### Mediator model

Call:
lm(formula = bili ~ trt + age + male + stage, data = data)

Residuals:
    Min      1Q  Median      3Q     Max 
-4.1854 -2.5979 -1.2638  0.5727 24.2813 

Coefficients:
            Estimate Std. Error t value Pr(>|t|)    
(Intercept) -2.54577    1.76354  -1.444 0.150018    
trt          0.60723    0.54646   1.111 0.267464    
age          0.02419    0.02706   0.894 0.372025    
male        -0.61583    0.84467  -0.729 0.466584    
stage        1.26164    0.32279   3.909 0.000117 ***
---
Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

Residual standard error: 4.472 on 271 degrees of freedom
Multiple R-squared:  0.06893,	Adjusted R-squared:  0.05518 
F-statistic: 5.016 on 4 and 271 DF,  p-value: 0.0006483

### Outcome model
Call:
survival::coxph(formula = Surv(time, status) ~ trt + bili + age + 
    male + stage, data = data, ties = "efron")

  n= 276, number of events= 129 

           coef exp(coef)  se(coef)      z Pr(>|z|)    
trt   -0.192511  0.824885  0.180450 -1.067   0.2860    
bili   0.140134  1.150428  0.014301  9.799  < 2e-16 ***
age    0.007463  1.007491  0.009537  0.782   0.4339    
male   0.504040  1.655395  0.240725  2.094   0.0363 *  
stage  0.674402  1.962859  0.126505  5.331 9.77e-08 ***
---
Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

      exp(coef) exp(-coef) lower .95 upper .95
trt      0.8249     1.2123    0.5792     1.175
bili     1.1504     0.8692    1.1186     1.183
age      1.0075     0.9926    0.9888     1.027
male     1.6554     0.6041    1.0328     2.653
stage    1.9629     0.5095    1.5318     2.515

Concordance= 0.803  (se = 0.017 )
Likelihood ratio test= 117.9  on 5 df,   p=<2e-16
Wald test            = 137.4  on 5 df,   p=<2e-16
Score (logrank) test = 185.8  on 5 df,   p=<2e-16

### Mediation analysis 
            est         se          Z         p       lower     upper  exp(est)
cde  -0.2310134 0.21654043 -1.0668374 0.2860453 -0.65542488 0.1933980 0.7937288
pnde -0.2310134 0.21654043 -1.0668374 0.2860453 -0.65542488 0.1933980 0.7937288
tnie  0.1021117 0.09248155  1.1041309 0.2695364 -0.07914877 0.2833723 1.1075072
tnde -0.2310134 0.21654043 -1.0668374 0.2860453 -0.65542488 0.1933980 0.7937288
pnie  0.1021117 0.09248155  1.1041309 0.2695364 -0.07914877 0.2833723 1.1075072
te   -0.1289017 0.23464650 -0.5493442 0.5827693 -0.58880037 0.3309970 0.8790604
pm   -0.7055718 1.69784813 -0.4155682 0.6777260 -4.03329294 2.6221494        NA
     exp(lower) exp(upper)
cde   0.5192214   1.213366
pnde  0.5192214   1.213366
tnie  0.9239025   1.327599
tnde  0.5192214   1.213366
pnie  0.9239025   1.327599
te    0.5549927   1.392356
pm           NA         NA

Evaluated at:
avar: trt
 a1 (intervened value of avar) = 2.3
 a0 (reference value of avar)  = 1.1
mvar: bili
 m_cde (intervend value of mvar for cde) = 1.4
cvar: age male stage
 c_cond (covariate vector value) = 50 1 2

Note that effect estimates do not vary over m_cde and c_cond values when interaction = FALSE.

### Re-evaluation at c_cond = cmean
            est         se          Z         p       lower     upper  exp(est)
cde  -0.2310134 0.21654043 -1.0668374 0.2860453 -0.65542488 0.1933980 0.7937288
pnde -0.2310134 0.21654043 -1.0668374 0.2860453 -0.65542488 0.1933980 0.7937288
tnie  0.1021117 0.09248155  1.1041309 0.2695364 -0.07914877 0.2833723 1.1075072
tnde -0.2310134 0.21654043 -1.0668374 0.2860453 -0.65542488 0.1933980 0.7937288
pnie  0.1021117 0.09248155  1.1041309 0.2695364 -0.07914877 0.2833723 1.1075072
te   -0.1289017 0.23464650 -0.5493442 0.5827693 -0.58880037 0.3309970 0.8790604
pm   -0.7055718 1.69784813 -0.4155682 0.6777260 -4.03329294 2.6221494        NA
     exp(lower) exp(upper)
cde   0.5192214   1.213366
pnde  0.5192214   1.213366
tnie  0.9239025   1.327599
tnde  0.5192214   1.213366
pnie  0.9239025   1.327599
te    0.5549927   1.392356
pm           NA         NA