R Under development (unstable) (2024-07-17 r86903 ucrt) -- "Unsuffered Consequences" Copyright (C) 2024 The R Foundation for Statistical Computing Platform: x86_64-w64-mingw32/x64 R is free software and comes with ABSOLUTELY NO WARRANTY. You are welcome to redistribute it under certain conditions. Type 'license()' or 'licence()' for distribution details. R is a collaborative project with many contributors. Type 'contributors()' for more information and 'citation()' on how to cite R or R packages in publications. Type 'demo()' for some demos, 'help()' for on-line help, or 'help.start()' for an HTML browser interface to help. Type 'q()' to quit R. > > library("survival") > library("multcomp") Loading required package: mvtnorm Loading required package: TH.data Loading required package: MASS Attaching package: 'TH.data' The following object is masked from 'package:MASS': geyser > set.seed(29) > > bladder1 <- bladder[bladder$enum < 5, ] > bladder1$number <- as.factor(bladder1$number) > > cm <- coxph(Surv(stop, event) ~ rx + size + number + strata(enum) + + cluster(id), data = bladder1) > summary(glht(cm, mcp(number = "Dunnett"))) Simultaneous Tests for General Linear Hypotheses Multiple Comparisons of Means: Dunnett Contrasts Fit: coxph(formula = Surv(stop, event) ~ rx + size + number + strata(enum), data = bladder1, cluster = id) Linear Hypotheses: Estimate Std. Error z value Pr(>|z|) 2 - 1 == 0 0.7895 0.5124 1.541 0.494 3 - 1 == 0 0.3848 0.4699 0.819 0.941 4 - 1 == 0 0.7933 0.6487 1.223 0.727 5 - 1 == 0 1.3446 0.6269 2.145 0.160 6 - 1 == 0 2.4325 0.3440 7.071 <0.001 *** 8 - 1 == 0 0.8000 0.3502 2.285 0.115 --- Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1 (Adjusted p values reported -- single-step method) > > wm <- survreg(Surv(stop, event) ~ rx + size + number + strata(enum) + + cluster(id), data = bladder1) > summary(glht(wm, mcp(number = "Dunnett"))) Simultaneous Tests for General Linear Hypotheses Multiple Comparisons of Means: Dunnett Contrasts Fit: survreg(formula = Surv(stop, event) ~ rx + size + number + strata(enum), data = bladder1, cluster = id) Linear Hypotheses: Estimate Std. Error z value Pr(>|z|) 2 - 1 == 0 -0.4609 0.3232 -1.426 0.5374 3 - 1 == 0 -0.2325 0.2918 -0.797 0.9328 4 - 1 == 0 -0.6017 0.3422 -1.758 0.3184 5 - 1 == 0 -1.0458 0.3844 -2.721 0.0338 * 6 - 1 == 0 -1.4714 0.2949 -4.989 <0.001 *** 8 - 1 == 0 -0.3075 0.2944 -1.044 0.8089 --- Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1 (Adjusted p values reported -- single-step method) > > > proc.time() user system elapsed 1.42 0.23 1.65