# Enrollment rate enroll_rate <- define_enroll_rate( duration = 18, rate = 20 ) # Failure rates fail_rate <- define_fail_rate( duration = c(4, 100), fail_rate = log(2) / 12, dropout_rate = .001, hr = c(1, .6) ) # Study duration in months study_duration <- 36 # Experimental / Control randomization ratio ratio <- 1 test_that("AHR", { x <- fixed_design_ahr( alpha = 0.025, power = 0.9, enroll_rate = enroll_rate, fail_rate = fail_rate, study_duration = study_duration, ratio = ratio ) y <- fixed_design_ahr( alpha = 0.025, enroll_rate = enroll_rate %>% dplyr::mutate(rate = x$analysis$n / duration), fail_rate = fail_rate, study_duration = study_duration, ratio = ratio ) expect_equal(y$analysis$power, 0.9) }) test_that("FH", { x <- fixed_design_fh( alpha = 0.025, power = 0.9, enroll_rate = enroll_rate, fail_rate = fail_rate, study_duration = study_duration, ratio = ratio, rho = 0.5, gamma = 0.5 ) |> to_integer() y <- fixed_design_fh( alpha = 0.025, enroll_rate = enroll_rate %>% dplyr::mutate(rate = x$analysis$n / duration), fail_rate = fail_rate, study_duration = study_duration, ratio = ratio, rho = 0.5, gamma = 0.5 ) expect_true(y$analysis$power >= 0.9) expect_equal(y$analysis$power, 0.9, tolerance = 0.01) }) test_that("MB", { x <- fixed_design_mb( alpha = 0.025, power = 0.9, enroll_rate = enroll_rate, fail_rate = fail_rate, study_duration = study_duration, ratio = ratio, tau = 8 ) |> to_integer() y <- fixed_design_mb( alpha = 0.025, enroll_rate = enroll_rate %>% dplyr::mutate(rate = x$analysis$n / duration), fail_rate = fail_rate, study_duration = study_duration, ratio = ratio, tau = 8 ) expect_true(y$analysis$power >= 0.9) expect_equal(y$analysis$power, 0.9, tolerance = 0.01) }) test_that("LF", { x <- fixed_design_lf( alpha = 0.025, power = 0.9, enroll_rate = enroll_rate, fail_rate = fail_rate, study_duration = study_duration, ratio = ratio ) |> to_integer() y <- fixed_design_lf( alpha = 0.025, enroll_rate = enroll_rate %>% dplyr::mutate(rate = x$analysis$n / duration), fail_rate = fail_rate, study_duration = study_duration, ratio = ratio ) expect_equal(y$analysis$power, 0.9, tolerance = 0.01) }) test_that("MaxCombo", { x <- fixed_design_maxcombo( alpha = 0.025, power = 0.9, enroll_rate = enroll_rate, fail_rate = fail_rate, study_duration = study_duration, ratio = ratio, rho = c(0, 0.5, 0.5), gamma = c(0, 0, 0.5), tau = c(-1, 4, 6) ) y <- fixed_design_maxcombo( alpha = 0.025, enroll_rate = enroll_rate %>% dplyr::mutate(rate = x$analysis$n / duration), fail_rate = fail_rate, study_duration = study_duration, ratio = ratio, rho = c(0, 0.5, 0.5), gamma = c(0, 0, 0.5), tau = c(-1, 4, 6) ) expect_equal(y$analysis$power, 0.9, tolerance = testthat_tolerance() * 100) }) test_that("RMST", { x <- fixed_design_rmst( alpha = 0.025, power = 0.9, enroll_rate = enroll_rate, fail_rate = fail_rate, study_duration = study_duration, ratio = ratio, tau = 18 ) y <- fixed_design_rmst( alpha = 0.025, enroll_rate = enroll_rate %>% dplyr::mutate(rate = x$analysis$n / duration), fail_rate = fail_rate, study_duration = study_duration, ratio = ratio, tau = 18 ) expect_equal(y$analysis$power, 0.9) }) test_that("RD", { x <- fixed_design_rd( alpha = 0.025, power = 0.9, p_c = .15, p_e = .1, rd0 = 0, ratio = ratio ) y <- fixed_design_rd( alpha = 0.025, n = x$analysis$n, p_c = .15, p_e = .1, rd0 = 0, ratio = ratio ) expect_equal(y$analysis$power, 0.9, tolerance = testthat_tolerance() * 2e+5) })