### Mediator model

Call:
glm(formula = bili_bin ~ trt + age + male + stage, family = binomial(link = "logit"), 
    data = data)

Coefficients:
            Estimate Std. Error z value Pr(>|z|)    
(Intercept) -1.53024    0.85116  -1.798  0.07220 .  
trt         -0.17117    0.25982  -0.659  0.51003    
age         -0.01386    0.01299  -1.067  0.28610    
male         1.33046    0.43911   3.030  0.00245 ** 
stage        0.74640    0.16356   4.563 5.03e-06 ***
---
Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

(Dispersion parameter for binomial family taken to be 1)

    Null deviance: 382.49  on 275  degrees of freedom
Residual deviance: 349.60  on 271  degrees of freedom
AIC: 359.6

Number of Fisher Scoring iterations: 4

### Outcome model

Call:
lm(formula = alk_phos ~ trt + bili_bin + trt:bili_bin + age + 
    male + stage, data = data)

Residuals:
    Min      1Q  Median      3Q     Max 
-2024.9 -1078.3  -594.4    44.3 12074.4 

Coefficients:
             Estimate Std. Error t value Pr(>|t|)  
(Intercept)  2140.824    918.685   2.330   0.0205 *
trt           -52.733    359.220  -0.147   0.8834  
bili_bin      565.487    816.683   0.692   0.4893  
age            -4.433     12.830  -0.346   0.7300  
male          -15.412    407.373  -0.038   0.9698  
stage         -49.156    159.301  -0.309   0.7579  
trt:bili_bin   42.041    510.197   0.082   0.9344  
---
Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

Residual standard error: 2116 on 269 degrees of freedom
Multiple R-squared:  0.02133,	Adjusted R-squared:  -0.0004967 
F-statistic: 0.9772 on 6 and 269 DF,  p-value: 0.441

### Mediation analysis 
             est         se           Z         p        lower      upper
cde    7.3490099 638.701879  0.01150617 0.9908196 -1244.483670 1259.18169
pnde -32.9351555 318.191908 -0.10350721 0.9175604  -656.579835  590.70952
tnie -33.1774995  56.236639 -0.58996235 0.5552159  -143.399286   77.04429
tnde -35.4628271 312.964803 -0.11331251 0.9097828  -648.862569  577.93691
pnie -30.6498279  49.883072 -0.61443344 0.5389289  -128.418853   67.11920
te   -66.1126550 318.108265 -0.20783067 0.8353612  -689.593397  557.36809
pm     0.5018328   2.489371  0.20159023 0.8402371    -4.377244    5.38091

Evaluated at:
avar: trt
 a1 (intervened value of avar) = 2.3
 a0 (reference value of avar)  = 1.1
mvar: bili_bin
 m_cde (intervend value of mvar for cde) = 1.4
cvar: age male stage
 c_cond (covariate vector value) = 50 1 2

Note that effect estimates can vary over m_cde and c_cond values when interaction = TRUE.

### Re-evaluation at c_cond = cmean
             est         se           Z         p        lower       upper
cde    7.3490099 638.701879  0.01150617 0.9908196 -1244.483670 1259.181690
pnde -37.7519518 310.711544 -0.12150161 0.9032937  -646.735388  571.231484
tnie -33.9211917  57.035087 -0.59474252 0.5520156  -145.707909   77.865525
tnde -40.3362826 311.210717 -0.12961084 0.8968743  -650.298079  569.625514
pnie -31.3368609  50.556449 -0.61983904 0.5353638  -130.425680   67.751958
te   -71.6731435 314.416441 -0.22795609 0.8196804  -687.918045  544.571758
pm     0.4732762   2.104913  0.22484353 0.8221010    -3.652278    4.598831