nmTest({ test_that("cov-focei", { dat <- warfarin %>% dplyr::filter(dvid == "cp") #### doesn't work with FOCEI ### doesn't work with SAEM with CRWES=True but does iwth CWRES=FALSE One.SD.ODE <- function() { ini({ # Where initial conditions/variables are specified lcl <- log(0.135) # log Cl (L/h) lv <- log(8) # log V (L) lmtt <- log(1.1) # log MTx prop.err <- 0.15 # proportional error (SD/mean) add.err <- 0.6 # additive error (mg/L) eta.cl + eta.v + eta.mtt ~ c( 0.1, 0.001, 0.1, 0.001, 0.001, 0.1 ) }) model({ # Where the model is specified cl <- exp(lcl + eta.cl) v <- exp(lv + eta.v) mtt <- exp(lmtt + eta.mtt) ktr <- 6 / mtt ## ODE example d / dt(depot) <- -ktr * depot d / dt(central) <- ktr * trans5 - (cl / v) * central d / dt(trans1) <- ktr * depot - ktr * trans1 d / dt(trans2) <- ktr * trans1 - ktr * trans2 d / dt(trans3) <- ktr * trans2 - ktr * trans3 d / dt(trans4) <- ktr * trans3 - ktr * trans4 d / dt(trans5) <- ktr * trans4 - ktr * trans5 ## Concentration is calculated cp <- central / v ## And is assumed to follow proportional and additive error cp ~ prop(prop.err) + add(add.err) }) } f <- suppressMessages(suppressWarnings(nlmixr(One.SD.ODE, dat, "posthoc"))) expect_s3_class(f, "nlmixr2.posthoc") }) })