### Mediator model

Call:
lm(formula = bili ~ trt, data = data)

Residuals:
    Min      1Q  Median      3Q     Max 
-3.4000 -2.5000 -1.7000  0.4434 24.3000 

Coefficients:
            Estimate Std. Error t value Pr(>|t|)  
(Intercept)   2.2132     0.8784   2.520   0.0123 *
trt           0.7434     0.5532   1.344   0.1801  
---
Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

Residual standard error: 4.594 on 274 degrees of freedom
Multiple R-squared:  0.006548,	Adjusted R-squared:  0.002923 
F-statistic: 1.806 on 1 and 274 DF,  p-value: 0.1801

### Outcome model
Call:
survival::coxph(formula = Surv(time, status) ~ trt + bili + trt:bili, 
    data = data, ties = "efron")

  n= 276, number of events= 129 

             coef exp(coef) se(coef)      z Pr(>|z|)    
trt      -0.08286   0.92048  0.22094 -0.375    0.708    
bili      0.19522   1.21558  0.04565  4.276  1.9e-05 ***
trt:bili -0.03103   0.96944  0.02608 -1.190    0.234    
---
Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

         exp(coef) exp(-coef) lower .95 upper .95
trt         0.9205     1.0864    0.5970     1.419
bili        1.2156     0.8227    1.1115     1.329
trt:bili    0.9694     1.0315    0.9211     1.020

Concordance= 0.782  (se = 0.019 )
Likelihood ratio test= 76.52  on 3 df,   p=<2e-16
Wald test            = 115.1  on 3 df,   p=<2e-16
Score (logrank) test = 158.6  on 3 df,   p=<2e-16

### Mediation analysis 
            est         se          Z         p       lower      upper
cde  -0.1515674 0.24167061 -0.6271652 0.5305510 -0.62523308 0.32209831
pnde -0.3242940 0.21724139 -1.4927820 0.1354943 -0.75007935 0.10149126
tnie  0.1104747 0.08434748  1.3097565 0.1902782 -0.05484337 0.27579269
tnde -0.3575153 0.22336190 -1.6006101 0.1094633 -0.79529658 0.08026597
pnie  0.1436959 0.10841715  1.3253985 0.1850390 -0.06879778 0.35618962
te   -0.2138194 0.23637352 -0.9045826 0.3656865 -0.67710297 0.24946421
pm   -0.4387225 0.72508267 -0.6050655 0.5451355 -1.85985839 0.98241344
      exp(est) exp(lower) exp(upper)
cde  0.8593600  0.5351367   1.380020
pnde 0.7230376  0.4723291   1.106820
tnie 1.1168081  0.9466334   1.317575
tnde 0.6994120  0.4514473   1.083575
pnie 1.1545330  0.9335154   1.427878
te   0.8074942  0.5080868   1.283338
pm          NA         NA         NA

Evaluated at:
avar: trt
 a1 (intervened value of avar) = 2.3
 a0 (reference value of avar)  = 1.1
mvar: bili
 m_cde (intervend value of mvar for cde) = 1.4
cvar: 
 c_cond (covariate vector value) = 

Note that effect estimates can vary over m_cde and c_cond values when interaction = TRUE.