R Under development (unstable) (2023-06-12 r84534 ucrt) -- "Unsuffered Consequences"
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> 
> library("multcomp")
Loading required package: mvtnorm
Loading required package: survival
Loading required package: TH.data
Loading required package: MASS

Attaching package: 'TH.data'

The following object is masked from 'package:MASS':

    geyser

> set.seed(290875)
> 
> testdata <- data.frame(y = rnorm(21), 
+                        f1 <- factor(c(rep(c("A", "B", "C"), 7))),
+                        f2 <- factor(c(rep("D", 10), rep("E", 11))),
+                        x <- rnorm(21))
> 
> # one-way ANOVA
> coef(amod <- aov(y ~ f1, data = testdata))
(Intercept)         f1B         f1C 
 -0.4394751   0.5151680   0.6886101 
> glht(amod, linfct = mcp(f1 = "Dunnett"))

	 General Linear Hypotheses

Multiple Comparisons of Means: Dunnett Contrasts


Linear Hypotheses:
           Estimate
B - A == 0   0.5152
C - A == 0   0.6886

> 
> # and a continuous covariable: ANCOVA
> coef(lmod <- lm(y ~ f1 + x, data = testdata))
 (Intercept)          f1B          f1C            x 
-0.434528566  0.509444592  0.686181780 -0.009491201 
> glht(lmod, linfct = mcp(f1 = "Dunnett"))

	 General Linear Hypotheses

Multiple Comparisons of Means: Dunnett Contrasts


Linear Hypotheses:
           Estimate
B - A == 0   0.5094
C - A == 0   0.6862

> 
> # ANCOVA with an additional factor as covariable
> coef(lmod <- lm(y ~ f1 + f2 + x, data = testdata))
(Intercept)         f1B         f1C         f2E           x 
-0.40849498  0.51296437  0.69200699 -0.05266965 -0.01613183 
> glht(lmod, linfct = mcp(f1 = "Dunnett"))

	 General Linear Hypotheses

Multiple Comparisons of Means: Dunnett Contrasts


Linear Hypotheses:
           Estimate
B - A == 0    0.513
C - A == 0    0.692

> 
> # and with interaction terms
> coef(lmod <- lm(y ~ f1 + f2 + f2:f1 + x, data = testdata))
(Intercept)         f1B         f1C         f2E           x     f1B:f2E 
-0.44532319  0.70282663  0.65613337  0.05552324 -0.03443721 -0.37862471 
    f1C:f2E 
 0.02753451 
> glht(lmod, linfct = mcp(f1 = "Dunnett"))

	 General Linear Hypotheses

Multiple Comparisons of Means: Dunnett Contrasts


Linear Hypotheses:
           Estimate
B - A == 0   0.7028
C - A == 0   0.6561

Warning message:
In mcp2matrix(model, linfct = linfct) :
  covariate interactions found -- default contrast might be inappropriate
> 
> # with contrasts as expressions
> glht(lmod, linfct = mcp(f1 = c("B - A = 0", "C - A = 0")))

	 General Linear Hypotheses

Multiple Comparisons of Means: User-defined Contrasts


Linear Hypotheses:
           Estimate
B - A == 0   0.7028
C - A == 0   0.6561

Warning message:
In mcp2matrix(model, linfct = linfct) :
  covariate interactions found -- default contrast might be inappropriate
> 
> tmp <- multcomp:::chrlinfct2matrix(c(l1 = "x1 - x2 = 2", 
+                                       l2 = "x2 + 3 * x3 = 1"), 
+                                       paste("x", 1:3, sep = ""))
> 
> stopifnot(max(abs(tmp$K - rbind(c(1, -1, 0), c(0, 1, 3)))) < sqrt(.Machine$double.eps))
> stopifnot(max(abs(tmp$m - c(2, 1))) < sqrt(.Machine$double.eps))
> 
> ### coef.survreg and vcov.survreg need special tuning
> ### thx to Z for pointing this out
> if (require("survival")) {
+     smod <- survreg(Surv(futime, fustat) ~ ecog.ps + rx, 
+                     data = ovarian, dist = 'weibull')
+     K <- diag(length(coef(smod)))
+     rownames(K) <- names(coef(smod))
+     glht(smod, linfct = K)
+ }

	 General Linear Hypotheses

Linear Hypotheses:
                 Estimate
(Intercept) == 0   6.8967
ecog.ps == 0      -0.3850
rx == 0            0.5286

> 
> ### new `means' comparisons
> amod <- aov(weight ~ dose + gesttime + number, data = litter)
> confint(glht(amod, linfct = mcp(dose = "Means")))

	 Simultaneous Confidence Intervals

Multiple Comparisons of Means: Mean Contrasts


Fit: aov(formula = weight ~ dose + gesttime + number, data = litter)

Quantile = 2.5558
95% family-wise confidence level
 

Linear Hypotheses:
         Estimate lwr     upr    
0 == 0   32.3651  30.0805 34.6498
5 == 0   29.0127  26.6372 31.3883
50 == 0  30.0743  27.5239 32.6246
500 == 0 29.6899  27.1591 32.2207

> 
> proc.time()
   user  system elapsed 
   1.28    0.18    1.45