context("basic HMM functions in phase-known intercross") test_that("p-k intercross nalleles works", { expect_equal(nalleles("f2pk"), 2) }) test_that("p-k intercross check_geno works", { # autosome for(i in 0:5) expect_true(test_check_geno("f2pk", i, TRUE, FALSE, FALSE, 0)) for(i in 1:4) expect_true(test_check_geno("f2pk", i, FALSE, FALSE, FALSE, 0)) for(i in c(-1, 6)) expect_false(test_check_geno("f2pk", i, TRUE, FALSE, FALSE, 0)) for(i in c(0, 5)) expect_false(test_check_geno("f2pk", i, FALSE, FALSE, FALSE, 0)) # X chromosome female, forward cross for(i in 0:5) expect_true(test_check_geno("f2pk", i, TRUE, TRUE, TRUE, 0)) for(i in 1:2) expect_true(test_check_geno("f2pk", i, FALSE, TRUE, TRUE, 0)) for(i in c(-1, 6)) expect_false(test_check_geno("f2pk", i, TRUE, TRUE, TRUE, 0)) for(i in c(0, 3, 4)) expect_false(test_check_geno("f2pk", i, FALSE, TRUE, TRUE, 0)) # X chromosome female, reverse cross for(i in 0:5) expect_true(test_check_geno("f2pk", i, TRUE, TRUE, TRUE, 1)) for(i in 3:4) expect_true(test_check_geno("f2pk", i, FALSE, TRUE, TRUE, 1)) for(i in c(-1, 6)) expect_false(test_check_geno("f2pk", i, TRUE, TRUE, TRUE, 1)) for(i in c(0, 1, 2, 5)) expect_false(test_check_geno("f2pk", i, FALSE, TRUE, TRUE, 1)) # X chromosome male for(i in 0:5) expect_true(test_check_geno("f2pk", i, TRUE, TRUE, FALSE, 0)) for(i in 5:6) expect_true(test_check_geno("f2pk", i, FALSE, TRUE, FALSE, 0)) for(i in c(-1, 6)) expect_false(test_check_geno("f2pk", i, TRUE, TRUE, FALSE, 0)) for(i in c(0:4, 7)) expect_false(test_check_geno("f2pk", i, FALSE, TRUE, FALSE, 0)) # X chromosome male for(i in 0:5) expect_true(test_check_geno("f2pk", i, TRUE, TRUE, FALSE, 1)) for(i in 5:6) expect_true(test_check_geno("f2pk", i, FALSE, TRUE, FALSE, 1)) for(i in c(-1, 6)) expect_false(test_check_geno("f2pk", i, TRUE, TRUE, FALSE, 1)) for(i in c(0:4, 7)) expect_false(test_check_geno("f2pk", i, FALSE, TRUE, FALSE, 1)) }) test_that("p-k intercross ngen works", { expect_equal(test_ngen("f2pk", FALSE), 4) expect_equal(test_ngen("f2pk", TRUE), 6) }) test_that("p-k intercross possible_gen works", { expect_equal(test_possible_gen("f2pk", FALSE, FALSE, 0), 1:4) expect_equal(test_possible_gen("f2pk", TRUE, TRUE, 0), 1:2) expect_equal(test_possible_gen("f2pk", TRUE, TRUE, 1), 3:4) expect_equal(test_possible_gen("f2pk", TRUE, FALSE, 0), 5:6) expect_equal(test_possible_gen("f2pk", TRUE, FALSE, 1), 5:6) }) test_that("p-k intercross nrec works", { # autosome expect_equal(test_nrec("f2pk", 1, 1, FALSE, FALSE, 0), 0) expect_equal(test_nrec("f2pk", 1, 2, FALSE, FALSE, 0), 1) expect_equal(test_nrec("f2pk", 1, 3, FALSE, FALSE, 0), 1) expect_equal(test_nrec("f2pk", 1, 4, FALSE, FALSE, 0), 2) expect_equal(test_nrec("f2pk", 2, 1, FALSE, FALSE, 0), 1) expect_equal(test_nrec("f2pk", 2, 2, FALSE, FALSE, 0), 0) expect_equal(test_nrec("f2pk", 2, 3, FALSE, FALSE, 0), 2) expect_equal(test_nrec("f2pk", 2, 4, FALSE, FALSE, 0), 1) expect_equal(test_nrec("f2pk", 3, 1, FALSE, FALSE, 0), 1) expect_equal(test_nrec("f2pk", 3, 2, FALSE, FALSE, 0), 2) expect_equal(test_nrec("f2pk", 3, 3, FALSE, FALSE, 0), 0) expect_equal(test_nrec("f2pk", 3, 4, FALSE, FALSE, 0), 1) expect_equal(test_nrec("f2pk", 4, 1, FALSE, FALSE, 0), 2) expect_equal(test_nrec("f2pk", 4, 2, FALSE, FALSE, 0), 1) expect_equal(test_nrec("f2pk", 4, 3, FALSE, FALSE, 0), 1) expect_equal(test_nrec("f2pk", 4, 4, FALSE, FALSE, 0), 0) # X female forward expect_equal(test_nrec("f2pk", 1, 1, TRUE, TRUE, 0), 0) expect_equal(test_nrec("f2pk", 1, 2, TRUE, TRUE, 0), 1) expect_equal(test_nrec("f2pk", 2, 1, TRUE, TRUE, 0), 1) expect_equal(test_nrec("f2pk", 2, 2, TRUE, TRUE, 0), 0) # X female reverse expect_equal(test_nrec("f2pk", 3, 3, TRUE, TRUE, 1), 0) expect_equal(test_nrec("f2pk", 3, 4, TRUE, TRUE, 1), 1) expect_equal(test_nrec("f2pk", 4, 3, TRUE, TRUE, 1), 1) expect_equal(test_nrec("f2pk", 4, 4, TRUE, TRUE, 1), 0) # X male expect_equal(test_nrec("f2pk", 5, 5, TRUE, FALSE, 0), 0) expect_equal(test_nrec("f2pk", 5, 6, TRUE, FALSE, 0), 1) expect_equal(test_nrec("f2pk", 6, 5, TRUE, FALSE, 0), 1) expect_equal(test_nrec("f2pk", 6, 6, TRUE, FALSE, 0), 0) # X male reverse expect_equal(test_nrec("f2pk", 5, 5, TRUE, FALSE, 1), 0) expect_equal(test_nrec("f2pk", 5, 6, TRUE, FALSE, 1), 1) expect_equal(test_nrec("f2pk", 6, 5, TRUE, FALSE, 1), 1) expect_equal(test_nrec("f2pk", 6, 6, TRUE, FALSE, 1), 0) }) test_that("p-k intercross init works", { # autosome for(i in 1:4) expect_equal(test_init("f2pk", i, FALSE, FALSE, 0), log(0.25)) # X female forward for(i in 1:2) expect_equal(test_init("f2pk", i, TRUE, TRUE, 0), log(0.5)) # X female reverse for(i in 3:4) expect_equal(test_init("f2pk", i, TRUE, TRUE, 1), log(0.5)) # X male for(i in 5:6) expect_equal(test_init("f2pk", i, TRUE, FALSE, 0), log(0.5)) # X male reverse for(i in 5:6) expect_equal(test_init("f2pk", i, TRUE, FALSE, 1), log(0.5)) }) test_that("p-k intercross emit works", { # autosome eps <- 0.02 for(i in 1:4) expect_equal(test_emit("f2pk", 0, i, eps, integer(0), FALSE, FALSE, 0), 0) expect_equal(test_emit("f2pk", 1, 1, eps, integer(0), FALSE, FALSE, 0), log(1-eps)) expect_equal(test_emit("f2pk", 2, 1, eps, integer(0), FALSE, FALSE, 0), log(eps/2)) expect_equal(test_emit("f2pk", 3, 1, eps, integer(0), FALSE, FALSE, 0), log(eps/2)) expect_equal(test_emit("f2pk", 4, 1, eps, integer(0), FALSE, FALSE, 0), log(1-eps/2)) expect_equal(test_emit("f2pk", 5, 1, eps, integer(0), FALSE, FALSE, 0), log(eps)) for(i in 2:3) { expect_equal(test_emit("f2pk", 1, i, eps, integer(0), FALSE, FALSE, 0), log(eps/2)) expect_equal(test_emit("f2pk", 2, i, eps, integer(0), FALSE, FALSE, 0), log(1-eps)) expect_equal(test_emit("f2pk", 3, i, eps, integer(0), FALSE, FALSE, 0), log(eps/2)) expect_equal(test_emit("f2pk", 4, i, eps, integer(0), FALSE, FALSE, 0), log(1-eps/2)) expect_equal(test_emit("f2pk", 5, i, eps, integer(0), FALSE, FALSE, 0), log(1-eps/2)) } expect_equal(test_emit("f2pk", 1, 4, eps, integer(0), FALSE, FALSE, 0), log(eps/2)) expect_equal(test_emit("f2pk", 2, 4, eps, integer(0), FALSE, FALSE, 0), log(eps/2)) expect_equal(test_emit("f2pk", 3, 4, eps, integer(0), FALSE, FALSE, 0), log(1-eps)) expect_equal(test_emit("f2pk", 4, 4, eps, integer(0), FALSE, FALSE, 0), log(eps)) expect_equal(test_emit("f2pk", 5, 4, eps, integer(0), FALSE, FALSE, 0), log(1-eps/2)) # X female forward for(i in 1:2) expect_equal(test_emit("f2pk", 0, i, eps, integer(0), TRUE, TRUE, 0), 0) expect_equal(test_emit("f2pk", 1, 1, eps, integer(0), TRUE, TRUE, 0), log(1-eps)) expect_equal(test_emit("f2pk", 2, 1, eps, integer(0), TRUE, TRUE, 0), log(eps)) expect_equal(test_emit("f2pk", 3, 1, eps, integer(0), TRUE, TRUE, 0), 0) expect_equal(test_emit("f2pk", 4, 1, eps, integer(0), TRUE, TRUE, 0), 0) expect_equal(test_emit("f2pk", 5, 1, eps, integer(0), TRUE, TRUE, 0), log(eps)) expect_equal(test_emit("f2pk", 1, 2, eps, integer(0), TRUE, TRUE, 0), log(eps)) expect_equal(test_emit("f2pk", 2, 2, eps, integer(0), TRUE, TRUE, 0), log(1-eps)) expect_equal(test_emit("f2pk", 3, 2, eps, integer(0), TRUE, TRUE, 0), 0) expect_equal(test_emit("f2pk", 4, 2, eps, integer(0), TRUE, TRUE, 0), 0) expect_equal(test_emit("f2pk", 5, 2, eps, integer(0), TRUE, TRUE, 0), log(1-eps)) # X female reverse for(i in 3:4) expect_equal(test_emit("f2pk", 0, i, eps, integer(0), TRUE, TRUE, 1), 0) expect_equal(test_emit("f2pk", 1, 4, eps, integer(0), TRUE, TRUE, 1), 0) expect_equal(test_emit("f2pk", 2, 4, eps, integer(0), TRUE, TRUE, 1), log(eps)) expect_equal(test_emit("f2pk", 3, 4, eps, integer(0), TRUE, TRUE, 1), log(1-eps)) expect_equal(test_emit("f2pk", 4, 4, eps, integer(0), TRUE, TRUE, 1), log(eps)) expect_equal(test_emit("f2pk", 5, 4, eps, integer(0), TRUE, TRUE, 1), 0) expect_equal(test_emit("f2pk", 1, 3, eps, integer(0), TRUE, TRUE, 1), 0) expect_equal(test_emit("f2pk", 2, 3, eps, integer(0), TRUE, TRUE, 1), log(1-eps)) expect_equal(test_emit("f2pk", 3, 3, eps, integer(0), TRUE, TRUE, 1), log(eps)) expect_equal(test_emit("f2pk", 4, 3, eps, integer(0), TRUE, TRUE, 1), log(1-eps)) expect_equal(test_emit("f2pk", 5, 3, eps, integer(0), TRUE, TRUE, 1), 0) # X male for(i in 5:6) expect_equal(test_emit("f2pk", 0, i, eps, integer(0), TRUE, FALSE, 0), 0) expect_equal(test_emit("f2pk", 1, 5, eps, integer(0), TRUE, FALSE, 0), log(1-eps)) expect_equal(test_emit("f2pk", 2, 5, eps, integer(0), TRUE, FALSE, 0), 0) expect_equal(test_emit("f2pk", 3, 5, eps, integer(0), TRUE, FALSE, 0), log(eps)) expect_equal(test_emit("f2pk", 4, 5, eps, integer(0), TRUE, FALSE, 0), log(1-eps)) expect_equal(test_emit("f2pk", 5, 5, eps, integer(0), TRUE, FALSE, 0), log(eps)) expect_equal(test_emit("f2pk", 1, 6, eps, integer(0), TRUE, FALSE, 0), log(eps)) expect_equal(test_emit("f2pk", 2, 6, eps, integer(0), TRUE, FALSE, 0), 0) expect_equal(test_emit("f2pk", 3, 6, eps, integer(0), TRUE, FALSE, 0), log(1-eps)) expect_equal(test_emit("f2pk", 4, 6, eps, integer(0), TRUE, FALSE, 0), log(eps)) expect_equal(test_emit("f2pk", 5, 6, eps, integer(0), TRUE, FALSE, 0), log(1-eps)) # X male reverse for(i in 5:6) expect_equal(test_emit("f2pk", 0, i, eps, integer(0), TRUE, FALSE, 1), 0) expect_equal(test_emit("f2pk", 1, 5, eps, integer(0), TRUE, FALSE, 1), log(1-eps)) expect_equal(test_emit("f2pk", 2, 5, eps, integer(0), TRUE, FALSE, 1), 0) expect_equal(test_emit("f2pk", 3, 5, eps, integer(0), TRUE, FALSE, 1), log(eps)) expect_equal(test_emit("f2pk", 4, 5, eps, integer(0), TRUE, FALSE, 1), log(1-eps)) expect_equal(test_emit("f2pk", 5, 5, eps, integer(0), TRUE, FALSE, 1), log(eps)) expect_equal(test_emit("f2pk", 1, 6, eps, integer(0), TRUE, FALSE, 1), log(eps)) expect_equal(test_emit("f2pk", 2, 6, eps, integer(0), TRUE, FALSE, 1), 0) expect_equal(test_emit("f2pk", 3, 6, eps, integer(0), TRUE, FALSE, 1), log(1-eps)) expect_equal(test_emit("f2pk", 4, 6, eps, integer(0), TRUE, FALSE, 1), log(eps)) expect_equal(test_emit("f2pk", 5, 6, eps, integer(0), TRUE, FALSE, 1), log(1-eps)) }) test_that("p-k intercross step works", { # autosome rf <- 0.15 expect_equal(test_step("f2pk", 1, 1, rf, FALSE, FALSE, 0), log((1-rf)^2)) expect_equal(test_step("f2pk", 1, 2, rf, FALSE, FALSE, 0), log(rf*(1-rf))) expect_equal(test_step("f2pk", 1, 3, rf, FALSE, FALSE, 0), log(rf*(1-rf))) expect_equal(test_step("f2pk", 1, 4, rf, FALSE, FALSE, 0), log(rf^2)) expect_equal(test_step("f2pk", 2, 1, rf, FALSE, FALSE, 0), log(rf*(1-rf))) expect_equal(test_step("f2pk", 2, 2, rf, FALSE, FALSE, 0), log((1-rf)^2)) expect_equal(test_step("f2pk", 2, 3, rf, FALSE, FALSE, 0), log(rf^2)) expect_equal(test_step("f2pk", 2, 4, rf, FALSE, FALSE, 0), log(rf*(1-rf))) expect_equal(test_step("f2pk", 3, 1, rf, FALSE, FALSE, 0), log(rf*(1-rf))) expect_equal(test_step("f2pk", 3, 2, rf, FALSE, FALSE, 0), log(rf^2)) expect_equal(test_step("f2pk", 3, 3, rf, FALSE, FALSE, 0), log((1-rf)^2)) expect_equal(test_step("f2pk", 3, 4, rf, FALSE, FALSE, 0), log(rf*(1-rf))) expect_equal(test_step("f2pk", 4, 1, rf, FALSE, FALSE, 0), log(rf^2)) expect_equal(test_step("f2pk", 4, 2, rf, FALSE, FALSE, 0), log(rf*(1-rf))) expect_equal(test_step("f2pk", 4, 3, rf, FALSE, FALSE, 0), log(rf*(1-rf))) expect_equal(test_step("f2pk", 4, 4, rf, FALSE, FALSE, 0), log((1-rf)^2)) # X female expect_equal(test_step("f2pk", 1, 1, rf, TRUE, TRUE, 0), log(1-rf)) expect_equal(test_step("f2pk", 1, 2, rf, TRUE, TRUE, 0), log(rf)) expect_equal(test_step("f2pk", 2, 1, rf, TRUE, TRUE, 0), log(rf)) expect_equal(test_step("f2pk", 2, 2, rf, TRUE, TRUE, 0), log(1-rf)) # X female reverse expect_equal(test_step("f2pk", 3, 3, rf, TRUE, TRUE, 1), log(1-rf)) expect_equal(test_step("f2pk", 3, 4, rf, TRUE, TRUE, 1), log(rf)) expect_equal(test_step("f2pk", 4, 3, rf, TRUE, TRUE, 1), log(rf)) expect_equal(test_step("f2pk", 4, 4, rf, TRUE, TRUE, 1), log(1-rf)) # X male expect_equal(test_step("f2pk", 5, 5, rf, TRUE, FALSE, 0), log(1-rf)) expect_equal(test_step("f2pk", 5, 6, rf, TRUE, FALSE, 0), log(rf)) expect_equal(test_step("f2pk", 6, 5, rf, TRUE, FALSE, 0), log(rf)) expect_equal(test_step("f2pk", 6, 6, rf, TRUE, FALSE, 0), log(1-rf)) # X male reverse expect_equal(test_step("f2pk", 5, 5, rf, TRUE, FALSE, 1), log(1-rf)) expect_equal(test_step("f2pk", 5, 6, rf, TRUE, FALSE, 1), log(rf)) expect_equal(test_step("f2pk", 6, 5, rf, TRUE, FALSE, 1), log(rf)) expect_equal(test_step("f2pk", 6, 6, rf, TRUE, FALSE, 1), log(1-rf)) })