nmTest({ test_that("nls makes sense", { d <- nlmixr2data::theo_sd d <- d[d$AMT != 0 | d$DV != 0, ] one.cmt <- function() { ini({ tka <- fix(0.45) tcl <- log(c(0, 2.7, 100)) tv <- 3.45 add.sd <- 0.7 }) model({ ka <- exp(tka) cl <- exp(tcl) v <- exp(tv) linCmt() ~ add(add.sd) }) } skip_if_not(rxode2parse::.linCmtSens()) fit1 <- nlmixr(one.cmt, d, est="nls") expect_true(inherits(fit1, "nlmixr2.nls")) fit1 <- nlmixr(one.cmt, d, est="nls", nlsControl(solveType = "fun")) Treated <- Puromycin[Puromycin$state == "treated", ] names(Treated) <- gsub("rate", "DV", gsub("conc", "time", names(Treated))) Treated$ID <- 1 f <- function() { ini({ Vm <- 200 K <- 0.1 prop.sd <- 0.1 }) model({ pred <- (Vm * time)/(K + time) pred ~ prop(prop.sd) }) } fit1 <- nlmixr(f, Treated, est="nls", control=nlsControl(algorithm="default")) expect_true(inherits(fit1, "nlmixr2.nls")) }) })