### Mediator model

Call:
glm(formula = bili_bin ~ trt + age + male + stage, family = binomial(link = "logit"), 
    data = data)

Coefficients:
            Estimate Std. Error z value Pr(>|z|)    
(Intercept) -1.53024    0.85116  -1.798  0.07220 .  
trt         -0.17117    0.25982  -0.659  0.51003    
age         -0.01386    0.01299  -1.067  0.28610    
male         1.33046    0.43911   3.030  0.00245 ** 
stage        0.74640    0.16356   4.563 5.03e-06 ***
---
Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

(Dispersion parameter for binomial family taken to be 1)

    Null deviance: 382.49  on 275  degrees of freedom
Residual deviance: 349.60  on 271  degrees of freedom
AIC: 359.6

Number of Fisher Scoring iterations: 4

### Outcome model
Call:
survival::coxph(formula = Surv(time, status) ~ trt + bili_bin + 
    trt:bili_bin + age + male + stage, data = data, ties = "efron")

  n= 276, number of events= 129 

                  coef exp(coef)  se(coef)      z Pr(>|z|)    
trt          -0.026402  0.973944  0.349565 -0.076  0.93979    
bili_bin      1.900175  6.687068  0.649277  2.927  0.00343 ** 
age           0.017670  1.017827  0.009092  1.943  0.05197 .  
male         -0.007798  0.992233  0.241523 -0.032  0.97424    
stage         0.590715  1.805278  0.130943  4.511 6.45e-06 ***
trt:bili_bin -0.225433  0.798170  0.407892 -0.553  0.58048    
---
Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

             exp(coef) exp(-coef) lower .95 upper .95
trt             0.9739     1.0268    0.4909     1.932
bili_bin        6.6871     0.1495    1.8731    23.873
age             1.0178     0.9825    0.9998     1.036
male            0.9922     1.0078    0.6181     1.593
stage           1.8053     0.5539    1.3966     2.333
trt:bili_bin    0.7982     1.2529    0.3588     1.775

Concordance= 0.793  (se = 0.019 )
Likelihood ratio test= 117  on 6 df,   p=<2e-16
Wald test            = 99.74  on 6 df,   p=<2e-16
Score (logrank) test = 118.3  on 6 df,   p=<2e-16

### Mediation analysis 
             est         se          Z         p      lower     upper  exp(est)
cde  -0.41040997 0.39551584 -1.0376575 0.2994295 -1.1856068 0.3647868 0.6633782
pnde -0.26780383 0.23080518 -1.1603025 0.2459257 -0.7201737 0.1845660 0.7650579
tnie -0.05496194 0.08634058 -0.6365713 0.5244041 -0.2241864 0.1142625 0.9465212
tnde -0.26115583 0.22771177 -1.1468702 0.2514353 -0.7074627 0.1851510 0.7701609
pnie -0.06160993 0.09652707 -0.6382658 0.5233007 -0.2507995 0.1275797 0.9402496
te   -0.32276576 0.24422404 -1.3215970 0.1863024 -0.8014361 0.1559046 0.7241435
pm    0.14831765 0.23229383  0.6384916 0.5231537 -0.3069699 0.6036052        NA
     exp(lower) exp(upper)
cde   0.3055607   1.440207
pnde  0.4866677   1.202696
tnie  0.7991662   1.121046
tnde  0.4928932   1.203400
pnie  0.7781784   1.136075
te    0.4486842   1.168715
pm           NA         NA

Evaluated at:
avar: trt
 a1 (intervened value of avar) = 2.3
 a0 (reference value of avar)  = 1.1
mvar: bili_bin
 m_cde (intervend value of mvar for cde) = 1.4
cvar: age male stage
 c_cond (covariate vector value) = 50 1 2

Note that effect estimates can vary over m_cde and c_cond values when interaction = TRUE.

### Re-evaluation at c_cond = cmean
             est         se          Z         p      lower     upper  exp(est)
cde  -0.41040997 0.39551584 -1.0376575 0.2994295 -1.1856068 0.3647868 0.6633782
pnde -0.25440700 0.22442467 -1.1335964 0.2569639 -0.6942713 0.1854573 0.7753762
tnie -0.06281427 0.09700377 -0.6475446 0.5172795 -0.2529382 0.1273096 0.9391179
tnde -0.24579044 0.22209372 -1.1066969 0.2684250 -0.6810861 0.1895052 0.7820861
pnie -0.07143083 0.10971539 -0.6510557 0.5150105 -0.2864690 0.1436074 0.9310607
te   -0.31722127 0.24408364 -1.2996417 0.1937238 -0.7956164 0.1611739 0.7281696
pm    0.17366176 0.25873752  0.6711889 0.5021002 -0.3334545 0.6807780        NA
     exp(lower) exp(upper)
cde   0.3055607   1.440207
pnde  0.4994383   1.203769
tnie  0.7765159   1.135769
tnde  0.5060670   1.208651
pnie  0.7509103   1.154431
te    0.4513030   1.174889
pm           NA         NA