## | ## | *Unit tests* ## | ## | This file is part of the R package rpact: ## | Confirmatory Adaptive Clinical Trial Design and Analysis ## | ## | Author: Gernot Wassmer, PhD, and Friedrich Pahlke, PhD ## | Licensed under "GNU Lesser General Public License" version 3 ## | License text can be found here: https://www.r-project.org/Licenses/LGPL-3 ## | ## | RPACT company website: https://www.rpact.com ## | RPACT package website: https://www.rpact.org ## | ## | Contact us for information about our services: info@rpact.com ## | ## | File name: test-class_summary.R ## | Creation date: 06 February 2023, 12:04:16 ## | File version: $Revision: 6801 $ ## | Last changed: $Date: 2023-02-06 15:29:57 +0100 (Mon, 06 Feb 2023) $ ## | Last changed by: $Author: pahlke $ ## | test_plan_section("Testing Class 'SummaryFactory'") test_that("Testing 'summary.ParameterSet': no errors occur", { .skipTestIfDisabled() # @refFS[Function]{fs:outputOfGenericFunctions} invisible(capture.output(expect_error(summary(getDesignGroupSequential( beta = 0.05, typeOfDesign = "asKD", gammaA = 1, typeBetaSpending = "bsOF" )), NA))) invisible(capture.output(expect_error(summary(getDesignGroupSequential(kMax = 1)), NA))) invisible(capture.output(expect_error(summary(getDesignGroupSequential(kMax = 4, sided = 2)), NA))) invisible(capture.output(expect_error(summary(getDesignGroupSequential(kMax = 4, sided = 2), digits = 0), NA))) invisible(capture.output(expect_error(summary(getDesignGroupSequential(kMax = 1, sided = 2)), NA))) invisible(capture.output(expect_error(summary(getDesignGroupSequential(futilityBounds = c(-6, 0))), NA))) invisible(capture.output(expect_error(summary(getDesignGroupSequential(futilityBounds = c(-6, 0)), digits = 5), NA))) invisible(capture.output(expect_error(summary(getDataset( n = c(13, 25), means = c(242, 222), stDevs = c(244, 221) )), NA))) invisible(capture.output(expect_error(summary(getDataset( n = c(13), means = c(242), stDevs = c(244) )), NA))) invisible(capture.output(expect_error(summary(getDataset( n1 = c(13, 25), n2 = c(15, NA), n3 = c(14, 27), n4 = c(12, 29), means1 = c(242, 222), means2 = c(188, NA), means3 = c(267, 277), means4 = c(92, 122), stDevs1 = c(244, 221), stDevs2 = c(212, NA), stDevs3 = c(256, 232), stDevs4 = c(215, 227) )), NA))) invisible(capture.output(expect_error(summary(getDataset( n1 = c(11, 13, 12, 13), n2 = c(8, 10, 9, 11), n3 = c(7, 10, 8, 9), events1 = c(10, 10, 12, 12), events2 = c(3, 5, 5, 6), events3 = c(2, 4, 3, 5) )), NA))) invisible(capture.output(expect_error(summary(getDataset( events1 = c(25, 32), events2 = c(18, NA), events3 = c(22, 36), logRanks1 = c(2.2, 1.8), logRanks2 = c(1.99, NA), logRanks3 = c(2.32, 2.11) )), NA))) invisible(capture.output(expect_error(summary(getDesignInverseNormal(kMax = 1)), NA))) invisible(capture.output(expect_error(summary(getDesignInverseNormal(futilityBounds = c(0, 1))), NA))) invisible(capture.output(expect_error(summary(getDesignInverseNormal(kMax = 1)), NA))) invisible(capture.output(expect_error(summary(getDesignInverseNormal(kMax = 4, sided = 2)), NA))) invisible(capture.output(expect_error(summary(getDesignInverseNormal(kMax = 4, sided = 2), digits = 0), NA))) invisible(capture.output(expect_error(summary(getDesignInverseNormal(kMax = 1, sided = 2)), NA))) invisible(capture.output(expect_error(summary(getDesignFisher()), NA))) invisible(capture.output(expect_error(summary(getDesignFisher(alpha0Vec = c(0.1, 0.2))), NA))) invisible(capture.output(expect_error(summary(getDesignFisher(kMax = 1)), NA))) invisible(capture.output(expect_error(summary(getDesignFisher(kMax = 4), digits = 5), NA))) invisible(capture.output(expect_error(summary(getDesignFisher(kMax = 4), digits = 0), NA))) invisible(capture.output(expect_error(summary(getDesignFisher(kMax = 1)), NA))) ## test design plans - means invisible(capture.output(expect_error(summary(getSampleSizeMeans(sided = 2, alternative = -0.5)), NA))) invisible(capture.output(expect_warning(summary(getSampleSizeMeans(sided = 2), alternative = -0.5)))) # warning expected invisible(capture.output(expect_error(summary(getPowerMeans( sided = 1, alternative = c(-0.5, -0.3), maxNumberOfSubjects = 100, directionUpper = FALSE )), NA))) invisible(capture.output(expect_error(summary(getSampleSizeMeans( thetaH0 = 0, alternative = 0.5, sided = 1, stDev = 2.5 )), NA))) invisible(capture.output(expect_error(summary(getSampleSizeMeans( thetaH0 = 0, alternative = 0.5, sided = 1, stDev = 1, groups = 1 )), NA))) invisible(capture.output(expect_error(summary(getSampleSizeMeans( thetaH0 = 0, sided = 2, stDev = 1, groups = 1 )), NA))) invisible(capture.output(expect_error(summary(getSampleSizeMeans( thetaH0 = 0, alternative = 1.2, sided = 2, stDev = 5 )), NA))) invisible(capture.output(expect_error(summary(getSampleSizeMeans( thetaH0 = 0, alternative = 1.2, sided = 2, stDev = 5, allocationRatioPlanned = 0 )), NA))) invisible(capture.output(expect_error(summary(getSampleSizeMeans( thetaH0 = 0, alternative = 1.2, sided = 2, stDev = 5, groups = 1 )), NA))) invisible(capture.output(expect_error(summary(getSampleSizeMeans( getDesignGroupSequential(futilityBounds = c(1, 2)) )), NA))) invisible(capture.output(expect_error(summary(getSampleSizeMeans( getDesignGroupSequential(futilityBounds = c(1, 2)) ), digits = 0), NA))) invisible(capture.output(expect_error(summary(getPowerMeans( getDesignGroupSequential(futilityBounds = c(1, 2)), maxNumberOfSubjects = 100, alternative = 1 )), NA))) invisible(capture.output(expect_error(summary(getSampleSizeMeans( getDesignGroupSequential(kMax = 4, sided = 2) )), NA))) invisible(capture.output(expect_error(summary(getPowerMeans( getDesignGroupSequential(kMax = 4, sided = 2), maxNumberOfSubjects = 100 )), NA))) invisible(capture.output(expect_error(summary(getPowerMeans( getDesignGroupSequential(kMax = 1, sided = 2), maxNumberOfSubjects = 100 )), NA))) invisible(capture.output(expect_error(summary(getSampleSizeMeans( getDesignGroupSequential(futilityBounds = c(1, 2)) )), NA))) invisible(capture.output(expect_error(summary(getSampleSizeMeans( getDesignGroupSequential(futilityBounds = c(1, 2)) ), digits = 4), NA))) invisible(capture.output(expect_error(summary(getSampleSizeMeans( getDesignGroupSequential(futilityBounds = c(1, 2)) ), digits = 3), NA))) invisible(capture.output(expect_error(summary(getSampleSizeMeans( getDesignGroupSequential(futilityBounds = c(1, 2)) ), digits = 2), NA))) invisible(capture.output(expect_error(summary(getSampleSizeMeans( getDesignGroupSequential(futilityBounds = c(1, 2)) ), digits = -1), NA))) ## test design plans - rates invisible(capture.output(expect_error(summary(getSampleSizeRates(pi2 = 0.3)), NA))) invisible(capture.output(expect_error(summary(getSampleSizeRates(groups = 1, thetaH0 = 0.3)), NA))) invisible(capture.output(expect_error(summary(getSampleSizeRates(groups = 1, thetaH0 = 0.45)), NA))) invisible(capture.output(expect_error(summary(getSampleSizeRates( groups = 2, thetaH0 = 0.45, allocationRatioPlanned = 0 )), NA))) invisible(capture.output(expect_error(summary(getSampleSizeRates( getDesignGroupSequential(futilityBounds = c(1, 2)) )), NA))) invisible(capture.output(expect_error(summary(getPowerRates( getDesignGroupSequential(futilityBounds = c(1, 2)), maxNumberOfSubjects = 100 )), NA))) invisible(capture.output(expect_error(summary(getSampleSizeRates( getDesignGroupSequential(kMax = 4, sided = 2) )), NA))) invisible(capture.output(expect_error(summary(getSampleSizeRates( getDesignGroupSequential(kMax = 4, sided = 2), groups = 1, thetaH0 = 0.3 )), NA))) invisible(capture.output(expect_error(summary(getSampleSizeRates( getDesignGroupSequential(kMax = 1, sided = 2), groups = 1, thetaH0 = 0.2, pi1 = c(0.4, 0.5) )), NA))) invisible(capture.output(expect_error(summary(getSampleSizeRates( getDesignGroupSequential(kMax = 1, sided = 2), groups = 1, thetaH0 = 0.2, pi1 = 0.4 )), NA))) invisible(capture.output(expect_error(summary(getSampleSizeRates( getDesignGroupSequential(kMax = 1, sided = 2), groups = 2, thetaH0 = 0, pi1 = 0.25 )), NA))) invisible(capture.output(expect_error(summary(getPowerRates( getDesignGroupSequential(kMax = 4, sided = 2), maxNumberOfSubjects = 100 )), NA))) ## test design plans - survival invisible(capture.output(expect_error(summary(getSampleSizeSurvival()), NA))) invisible(capture.output(expect_error(summary(getSampleSizeSurvival(lambda2 = 0.3, hazardRatio = 1.2)), NA))) invisible(capture.output(expect_error(summary(getSampleSizeSurvival(lambda2 = 0.3, hazardRatio = c(1.2, 2))), NA))) invisible(capture.output(expect_error(summary(getSampleSizeSurvival(pi2 = 0.3, hazardRatio = 1.2)), NA))) invisible(capture.output(expect_error(summary(getSampleSizeSurvival(pi1 = 0.1, pi2 = 0.3)), NA))) invisible(capture.output(expect_error(summary(getSampleSizeSurvival(lambda2 = 0.03, lambda1 = c(0.040))), NA))) invisible(capture.output(expect_error(summary(getSampleSizeSurvival(piecewiseSurvivalTime = list( "0 - <6" = 0.025, "6 - <9" = 0.04, "9 - <15" = 0.015, "15 - <21" = 0.01, ">=21" = 0.007 ), hazardRatio = 1.2)), NA))) invisible(capture.output(expect_error(summary(getSampleSizeSurvival( getDesignGroupSequential(futilityBounds = c(1, 2)) )), NA))) invisible(capture.output(expect_error(summary(getPowerSurvival( getDesignGroupSequential(futilityBounds = c(1, 2)), maxNumberOfSubjects = 100, maxNumberOfEvents = 60 )), NA))) invisible(capture.output(expect_error(summary(getSampleSizeSurvival( getDesignGroupSequential(kMax = 4, sided = 2) )), NA))) invisible(capture.output(expect_error(summary(getPowerSurvival( getDesignGroupSequential(kMax = 4, sided = 2), maxNumberOfSubjects = 100, maxNumberOfEvents = 60 )), NA))) invisible(capture.output(expect_error(summary(getSampleSizeSurvival(sided = 2, lambda2 = log(2) / 6, lambda1 = log(2) / 8)), NA))) invisible(capture.output(expect_error(summary(getPowerSurvival(sided = 2, maxNumberOfSubjects = 200, maxNumberOfEvents = 40, lambda2 = log(2) / 6, lambda1 = log(2) / 8)), NA))) invisible(capture.output(expect_error(summary(getSampleSizeSurvival( getDesignGroupSequential(sided = 2), lambda2 = log(2) / 6, hazardRatio = c(0.55), accrualTime = c(0, 10), accrualIntensity = 20 )), NA))) invisible(capture.output(expect_error(summary(getPowerSurvival( getDesignGroupSequential(kMax = 2), maxNumberOfEvents = 200, maxNumberOfSubjects = 400, lambda2 = log(2) / 60, lambda1 = log(2) / 50, dropoutRate1 = 0.025, dropoutRate2 = 0.025, dropoutTime = 12, accrualTime = 0, accrualIntensity = 30 )), NA))) invisible(capture.output(expect_error(summary(getPowerSurvival( getDesignGroupSequential(kMax = 3), maxNumberOfEvents = 200, maxNumberOfSubjects = 400, lambda2 = log(2) / 60, lambda1 = c(log(2) / 50, log(2) / 60), dropoutRate1 = 0.025, dropoutRate2 = 0.025, dropoutTime = 12, accrualTime = 0, accrualIntensity = 30 )), NA))) invisible(capture.output(expect_error(summary(getPowerSurvival( getDesignGroupSequential(kMax = 3), maxNumberOfEvents = 200, maxNumberOfSubjects = 400, lambda2 = log(2) / 60, hazardRatio = c(0.7, 0.8), directionUpper = FALSE, dropoutRate1 = 0.025, dropoutRate2 = 0.025, dropoutTime = 12, accrualTime = 0, accrualIntensity = 30 )), NA))) design1 <- getDesignGroupSequential( sided = 2, alpha = 0.05, beta = 0.2, informationRates = c(0.6, 1), typeOfDesign = "asOF", twoSidedPower = FALSE ) invisible(capture.output(expect_error(summary(getSampleSizeSurvival( design1, lambda2 = log(2) / 60, hazardRatio = 0.74, dropoutRate1 = 0.025, dropoutRate2 = 0.025, dropoutTime = 12, accrualTime = 0, accrualIntensity = 30, followUpTime = 12 )), NA))) invisible(capture.output(expect_error(summary(getSampleSizeSurvival( design1, lambda2 = log(2) / 60, lambda1 = log(2) / 50, dropoutRate1 = 0.025, dropoutRate2 = 0.025, dropoutTime = 12, accrualTime = 0, accrualIntensity = 30, followUpTime = 12 )), NA))) invisible(capture.output(expect_error(summary(getSampleSizeSurvival( getDesignGroupSequential(kMax = 4, sided = 2) )), NA))) ## simulations design2 <- getDesignInverseNormal( alpha = 0.05, kMax = 4, futilityBounds = c(0, 0, 0), sided = 1, typeOfDesign = "WT", deltaWT = 0.1 ) invisible(capture.output(expect_error(summary(getSimulationSurvival(design2, lambda2 = log(2) / 60, lambda1 = c(log(2) / 80), maxNumberOfSubjects = 1000, plannedEvents = c(50, 100, 150, 200), seed = 12345, directionUpper = FALSE )), NA))) invisible(capture.output(expect_error(summary(getSimulationSurvival(design2, lambda2 = log(2) / 60, hazardRatio = c(1.2, 1.4), maxNumberOfSubjects = 1000, plannedEvents = c(50, 100, 150, 200), seed = 12345 )), NA))) design3 <- getDesignGroupSequential(typeOfDesign = "P", futilityBounds = c(1, 1)) invisible(capture.output(expect_error(summary(getSampleSizeMeans(design3)), NA))) invisible(capture.output(expect_error(summary(getSimulationMeans(design3, stDev = 4, plannedSubjects = (1:3) * 200, alternative = c(1, 2))), NA))) invisible(capture.output(expect_error(summary(getSimulationRates(design3, plannedSubjects = (1:3) * 200, pi1 = c(0.3, 0.4), maxNumberOfIterations = 1000, minNumberOfSubjectsPerStage = c(NA, 40, 40), maxNumberOfSubjectsPerStage = c(NA, 40, 400), conditionalPower = 0.8 )), NA))) invisible(capture.output(expect_error(summary(getSimulationMeans( getDesignGroupSequential(kMax = 1), stDev = 4, plannedSubjects = 200, alternative = c(1) )), NA))) }) test_that("Testing 'summary.ParameterSet': output will be produced", { .skipTestIfDisabled() # @refFS[Function]{fs:outputOfGenericFunctions} expect_output(summary(getDesignGroupSequential(beta = 0.05, typeOfDesign = "asKD", gammaA = 1, typeBetaSpending = "bsOF"))$show()) expect_output(summary(getDesignGroupSequential(kMax = 1))$show()) expect_output(summary(getDesignGroupSequential(kMax = 4, sided = 2))$show()) expect_output(summary(getDesignGroupSequential(kMax = 4, sided = 2), digits = 0)$show()) expect_output(summary(getDesignGroupSequential(kMax = 1, sided = 2))$show()) expect_output(summary(getDesignGroupSequential(futilityBounds = c(-6, 0)))$show()) expect_output(summary(getDesignGroupSequential(futilityBounds = c(-6, 0)), digits = 5)$show()) expect_output(summary(getDataset( n = c(13, 25), means = c(242, 222), stDevs = c(244, 221) ))$show()) expect_output(summary(getDataset( n = c(13), means = c(242), stDevs = c(244) ))$show()) expect_output(summary(getDataset( n1 = c(13, 25), n2 = c(15, NA), n3 = c(14, 27), n4 = c(12, 29), means1 = c(242, 222), means2 = c(188, NA), means3 = c(267, 277), means4 = c(92, 122), stDevs1 = c(244, 221), stDevs2 = c(212, NA), stDevs3 = c(256, 232), stDevs4 = c(215, 227) ))$show()) expect_output(summary(getDataset( n1 = c(11, 13, 12, 13), n2 = c(8, 10, 9, 11), n3 = c(7, 10, 8, 9), events1 = c(10, 10, 12, 12), events2 = c(3, 5, 5, 6), events3 = c(2, 4, 3, 5) ))$show()) expect_output(summary(getDataset( events1 = c(25, 32), events2 = c(18, NA), events3 = c(22, 36), logRanks1 = c(2.2, 1.8), logRanks2 = c(1.99, NA), logRanks3 = c(2.32, 2.11) ))$show()) expect_output(summary(getDesignInverseNormal(kMax = 1))$show()) expect_output(summary(getDesignInverseNormal(futilityBounds = c(0, 1)))$show()) expect_output(summary(getDesignInverseNormal(kMax = 1))$show()) expect_output(summary(getDesignInverseNormal(kMax = 4, sided = 2))$show()) expect_output(summary(getDesignInverseNormal(kMax = 4, sided = 2), digits = 0)$show()) expect_output(summary(getDesignInverseNormal(kMax = 1, sided = 2))$show()) expect_output(summary(getDesignFisher())$show()) expect_output(summary(getDesignFisher(alpha0Vec = c(0.1, 0.2)))$show()) expect_output(summary(getDesignFisher(kMax = 1))$show()) expect_output(summary(getDesignFisher(kMax = 4), digits = 5)$show()) expect_output(summary(getDesignFisher(kMax = 4), digits = 0)$show()) expect_output(summary(getDesignFisher(kMax = 1))$show()) ## test design plans - means expect_output(summary(getSampleSizeMeans(sided = 2, alternative = -0.5))$show()) expect_output(summary(getPowerMeans(sided = 1, alternative = c(-0.5, -0.3), maxNumberOfSubjects = 100, directionUpper = FALSE))$show()) expect_output(summary(getSampleSizeMeans(thetaH0 = 0, alternative = 0.5, sided = 1, stDev = 2.5))$show()) expect_output(summary(getSampleSizeMeans(thetaH0 = 0, alternative = 0.5, sided = 1, stDev = 1, groups = 1))$show()) expect_output(summary(getSampleSizeMeans(thetaH0 = 0, sided = 2, stDev = 1, groups = 1))$show()) expect_output(summary(getSampleSizeMeans(thetaH0 = 0, alternative = 1.2, sided = 2, stDev = 5))$show()) expect_output(summary(getSampleSizeMeans(thetaH0 = 0, alternative = 1.2, sided = 2, stDev = 5, allocationRatioPlanned = 0))$show()) expect_output(summary(getSampleSizeMeans(thetaH0 = 0, alternative = 1.2, sided = 2, stDev = 5, groups = 1))$show()) expect_output(summary(getSampleSizeMeans( getDesignGroupSequential(futilityBounds = c(1, 2)) ))$show()) expect_output(summary(getSampleSizeMeans( getDesignGroupSequential(futilityBounds = c(1, 2)) ), digits = 0)$show()) expect_output(summary(getPowerMeans( getDesignGroupSequential(futilityBounds = c(1, 2)), maxNumberOfSubjects = 100, alternative = 1 ))$show()) expect_output(summary(getSampleSizeMeans( getDesignGroupSequential(kMax = 4, sided = 2) ))$show()) expect_output(summary(getPowerMeans( getDesignGroupSequential(kMax = 4, sided = 2), maxNumberOfSubjects = 100 ))$show()) expect_output(summary(getPowerMeans( getDesignGroupSequential(kMax = 1, sided = 2), maxNumberOfSubjects = 100 ))$show()) expect_output(summary(getSampleSizeMeans(getDesignGroupSequential(futilityBounds = c(1, 2))))$show()) expect_output(summary(getSampleSizeMeans(getDesignGroupSequential(futilityBounds = c(1, 2))), digits = 4)$show()) expect_output(summary(getSampleSizeMeans(getDesignGroupSequential(futilityBounds = c(1, 2))), digits = 3)$show()) expect_output(summary(getSampleSizeMeans(getDesignGroupSequential(futilityBounds = c(1, 2))), digits = 2)$show()) expect_output(summary(getSampleSizeMeans(getDesignGroupSequential(futilityBounds = c(1, 2))), digits = -1)$show()) ## test design plans - rates expect_output(summary(getSampleSizeRates(pi2 = 0.3))$show()) expect_output(summary(getSampleSizeRates(groups = 1, thetaH0 = 0.3))$show()) expect_output(summary(getSampleSizeRates(groups = 1, thetaH0 = 0.45))$show()) expect_output(summary(getSampleSizeRates(groups = 2, thetaH0 = 0.45, allocationRatioPlanned = 0))$show()) expect_output(summary(getSampleSizeRates(getDesignGroupSequential(futilityBounds = c(1, 2))))$show()) expect_output(summary(getPowerRates(getDesignGroupSequential(futilityBounds = c(1, 2)), maxNumberOfSubjects = 100))$show()) expect_output(summary(getSampleSizeRates(getDesignGroupSequential(kMax = 4, sided = 2)))$show()) expect_output(summary(getSampleSizeRates(getDesignGroupSequential(kMax = 4, sided = 2), groups = 1, thetaH0 = 0.3))$show()) expect_output(summary(getSampleSizeRates(getDesignGroupSequential(kMax = 1, sided = 2), groups = 1, thetaH0 = 0.2, pi1 = c(0.4, 0.5) ))$show()) expect_output(summary(getSampleSizeRates(getDesignGroupSequential( kMax = 1, sided = 2 ), groups = 1, thetaH0 = 0.2, pi1 = 0.4))$show()) expect_output(summary(getSampleSizeRates(getDesignGroupSequential( kMax = 1, sided = 2 ), groups = 2, thetaH0 = 0, pi1 = 0.25))$show()) expect_output(summary(getPowerRates(getDesignGroupSequential(kMax = 4, sided = 2), maxNumberOfSubjects = 100))$show()) ## test design plans - survival expect_output(summary(getSampleSizeSurvival())$show()) expect_output(summary(getSampleSizeSurvival(lambda2 = 0.3, hazardRatio = 1.2))$show()) expect_output(summary(getSampleSizeSurvival(lambda2 = 0.3, hazardRatio = c(1.2, 2)))$show()) expect_output(summary(getSampleSizeSurvival(pi2 = 0.3, hazardRatio = 1.2))$show()) expect_output(summary(getSampleSizeSurvival(pi1 = 0.1, pi2 = 0.3))$show()) expect_output(summary(getSampleSizeSurvival(lambda2 = 0.03, lambda1 = c(0.040)))$show()) expect_output(summary(getSampleSizeSurvival(piecewiseSurvivalTime = list( "0 - <6" = 0.025, "6 - <9" = 0.04, "9 - <15" = 0.015, "15 - <21" = 0.01, ">=21" = 0.007 ), hazardRatio = 1.2))$show()) expect_output(summary(getSampleSizeSurvival(getDesignGroupSequential(futilityBounds = c(1, 2))))$show()) expect_output(summary(getPowerSurvival(getDesignGroupSequential(futilityBounds = c(1, 2)), maxNumberOfSubjects = 100, maxNumberOfEvents = 60 ))$show()) expect_output(summary(getSampleSizeSurvival(getDesignGroupSequential(kMax = 4, sided = 2)))$show()) expect_output(summary(getPowerSurvival(getDesignGroupSequential(kMax = 4, sided = 2), maxNumberOfSubjects = 100, maxNumberOfEvents = 60 ))$show()) expect_output(summary(getSampleSizeSurvival(sided = 2, lambda2 = log(2) / 6, lambda1 = log(2) / 8))$show()) expect_output(summary(getPowerSurvival( sided = 2, maxNumberOfSubjects = 200, maxNumberOfEvents = 40, lambda2 = log(2) / 6, lambda1 = log(2) / 8 ))$show()) expect_warning(expect_output(summary(getSampleSizeSurvival(getDesignGroupSequential(sided = 2), lambda2 = log(2) / 6, hazardRatio = c(0.55), accrualTime = c(0, 10), accrualIntensity = 60 ))$show()), "Accrual duration longer than maximal study duration (time to maximal number of events); followUpTime = -2.959", fixed = TRUE ) expect_output(summary(getPowerSurvival(getDesignGroupSequential(kMax = 2), maxNumberOfEvents = 150, maxNumberOfSubjects = 400, lambda2 = log(2) / 60, lambda1 = log(2) / 50, dropoutRate1 = 0.025, dropoutRate2 = 0.025, dropoutTime = 12, accrualTime = 0, accrualIntensity = 30 ))$show()) expect_output(summary(getPowerSurvival(getDesignGroupSequential(kMax = 3), maxNumberOfEvents = 200, maxNumberOfSubjects = 400, lambda2 = log(2) / 60, lambda1 = c(log(2) / 50, log(2) / 60), dropoutRate1 = 0.025, dropoutRate2 = 0.025, dropoutTime = 12, accrualTime = 0, accrualIntensity = 30 ))$show()) expect_output(summary(getPowerSurvival(getDesignGroupSequential(kMax = 3), maxNumberOfEvents = 200, maxNumberOfSubjects = 400, lambda2 = log(2) / 60, hazardRatio = c(0.7, 0.8), directionUpper = FALSE, dropoutRate1 = 0.025, dropoutRate2 = 0.025, dropoutTime = 12, accrualTime = 0, accrualIntensity = 30 ))$show()) design1 <- getDesignGroupSequential( sided = 2, alpha = 0.05, beta = 0.2, informationRates = c(0.6, 1), typeOfDesign = "asOF", twoSidedPower = FALSE ) expect_output(summary(getSampleSizeSurvival( design1, lambda2 = log(2) / 60, hazardRatio = 0.74, dropoutRate1 = 0.025, dropoutRate2 = 0.025, dropoutTime = 12, accrualTime = 0, accrualIntensity = 30, followUpTime = 12 ))$show()) expect_output(summary(getSampleSizeSurvival( design1, lambda2 = log(2) / 60, lambda1 = log(2) / 50, dropoutRate1 = 0.025, dropoutRate2 = 0.025, dropoutTime = 12, accrualTime = 0, accrualIntensity = 30, followUpTime = 12 ))$show()) expect_output(summary(getSampleSizeSurvival(getDesignGroupSequential(kMax = 4, sided = 2)))$show()) ## simulations design2 <- getDesignInverseNormal( alpha = 0.05, kMax = 4, futilityBounds = c(0, 0, 0), sided = 1, typeOfDesign = "WT", deltaWT = 0.1 ) expect_output(summary(getSimulationSurvival(design2, lambda2 = log(2) / 60, lambda1 = c(log(2) / 80), maxNumberOfSubjects = 1000, plannedEvents = c(50, 100, 150, 200), seed = 12345, directionUpper = FALSE ))$show()) expect_output(summary(getSimulationSurvival(design2, lambda2 = log(2) / 60, hazardRatio = c(1.2, 1.4), maxNumberOfSubjects = 1000, plannedEvents = c(50, 100, 150, 200), seed = 12345 ))$show()) design3 <- getDesignGroupSequential(typeOfDesign = "P", futilityBounds = c(1, 1)) expect_output(summary(getSampleSizeMeans(design3))$show()) expect_output(summary(getSimulationMeans(design3, stDev = 4, plannedSubjects = (1:3) * 200, alternative = c(1, 2)))$show()) expect_output(summary(getSimulationRates(design3, plannedSubjects = (1:3) * 200, pi1 = c(0.3, 0.4), maxNumberOfIterations = 1000, minNumberOfSubjectsPerStage = c(NA, 40, 40), maxNumberOfSubjectsPerStage = c(NA, 40, 400), conditionalPower = 0.8 ))$show()) expect_output(summary(getSimulationMeans(getDesignGroupSequential(kMax = 1), stDev = 4, plannedSubjects = 200, alternative = 1 ))$show()) })