### Mediator model Call: glm(formula = bili_bin ~ trt + age + male + stage, family = binomial(link = "logit"), data = data) Coefficients: Estimate Std. Error z value Pr(>|z|) (Intercept) -1.53024 0.85116 -1.798 0.07220 . trt -0.17117 0.25982 -0.659 0.51003 age -0.01386 0.01299 -1.067 0.28610 male 1.33046 0.43911 3.030 0.00245 ** stage 0.74640 0.16356 4.563 5.03e-06 *** --- Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1 (Dispersion parameter for binomial family taken to be 1) Null deviance: 382.49 on 275 degrees of freedom Residual deviance: 349.60 on 271 degrees of freedom AIC: 359.6 Number of Fisher Scoring iterations: 4 ### Outcome model Call: glm(formula = spiders ~ trt + bili_bin + age + male + stage, family = binomial(link = "logit"), data = data) Coefficients: Estimate Std. Error z value Pr(>|z|) (Intercept) -3.637453 1.040043 -3.497 0.000470 *** trt -0.213652 0.299018 -0.715 0.474910 bili_bin 1.099999 0.306126 3.593 0.000327 *** age -0.006266 0.014950 -0.419 0.675139 male -1.629057 0.588212 -2.770 0.005614 ** stage 0.917829 0.215159 4.266 1.99e-05 *** --- Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1 (Dispersion parameter for binomial family taken to be 1) Null deviance: 332.32 on 275 degrees of freedom Residual deviance: 278.77 on 270 degrees of freedom AIC: 290.77 Number of Fisher Scoring iterations: 5 ### Mediation analysis est se Z p lower upper cde -0.25638256 0.35882155 -0.7145127 0.4749102 -0.9596599 0.44689474 pnde -0.25638256 0.35882155 -0.7145127 0.4749102 -0.9596599 0.44689474 tnie -0.04659889 0.07309229 -0.6375350 0.5237764 -0.1898571 0.09665937 tnde -0.25638256 0.35882155 -0.7145127 0.4749102 -0.9596599 0.44689474 pnie -0.04659889 0.07309229 -0.6375350 0.5237764 -0.1898571 0.09665937 te -0.30298146 0.36608377 -0.8276287 0.4078808 -1.0204925 0.41452956 pm 0.13479265 0.25743161 0.5236056 0.6005529 -0.3697640 0.63934933 exp(est) exp(lower) exp(upper) cde 0.7738459 0.3830231 1.563450 pnde 0.7738459 0.3830231 1.563450 tnie 0.9544702 0.8270773 1.101485 tnde 0.7738459 0.3830231 1.563450 pnie 0.9544702 0.8270773 1.101485 te 0.7386128 0.3604174 1.513658 pm NA NA NA Evaluated at: avar: trt a1 (intervened value of avar) = 2.3 a0 (reference value of avar) = 1.1 mvar: bili_bin m_cde (intervend value of mvar for cde) = 1.4 cvar: age male stage c_cond (covariate vector value) = 50 1 2 Note that effect estimates do not vary over m_cde and c_cond values when interaction = FALSE. ### Re-evaluation at c_cond = cmean est se Z p lower upper exp(est) cde -0.2563826 0.35882155 -0.7145127 0.4749102 -0.9596599 0.4468947 0.7738459 pnde -0.2563826 0.35882155 -0.7145127 0.4749102 -0.9596599 0.4468947 0.7738459 tnie -0.0523180 0.08080341 -0.6474726 0.5173261 -0.2106898 0.1060538 0.9490270 tnde -0.2563826 0.35882155 -0.7145127 0.4749102 -0.9596599 0.4468947 0.7738459 pnie -0.0523180 0.08080341 -0.6474726 0.5173261 -0.2106898 0.1060538 0.9490270 te -0.3087006 0.36767629 -0.8395988 0.4011334 -1.0293329 0.4119317 0.7344006 pm 0.1485140 0.27672463 0.5366851 0.5914851 -0.3938563 0.6908843 NA exp(lower) exp(upper) cde 0.3830231 1.563450 pnde 0.3830231 1.563450 tnie 0.8100253 1.111882 tnde 0.3830231 1.563450 pnie 0.8100253 1.111882 te 0.3572452 1.509731 pm NA NA