testthat::context("Survival endpoint sample size") testthat::test_that("Testing nSurv vs nSurvival and nEvents", { # consider a trial with 2 year maximum follow-up, # 6 month uniform enrollment # Treatment/placebo hazards = 0.14/0.2 per 1 person-year # HR = 0.7 # drop out hazard 0.1 per 1 person-year # alpha = 0.025 (1-sided) # power = 0.9 (default beta=.1) ss <- nSurvival( lambda1 = .2, lambda2 = .14, eta = .1, Ts = 2, Tr = .5, sided = 1, alpha = .025 ) ns <- nSurv(lambdaC = .2, hr = .7, eta = .1, T=2, minfup=1.5) nsg <- nSurv(lambdaC = .2, hr = .7, eta = .1, R = 0.5, gamma = ns$gamma) ne <- nEvents(hr=.7) testthat::expect_equal(ss$n, ns$n, info = "Checking sample size") testthat::expect_equal(round(ns$n,3), round(nsg$n,3), info = "Checking sample size") testthat::expect_equal(ss$nEvents, ns$d, info = "Checking event count") testthat::expect_lt(abs(ns$d - ne),3) }) testthat::test_that("Checking consistency of Schoenfeld approximations", { z <- hrn2z(hr = .7, n = 100, ratio = 1.5) hr <- zn2hr(z = -z, n = 100, ratio = 1.5) n <- hrz2n(z = -z, hr = .7, ratio = 1.5) testthat::expect_equal(hr, .7, info = "Checking zn2hr vs hrn2z") testthat::expect_equal(n, 100, info = "Checking hrz2n vs hrn2z") }) testthat::test_that("Checking consistency nEvents power vs sample size", { ss <- nEvents(hr = .7, tbl = TRUE) ne <- nEvents(hr = .7) pwr <- nEvents(hr = .7, n = ne, tbl = TRUE) testthat::expect_equal(ss$n, ceiling(ne), info = "Checking tabular output") testthat::expect_equal(pwr$Power, .9, info = "Checking power calculation") })