### Mediator model Call: lm(formula = bili ~ trt, data = data) Residuals: Min 1Q Median 3Q Max -3.4000 -2.5000 -1.7000 0.4434 24.3000 Coefficients: Estimate Std. Error t value Pr(>|t|) (Intercept) 2.2132 0.8784 2.520 0.0123 * trt 0.7434 0.5532 1.344 0.1801 --- Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1 Residual standard error: 4.594 on 274 degrees of freedom Multiple R-squared: 0.006548, Adjusted R-squared: 0.002923 F-statistic: 1.806 on 1 and 274 DF, p-value: 0.1801 ### Outcome model Call: lm(formula = alk_phos ~ trt + bili + trt:bili, data = data) Residuals: Min 1Q Median 3Q Max -1783.9 -1053.4 -618.9 -2.2 12092.2 Coefficients: Estimate Std. Error t value Pr(>|t|) (Intercept) 2163.95 512.54 4.222 3.3e-05 *** trt -240.62 317.49 -0.758 0.449 bili -16.36 104.49 -0.157 0.876 trt:bili 47.96 59.70 0.803 0.422 --- Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1 Residual standard error: 2104 on 272 degrees of freedom Multiple R-squared: 0.02201, Adjusted R-squared: 0.01122 F-statistic: 2.041 on 3 and 272 DF, p-value: 0.1085 ### Mediation analysis est se Z p lower upper cde -208.173326 330.74706 -0.62940341 0.5290850 -856.42564 440.07899 pnde -114.314420 305.81912 -0.37379749 0.7085550 -713.70888 485.08004 tnie 83.798808 74.56189 1.12388258 0.2610628 -62.33981 229.93743 tnde -62.977859 310.86035 -0.20259213 0.8394538 -672.25295 546.29723 pnie 32.462248 46.60957 0.69647173 0.4861335 -58.89083 123.81533 te -30.515611 309.05348 -0.09873893 0.9213456 -636.24931 575.21808 pm -2.746096 28.31465 -0.09698499 0.9227383 -58.24180 52.74961 Evaluated at: avar: trt a1 (intervened value of avar) = 2.3 a0 (reference value of avar) = 1.1 mvar: bili m_cde (intervend value of mvar for cde) = 1.4 cvar: c_cond (covariate vector value) = Note that effect estimates can vary over m_cde and c_cond values when interaction = TRUE.