R Under development (unstable) (2024-10-21 r87258 ucrt) -- "Unsuffered Consequences" Copyright (C) 2024 The R Foundation for Statistical Computing Platform: x86_64-w64-mingw32/x64 R is free software and comes with ABSOLUTELY NO WARRANTY. You are welcome to redistribute it under certain conditions. Type 'license()' or 'licence()' for distribution details. R is a collaborative project with many contributors. Type 'contributors()' for more information and 'citation()' on how to cite R or R packages in publications. Type 'demo()' for some demos, 'help()' for on-line help, or 'help.start()' for an HTML browser interface to help. Type 'q()' to quit R. > library(testthat) > library(rxode2) rxode2 3.0.1 using 2 threads (see ?getRxThreads) no cache: create with `rxCreateCache()` > library(nlmixr2est) Loading required package: nlmixr2data Attaching package: 'nlmixr2est' The following objects are masked from 'package:rxode2': boxCox, yeoJohnson > verbose_minimization <- FALSE > test_check("nlmixr2est") R Under development (unstable) (2024-10-21 r87258 ucrt) -- "Unsuffered Consequences" Copyright (C) 2024 The R Foundation for Statistical Computing Platform: x86_64-w64-mingw32/x64 R is free software and comes with ABSOLUTELY NO WARRANTY. You are welcome to redistribute it under certain conditions. Type 'license()' or 'licence()' for distribution details. Natural language support but running in an English locale R is a collaborative project with many contributors. Type 'contributors()' for more information and 'citation()' on how to cite R or R packages in publications. Type 'demo()' for some demos, 'help()' for on-line help, or 'help.start()' for an HTML browser interface to help. Type 'q()' to quit R. > library(nlmixr2est) Loading required package: nlmixr2data > rxode2::rxClean() > one.cmt <- function() { + ini({ + tka <- 0.45 + tcl <- log(c(0, 2.7, 100)) + tv <- 3.45 + eta.ka ~ 0.6 + eta.cl ~ 0.3 + eta.v ~ 0.1 + add.sd <- 0.7 + }) + model({ + ka <- exp(tka + eta.ka) + cl <- exp(tcl + eta.cl) + v <- exp(tv + eta.v) + linCmt() ~ add(add.sd) + }) + } > fit <- nlmixr(one.cmt, theo_sd, est = "saem", control = saemControl(print = 0, + nBurn = 1, nEm = 1)) ℹ parameter labels from comments are typically ignored in non-interactive mode ℹ Need to run with the source intact to parse comments → loading into symengine environment... → pruning branches (`if`/`else`) of saem model... ✔ done → finding duplicate expressions in saem model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 ✔ done using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2_model_shared.h:3, from rx_8e6f160ecce77c94170d561e7c773c05_x64.c:121: D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition ℹ calculate uninformed etas ℹ done rxode2 3.0.1 using 2 threads (see ?getRxThreads) no cache: create with `rxCreateCache()` Attaching package: 'rxode2' The following objects are masked from 'package:nlmixr2est': boxCox, yeoJohnson Calculating covariance matrix [====|====|====|====|====|====|====|====|====|====] 0:00:00 → loading into symengine environment... → pruning branches (`if`/`else`) of saem model... ✔ done → finding duplicate expressions in saem predOnly model 0... [====|====|====|====|====|====|====|====|====|====] 0:00:00 → finding duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 → finding duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 ✔ done using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2_model_shared.h:3, from rx_77b49ad6a7ebb4661bf2df11a8e0181a_x64.c:121: D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition → Calculating residuals/tables ✔ done → compress origData in nlmixr2 object, save 5952 → compress phiM in nlmixr2 object, save 280 → compress parHistData in nlmixr2 object, save 1864 → compress saem0 in nlmixr2 object, save 28104 > saveRDS(fit, "fit.rds") > > proc.time() user system elapsed 8.21 0.84 12.51 Calculating -2LL by Gaussian quadrature (nnodes=3,nsd=1.6) [====|====|====|====|====|====|====|====|====|====] 0:00:00 > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2_model_shared.h:3, from rx_ee48ff2fd7af9031abc3f61894a5962a_x64.c:121: D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition i calculate uninformed etas i done Calculating covariance matrix [====|====|====|====|====|====|====|====|====|====] 0:00:00 > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem predOnly model 0... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2_model_shared.h:3, from rx_089c0144bfb7f96e97d011ee2b68e7ba_x64.c:121: D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition > compress origData in nlmixr2 object, save 7056 > compress phiM in nlmixr2 object, save 280 > compress parHistData in nlmixr2 object, save 1856 > compress saem0 in nlmixr2 object, save 21120 i change initial estimate of `covwt` to `100` > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2_model_shared.h:3, from rx_c3f5caa02faaf4e7b2a04a21ab962f1d_x64.c:121: D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition i calculate uninformed etas i done Calculating covariance matrix [====|====|====|====|====|====|====|====|====|====] 0:00:00 > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem predOnly model 0... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2_model_shared.h:3, from rx_a01b86a7682c8d0c0b7a68ffbe237db3_x64.c:121: D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition > compress origData in nlmixr2 object, save 7056 > compress phiM in nlmixr2 object, save 272 > compress parHistData in nlmixr2 object, save 1856 > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2_model_shared.h:3, from rx_c80b887c634cead2f5047ae03e284441_x64.c:121: D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition i calculate uninformed etas i done Calculating covariance matrix [====|====|====|====|====|====|====|====|====|====] 0:00:00 > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem predOnly model 0... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2_model_shared.h:3, from rx_9c701b00941601b60be59ab1dfd341f2_x64.c:121: D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition > Calculating residuals/tables v done > compress origData in nlmixr2 object, save 5952 > compress phiM in nlmixr2 object, save 280 > compress parHistData in nlmixr2 object, save 1640 > compress saem0 in nlmixr2 object, save 12920 > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done i calculate uninformed etas i done Calculating covariance matrix [====|====|====|====|====|====|====|====|====|====] 0:00:00 > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem predOnly model 0... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done > Calculating residuals/tables v done > compress origData in nlmixr2 object, save 5952 > compress phiM in nlmixr2 object, save 280 > compress parHistData in nlmixr2 object, save 1640 > loading into symengine environment... > pruning branches (`if`/`else`) of full model... v done > calculate jacobian > calculate d(f)/d(eta) [====|====|====|====|====|====|====|====|====|====] 0:00:00 > calculate d(R^2)/d(eta) [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in inner model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in inner model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in EBE model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in EBE model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > compiling inner model... using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2_model_shared.h:3, from rx_f0011f5ffe926d5be7894971cb2fd389_x64.c:121: D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition v done > finding duplicate expressions in FD model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > compiling EBE model... using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2_model_shared.h:3, from rx_ee0f6b855d29eed9664c3a6f572d3c43_x64.c:121: D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition v done > compiling events FD model... using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2_model_shared.h:3, from rx_56178496173ef01c27d034460c4387e8_x64.c:121: D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition v done > Calculating residuals/tables v done > compress origData in nlmixr2 object, save 5952 > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2_model_shared.h:3, from rx_f1919b63c51c1f40cb57bebbbaac58d9_x64.c:121: D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition i calculate uninformed etas i done > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem predOnly model 0... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2_model_shared.h:3, from rx_1337d397c3c6af3a61d9f650e645e92d_x64.c:121: D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition > Calculating residuals/tables v done > compress origData in nlmixr2 object, save 5952 > compress phiM in nlmixr2 object, save 1704 > compress parHistData in nlmixr2 object, save 1432 > compress saem0 in nlmixr2 object, save 23992 > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem predOnly model 0... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2_model_shared.h:3, from rx_cd3aa08cbd4703ae3a90280568227141_x64.c:121: D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2_model_shared.h:3, from rx_3f1d4a3d705e72c8806f6ae3cb9f1b2c_x64.c:121: D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition i calculate uninformed etas i done > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem predOnly model 0... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done > Calculating residuals/tables v done > compress origData in nlmixr2 object, save 5952 > compress phiM in nlmixr2 object, save 680 > compress parHistData in nlmixr2 object, save 1440 i parameter labels from comments will be replaced by 'label()' using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2_model_shared.h:3, from rx_18c0c22fa03c748a83b9526e6548a516_x64.c:121: D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition i parameter labels from comments will be replaced by 'label()' > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done i calculate uninformed etas i done Calculating covariance matrix [====|====|====|====|====|====|====|====|====|====] 0:00:00 > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem predOnly model 0... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2_model_shared.h:3, from rx_47c3b860d3bcb8c2452510f06d537fbb_x64.c:121: D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition > Calculating residuals/tables v done > compress origData in nlmixr2 object, save 3696 > compress phiM in nlmixr2 object, save 49608 > compress parHistData in nlmixr2 object, save 14872 > compress saem0 in nlmixr2 object, save 10560 i parameter labels from comments will be replaced by 'label()' > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done Calculating covariance matrix [====|====|====|====|====|====|====|====|====|====] 0:00:00 > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem predOnly model 0... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done > Calculating residuals/tables v done > compress origData in nlmixr2 object, save 3696 > compress phiM in nlmixr2 object, save 44008 > compress parHistData in nlmixr2 object, save 14296 i parameter labels from comments will be replaced by 'label()' > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2_model_shared.h:3, from rx_8ca57fd176749714567b521a7bb689e0_x64.c:121: D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition i calculate uninformed etas i done Calculating covariance matrix [====|====|====|====|====|====|====|====|====|====] 0:00:00 > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem predOnly model 0... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2_model_shared.h:3, from rx_eb70b097271d0fa6899e99e25dea8701_x64.c:121: D:\RCompile\CRANpkg\lib\4.5\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition > Calculating residuals/tables v done > compress origData in nlmixr2 object, save 3696 > compress phiM in nlmixr2 object, save 48248 > compress parHistData in nlmixr2 object, save 14584 i parameter labels from comments will be replaced by 'label()' > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done Calculating covariance matrix [====|====|====|====|====|====|====|====|====|====] 0:00:00 > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem predOnly model 0... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done > Calculating residuals/tables v done > compress origData in nlmixr2 object, save 3696 > compress phiM in nlmixr2 object, save 48664 > compress parHistData in nlmixr2 object, save 14600 [ FAIL 0 | WARN 1 | SKIP 0 | PASS 226 ] [ FAIL 0 | WARN 1 | SKIP 0 | PASS 226 ] > ## test_check("nlmixr2est", stop_on_failure = FALSE, wrap=TRUE, > ## reporter = testthat::LocationReporter) > > proc.time() user system elapsed 217.32 12.87 291.09