R Under development (unstable) (2024-09-17 r87161 ucrt) -- "Unsuffered Consequences" Copyright (C) 2024 The R Foundation for Statistical Computing Platform: x86_64-w64-mingw32/x64 R is free software and comes with ABSOLUTELY NO WARRANTY. You are welcome to redistribute it under certain conditions. Type 'license()' or 'licence()' for distribution details. R is a collaborative project with many contributors. Type 'contributors()' for more information and 'citation()' on how to cite R or R packages in publications. Type 'demo()' for some demos, 'help()' for on-line help, or 'help.start()' for an HTML browser interface to help. Type 'q()' to quit R. > library(testthat) > library(rxode2) rxode2 3.0.0 using 2 threads (see ?getRxThreads) no cache: create with `rxCreateCache()` > library(nlmixr2est) Loading required package: nlmixr2data Attaching package: 'nlmixr2est' The following objects are masked from 'package:rxode2': boxCox, yeoJohnson > verbose_minimization <- FALSE > test_check("nlmixr2est") R Under development (unstable) (2024-09-17 r87161 ucrt) -- "Unsuffered Consequences" Copyright (C) 2024 The R Foundation for Statistical Computing Platform: x86_64-w64-mingw32/x64 R is free software and comes with ABSOLUTELY NO WARRANTY. You are welcome to redistribute it under certain conditions. Type 'license()' or 'licence()' for distribution details. Natural language support but running in an English locale R is a collaborative project with many contributors. Type 'contributors()' for more information and 'citation()' on how to cite R or R packages in publications. Type 'demo()' for some demos, 'help()' for on-line help, or 'help.start()' for an HTML browser interface to help. Type 'q()' to quit R. > library(nlmixr2est) Loading required package: nlmixr2data > rxode2::rxClean() > one.cmt <- function() { + ini({ + tka <- 0.45 + tcl <- log(c(0, 2.7, 100)) + tv <- 3.45 + eta.ka ~ 0.6 + eta.cl ~ 0.3 + eta.v ~ 0.1 + add.sd <- 0.7 + }) + model({ + ka <- exp(tka + eta.ka) + cl <- exp(tcl + eta.cl) + v <- exp(tv + eta.v) + linCmt() ~ add(add.sd) + }) + } > fit <- nlmixr(one.cmt, theo_sd, est = "saem", control = saemControl(print = 0, + nBurn = 1, nEm = 1)) ℹ parameter labels from comments are typically ignored in non-interactive mode ℹ Need to run with the source intact to parse comments → loading into symengine environment... → pruning branches (`if`/`else`) of saem model... ✔ done → finding duplicate expressions in saem model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 ✔ done using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2_model_shared.h:3, from rx_91c94588febc8e2bb372e99b7fb9467f_x64.c:121: D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition ℹ calculate uninformed etas ℹ done rxode2 3.0.0 using 2 threads (see ?getRxThreads) no cache: create with `rxCreateCache()` Attaching package: 'rxode2' The following objects are masked from 'package:nlmixr2est': boxCox, yeoJohnson Calculating covariance matrix [====|====|====|====|====|====|====|====|====|====] 0:00:00 → loading into symengine environment... → pruning branches (`if`/`else`) of saem model... ✔ done → finding duplicate expressions in saem predOnly model 0... [====|====|====|====|====|====|====|====|====|====] 0:00:00 → finding duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 → finding duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 ✔ done using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2_model_shared.h:3, from rx_dd0467a22db7928be7392f626c91d8f5_x64.c:121: D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition → Calculating residuals/tables ✔ done → compress origData in nlmixr2 object, save 5952 → compress phiM in nlmixr2 object, save 280 → compress parHistData in nlmixr2 object, save 1864 → compress saem0 in nlmixr2 object, save 28104 > saveRDS(fit, "fit.rds") > > proc.time() user system elapsed 7.34 0.75 11.53 Calculating -2LL by Gaussian quadrature (nnodes=3,nsd=1.6) [====|====|====|====|====|====|====|====|====|====] 0:00:00 > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2_model_shared.h:3, from rx_c21071407ff969e0103745895efe74a3_x64.c:121: D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition i calculate uninformed etas i done Calculating covariance matrix [====|====|====|====|====|====|====|====|====|====] 0:00:00 > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem predOnly model 0... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2_model_shared.h:3, from rx_580d89ec11850acf604ed89d95a5acdf_x64.c:121: D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition > compress origData in nlmixr2 object, save 7056 > compress phiM in nlmixr2 object, save 280 > compress parHistData in nlmixr2 object, save 1856 > compress saem0 in nlmixr2 object, save 21136 i change initial estimate of `covwt` to `100` > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2_model_shared.h:3, from rx_6bfd908ab51e4190d8773e8f9051b4e8_x64.c:121: D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition i calculate uninformed etas i done Calculating covariance matrix [====|====|====|====|====|====|====|====|====|====] 0:00:00 > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem predOnly model 0... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2_model_shared.h:3, from rx_9acbb78fd5108e889db04916a7a405a0_x64.c:121: D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition > compress origData in nlmixr2 object, save 7056 > compress phiM in nlmixr2 object, save 272 > compress parHistData in nlmixr2 object, save 1856 > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2_model_shared.h:3, from rx_1ebb9482341b1c907e4dd5c1c66bb34a_x64.c:121: D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition i calculate uninformed etas i done Calculating covariance matrix [====|====|====|====|====|====|====|====|====|====] 0:00:00 > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem predOnly model 0... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2_model_shared.h:3, from rx_5b03389f367c38d2a0dc4ab252ebf352_x64.c:121: D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition > Calculating residuals/tables v done > compress origData in nlmixr2 object, save 5952 > compress phiM in nlmixr2 object, save 280 > compress parHistData in nlmixr2 object, save 1640 > compress saem0 in nlmixr2 object, save 12928 > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done i calculate uninformed etas i done Calculating covariance matrix [====|====|====|====|====|====|====|====|====|====] 0:00:00 > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem predOnly model 0... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done > Calculating residuals/tables v done > compress origData in nlmixr2 object, save 5952 > compress phiM in nlmixr2 object, save 280 > compress parHistData in nlmixr2 object, save 1640 > loading into symengine environment... > pruning branches (`if`/`else`) of full model... v done > calculate jacobian > calculate d(f)/d(eta) [====|====|====|====|====|====|====|====|====|====] 0:00:00 > calculate d(R^2)/d(eta) [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in inner model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in inner model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in EBE model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in EBE model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > compiling inner model... using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2_model_shared.h:3, from rx_1fb409061998cb032f2f3c366497b5c9_x64.c:121: D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition v done > finding duplicate expressions in FD model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > compiling EBE model... using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2_model_shared.h:3, from rx_1e99bc39a4a80bbf3d15cc7879159cb5_x64.c:121: D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition v done > compiling events FD model... using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2_model_shared.h:3, from rx_d756c7b7ea5f66178f412b738a0f27bb_x64.c:121: D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition v done > Calculating residuals/tables v done > compress origData in nlmixr2 object, save 5952 > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2_model_shared.h:3, from rx_86e466ae88556d514df0a0f900dba69b_x64.c:121: D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition i calculate uninformed etas i done > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem predOnly model 0... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2_model_shared.h:3, from rx_7b57673dbed81f563d7d48e31b6846f1_x64.c:121: D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition > Calculating residuals/tables v done > compress origData in nlmixr2 object, save 5952 > compress phiM in nlmixr2 object, save 1704 > compress parHistData in nlmixr2 object, save 1432 > compress saem0 in nlmixr2 object, save 24000 > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem predOnly model 0... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2_model_shared.h:3, from rx_f403f94913f0b5358360495a66df8f34_x64.c:121: D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2_model_shared.h:3, from rx_f747e580a4dda5700fb42ead4278a0e6_x64.c:121: D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition i calculate uninformed etas i done > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem predOnly model 0... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done > Calculating residuals/tables v done > compress origData in nlmixr2 object, save 5952 > compress phiM in nlmixr2 object, save 680 > compress parHistData in nlmixr2 object, save 1440 i parameter labels from comments will be replaced by 'label()' using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2_model_shared.h:3, from rx_b79e69df944e13bbf97aac8afd5c33a9_x64.c:121: D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition i parameter labels from comments will be replaced by 'label()' > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done i calculate uninformed etas i done Calculating covariance matrix [====|====|====|====|====|====|====|====|====|====] 0:00:00 > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem predOnly model 0... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2_model_shared.h:3, from rx_efd18f8062630ae84eaec854283bcf74_x64.c:121: D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition > Calculating residuals/tables v done > compress origData in nlmixr2 object, save 3696 > compress phiM in nlmixr2 object, save 49608 > compress parHistData in nlmixr2 object, save 14872 > compress saem0 in nlmixr2 object, save 10568 i parameter labels from comments will be replaced by 'label()' > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done Calculating covariance matrix [====|====|====|====|====|====|====|====|====|====] 0:00:00 > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem predOnly model 0... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done > Calculating residuals/tables v done > compress origData in nlmixr2 object, save 3696 > compress phiM in nlmixr2 object, save 44008 > compress parHistData in nlmixr2 object, save 14296 i parameter labels from comments will be replaced by 'label()' > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2_model_shared.h:3, from rx_8e932dd540bfde0675fbe869bc4749c6_x64.c:121: D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition i calculate uninformed etas i done Calculating covariance matrix [====|====|====|====|====|====|====|====|====|====] 0:00:00 > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem predOnly model 0... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2_model_shared.h:3, from rx_c879014bda637c419d772b4cd0994f2c_x64.c:121: D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition > Calculating residuals/tables v done > compress origData in nlmixr2 object, save 3696 > compress phiM in nlmixr2 object, save 48248 > compress parHistData in nlmixr2 object, save 14584 i parameter labels from comments will be replaced by 'label()' > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done Calculating covariance matrix [====|====|====|====|====|====|====|====|====|====] 0:00:00 > loading into symengine environment... > pruning branches (`if`/`else`) of saem model... v done > finding duplicate expressions in saem predOnly model 0... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem predOnly model 1... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > finding duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in saem predOnly model 2... [====|====|====|====|====|====|====|====|====|====] 0:00:00 v done > Calculating residuals/tables v done > compress origData in nlmixr2 object, save 3696 > compress phiM in nlmixr2 object, save 48664 > compress parHistData in nlmixr2 object, save 14600 [ FAIL 0 | WARN 1 | SKIP 0 | PASS 225 ] [ FAIL 0 | WARN 1 | SKIP 0 | PASS 225 ] > ## test_check("nlmixr2est", stop_on_failure = FALSE, wrap=TRUE, > ## reporter = testthat::LocationReporter) > > proc.time() user system elapsed 174.90 8.67 236.71