nmTest({ test_that("non-mu simple test", { # Data' purpose illustrates the error and my data set df <- data.frame( ID = c(rep(1, 6), rep(2, 6)), TIME = c(0.00, 12.11, 18.41, 23.89, 36.00, 43.51, 0.00, 12.00, 20.00, 24.00, 36.80, 45.00), AMT = c(1000, 1000, NA, 1000, 1000, NA, 1000, 2000, NA, 1000, 1000, NA), DUR = c(2.5, 2.5, NA, 2.5, 2.5, NA, 2.5, 2.5, NA, 2.5, 2.5, NA), DV = c(NA, NA, 3.0, NA, NA, 9.6, NA, NA, 7.0, NA, NA, 2.8), WT = c(rep(55, 6), rep(48, 6)) ) |> dplyr::mutate(EVID = ifelse(is.na(DV), 1, 0)) fun <- function() { ini({ tvCl <- c(0, 4, Inf) tvVc <- c(0, 48, Inf) eta.Vc ~ 0.62 prop.sd <- 0.051529 }) model({ Cl <- tvCl Vc <- tvVc*(WT/70)*exp(eta.Vc) # dynamical system linCmt() ~ prop(prop.sd) }) } skip_if_not(rxode2::.linCmtSensB()) fit <- nlmixr2(fun, df, list(print=0), est="posthoc") expect_error(fit$dataMergeInner, NA) expect_error(fit$fitMergeInner, NA) tmp <- fit$dataMergeInner # Should have llikObs expect_true("nlmixrLlikObs" %in% names(tmp)) expect_true(all(names(fit$etaSE) == c("ID", "eta.Vc"))) expect_true(all(names(fit$etaRSE) == c("ID", "rse(eta.Vc)%"))) }) test_that("another merge issue", { dat <- xgxr::case1_pkpd %>% dplyr::rename(DV=LIDV) %>% dplyr::filter(CMT %in% 1:2) %>% dplyr::filter(TRTACT != "Placebo") doses <- unique(dat$DOSE) nid <- 3 # 7 ids per dose group dat2 <- do.call("rbind", lapply(doses, function(x) { ids <- dat %>% dplyr::filter(DOSE == x) %>% dplyr::reframe(ids=unique(ID)) %>% dplyr::pull() ids <- ids[seq(1, nid)] dat %>% dplyr::filter(ID %in% ids) })) cmt2 <- function() { ini({ lka <- log(0.1) # log Ka lv <- log(10) # Log Vc lcl <- log(4) # Log Cl lq <- log(10) # log Q lvp <- log(20) # Log Vp eta.ka ~ 0.01 eta.v ~ 0.1 eta.cl ~ 0.1 logn.sd = 10 }) model({ ka <- exp(lka + eta.ka) cl <- exp(lcl + eta.cl) v <- exp(lv + eta.v) q <- exp(lq) vp <- exp(lvp) linCmt() ~ lnorm(logn.sd) }) } skip_if_not(rxode2::.linCmtSensB()) cmt2fit.logn <- nlmixr(cmt2, dat2, "posthoc", control=list(print=0), table=tableControl(cwres=TRUE, npde=TRUE)) expect_error(cmt2fit.logn$dataMergeLeft, NA) expect_error(cmt2fit.logn$fitMergeLeft, NA) expect_true(any(names(cmt2fit.logn$dataMergeLeft) == "nlmixrLlikObs")) # Now force an error .llikObs <- c(cmt2fit.logn$env$llikObs, 10) assign("llikObs", .llikObs, envir=cmt2fit.logn$env) expect_warning(cmt2fit.logn$dataMergeLeft) expect_warning(cmt2fit.logn$fitMergeLeft) .dat <- suppressWarnings(cmt2fit.logn$dataMergeLeft) expect_false(any(names(.dat) == "nlmixrLlikObs")) }) })