rxTest({
  test_that("Test Issue RxODE#169, NAs everywhere", {
    Book4 <- readRDS(test_path("test-issue-169.rds"))
    mod1 <- rxode2({
      KA <- 2.94E-01
      CL <- 1.86E+01
      V2 <- 4.02E+01
      Q <- 1.05E+01
      V3 <- 2.97E+02
      Kin <- 1
      Kout <- 1
      EC50 <- 200
      C2 <- centr / V2
      C3 <- peri / V3
      d / dt(depot) <- -KA * depot
      d / dt(centr) <- KA * depot - CL * C2 - Q * C2 + Q * C3
      d / dt(peri) <- Q * C2 - Q * C3
      d / dt(eff) <- Kin - Kout * (1 - C2 / (EC50 + C2)) * eff
      eff(0) <- 1
    })
    trans <- etTrans(Book4, mod1)
    
    expect_equal(trans$EVID, c(
      101L, 0L, 0L, 0L, 0L, 0L, 0L, 0L, 0L, 101L, 0L, 0L, 0L, 0L,
      0L, 0L, 0L, 0L
    ))
    expect_true(all(trans$II == 0.0))
  })
})