### Mediator model Call: glm(formula = bili_bin ~ trt, family = binomial(link = "logit"), data = data) Coefficients: Estimate Std. Error z value Pr(>|z|) (Intercept) 0.08577 0.38245 0.224 0.823 trt -0.08577 0.24091 -0.356 0.722 (Dispersion parameter for binomial family taken to be 1) Null deviance: 382.49 on 275 degrees of freedom Residual deviance: 382.36 on 274 degrees of freedom AIC: 386.36 Number of Fisher Scoring iterations: 3 ### Outcome model Call: lm(formula = alk_phos ~ trt + bili_bin + trt:bili_bin, data = data) Residuals: Min 1Q Median 3Q Max -1991.1 -1056.1 -598.5 66.9 12182.8 Coefficients: Estimate Std. Error t value Pr(>|t|) (Intercept) 1775.12 566.98 3.131 0.00193 ** trt -47.75 354.84 -0.135 0.89304 bili_bin 536.00 805.22 0.666 0.50619 trt:bili_bin 42.76 507.20 0.084 0.93287 --- Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1 Residual standard error: 2105 on 272 degrees of freedom Multiple R-squared: 0.02031, Adjusted R-squared: 0.009503 F-statistic: 1.879 on 3 and 272 DF, p-value: 0.1333 ### Mediation analysis est se Z p lower upper cde 14.5399178 632.236792 0.02299758 0.9816522 -1224.621425 1253.701261 pnde -31.7556539 304.304349 -0.10435491 0.9168877 -628.181219 564.669911 tnie -16.3037844 47.356520 -0.34427750 0.7306376 -109.120857 76.513289 tnde -33.0745702 304.449984 -0.10863712 0.9134903 -629.785574 563.636434 pnie -14.9848681 42.882020 -0.34944408 0.7267559 -99.032082 69.062346 te -48.0594383 307.469544 -0.15630634 0.8757916 -650.688670 554.569793 pm 0.3392421 2.251145 0.15069758 0.8802143 -4.072921 4.751405 Evaluated at: avar: trt a1 (intervened value of avar) = 2.3 a0 (reference value of avar) = 1.1 mvar: bili_bin m_cde (intervend value of mvar for cde) = 1.4 cvar: c_cond (covariate vector value) = Note that effect estimates can vary over m_cde and c_cond values when interaction = TRUE.