### Mediator model Call: glm(formula = bili_bin ~ trt + age + male + stage, family = binomial(link = "logit"), data = data) Coefficients: Estimate Std. Error z value Pr(>|z|) (Intercept) -1.53024 0.85116 -1.798 0.07220 . trt -0.17117 0.25982 -0.659 0.51003 age -0.01386 0.01299 -1.067 0.28610 male 1.33046 0.43911 3.030 0.00245 ** stage 0.74640 0.16356 4.563 5.03e-06 *** --- Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1 (Dispersion parameter for binomial family taken to be 1) Null deviance: 382.49 on 275 degrees of freedom Residual deviance: 349.60 on 271 degrees of freedom AIC: 359.6 Number of Fisher Scoring iterations: 4 ### Outcome model Call: glm(formula = spiders ~ trt + bili_bin + trt:bili_bin + age + male + stage, family = binomial(link = "logit"), data = data) Coefficients: Estimate Std. Error z value Pr(>|z|) (Intercept) -3.582569 1.180438 -3.035 0.00241 ** trt -0.249105 0.470069 -0.530 0.59616 bili_bin 1.011176 0.958044 1.055 0.29122 age -0.006281 0.014951 -0.420 0.67441 male -1.628478 0.588097 -2.769 0.00562 ** stage 0.917657 0.215085 4.266 1.99e-05 *** trt:bili_bin 0.058788 0.601373 0.098 0.92213 --- Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1 (Dispersion parameter for binomial family taken to be 1) Null deviance: 332.32 on 275 degrees of freedom Residual deviance: 278.76 on 269 degrees of freedom AIC: 292.76 Number of Fisher Scoring iterations: 5 ### Mediation analysis est se Z p lower upper cde -0.20016298 0.67777364 -0.2953242 0.7677462 -1.5285749 1.12824895 pnde -0.24101369 0.39220476 -0.6145099 0.5388785 -1.0097209 0.52769350 tnie -0.04808174 0.07685787 -0.6255930 0.5315819 -0.1987204 0.10255690 tnde -0.24328543 0.38349311 -0.6343932 0.5258242 -0.9949181 0.50834725 pnie -0.04581000 0.07233111 -0.6333375 0.5265133 -0.1875764 0.09595636 te -0.28909544 0.39349183 -0.7346923 0.4625269 -1.0603253 0.48213439 pm 0.14693797 0.31342905 0.4688078 0.6392071 -0.4673717 0.76124762 exp(est) exp(lower) exp(upper) cde 0.8185973 0.2168445 3.090241 pnde 0.7858309 0.3643207 1.695018 tnie 0.9530559 0.8197791 1.108000 tnde 0.7840477 0.3697537 1.662541 pnie 0.9552234 0.8289658 1.100711 te 0.7489407 0.3463431 1.619527 pm NA NA NA Evaluated at: avar: trt a1 (intervened value of avar) = 2.3 a0 (reference value of avar) = 1.1 mvar: bili_bin m_cde (intervend value of mvar for cde) = 1.4 cvar: age male stage c_cond (covariate vector value) = 50 1 2 Note that effect estimates can vary over m_cde and c_cond values when interaction = TRUE. ### Re-evaluation at c_cond = cmean est se Z p lower upper exp(est) cde -0.20016298 0.67777364 -0.2953242 0.7677462 -1.5285749 1.1282489 0.8185973 pnde -0.24553980 0.37599157 -0.6530460 0.5137266 -0.9824697 0.4913901 0.7822821 tnie -0.05415201 0.08560184 -0.6326033 0.5269927 -0.2219285 0.1136245 0.9472881 tnde -0.24834485 0.36849213 -0.6739489 0.5003438 -0.9705762 0.4738865 0.7800909 pnie -0.05134695 0.07996863 -0.6420887 0.5208156 -0.2080826 0.1053887 0.9499490 te -0.29969181 0.37967559 -0.7893365 0.4299153 -1.0438423 0.4444587 0.7410466 pm 0.15923935 0.32031178 0.4971386 0.6190913 -0.4685602 0.7870389 NA exp(lower) exp(upper) cde 0.2168445 3.090241 pnde 0.3743853 1.634587 tnie 0.8009726 1.120331 tnde 0.3788647 1.606225 pnie 0.8121400 1.111142 te 0.3520992 1.559646 pm NA NA