### Mediator model Call: glm(formula = bili_bin ~ trt, family = binomial(link = "logit"), data = data) Coefficients: Estimate Std. Error z value Pr(>|z|) (Intercept) 0.08577 0.38245 0.224 0.823 trt -0.08577 0.24091 -0.356 0.722 (Dispersion parameter for binomial family taken to be 1) Null deviance: 382.49 on 275 degrees of freedom Residual deviance: 382.36 on 274 degrees of freedom AIC: 386.36 Number of Fisher Scoring iterations: 3 ### Outcome model Call: survival::survreg(formula = Surv(time, status) ~ trt + bili_bin + trt:bili_bin, data = data, dist = "exponential") Value Std. Error z p (Intercept) 9.2078 0.5557 16.57 <2e-16 trt 0.0274 0.3483 0.08 0.9374 bili_bin -1.6564 0.6408 -2.59 0.0097 trt:bili_bin 0.0437 0.4038 0.11 0.9138 Scale fixed at 1 Exponential distribution Loglik(model)= -1169.3 Loglik(intercept only)= -1206.3 Chisq= 74.05 on 3 degrees of freedom, p= 5.8e-16 Number of Newton-Raphson Iterations: 5 n= 276 ### Mediation analysis est se Z p lower upper exp(est) cde 0.10629627 0.38178196 0.2784214 0.7806889 -0.6419826 0.8545752 1.112151 pnde 0.04173257 0.34924907 0.1194923 0.9048853 -0.6427830 0.7262482 1.042616 tnie 0.03285015 0.09188457 0.3575154 0.7207060 -0.1472403 0.2129406 1.033396 tnde 0.04099885 0.35469634 0.1155886 0.9079786 -0.6541932 0.7361909 1.041851 pnie 0.03358388 0.09383305 0.3579110 0.7204099 -0.1503255 0.2174933 1.034154 te 0.07458273 0.36475046 0.2044760 0.8379815 -0.6403150 0.7894805 1.077434 pm 0.44965572 2.11928459 0.2121734 0.8319718 -3.7040658 4.6033772 NA exp(lower) exp(upper) cde 0.5262480 2.350376 pnde 0.5258270 2.067310 tnie 0.8630866 1.237311 tnde 0.5198613 2.087967 pnie 0.8604278 1.242957 te 0.5271263 2.202252 pm NA NA Evaluated at: avar: trt a1 (intervened value of avar) = 2.3 a0 (reference value of avar) = 1.1 mvar: bili_bin m_cde (intervend value of mvar for cde) = 1.4 cvar: c_cond (covariate vector value) = Note that effect estimates can vary over m_cde and c_cond values when interaction = TRUE.