3~SEX==\"M\";\nrx_expr_4~exp(rx_expr_1);\nrx_expr_5~(rx_expr_2)*THETA[2];\nrx_expr_6~(rx_expr_3)*THETA[1];\nrx_expr_7~rx_expr_5+rx_expr_6;\nrx_expr_8~exp(rx_expr_7);\nrx_expr_9~rx_expr_4-rx_expr_8;\nrx_expr_10~(-2+NTS_birth)*(rx_expr_9);\nrx_expr_11~rx_expr_10/(-2+NTS_birth+rx_expr_0);\nrx_pred_=rx_expr_11+rx_expr_8;\nrx__sens_rx_pred__BY_ETA_1___=rx_expr_4*(-2+NTS_birth)/(-2+NTS_birth+rx_expr_0);\nrx_r_=Rx_pow_di((THETA[6]+THETA[5]*(rx_expr_11+rx_expr_8)),2);\nrx__sens_rx_r__BY_ETA_1___=2*rx_expr_4*(-2+NTS_birth)*(THETA[6]+THETA[5]*(rx_expr_11+rx_expr_8))*THETA[5]/(-2+NTS_birth+rx_expr_0);sexf=(SEX==\"F\");\nsexm=(SEX==\"M\");\ncmt(effect);\n")

    est <- c("THETA[1]" = 7.3132203870903, "THETA[2]" = 7.60090245954208, "THETA[3]" = 6.90775527898214, "THETA[4]" = 0.693147180559945, "THETA[5]" = 0.2, "THETA[6]" = 1, "ETA[1]" = 0)
    
    d <-
      data.frame(
        ID = rep(1:2, each = 2),
        CMT = "EFFECT",
        DV = 1000 + rnorm(4),
        NTS_birth = rep(2:3, 2),
        SEX = rep(c("F", "M"), each = 2),
        TIME = 1
      )
    
    e <- etTrans(d, mod)
    
    expect_error(rxSolve(mod, est, d), NA)
    
    s <- rxSolve(mod, est, d, addCov = TRUE)
    expect_s3_class(s$SEX, "factor")
    expect_equal(paste(d$SEX), paste(s$SEX))
    expect_equal((d$SEX == "F") * 1.0, s$sexf)
    expect_equal((d$SEX == "M") * 1.0, s$sexm)
  })
})