### Mediator model Call: glm(formula = bili_bin ~ trt + age + male + stage, family = binomial(link = "logit"), data = data) Coefficients: Estimate Std. Error z value Pr(>|z|) (Intercept) -1.09095 1.02743 -1.062 0.288315 trt -0.22689 0.32051 -0.708 0.479009 age -0.02366 0.01586 -1.492 0.135744 male 1.77461 0.47253 3.756 0.000173 *** stage 0.66646 0.19644 3.393 0.000692 *** --- Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1 (Dispersion parameter for binomial family taken to be 1) Null deviance: 264.30 on 195 degrees of freedom Residual deviance: 234.79 on 191 degrees of freedom AIC: 244.79 Number of Fisher Scoring iterations: 4 ### Outcome model Call: glm(formula = spiders ~ trt + bili_bin + trt:bili_bin + age + male + stage, family = binomial(link = "logit"), data = data) Coefficients: Estimate Std. Error z value Pr(>|z|) (Intercept) -3.582569 1.180438 -3.035 0.00241 ** trt -0.249105 0.470069 -0.530 0.59616 bili_bin 1.011176 0.958044 1.055 0.29122 age -0.006281 0.014951 -0.420 0.67441 male -1.628478 0.588097 -2.769 0.00562 ** stage 0.917657 0.215085 4.266 1.99e-05 *** trt:bili_bin 0.058788 0.601373 0.098 0.92213 --- Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1 (Dispersion parameter for binomial family taken to be 1) Null deviance: 332.32 on 275 degrees of freedom Residual deviance: 278.76 on 269 degrees of freedom AIC: 292.76 Number of Fisher Scoring iterations: 5 ### Mediation analysis est se Z p lower upper exp(est) cde -0.20016298 0.67777364 -0.2953242 0.7677462 -1.5285749 1.1282489 0.8185973 pnde -0.23932319 0.39943518 -0.5991540 0.5490702 -1.0222018 0.5435554 0.7871604 tnie -0.06015561 0.09070684 -0.6631872 0.5072107 -0.2379377 0.1176265 0.9416180 tnde -0.24208214 0.38797292 -0.6239666 0.5326495 -1.0024951 0.5183308 0.7849917 pnie -0.05739666 0.08541894 -0.6719431 0.5016199 -0.2248147 0.1100214 0.9442195 te -0.29947881 0.40152620 -0.7458512 0.4557573 -1.0864557 0.4874981 0.7412044 pm 0.17757647 0.36243520 0.4899537 0.6241667 -0.5327835 0.8879364 NA exp(lower) exp(upper) cde 0.2168445 3.090241 pnde 0.3598019 1.722119 tnie 0.7882518 1.124824 tnde 0.3669627 1.679222 pnie 0.7986642 1.116302 te 0.3374103 1.628237 pm NA NA Evaluated at: avar: trt a1 (intervened value of avar) = 2.3 a0 (reference value of avar) = 1.1 mvar: bili_bin m_cde (intervend value of mvar for cde) = 1.4 cvar: age male stage c_cond (covariate vector value) = 50 1 2 Note that effect estimates can vary over m_cde and c_cond values when interaction = TRUE. ### Re-evaluation at c_cond = cmean est se Z p lower upper exp(est) cde -0.20016298 0.6777736 -0.2953242 0.7677462 -1.5285749 1.1282489 0.8185973 pnde -0.24969887 0.3656050 -0.6829744 0.4946230 -0.9662715 0.4668738 0.7790353 tnie -0.07539333 0.1117265 -0.6748026 0.4998012 -0.2943732 0.1435866 0.9273786 tnde -0.25395145 0.3598610 -0.7056932 0.4803790 -0.9592661 0.4513632 0.7757295 pnie -0.07114074 0.1032713 -0.6888723 0.4909037 -0.2735488 0.1312673 0.9313308 te -0.32509220 0.3761906 -0.8641689 0.3874951 -1.0624122 0.4122278 0.7224607 pm 0.20384360 0.3643753 0.5594330 0.5758662 -0.5103190 0.9180061 NA exp(lower) exp(upper) cde 0.2168445 3.090241 pnde 0.3804991 1.595000 tnie 0.7449984 1.154407 tnde 0.3831740 1.570451 pnie 0.7606752 1.140273 te 0.3456211 1.510178 pm NA NA