if(identical(Sys.getenv("NOT_CRAN"), "true")& .Machine$sizeof.pointer != 4){ library(ctsem) library(testthat) cores=2 context("randomEffects") test_that("randomEffectsTDPREDEFFECT", { nsubjects <- 1000 ntimes <- 20 baseline <- rnorm(nsubjects,2, 2) t0m <- rnorm(nsubjects,baseline/2,1) effect <- rnorm(nsubjects, 5-baseline/3, 0.5) for(i in 1:nsubjects){ gm <- suppressMessages(ctModel(silent=TRUE,Tpoints=ntimes, LAMBDA=matrix(c(1,0),1,2), DRIFT= c(-1,1, 0,-.5), T0MEANS = c(t0m[i],0), DIFFUSION=c(0.5,0,0,1e-6), MANIFESTVAR = 0.5, T0VAR = c(0,0,0,0), TDPREDMEANS = matrix(c(rep(0,9),1,rep(0,ntimes-10))), TDPREDEFFECT = matrix(c(0,effect[i]),2), MANIFESTMEANS = baseline[i])) d <- suppressMessages(data.frame(ctGenerate(ctmodelobj = gm,n.subjects = 1,burnin = 0,dtmean = 1,logdtsd = 0))) d$id <- i if(i==1) dat <- d else dat <- rbind(dat,d) } #regular bw effect approach m <- ctModel(silent=TRUE,type='stanct', LAMBDA=matrix(c(1,0),1,2), DRIFT= c('drift',1, 0,-0.5), T0MEANS = c('t0m',0), T0VAR = diag(1e-3,2), DIFFUSION=c('diffusion',0,0,0), TDPREDEFFECT = matrix(c(0,'tdpredeffect|param|TRUE'))) #manual bw effects m2 <- ctModel(silent=TRUE,type='omx',Tpoints=3, LAMBDA=matrix(c(1,0,0,0),1,4), DRIFT= c('drift',1,0,0, 0,-0.5,0,0, 0,0,-1e-6,0, 0,0,0,-1e-6), DIFFUSION=c('diffusion',0,0,0, 0,0,0,0, 0,0,0,0, 0,0,0,0), T0MEANS = c('t0m',0,'mm','tdpredeffect'), TDPREDEFFECT = matrix(c(0,'state[4]',0,0)), MANIFESTMEANS='state[3]') m2$T0VAR[2,]=m2$T0VAR[,2]=0 m2=ctStanModel(m2,type='stanct') m2$pars$indvarying=F f <- ctStanFit(datalong = dat,ctstanmodel = m,cores=cores) s=summary(f) s subjpars=ctStanSubjectPars(f)[1,,] #calculate subject specific parameter estimates f2 <- ctStanFit(datalong = dat,ctstanmodel = m2,cores=cores,derrind=1) s2=summary(f2) s2 cp2=ctStanContinuousPars(f2) # checks ------------------------------------------------------------------ plot(subjpars[,1],baseline) abline(0,1) plot(subjpars[,2],t0m) abline(0,1) plot(subjpars[,3],effect) abline(0,1) f$stanfit$transformedparsfull$popsd log1p_exp(2*f$stanfit$transformedparsfull$rawpopsdbase-1) #sd checks dfsd=data.frame(trueSample=c(sd(baseline),sd(t0m),sd(effect)), #sample sd subjPars=sqrt(diag(cov(subjpars))), #sd of individual effect point estimates f2est=sqrt(diag(f2$stanfit$transformedparsfull$pop_T0cov[1,,]))[c(3,1,4)], s$popsd[c('mm_Y1','t0m','tdpredeffect'),]) #population estimate #test sd of ctsem between subjects setup vs manual specification testthat::expect_equivalent(dfsd$f2est,dfsd$X50.,tol=1e-2) #test sd of ctsem between subjects setup vs subject specific pars testthat::expect_equivalent(dfsd$mean,dfsd$subjPars,tol=.2) #test sd of ctsem between subjects setup vs true sample sd -- why is t0means sd overestimated? testthat::expect_equivalent(dfsd[,'trueSample'], dfsd[,'X50.'],tol=1e-1) plot(density(sqrt(f2$stanfit$transformedpars$pop_T0cov[,4,4]))) #distribution of pop sd estimates points(density(f$stanfit$transformedpars$popsd[,3]),col=2,type='l') #distribution of pop sd estimates #cov checks f$stanfit$transformedparsfull$popcov[1,,] cov(subjpars) cov(cbind(baseline,t0m,effect)) #true sample cov #corr checks dfcorr <- data.frame(trueSample=cor(cbind(t0m,baseline,effect))[lower.tri(diag(3))], #true sample cor, subjPars=cor(subjpars[,c('t0m','mm_Y1','tdpredeffect')])[lower.tri(diag(3))], f1popCovbased=cov2cor(f$stanfit$transformedparsfull$popcov[1,,])[lower.tri(diag(3))], f2est=cov2cor(f2$stanfit$transformedparsfull$pop_T0cov[1,-2,-2])[lower.tri(diag(3))], s$rawpopcorr ) #test corr of ctsem between subjects setup vs manual specification testthat::expect_equivalent(dfcorr$f2est,dfcorr$X50.,tol=1e-2) #test corr of ctsem between subjects setup vs subject specific pars # testthat::expect_equivalent(dfcorr$mean,dfcorr$subjPars,tol=.2) #test corr of ctsem between subjects setup vs true sample sd testthat::expect_equivalent(dfcorr[,'trueSample'], dfcorr[,'X50.'],tol=1e-1) }) test_that("randomEffectsLambda", { set.seed(1) nsubjects <- 1000 ntimes <- 20 baseline <- rnorm(nsubjects,2, 2) t0m <- rnorm(nsubjects,baseline/2,1) effect <- rnorm(nsubjects, 5-baseline/3, 0.5) for(i in 1:nsubjects){ gm <- suppressMessages(ctModel(silent=TRUE,Tpoints=ntimes, LAMBDA=matrix(c(1,effect[i]),1,2), DRIFT= c(-1,0, 0,-.5), T0MEANS = c(t0m[i],0), DIFFUSION=c(0.5,0,0,1e-6), MANIFESTVAR = 0.5, T0VAR = c(0,0,0,0), TDPREDMEANS = matrix(c(rep(0,9),1,rep(0,ntimes-10))), TDPREDEFFECT = matrix(c(0,1),2), MANIFESTMEANS = baseline[i])) d <- suppressMessages(data.frame(ctGenerate(ctmodelobj = gm,n.subjects = 1,burnin = 0,dtmean = 1,logdtsd = 0))) d$id <- i if(i==1) dat <- d else dat <- rbind(dat,d) } #regular bw effect approach m <- ctModel(silent=TRUE,type='stanct', LAMBDA=matrix(c(1,'tdpredeffect|param|TRUE'),1,2), DRIFT= c('drift',0, 0,-0.5), T0MEANS = c('t0m',0), T0VAR = diag(1e-3,2), DIFFUSION=c('diffusion',0,0,0), TDPREDEFFECT = matrix(c(0,1))) #manual bw effects m2 <- ctModel(silent=TRUE,type='omx',Tpoints=3, LAMBDA=matrix(c(1,'state[4]',0,0),1,4), DRIFT= c('drift',0,0,0, 0,-0.5,0,0, 0,0,-1e-6,0, 0,0,0,-1e-6), DIFFUSION=c('diffusion',0,0,0, 0,0,0,0, 0,0,0,0, 0,0,0,0), T0MEANS = c('t0m',0,'mm','tdpredeffect'), TDPREDEFFECT = matrix(c(0,1,0,0)), MANIFESTMEANS='state[3]') m2$T0VAR[2,]=m2$T0VAR[,2]=0 m2=ctStanModel(m2,type='stanct') m2$pars$indvarying=F f <- ctStanFit(datalong = dat,ctstanmodel = m,cores=cores) s=summary(f) s subjpars=ctStanSubjectPars(f)[1,,] #calculate subject specific parameter estimates f2 <- ctStanFit(datalong = dat,ctstanmodel = m2,cores=cores,derrind=1) s2=summary(f2) s2 cp2=ctStanContinuousPars(f2) # checks ------------------------------------------------------------------ f$stanfit$transformedparsfull$popsd log1p_exp(2*f$stanfit$transformedparsfull$rawpopsdbase-1) #sd checks dfsd=data.frame(trueSample=c(sd(baseline),sd(t0m),sd(effect)), #sample sd subjPars=sqrt(diag(cov(subjpars))), #sd of individual effect point estimates f2est=sqrt(diag(f2$stanfit$transformedparsfull$pop_T0cov[1,,]))[c(3,1,4)], s$popsd[c('mm_Y1','t0m','tdpredeffect'),]) #population estimate #test sd of ctsem between subjects setup vs manual specification testthat::expect_equivalent(dfsd$f2est,dfsd$X50.,tol=1e-2) #test sd of ctsem between subjects setup vs subject specific pars testthat::expect_equivalent(dfsd$mean,dfsd$subjPars,tol=.2) #test sd of ctsem between subjects setup vs true sample sd -- why is t0means sd overestimated? testthat::expect_equivalent(dfsd[,'trueSample'], dfsd[,'X50.'],tol=1e-1) plot(density(sqrt(f2$stanfit$transformedpars$pop_T0cov[,4,4]))) #distribution of pop sd estimates points(density(f$stanfit$transformedpars$popsd[,2]),col=2,type='l') #distribution of pop sd estimates #cov checks f$stanfit$transformedparsfull$popcov[1,,] cov(subjpars) cov(cbind(baseline,t0m,effect)) #true sample cov #corr checks dfcorr <- data.frame(trueSample=cor(cbind(baseline,t0m,effect))[lower.tri(diag(3))][c(3,1,2)], #true sample cor, subjPars=cor(subjpars[,c('t0m','tdpredeffect','mm_Y1')])[lower.tri(diag(3))], f1popCovbased=cov2cor(f$stanfit$transformedparsfull$popcov[1,,])[lower.tri(diag(3))], f2est=cov2cor(f2$stanfit$transformedparsfull$pop_T0cov[1,-2,-2])[lower.tri(diag(3))][c(2,1,3)], s$rawpopcorr ) #test corr of ctsem between subjects setup vs manual specification testthat::expect_equivalent(dfcorr$f2est,dfcorr$X50.,tol=1e-2) #test corr of ctsem between subjects setup vs subject specific pars testthat::expect_equivalent(dfcorr$mean,dfcorr$subjPars,tol=.2) #test corr of ctsem between subjects setup vs true sample sd testthat::expect_equivalent(dfcorr[,'trueSample'], dfcorr[,'X50.'],tol=1e-1) }) test_that("randomEffectsDRIFT", { set.seed(1) nsubjects <- 400 ntimes <- 50 baseline <- rnorm(nsubjects,2, 2) t0m <- rnorm(nsubjects,baseline/2,1) raweffect <- rnorm(nsubjects, baseline/2, 0.5) effect <- -log1p(exp(-raweffect)) for(i in 1:nsubjects){ gm <- suppressMessages(ctModel(silent=TRUE,Tpoints=ntimes, LAMBDA=matrix(1), DRIFT= c(effect[i]), T0MEANS = c(t0m[i]), DIFFUSION=c(0.5), MANIFESTVAR = 0.5, T0VAR = c(0), CINT = c(baseline[i]),MANIFESTMEANS=0)) d <- suppressMessages(data.frame(ctGenerate(ctmodelobj = gm,n.subjects = 1,burnin = 0,dtmean = 1,logdtsd = 0))) d$id <- i if(i==1) dat <- d else dat <- rbind(dat,d) } #regular bw effect approach m <- ctModel(silent=TRUE,type='stanct', CINT='cint',MANIFESTMEANS=0, LAMBDA=matrix(1),DRIFT='drift|-log1p_exp(-param)|TRUE') #manual bw effects m2 <- ctModel(silent=TRUE,type='omx',Tpoints=3, LAMBDA=matrix(c(1,0,0),ncol=3), DRIFT= c('-log1p_exp(-state[2])',0,0, 0,-1e-6,0, 0,0,-1e-6), DIFFUSION=c('diffusion',0,0, 0,0,0, 0,0,0), T0MEANS = c('t0m','drift','cint'), CINT=c('state[3]',0,0),MANIFESTMEANS=0) m2=ctStanModel(m2,type='stanct') m2$pars$indvarying=F f <- ctStanFit(datalong = dat,ctstanmodel = m,cores=cores,optimcontrol = list(stochastic=F,carefulfit=F)) s=summary(f) s subjpars=ctStanSubjectPars(f)[1,,c('T0m_eta1','drift','cint')] #calculate subject specific parameter estimates f2 <- ctStanFit(datalong = dat,ctstanmodel = m2,cores=cores,derrind=1,optimcontrol = list(stochastic=F,carefulfit=F)) s2=summary(f2) s2 cp2=ctStanContinuousPars(f2) # checks ------------------------------------------------------------------ mean(effect) plot(subjpars[,'cint'],baseline) abline(0,1) plot(subjpars[,'drift'],effect) abline(0,1) plot(subjpars[,'T0m_eta1'],t0m) abline(0,1) plot(subjpars[,c('cint','drift')]) f$stanfit$transformedparsfull$popsd log1p_exp(2*f$stanfit$transformedparsfull$rawpopsdbase-1) #loglik checks testthat::expect_equivalent(s$loglik,s2$loglik,tol=1e-2) #sd checks (f2 differences expected) dfsd=data.frame(trueSample=c(sd(t0m),sd(effect),sd(baseline)), #sample sd subjPars=sqrt(diag(cov(subjpars))), #sd of individual effect point estimates f2est=sqrt(diag(f2$stanfit$transformedparsfull$pop_T0cov[1,,])), s$popsd[c('T0m_eta1','drift','cint'),]) #population estimate #test sd of ctsem between subjects setup vs manual specification testthat::expect_equivalent(sqrt(diag(f2$stanfit$transformedparsfull$pop_T0cov[1,,])), f$stanfit$transformedparsfull$rawpopsd*c(10,1,10),tol=1e-2) #test sd of ctsem between subjects setup vs subject specific pars testthat::expect_equivalent(dfsd$mean,dfsd$subjPars,tol=.1) #test sd of ctsem between subjects setup vs true sample sd testthat::expect_equivalent(dfsd[,'trueSample'], dfsd[,'X50.'],tol=1e-1) plot(density(sqrt(f2$stanfit$transformedpars$pop_T0cov[,2,2]))) #distribution of pop sd estimates points(density(f$stanfit$transformedpars$rawpopsd[,2]),col=2,type='l') #distribution of pop sd estimates #cov checks f$stanfit$transformedparsfull$popcov[1,,] cov(subjpars) cov(cbind(baseline,t0m,effect)) #true sample cov #corr checks dfcorr <- data.frame(trueSample=cor(cbind(t0m,raweffect,baseline))[lower.tri(diag(3))], #true (raw) sample cor, subjPars=cor(subjpars)[lower.tri(diag(3))], f1popCovbased=cov2cor(f$stanfit$transformedparsfull$popcov[1,,])[lower.tri(diag(3))], f2est=cov2cor(f2$stanfit$transformedparsfull$pop_T0cov[1,,])[lower.tri(diag(3))], s$rawpopcorr ) #test corr of ctsem between subjects setup vs manual specification testthat::expect_equivalent(dfcorr$f2est,dfcorr$X50.,tol=1e-2) #test corr of ctsem between subjects setup vs subject specific pars testthat::expect_equivalent(dfcorr$mean,dfcorr$subjPars,tol=.2) #test corr of ctsem between subjects setup vs true sample sd -- why is t0means sd overestimated? testthat::expect_equivalent(dfcorr[,'trueSample'], dfcorr[,'X50.'],tol=1e-1) }) test_that("randomEffectsDIFFUSION", { set.seed(1) nsubjects <- 400 ntimes <- 50 baseline <- rnorm(nsubjects,2, 2) t0m <- rnorm(nsubjects,baseline/2,1) raweffect <- rnorm(nsubjects,-baseline/3, .1) effect <- log1p(exp(raweffect)) for(i in 1:nsubjects){ gm <- suppressMessages(ctModel(silent=TRUE,Tpoints=ntimes, LAMBDA=matrix(1), DRIFT= -1, T0MEANS = c(t0m[i]), DIFFUSION=effect[i], MANIFESTVAR = 0.5, T0VAR = c(0), CINT = baseline[i], MANIFESTMEANS=0)) d <- suppressMessages(data.frame(ctGenerate(ctmodelobj = gm,n.subjects = 1,burnin = 0,dtmean = .1,logdtsd = 0))) d$id <- i if(i==1) dat <- d else dat <- rbind(dat,d) } #regular bw effect approach m <- ctModel(silent=TRUE,type='stanct', T0MEANS='t0m|param', MANIFESTVAR=.5, MANIFESTMEANS=0,CINT='cint|param', LAMBDA=matrix(1),DIFFUSION='diffusion|log1p_exp(param)|TRUE') #manual bw effects m2 <- ctModel(silent=TRUE,type='omx',Tpoints=3, LAMBDA=matrix(c(1,0,0),ncol=3), DRIFT= c('drift',0,0, 0,-1e-12,0, 0,0,-1e-12), DIFFUSION=c('log1p_exp(state[2])',0,0, 0,0,0, 0,0,0), MANIFESTVAR=.5, T0MEANS = c('t0m|param','diffusion|param','cint|param'), CINT=c('state[3]',0,0), MANIFESTMEANS=0) m2$T0VAR[diag(3)==1] <- paste0(m2$T0VAR[diag(3)==1] ,'|log1p_exp(2*param-1)') m2=ctStanModel(m2,type='stanct') m2$pars$indvarying=F f <- ctStanFit(datalong = dat,ctstanmodel = m,cores=cores, optimcontrol = list(stochastic=F,carefulfit=F))#,init=f$stanfit$rawest) s=summary(f) s subjpars=ctStanSubjectPars(f)[1,,c('t0m','diffusion','cint')] #calculate subject specific parameter estimates f2 <- ctStanFit(datalong = dat,ctstanmodel = m2,cores=cores,derrind=1,optimcontrol = list(stochastic=F,carefulfit=F)) s2=summary(f2) s2 cp2=ctStanContinuousPars(f2) # checks ------------------------------------------------------------------ mean(effect) plot(subjpars[,'cint'],baseline) abline(0,1) plot(subjpars[,'diffusion'],effect) abline(0,1) plot(subjpars[,'t0m'],t0m) abline(0,1) plot(subjpars[,c('diffusion','cint')]) f$stanfit$transformedparsfull$popsd log1p_exp(2*f$stanfit$transformedparsfull$rawpopsdbase-1) #loglik checks testthat::expect_equivalent(s$loglik,s2$loglik,tol=1e-2) #sd checks dfsd=data.frame(trueSample=c(sd(t0m),sd(raweffect),sd(baseline)), #sample sd # subjPars=sqrt(diag(cov(subjpars)))[c(2,3,1)], #sd of individual effect point estimates f2est=sqrt(diag(f2$stanfit$transformedparsfull$pop_T0cov[1,,])), f1est=c(f$stanfit$transformedparsfull$rawpopsd)) #population estimate dfsdtf=data.frame(trueSample=c(sd(t0m),sd(effect),sd(baseline)), #sample sd subjPars=sqrt(diag(cov(subjpars))), #sd of individual effect point estimates s$popsd) #population estimate #test sd of ctsem between subjects setup vs manual specification testthat::expect_equivalent(sqrt(diag(f2$stanfit$transformedparsfull$pop_T0cov[1,,])), f$stanfit$transformedparsfull$rawpopsd,tol=.05) #test sd of ctsem between subjects setup vs subject specific pars testthat::expect_equivalent(dfsdtf$X50.,dfsdtf$subjPars,tol=.1) #test sd of ctsem between subjects setup vs true sample sd testthat::expect_equivalent(dfsd[,'trueSample'],dfsd[,'f1est'],tol=.1) testthat::expect_equivalent(dfsdtf$X50.,dfsdtf[,'trueSample'],tol=.1) plot(density(sqrt(f2$stanfit$transformedpars$pop_T0cov[,2,2])),type='l') #distribution of pop sd estimates points(density(f$stanfit$transformedpars$rawpopsd[,2]),col=2,type='l') #distribution of pop sd estimates #cov checks f$stanfit$transformedparsfull$popcov[1,,] cov(subjpars) cov(cbind(baseline,t0m,effect)) #true sample cov #rawcorr checks dfcorr <- data.frame(trueSample=cor(cbind(t0m,raweffect,baseline))[lower.tri(diag(3))], #true sample cor, # subjPars=cor(subjpars[,c(3,1,2)])[lower.tri(diag(3))], # f1popCovbased=cov2cor(f$stanfit$transformedparsfull$popcov[1,,])[lower.tri(diag(3))], f2est=cov2cor(f2$stanfit$transformedparsfull$pop_T0cov[1,,])[lower.tri(diag(3))], s$rawpopcorr ) #test corr of ctsem between subjects setup vs manual specification testthat::expect_equivalent(dfcorr$f2est,dfcorr$X50.,tol=.05) # #test corr of ctsem between subjects setup vs subject specific pars # testthat::expect_equivalent(dfcorr$mean,dfcorr$subjPars,tol=.2) #test corr of ctsem between subjects setup vs true sample sd -- why is t0means sd overestimated? testthat::expect_equivalent(dfcorr[,'trueSample'], dfcorr[,'X50.'],tol=.2) }) test_that("randomEffectsMANIFESTVAR", { set.seed(1) nsubjects <- 400 ntimes <- 50 baseline <- rnorm(nsubjects,2, 2) t0m <- rnorm(nsubjects,baseline/2,1) raweffect <- rnorm(nsubjects,-baseline/5, .3) effect <- log1p(exp(raweffect)) for(i in 1:nsubjects){ gm <- suppressMessages(ctModel(silent=TRUE,Tpoints=ntimes, LAMBDA=matrix(1), DRIFT= -1, T0MEANS = c(t0m[i]), MANIFESTVAR=effect[i], DIFFUSION = 0.5, T0VAR = c(0), CINT = baseline[i], MANIFESTMEANS=0)) d <- suppressMessages(data.frame(ctGenerate(ctmodelobj = gm,n.subjects = 1,burnin = 0,dtmean = .1,logdtsd = 0))) d$id <- i if(i==1) dat <- d else dat <- rbind(dat,d) } #regular bw effect approach m <- ctModel(silent=TRUE,type='stanct', T0MEANS='t0m|param', DIFFUSION=.5, MANIFESTMEANS=0,CINT='cint|param', LAMBDA=matrix(1),MANIFESTVAR='errsd|log1p_exp(param)|TRUE') #manual bw effects m2 <- ctModel(silent=TRUE,type='omx',Tpoints=3, LAMBDA=matrix(c(1,0,0),ncol=3), DRIFT= c('drift',0,0, 0,-1e-12,0, 0,0,-1e-12), DIFFUSION=c(.5,0,0, 0,0,0, 0,0,0), MANIFESTVAR='log1p_exp(state[2])', T0MEANS = c('t0m|param','errsd|param','cint|param'), CINT=c('state[3]',0,0), MANIFESTMEANS=0) m2$T0VAR[diag(3)==1] <- paste0(m2$T0VAR[diag(3)==1] ,'|log1p_exp(2*param-1)') m2=ctStanModel(m2,type='stanct') m2$pars$indvarying=F f <- ctStanFit(datalong = dat,ctstanmodel = m,cores=cores, optimcontrol = list(stochastic=F,carefulfit=F))#,init=f$stanfit$rawest) s=summary(f) s subjpars=ctStanSubjectPars(f)[1,,c('t0m','errsd','cint')] #calculate subject specific parameter estimates f2 <- ctStanFit(datalong = dat,ctstanmodel = m2,cores=cores,optimcontrol = list(stochastic=F,carefulfit=F)) s2=summary(f2) s2 cp2=ctStanContinuousPars(f2) # checks ------------------------------------------------------------------ mean(effect) plot(subjpars[,'cint'],baseline) abline(0,1) plot(subjpars[,'errsd'],effect) abline(0,1) plot(subjpars[,'t0m'],t0m) abline(0,1) plot(subjpars[,c('errsd','cint')]) f$stanfit$transformedparsfull$popsd log1p_exp(2*f$stanfit$transformedparsfull$rawpopsdbase-1) #loglik checks testthat::expect_equivalent(s$loglik,s2$loglik,tol=1e-2) #sd checks dfsd=data.frame(trueSample=c(sd(t0m),sd(raweffect),sd(baseline)), #sample sd # subjPars=sqrt(diag(cov(subjpars)))[c(2,3,1)], #sd of individual effect point estimates f2est=sqrt(diag(f2$stanfit$transformedparsfull$pop_T0cov[1,,])), f1est=c(f$stanfit$transformedparsfull$rawpopsd)) #population estimate dfsdtf=data.frame(trueSample=c(sd(t0m),sd(effect),sd(baseline)), #sample sd subjPars=sqrt(diag(cov(subjpars))), #sd of individual effect point estimates s$popsd) #population estimate #test sd of ctsem between subjects setup vs manual specification testthat::expect_equivalent(sqrt(diag(f2$stanfit$transformedparsfull$pop_T0cov[1,,])), f$stanfit$transformedparsfull$rawpopsd,tol=.1) #test sd of ctsem between subjects setup vs subject specific pars testthat::expect_equivalent(dfsdtf$X50.,dfsdtf$subjPars,tol=.1) #test sd of ctsem between subjects setup vs true sample sd testthat::expect_equivalent(dfsd[,'trueSample'],dfsd[,'f1est'],tol=.1) testthat::expect_equivalent(dfsdtf$X50.,dfsdtf[,'trueSample'],tol=.1) plot(density(sqrt(f2$stanfit$transformedpars$pop_T0cov[,2,2])),type='l') #distribution of pop sd estimates points(density(f$stanfit$transformedpars$rawpopsd[,2]),col=2,type='l') #distribution of pop sd estimates #cov checks f$stanfit$transformedparsfull$popcov[1,,] cov(subjpars) cov(cbind(baseline,t0m,effect)) #true sample cov #rawcorr checks dfcorr <- data.frame(trueSample=cor(cbind(t0m,raweffect,baseline))[lower.tri(diag(3))], #true sample cor, # subjPars=cor(subjpars[,c(3,1,2)])[lower.tri(diag(3))], # f1popCovbased=cov2cor(f$stanfit$transformedparsfull$popcov[1,,])[lower.tri(diag(3))], f2est=cov2cor(f2$stanfit$transformedparsfull$pop_T0cov[1,,])[lower.tri(diag(3))], s$rawpopcorr ) #test corr of ctsem between subjects setup vs manual specification testthat::expect_equivalent(dfcorr$f2est,dfcorr$X50.,tol=.1) # #test corr of ctsem between subjects setup vs subject specific pars # testthat::expect_equivalent(dfcorr$mean,dfcorr$subjPars,tol=.2) #test corr of ctsem between subjects setup vs true sample sd testthat::expect_equivalent(dfcorr[,'trueSample'], dfcorr[,'X50.'],tol=.2) }) }