R Under development (unstable) (2025-04-29 r88182 ucrt) -- "Unsuffered Consequences"
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> # R CMD BATCH --no-timing --no-restore --no-save other_tests.R other_tests.Rout
> 
> # Get rid of anything in the workspace:
> rm(list=ls()) 
> 
> library(httk)
> 
> calc_css(chem.name='nicotine')
$avg
[1] 0.3976

$frac
[1] 0.9623

$max
[1] 0.5331

$the.day
[1] 2

Warning messages:
1: In get_clint(dtxsid = dtxsid, chem.name = chem.name, chem.cas = chem.cas,  :
  Clint is provided as a distribution.
2: In apply_clint_adjustment(Clint.point, Fu_hep = Fu_hep, suppress.messages = suppress.messages) :
  Clint adjusted for in vitro partitioning (Kilford, 2008), see calc_hep_fu.
3: In get_fup(dtxsid = dtxsid, chem.name = chem.name, chem.cas = chem.cas,  :
  Fraction unbound is provided as a distribution.
4: In apply_fup_adjustment(fup.point, fup.correction = fup.adjustment,  :
  Fup adjusted for in vivo lipid partitioning (Pearce, 2017), see calc_fup_correction.
5: In available_rblood2plasma(chem.cas = chem.cas, species = species,  :
  Human in vivo measured Rblood2plasma used.
6: In get_caco2(chem.cas = chem.cas, chem.name = chem.name, dtxsid = dtxsid,  :
  Default value of 1.6 used for Caco2 permeability.
> 
> calc_tkstats(chem.name='nicotine',days=10)
Human plasma concentrations returned in uM units.
AUC is area under plasma concentration curve in uM * days units with Rblood2plasma = 0.8238 .
$AUC
[1] 4.117

$peak
[1] 1.217

$mean
[1] 0.4117

> 
> calc_analytic_css(
+   chem.name='Bisphenol-A',
+   tissue='liver',
+   species='rabbit',
+   parameterize.args.list = list(
+     default.to.human=TRUE,
+     adjusted.Funbound.plasma=TRUE,
+     regression=TRUE,
+     minimum.Funbound.plasma=1e-4),
+   daily.dose=2)
Plasma concentration for liver returned in uM units.
[1] 31
There were 14 warnings (use warnings() to see them)
> 
> predict_partitioning_schmitt(chem.name='nicotine')
$Kadipose2pu
[1] 1.194

$Kbone2pu
[1] 1.355

$Kbrain2pu
[1] 2.616

$Kgut2pu
[1] 3.846

$Kheart2pu
[1] 2.97

$Kkidney2pu
[1] 5.886

$Kliver2pu
[1] 6.19

$Klung2pu
[1] 5.62

$Kmuscle2pu
[1] 2.952

$Kskin2pu
[1] 3.226

$Kspleen2pu
[1] 2.677

$Krbc2pu
[1] 1.254

$Krest2pu
[1] 3.496

Warning messages:
1: In get_fup(dtxsid = dtxsid, chem.name = chem.name, chem.cas = chem.cas,  :
  Fraction unbound is provided as a distribution.
2: In apply_fup_adjustment(fup.point, fup.correction = fup.adjustment,  :
  Fup adjusted for in vivo lipid partitioning (Pearce, 2017), see calc_fup_correction.
> 
> quit("no")
> proc.time()
   user  system elapsed 
   5.79    0.25    6.04