### Mediator model Call: lm(formula = bili ~ trt, data = data) Residuals: Min 1Q Median 3Q Max -3.4000 -2.5000 -1.7000 0.4434 24.3000 Coefficients: Estimate Std. Error t value Pr(>|t|) (Intercept) 2.2132 0.8784 2.520 0.0123 * trt 0.7434 0.5532 1.344 0.1801 --- Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1 Residual standard error: 4.594 on 274 degrees of freedom Multiple R-squared: 0.006548, Adjusted R-squared: 0.002923 F-statistic: 1.806 on 1 and 274 DF, p-value: 0.1801 ### Outcome model Call: survival::survreg(formula = Surv(time, status) ~ trt + bili, data = data, dist = "weibull") Value Std. Error z p (Intercept) 8.26928 0.19748 41.87 <2e-16 trt 0.15845 0.12738 1.24 0.21 bili -0.10040 0.00934 -10.75 <2e-16 Log(scale) -0.34643 0.07511 -4.61 4e-06 Scale= 0.707 Weibull distribution Loglik(model)= -1165.7 Loglik(intercept only)= -1203.8 Chisq= 76.03 on 2 degrees of freedom, p= 3.1e-17 Number of Newton-Raphson Iterations: 6 n= 276 ### Mediation analysis est se Z p lower upper exp(est) cde 0.19014456 0.1528561 1.2439446 0.2135200 -0.1094480 0.48973708 1.2094244 pnde 0.19014456 0.1528561 1.2439446 0.2135200 -0.1094480 0.48973708 1.2094244 tnie -0.08956246 0.0671626 -1.3335168 0.1823623 -0.2211987 0.04207382 0.9143312 tnde 0.19014456 0.1528561 1.2439446 0.2135200 -0.1094480 0.48973708 1.2094244 pnie -0.08956246 0.0671626 -1.3335168 0.1823623 -0.2211987 0.04207382 0.9143312 te 0.10058210 0.1653583 0.6082676 0.5430100 -0.2235142 0.42467843 1.1058144 pm -0.97916699 1.9566679 -0.5004258 0.6167753 -4.8141656 2.85583157 NA exp(lower) exp(upper) cde 0.8963288 1.631887 pnde 0.8963288 1.631887 tnie 0.8015574 1.042971 tnde 0.8963288 1.631887 pnie 0.8015574 1.042971 te 0.7997035 1.529099 pm NA NA Evaluated at: avar: trt a1 (intervened value of avar) = 2.3 a0 (reference value of avar) = 1.1 mvar: bili m_cde (intervend value of mvar for cde) = 1.4 cvar: c_cond (covariate vector value) = Note that effect estimates do not vary over m_cde and c_cond values when interaction = FALSE.