### Mediator model Call: lm(formula = bili ~ trt + age + male + stage, data = data) Residuals: Min 1Q Median 3Q Max -4.1854 -2.5979 -1.2638 0.5727 24.2813 Coefficients: Estimate Std. Error t value Pr(>|t|) (Intercept) -2.54577 1.76354 -1.444 0.150018 trt 0.60723 0.54646 1.111 0.267464 age 0.02419 0.02706 0.894 0.372025 male -0.61583 0.84467 -0.729 0.466584 stage 1.26164 0.32279 3.909 0.000117 *** --- Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1 Residual standard error: 4.472 on 271 degrees of freedom Multiple R-squared: 0.06893, Adjusted R-squared: 0.05518 F-statistic: 5.016 on 4 and 271 DF, p-value: 0.0006483 ### Outcome model Call: glm(formula = platelet ~ trt + bili + trt:bili + age + male + stage, family = poisson(link = "log"), data = data) Coefficients: Estimate Std. Error z value Pr(>|z|) (Intercept) 5.9434262 0.0250527 237.237 < 2e-16 *** trt 0.0285808 0.0094512 3.024 0.00249 ** bili -0.0025516 0.0032934 -0.775 0.43847 age -0.0031630 0.0003757 -8.420 < 2e-16 *** male -0.0739842 0.0121126 -6.108 1.01e-09 *** stage -0.0823507 0.0045798 -17.981 < 2e-16 *** trt:bili 0.0004134 0.0018456 0.224 0.82276 --- Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1 (Dispersion parameter for poisson family taken to be 1) Null deviance: 9286.7 on 275 degrees of freedom Residual deviance: 8669.7 on 269 degrees of freedom AIC: 10708 Number of Fisher Scoring iterations: 4 ### Mediation analysis est se Z p lower upper cde 0.034991508 0.009807496 3.5678331 0.0003599456 0.015769170 0.054213846 pnde 0.034893470 0.009988888 3.4932288 0.0004772175 0.015315610 0.054471330 tnie -0.001166440 0.001447008 -0.8061049 0.4201823426 -0.004002524 0.001669644 tnde 0.035254966 0.009441550 3.7340231 0.0001884452 0.016749868 0.053760064 pnie -0.001527937 0.001726947 -0.8847619 0.3762850418 -0.004912692 0.001856817 te 0.033727029 0.009739136 3.4630411 0.0005341068 0.014638673 0.052815385 pm -0.035191757 0.043820132 -0.8030957 0.4219194514 -0.121077637 0.050694123 exp(est) exp(lower) exp(upper) cde 1.0356109 1.0158942 1.055710 pnde 1.0355094 1.0154335 1.055982 tnie 0.9988342 0.9960055 1.001671 tnde 1.0358838 1.0168909 1.055231 pnie 0.9984732 0.9950994 1.001859 te 1.0343022 1.0147463 1.054235 pm NA NA NA Evaluated at: avar: trt a1 (intervened value of avar) = 2.3 a0 (reference value of avar) = 1.1 mvar: bili m_cde (intervend value of mvar for cde) = 1.4 cvar: age male stage c_cond (covariate vector value) = 50 1 2 Note that effect estimates can vary over m_cde and c_cond values when interaction = TRUE. ### Re-evaluation at c_cond = cmean est se Z p lower upper cde 0.034991508 0.009807496 3.5678331 3.599456e-04 0.015769170 0.054213846 pnde 0.035809795 0.009091612 3.9387731 8.189934e-05 0.017990564 0.053629026 tnie -0.001166440 0.001447008 -0.8061049 4.201823e-01 -0.004002524 0.001669644 tnde 0.036171292 0.009230635 3.9186138 8.905969e-05 0.018079580 0.054263003 pnie -0.001527937 0.001726947 -0.8847619 3.762850e-01 -0.004912692 0.001856817 te 0.034643354 0.009173282 3.7765495 1.590160e-04 0.016664051 0.052622657 pm -0.034276538 0.044634481 -0.7679385 4.425237e-01 -0.121758514 0.053205438 exp(est) exp(lower) exp(upper) cde 1.0356109 1.0158942 1.055710 pnde 1.0364587 1.0181534 1.055093 tnie 0.9988342 0.9960055 1.001671 tnde 1.0368334 1.0182440 1.055762 pnie 0.9984732 0.9950994 1.001859 te 1.0352504 1.0168037 1.054032 pm NA NA NA