context("basic HMM functions in risib") test_that("risib nalleles works", { expect_equal(nalleles("risib"), 2) }) test_that("risib check_geno works", { # autosome expect_true(test_check_geno("risib", 0, TRUE, FALSE, FALSE, 0)) expect_true(test_check_geno("risib", 1, TRUE, FALSE, FALSE, 0)) expect_true(test_check_geno("risib", 2, TRUE, FALSE, FALSE, 0)) expect_true(test_check_geno("risib", 1, FALSE, FALSE, FALSE, 0)) expect_true(test_check_geno("risib", 2, FALSE, FALSE, FALSE, 0)) expect_false(test_check_geno("risib", 3, TRUE, FALSE, FALSE, 0)) expect_false(test_check_geno("risib", 0, FALSE, FALSE, FALSE, 0)) expect_false(test_check_geno("risib", 3, FALSE, FALSE, FALSE, 0)) # X chromosome expect_true(test_check_geno("risib", 0, TRUE, TRUE, TRUE, 0)) expect_true(test_check_geno("risib", 1, TRUE, TRUE, TRUE, 0)) expect_true(test_check_geno("risib", 2, TRUE, TRUE, TRUE, 0)) expect_true(test_check_geno("risib", 1, FALSE, TRUE, TRUE, 0)) expect_true(test_check_geno("risib", 2, FALSE, TRUE, TRUE, 0)) expect_false(test_check_geno("risib", 3, TRUE, TRUE, TRUE, 0)) expect_false(test_check_geno("risib", 0, FALSE, TRUE, TRUE, 0)) expect_false(test_check_geno("risib", 3, FALSE, TRUE, TRUE, 0)) # X chr reverse expect_true(test_check_geno("risib", 0, TRUE, TRUE, TRUE, 1)) expect_true(test_check_geno("risib", 1, TRUE, TRUE, TRUE, 1)) expect_true(test_check_geno("risib", 2, TRUE, TRUE, TRUE, 1)) expect_true(test_check_geno("risib", 1, FALSE, TRUE, TRUE, 1)) expect_true(test_check_geno("risib", 2, FALSE, TRUE, TRUE, 1)) expect_false(test_check_geno("risib", 3, TRUE, TRUE, TRUE, 1)) expect_false(test_check_geno("risib", 0, FALSE, TRUE, TRUE, 1)) expect_false(test_check_geno("risib", 3, FALSE, TRUE, TRUE, 1)) }) test_that("risib ngen works", { expect_equal(test_ngen("risib", FALSE), 2) expect_equal(test_ngen("risib", TRUE), 2) }) test_that("risib possible_gen works", { # autosome expect_equal(test_possible_gen("risib", FALSE, FALSE, 0), 1:2) # X chr expect_equal(test_possible_gen("risib", TRUE, TRUE, 0), 1:2) # X chr reverse expect_equal(test_possible_gen("risib", TRUE, TRUE, 1), 1:2) }) test_that("risib nrec works", { # autosome expect_equal(test_nrec("risib", 1, 1, FALSE, FALSE, 0), 0) expect_equal(test_nrec("risib", 1, 2, FALSE, FALSE, 0), 1) expect_equal(test_nrec("risib", 2, 1, FALSE, FALSE, 0), 1) expect_equal(test_nrec("risib", 2, 2, FALSE, FALSE, 0), 0) # X chr expect_equal(test_nrec("risib", 1, 1, TRUE, TRUE, 0), 0) expect_equal(test_nrec("risib", 1, 2, TRUE, TRUE, 0), 1) expect_equal(test_nrec("risib", 2, 1, TRUE, TRUE, 0), 1) expect_equal(test_nrec("risib", 2, 2, TRUE, TRUE, 0), 0) # X chr reverse expect_equal(test_nrec("risib", 1, 1, TRUE, TRUE, 1), 0) expect_equal(test_nrec("risib", 1, 2, TRUE, TRUE, 1), 1) expect_equal(test_nrec("risib", 2, 1, TRUE, TRUE, 1), 1) expect_equal(test_nrec("risib", 2, 2, TRUE, TRUE, 1), 0) }) test_that("risib init works", { # autosome expect_equal(test_init("risib", 1, FALSE, FALSE, 0), log(0.5)) expect_equal(test_init("risib", 2, FALSE, FALSE, 0), log(0.5)) # X chr expect_equal(test_init("risib", 1, TRUE, TRUE, 0), log(2/3)) expect_equal(test_init("risib", 2, TRUE, TRUE, 0), log(1/3)) # X chr reverse expect_equal(test_init("risib", 1, TRUE, TRUE, 1), log(1/3)) expect_equal(test_init("risib", 2, TRUE, TRUE, 1), log(2/3)) }) test_that("risib emit works", { # autosome eps <- 0.01 expect_equal(test_emit("risib", 0, 1, eps, integer(0), FALSE, FALSE, 0), 0) expect_equal(test_emit("risib", 0, 2, eps, integer(0), FALSE, FALSE, 0), 0) expect_equal(test_emit("risib", 1, 1, eps, integer(0), FALSE, FALSE, 0), log(1-eps)) expect_equal(test_emit("risib", 1, 2, eps, integer(0), FALSE, FALSE, 0), log(eps)) expect_equal(test_emit("risib", 2, 1, eps, integer(0), FALSE, FALSE, 0), log(eps)) expect_equal(test_emit("risib", 2, 2, eps, integer(0), FALSE, FALSE, 0), log(1-eps)) # X chr expect_equal(test_emit("risib", 0, 1, eps, integer(0), TRUE, TRUE, 0), 0) expect_equal(test_emit("risib", 0, 2, eps, integer(0), TRUE, TRUE, 0), 0) expect_equal(test_emit("risib", 1, 1, eps, integer(0), TRUE, TRUE, 0), log(1-eps)) expect_equal(test_emit("risib", 1, 2, eps, integer(0), TRUE, TRUE, 0), log(eps)) expect_equal(test_emit("risib", 2, 1, eps, integer(0), TRUE, TRUE, 0), log(eps)) expect_equal(test_emit("risib", 2, 2, eps, integer(0), TRUE, TRUE, 0), log(1-eps)) # X chr reverse expect_equal(test_emit("risib", 0, 1, eps, integer(0), TRUE, FALSE, 1), 0) expect_equal(test_emit("risib", 0, 2, eps, integer(0), TRUE, FALSE, 1), 0) expect_equal(test_emit("risib", 1, 1, eps, integer(0), TRUE, FALSE, 1), log(1-eps)) expect_equal(test_emit("risib", 1, 2, eps, integer(0), TRUE, FALSE, 1), log(eps)) expect_equal(test_emit("risib", 2, 1, eps, integer(0), TRUE, FALSE, 1), log(eps)) expect_equal(test_emit("risib", 2, 2, eps, integer(0), TRUE, FALSE, 1), log(1-eps)) # errors expect_equal(test_emit("risib", 0, 0, eps, integer(0), FALSE, FALSE, 0), 0) expect_equal(test_emit("risib", 0, 3, eps, integer(0), FALSE, FALSE, 0), 0) expect_equal(test_emit("risib", 3, 1, eps, integer(0), FALSE, FALSE, 0), 0) # X chr expect_equal(test_emit("risib", 0, 0, eps, integer(0), TRUE, TRUE, 0), 0) expect_equal(test_emit("risib", 0, 3, eps, integer(0), TRUE, TRUE, 0), 0) expect_equal(test_emit("risib", 3, 1, eps, integer(0), TRUE, TRUE, 0), 0) # X chr reverse expect_equal(test_emit("risib", 0, 0, eps, integer(0), TRUE, FALSE, 1), 0) expect_equal(test_emit("risib", 0, 3, eps, integer(0), TRUE, FALSE, 1), 0) expect_equal(test_emit("risib", 3, 1, eps, integer(0), TRUE, FALSE, 1), 0) }) test_that("risib step works", { # autosome rf <- 0.01 RF <- 4*rf/(1+6*rf) expect_equal(test_step("risib", 1, 1, rf, FALSE, FALSE, 0), log(1-RF)) expect_equal(test_step("risib", 1, 2, rf, FALSE, FALSE, 0), log(RF)) expect_equal(test_step("risib", 2, 1, rf, FALSE, FALSE, 0), log(RF)) expect_equal(test_step("risib", 2, 2, rf, FALSE, FALSE, 0), log(1-RF)) # X chr (see table 3 in Broman, Genetics 169:1133-1146, 2005) t11 <- (1+2*rf)/(1+4*rf) t12 <- 2*rf/(1+4*rf) t21 <- 4*rf/(1+4*rf) t22 <- 1/(1+4*rf) expect_equal(test_step("risib", 1, 1, rf, TRUE, TRUE, 0), log(t11)) expect_equal(test_step("risib", 1, 2, rf, TRUE, TRUE, 0), log(t12)) expect_equal(test_step("risib", 2, 1, rf, TRUE, TRUE, 0), log(t21)) expect_equal(test_step("risib", 2, 2, rf, TRUE, TRUE, 0), log(t22)) # X chr reverse expect_equal(test_step("risib", 1, 1, rf, TRUE, FALSE, 1), log(t22)) expect_equal(test_step("risib", 1, 2, rf, TRUE, FALSE, 1), log(t21)) expect_equal(test_step("risib", 2, 1, rf, TRUE, FALSE, 1), log(t12)) expect_equal(test_step("risib", 2, 2, rf, TRUE, FALSE, 1), log(t11)) }) test_that("geno_names works", { expect_equal(geno_names("risib", c("B", "R"), FALSE), c("BB", "RR")) expect_equal(geno_names("risib", c("B", "R"), TRUE), c("BB", "RR")) })