### Mediator model Call: glm(formula = bili_bin ~ trt + age + male + stage, family = binomial(link = "logit"), data = data) Coefficients: Estimate Std. Error z value Pr(>|z|) (Intercept) -1.09095 1.02743 -1.062 0.288315 trt -0.22689 0.32051 -0.708 0.479009 age -0.02366 0.01586 -1.492 0.135744 male 1.77461 0.47253 3.756 0.000173 *** stage 0.66646 0.19644 3.393 0.000692 *** --- Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1 (Dispersion parameter for binomial family taken to be 1) Null deviance: 264.30 on 195 degrees of freedom Residual deviance: 234.79 on 191 degrees of freedom AIC: 244.79 Number of Fisher Scoring iterations: 4 ### Outcome model Call: glm(formula = spiders ~ trt + bili_bin + age + male + stage, family = binomial(link = "logit"), data = data) Coefficients: Estimate Std. Error z value Pr(>|z|) (Intercept) -3.637453 1.040043 -3.497 0.000470 *** trt -0.213652 0.299018 -0.715 0.474910 bili_bin 1.099999 0.306126 3.593 0.000327 *** age -0.006266 0.014950 -0.419 0.675139 male -1.629057 0.588212 -2.770 0.005614 ** stage 0.917829 0.215159 4.266 1.99e-05 *** --- Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1 (Dispersion parameter for binomial family taken to be 1) Null deviance: 332.32 on 275 degrees of freedom Residual deviance: 278.77 on 270 degrees of freedom AIC: 290.77 Number of Fisher Scoring iterations: 5 ### Mediation analysis est se Z p lower upper exp(est) cde -0.25638256 0.35882155 -0.7145127 0.4749102 -0.9596599 0.4468947 0.7738459 pnde -0.25638256 0.35882155 -0.7145127 0.4749102 -0.9596599 0.4468947 0.7738459 tnie -0.05835565 0.08624365 -0.6766370 0.4986363 -0.2273901 0.1106788 0.9433144 tnde -0.25638256 0.35882155 -0.7145127 0.4749102 -0.9596599 0.4468947 0.7738459 pnie -0.05835565 0.08624365 -0.6766370 0.4986363 -0.2273901 0.1106788 0.9433144 te -0.31473821 0.36891196 -0.8531526 0.3935747 -1.0377924 0.4083159 0.7299800 pm 0.16245429 0.29131883 0.5576512 0.5770826 -0.4085201 0.7334287 NA exp(lower) exp(upper) cde 0.3830231 1.563450 pnde 0.3830231 1.563450 tnie 0.7966100 1.117036 tnde 0.3830231 1.563450 pnie 0.7966100 1.117036 te 0.3542358 1.504282 pm NA NA Evaluated at: avar: trt a1 (intervened value of avar) = 2.3 a0 (reference value of avar) = 1.1 mvar: bili_bin m_cde (intervend value of mvar for cde) = 1.4 cvar: age male stage c_cond (covariate vector value) = 50 1 2 Note that effect estimates do not vary over m_cde and c_cond values when interaction = FALSE. ### Re-evaluation at c_cond = cmean est se Z p lower upper exp(est) cde -0.25638256 0.3588215 -0.7145127 0.4749102 -0.9596599 0.4468947 0.7738459 pnde -0.25638256 0.3588215 -0.7145127 0.4749102 -0.9596599 0.4468947 0.7738459 tnie -0.07260819 0.1042086 -0.6967584 0.4859540 -0.2768532 0.1316368 0.9299651 tnde -0.25638256 0.3588215 -0.7145127 0.4749102 -0.9596599 0.4468947 0.7738459 pnie -0.07260819 0.1042086 -0.6967584 0.4859540 -0.2768532 0.1316368 0.9299651 te -0.32899076 0.3734523 -0.8809444 0.3783479 -1.0609439 0.4029624 0.7196497 pm 0.19331598 0.3286213 0.5882636 0.5563554 -0.4507700 0.8374020 NA exp(lower) exp(upper) cde 0.3830231 1.563450 pnde 0.3830231 1.563450 tnie 0.7581658 1.140694 tnde 0.3830231 1.563450 pnie 0.7581658 1.140694 te 0.3461290 1.496251 pm NA NA