### Mediator model

Call:
lm(formula = bili ~ trt + age + male + stage, data = data)

Residuals:
    Min      1Q  Median      3Q     Max 
-4.1854 -2.5979 -1.2638  0.5727 24.2813 

Coefficients:
            Estimate Std. Error t value Pr(>|t|)    
(Intercept) -2.54577    1.76354  -1.444 0.150018    
trt          0.60723    0.54646   1.111 0.267464    
age          0.02419    0.02706   0.894 0.372025    
male        -0.61583    0.84467  -0.729 0.466584    
stage        1.26164    0.32279   3.909 0.000117 ***
---
Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

Residual standard error: 4.472 on 271 degrees of freedom
Multiple R-squared:  0.06893,	Adjusted R-squared:  0.05518 
F-statistic: 5.016 on 4 and 271 DF,  p-value: 0.0006483

### Outcome model

Call:
survival::survreg(formula = Surv(time, status) ~ trt + bili + 
    age + male + stage, data = data, dist = "exponential")
               Value Std. Error     z       p
(Intercept) 10.85527    0.63897 16.99 < 2e-16
trt          0.16639    0.17941  0.93   0.354
bili        -0.11637    0.01322 -8.80 < 2e-16
age         -0.00885    0.00929 -0.95   0.340
male        -0.48484    0.24202 -2.00   0.045
stage       -0.59017    0.12324 -4.79 1.7e-06

Scale fixed at 1 

Exponential distribution
Loglik(model)= -1156.8   Loglik(intercept only)= -1206.3
	Chisq= 98.9 on 5 degrees of freedom, p= 9e-20 
Number of Newton-Raphson Iterations: 5 
n= 276 

### Mediation analysis 
             est         se          Z         p      lower     upper  exp(est)
cde   0.19966740 0.21529505  0.9274128 0.3537122 -0.2223032 0.6216379 1.2209966
pnde  0.19966740 0.21529505  0.9274128 0.3537122 -0.2223032 0.6216379 1.2209966
tnie -0.08479483 0.07691408 -1.1024618 0.2702610 -0.2355437 0.0659540 0.9187008
tnde  0.19966740 0.21529505  0.9274128 0.3537122 -0.2223032 0.6216379 1.2209966
pnie -0.08479483 0.07691408 -1.1024618 0.2702610 -0.2355437 0.0659540 0.9187008
te    0.11487256 0.22758780  0.5047395 0.6137418 -0.3311913 0.5609365 1.1217305
pm   -0.81545808 1.91906990 -0.4249236 0.6708924 -4.5767660 2.9458498        NA
     exp(lower) exp(upper)
cde   0.8006726   1.861975
pnde  0.8006726   1.861975
tnie  0.7901412   1.068178
tnde  0.8006726   1.861975
pnie  0.7901412   1.068178
te    0.7180678   1.752313
pm           NA         NA

Evaluated at:
avar: trt
 a1 (intervened value of avar) = 2.3
 a0 (reference value of avar)  = 1.1
mvar: bili
 m_cde (intervend value of mvar for cde) = 1.4
cvar: age male stage
 c_cond (covariate vector value) = 50 1 2

Note that effect estimates do not vary over m_cde and c_cond values when interaction = FALSE.

### Re-evaluation at c_cond = cmean
             est         se          Z         p      lower     upper  exp(est)
cde   0.19966740 0.21529505  0.9274128 0.3537122 -0.2223032 0.6216379 1.2209966
pnde  0.19966740 0.21529505  0.9274128 0.3537122 -0.2223032 0.6216379 1.2209966
tnie -0.08479483 0.07691408 -1.1024618 0.2702610 -0.2355437 0.0659540 0.9187008
tnde  0.19966740 0.21529505  0.9274128 0.3537122 -0.2223032 0.6216379 1.2209966
pnie -0.08479483 0.07691408 -1.1024618 0.2702610 -0.2355437 0.0659540 0.9187008
te    0.11487256 0.22758780  0.5047395 0.6137418 -0.3311913 0.5609365 1.1217305
pm   -0.81545808 1.91906990 -0.4249236 0.6708924 -4.5767660 2.9458498        NA
     exp(lower) exp(upper)
cde   0.8006726   1.861975
pnde  0.8006726   1.861975
tnie  0.7901412   1.068178
tnde  0.8006726   1.861975
pnie  0.7901412   1.068178
te    0.7180678   1.752313
pm           NA         NA