### ### Tests for calibration curves produced using BLR-IPCW (calib.type = 'blr') ### test_that("check calib_msm output, (j = 1, s = 0), curve.type = rcs, stabilised vs unstabilised", { ## Extract relevant predicted risks from tps0 tp.pred <- dplyr::select(dplyr::filter(tps0, j == 1), dplyr::any_of(paste("pstate", 1:6, sep = ""))) ### ### Calculate observed event probabilities dat.calib.blr <- calib_msm(data.ms = msebmtcal, data.raw = ebmtcal, j=1, s=0, t = 1826, tp.pred = tp.pred, calib.type = 'blr', curve.type = "rcs", rcs.nk = 3, w.covs = c("year", "agecl", "proph", "match")) expect_type(dat.calib.blr, "list") expect_equal(class(dat.calib.blr), c("calib_blr", "calib_msm")) expect_length(dat.calib.blr[["mean"]], 6) expect_length(dat.calib.blr[["plotdata"]], 6) expect_length(dat.calib.blr[["plotdata"]][[1]]$id, 1778) expect_length(dat.calib.blr[["plotdata"]][[6]]$id, 1778) expect_false(dat.calib.blr[["metadata"]]$CI) expect_no_error(summary(dat.calib.blr)) ### ### Calculate observed event probabilities with stabilised weights dat.calib.blr.stab <- calib_msm(data.ms = msebmtcal, data.raw = ebmtcal, j=1, s=0, t = 1826, tp.pred = tp.pred, calib.type = 'blr', curve.type = "rcs", rcs.nk = 3, w.covs = c("year", "agecl", "proph", "match"), w.stabilised = TRUE) expect_type(dat.calib.blr.stab, "list") expect_equal(class(dat.calib.blr.stab), c("calib_blr", "calib_msm")) expect_length(dat.calib.blr.stab[["plotdata"]], 6) expect_length(dat.calib.blr.stab[["plotdata"]][[1]]$id, 1778) expect_length(dat.calib.blr.stab[["plotdata"]][[6]]$id, 1778) expect_false(dat.calib.blr.stab[["metadata"]]$CI) ### Check answer is same whether stabilisation used or not expect_equal(dat.calib.blr[["plotdata"]][[1]], dat.calib.blr.stab[["plotdata"]][[1]]) }) test_that("check calib_msm output, (j = 1, s = 0), curve.type = loess", { ## Extract relevant predicted risks from tps0 tp.pred <- dplyr::select(dplyr::filter(tps0, j == 1), any_of(paste("pstate", 1:6, sep = ""))) ## Calculate observed event probabilities dat.calib.blr <- calib_msm(data.ms = msebmtcal, data.raw = ebmtcal, j=1, s=0, t = 1826, tp.pred = tp.pred, calib.type = 'blr', curve.type = "loess", w.covs = c("year", "agecl", "proph", "match")) expect_type(dat.calib.blr, "list") expect_equal(class(dat.calib.blr), c("calib_blr", "calib_msm")) expect_length(dat.calib.blr[["mean"]], 6) expect_length(dat.calib.blr[["plotdata"]], 6) expect_length(dat.calib.blr[["plotdata"]][[1]]$id, 1778) expect_length(dat.calib.blr[["plotdata"]][[6]]$id, 1778) expect_false(dat.calib.blr[["metadata"]]$CI) expect_no_error(summary(dat.calib.blr)) ## Calculate observed event probabilities dat.calib.blr.stab <- calib_msm(data.ms = msebmtcal, data.raw = ebmtcal, j=1, s=0, t = 1826, tp.pred = tp.pred, calib.type = 'blr', curve.type = "loess", w.covs = c("year", "agecl", "proph", "match"), w.stabilised = TRUE) expect_type(dat.calib.blr.stab, "list") expect_equal(class(dat.calib.blr.stab), c("calib_blr", "calib_msm")) expect_length(dat.calib.blr.stab[["plotdata"]], 6) expect_length(dat.calib.blr.stab[["plotdata"]][[1]]$id, 1778) expect_length(dat.calib.blr.stab[["plotdata"]][[6]]$id, 1778) expect_false(dat.calib.blr.stab[["metadata"]]$CI) ### Check answer is same whether stabilisation used or not expect_equal(dat.calib.blr[["plotdata"]][[1]], dat.calib.blr.stab[["plotdata"]][[1]]) ## Calculate observed event probabilities dat.calib.blr.w.function <- calib_msm(data.ms = msebmtcal, data.raw = ebmtcal, j=1, s=0, t = 1826, tp.pred = tp.pred, calib.type = 'blr', curve.type = "loess", w.function = calc_weights, w.covs = c("year", "agecl", "proph", "match")) expect_type(dat.calib.blr.w.function, "list") expect_equal(class(dat.calib.blr.w.function), c("calib_blr", "calib_msm")) expect_length(dat.calib.blr.w.function[["mean"]], 6) expect_length(dat.calib.blr.w.function[["plotdata"]], 6) expect_length(dat.calib.blr.w.function[["plotdata"]][[1]]$id, 1778) expect_length(dat.calib.blr.w.function[["plotdata"]][[6]]$id, 1778) expect_false(dat.calib.blr.w.function[["metadata"]]$CI) ### Check answer is same whether stabilisation used or not expect_equal(dat.calib.blr[["plotdata"]][[1]], dat.calib.blr.w.function[["plotdata"]][[1]]) expect_equal(dat.calib.blr[["plotdata"]][[6]], dat.calib.blr.w.function[["plotdata"]][[6]]) }) test_that("check calib_msm output, (j = 1, s = 0), with CI", { skip_on_cran() ## Extract relevant predicted risks from tps0 tp.pred <- dplyr::select(dplyr::filter(tps0, j == 1), any_of(paste("pstate", 1:6, sep = ""))) ## Calculate observed event probabilities no CI dat.calib.blr.noCI <- calib_msm(data.ms = msebmtcal, data.raw = ebmtcal, j=1, s=0, t = 1826, tp.pred = tp.pred, calib.type = 'blr', curve.type = "rcs", rcs.nk = 3, w.covs = c("year", "agecl", "proph", "match")) ## Calculate observed event probabilities with CI dat.calib.blr <- calib_msm(data.ms = msebmtcal, data.raw = ebmtcal, j=1, s=0, t = 1826, tp.pred = tp.pred, calib.type = 'blr', curve.type = "rcs", rcs.nk = 3, w.covs = c("year", "agecl", "proph", "match"), CI = 95, CI.R.boot = 5) expect_type(dat.calib.blr, "list") expect_equal(class(dat.calib.blr), c("calib_blr", "calib_msm")) expect_length(dat.calib.blr[["mean"]], 6) expect_length(dat.calib.blr[["plotdata"]], 6) expect_equal(ncol(dat.calib.blr[["plotdata"]][[1]]), 5) expect_equal(ncol(dat.calib.blr[["plotdata"]][[6]]), 5) expect_length(dat.calib.blr[["plotdata"]][[1]]$id, 1778) expect_length(dat.calib.blr[["plotdata"]][[6]]$id, 1778) expect_equal(dat.calib.blr[["metadata"]]$CI, 95) expect_no_error(summary(dat.calib.blr)) expect_equal(dat.calib.blr.noCI[["plotdata"]][[1]]$obs, dat.calib.blr[["plotdata"]][[1]]$obs) expect_equal(dat.calib.blr.noCI[["plotdata"]][[6]]$obs, dat.calib.blr[["plotdata"]][[6]]$obs) }) test_that("check calib_msm output, (j = 3, s = 100)", { ## Extract relevant predicted risks from tps100 tp.pred <- dplyr::select(dplyr::filter(tps100, j == 3), any_of(paste("pstate", 1:6, sep = ""))) ## Calculate observed event probabilities dat.calib.blr <- calib_msm(data.ms = msebmtcal, data.raw = ebmtcal, j=3, s=100, t = 1826, tp.pred = tp.pred, calib.type = 'blr', curve.type = "rcs", rcs.nk = 3, w.covs = c("year", "agecl", "proph", "match")) expect_type(dat.calib.blr, "list") expect_equal(class(dat.calib.blr), c("calib_blr", "calib_msm")) expect_length(dat.calib.blr[["mean"]], 4) expect_length(dat.calib.blr[["plotdata"]], 4) expect_length(dat.calib.blr[["plotdata"]][["state3"]]$id, 359) expect_length(dat.calib.blr[["plotdata"]][["state6"]]$id, 359) expect_error(dat.calib.blr[["plotdata"]][[6]]) expect_false(dat.calib.blr[["metadata"]]$CI) names(dat.calib.blr[["plotdata"]]) }) test_that("check calib_msm output, (j = 1, s = 0), null covs", { ## Extract relevant predicted risks from tps0 tp.pred <- dplyr::select(dplyr::filter(tps0, j == 1), any_of(paste("pstate", 1:6, sep = ""))) ## Calculate observed event probabilities dat.calib.blr <- calib_msm(data.ms = msebmtcal, data.raw = ebmtcal, j=1, s=0, t = 1826, tp.pred = tp.pred, calib.type = 'blr', curve.type = "rcs", rcs.nk = 3) expect_type(dat.calib.blr, "list") expect_equal(class(dat.calib.blr), c("calib_blr", "calib_msm")) expect_length(dat.calib.blr[["mean"]], 6) expect_length(dat.calib.blr[["plotdata"]], 6) expect_length(dat.calib.blr[["plotdata"]][[1]]$id, 1778) expect_length(dat.calib.blr[["plotdata"]][[6]]$id, 1778) expect_false(dat.calib.blr[["metadata"]]$CI) ## Calculate observed event probabilities dat.calib.blr <- calib_msm(data.ms = msebmtcal, data.raw = ebmtcal, j=1, s=0, t = 1826, tp.pred = tp.pred, calib.type = 'blr', curve.type = "rcs", rcs.nk = 3, w.covs = c("year", "agecl", "proph", "match"), w.stabilised = TRUE) expect_type(dat.calib.blr, "list") expect_equal(class(dat.calib.blr), c("calib_blr", "calib_msm")) expect_length(dat.calib.blr[["mean"]], 6) expect_length(dat.calib.blr[["plotdata"]], 6) expect_length(dat.calib.blr[["plotdata"]][[1]]$id, 1778) expect_length(dat.calib.blr[["plotdata"]][[6]]$id, 1778) expect_false(dat.calib.blr[["metadata"]]$CI) }) ### Run tests for manually inputted predicted probailities test_that("check calib_msm output, (j = 1, s = 0), curve.type = loess, CI.type = bootstrap", { skip_on_cran() ## Extract relevant predicted risks from tps0 for creating plots tp.pred <- dplyr::select(dplyr::filter(tps0, j == 1), any_of(paste("pstate", 1:6, sep = ""))) ### Create an object of only 50 observations over which to plot, which we specify manually id.lmk <- 1:50 tp.pred.plot <- tps0 |> dplyr::filter(id %in% id.lmk) |> dplyr::filter(j == 1) |> dplyr::select(any_of(paste("pstate", 1:6, sep = ""))) ## No confidence interval dat.calib.blr <- calib_msm(data.ms = msebmtcal, data.raw = ebmtcal, j = 1, s = 0, t = 1826, tp.pred = tp.pred, calib.type = 'blr', curve.type = "loess", tp.pred.plot = tp.pred.plot, transitions.out = NULL) ## Should be one less column in plotdata (no patient ids) expect_equal(class(dat.calib.blr), c("calib_blr", "calib_msm")) expect_equal(ncol(dat.calib.blr[["plotdata"]][[1]]), 2) expect_equal(nrow(dat.calib.blr[["plotdata"]][[1]]), 50) expect_no_error(summary(dat.calib.blr)) ## With confidence interval dat.calib.blr <- calib_msm(data.ms = msebmtcal, data.raw = ebmtcal, j = 1, s = 0, t = 1826, tp.pred = tp.pred, calib.type = 'blr', curve.type = "loess", CI = 95, CI.R.boot = 3, tp.pred.plot = tp.pred.plot, transitions.out = NULL) ## Should be one less column in plotdata (no patient ids) expect_equal(class(dat.calib.blr), c("calib_blr", "calib_msm")) expect_equal(ncol(dat.calib.blr[["plotdata"]][[1]]), 4) expect_equal(nrow(dat.calib.blr[["plotdata"]][[1]]), 50) expect_no_error(summary(dat.calib.blr)) }) ### Run tests for warnings with small cohort test_that("Test warnings for bootstrapping with small cohort", { skip_on_cran() ## Reduce to 50 individuals # Extract the predicted transition probabilities out of state j = 1 for first 100 individuals tp.pred <- tps0 |> dplyr::filter(id %in% 1:50) |> dplyr::filter(j == 1) |> dplyr::select(any_of(paste("pstate", 1:6, sep = ""))) # Reduce ebmtcal to first 50 individuals ebmtcal <- ebmtcal |> dplyr::filter(id %in% 1:50) # Reduce msebmtcal.cmprsk to first 100 individuals msebmtcal <- msebmtcal |> dplyr::filter(id %in% 1:50) ## No confidence interval expect_warning(calib_msm(data.ms = msebmtcal, data.raw = ebmtcal, j = 1, s = 0, t = 1826, tp.pred = tp.pred, calib.type = 'blr', curve.type = "loess", CI = 95, CI.R.boot = 3, transitions.out = c(1))) }) test_that("check calib_msm output, (j = 1, s = 0), manual weights, manually define vector of predicted probabilities, manually define transition out, estimate curves using rcs", { ## Extract relevant predicted risks from tps0 tp.pred <- dplyr::select(dplyr::filter(tps0, j == 1), any_of(paste("pstate", 1:6, sep = ""))) ## Define t t <- 1826 ## Extract data for plot manually ids.uncens <- ebmtcal |> subset(dtcens > t | (dtcens < t & dtcens.s == 0)) |> dplyr::pull(id) tp.pred.plot <- tps0 |> dplyr::filter(j == 1 & id %in% ids.uncens) |> dplyr::select(any_of(paste("pstate", 1:6, sep = ""))) ## Calculate manual weights weights.manual <- calc_weights(data.ms = msebmtcal, data.raw = ebmtcal, t = 1826, s = 0, landmark.type = "state", j = 1, max.weight = 10, stabilised = FALSE) ## Calculate observed event probabilities using weights.manual dat.calib.blr.w.manual <- calib_msm(data.ms = msebmtcal, data.raw = ebmtcal, j=1, s=0, t = 1826, tp.pred = tp.pred, calib.type = 'blr', curve.type = "rcs", rcs.nk = 3, weights = weights.manual$ipcw, tp.pred.plot = tp.pred.plot, transitions.out = c(1,2,3,4,5,6)) expect_type(dat.calib.blr.w.manual, "list") expect_equal(class(dat.calib.blr.w.manual), c("calib_blr", "calib_msm")) expect_length(dat.calib.blr.w.manual[["mean"]], 6) expect_length(dat.calib.blr.w.manual[["plotdata"]], 6) expect_length(dat.calib.blr.w.manual[["plotdata"]][[1]]$pred, 1778) expect_length(dat.calib.blr.w.manual[["plotdata"]][[6]]$pred, 1778) expect_false(dat.calib.blr.w.manual[["metadata"]]$CI) }) test_that("check calib_msm output, (j = 1, s = 0), manual weights, manually define vector of predicted probabilities, manually define transition out, estimate curves using loess", { ## Extract relevant predicted risks from tps0 tp.pred <- dplyr::select(dplyr::filter(tps0, j == 1), any_of(paste("pstate", 1:6, sep = ""))) ## Define t t <- 1826 ## Extract data for plot manually ids.uncens <- ebmtcal |> subset(dtcens > t | (dtcens < t & dtcens.s == 0)) |> dplyr::pull(id) tp.pred.plot <- tps0 |> dplyr::filter(j == 1 & id %in% ids.uncens) |> dplyr::select(any_of(paste("pstate", 1:6, sep = ""))) ## Calculate manual weights weights.manual <- calc_weights(data.ms = msebmtcal, data.raw = ebmtcal, t = 1826, s = 0, landmark.type = "state", j = 1, max.weight = 10, stabilised = FALSE) ## Calculate observed event probabilities using weights.manual dat.calib.blr.w.manual <- calib_msm(data.ms = msebmtcal, data.raw = ebmtcal, j=1, s=0, t = 1826, tp.pred = tp.pred, calib.type = 'blr', curve.type = "loess", rcs.nk = 3, weights = weights.manual$ipcw, tp.pred.plot = tp.pred.plot, transitions.out = c(1,2,3,4,5,6)) expect_type(dat.calib.blr.w.manual, "list") expect_equal(class(dat.calib.blr.w.manual), c("calib_blr", "calib_msm")) expect_length(dat.calib.blr.w.manual[["mean"]], 6) expect_length(dat.calib.blr.w.manual[["plotdata"]], 6) expect_length(dat.calib.blr.w.manual[["plotdata"]][[1]]$pred, 1778) expect_length(dat.calib.blr.w.manual[["plotdata"]][[6]]$pred, 1778) expect_false(dat.calib.blr.w.manual[["metadata"]]$CI) }) test_that("check calib_msm output, (j = 1, s = 0), with CI, manually define vector of predicted probabilities, manually define transition out", { skip_on_cran() ## Extract relevant predicted risks from tps0 tp.pred <- dplyr::select(dplyr::filter(tps0, j == 1), any_of(paste("pstate", 1:6, sep = ""))) ## Define t t <- 1826 ## Extract data for plot manually ids.uncens <- ebmtcal |> subset(dtcens > t | (dtcens < t & dtcens.s == 0)) |> dplyr::pull(id) tp.pred.plot <- tps0 |> dplyr::filter(j == 1 & id %in% ids.uncens) |> dplyr::select(any_of(paste("pstate", 1:6, sep = ""))) ## Calculate observed event probabilities dat.calib.blr <- calib_msm(data.ms = msebmtcal, data.raw = ebmtcal, j=1, s=0, t = 1826, tp.pred = tp.pred, calib.type = 'blr', curve.type = "rcs", rcs.nk = 3, w.covs = c("year", "agecl", "proph", "match"), CI = 95, CI.R.boot = 5, tp.pred.plot = tp.pred.plot, transitions.out = c(1,2,3,4,5,6)) expect_type(dat.calib.blr, "list") expect_equal(class(dat.calib.blr), c("calib_blr", "calib_msm")) expect_length(dat.calib.blr[["mean"]], 6) expect_length(dat.calib.blr[["plotdata"]], 6) expect_length(dat.calib.blr[["plotdata"]][[1]]$pred, 1778) expect_length(dat.calib.blr[["plotdata"]][[6]]$pred, 1778) expect_equal(dat.calib.blr[["metadata"]]$CI, 95) }) test_that("check calib_msm output, (j = 1, s = 0), Manually define function to estimate weights", { skip_on_cran() ## Extract relevant predicted risks from tps0 tp.pred <- dplyr::select(dplyr::filter(tps0, j == 1), dplyr::any_of(paste("pstate", 1:6, sep = ""))) ### ### Calculate observed event probabilities dat.calib.blr <- calib_msm(data.ms = msebmtcal, data.raw = ebmtcal, j=1, s=0, t = 1826, tp.pred = tp.pred, calib.type = 'blr', curve.type = "rcs", rcs.nk = 3, w.covs = c("year", "agecl", "proph", "match")) ### ### Calculate manual weights weights.manual <- calc_weights(data.ms = msebmtcal, data.raw = ebmtcal, covs = c("year", "agecl", "proph", "match"), t = 1826, s = 0, landmark.type = "state", j = 1, max.weight = 10, stabilised = FALSE) ### ### Calculate observed event probabilities same function as internal procedure, and check it agrees with dat.calib.blr dat.calib.blr.w.manual <- calib_msm(data.ms = msebmtcal, data.raw = ebmtcal, j=1, s=0, t = 1826, tp.pred = tp.pred, calib.type = 'blr', curve.type = "rcs", rcs.nk = 3, weights = weights.manual$ipcw) expect_equal(dat.calib.blr[["plotdata"]][[1]], dat.calib.blr.w.manual[["plotdata"]][[1]]) ### ### Calculate observed event probabilities using an incorrect vector of weights, and see if its different from dat.calib.blr dat.calib.blr.w.manual <- calib_msm(data.ms = msebmtcal, data.raw = ebmtcal, j=1, s=0, t = 1826, tp.pred = tp.pred, calib.type = 'blr', curve.type = "rcs", rcs.nk = 3, weights = rep(1,nrow(weights.manual))) expect_false(any(dat.calib.blr[["plotdata"]][[1]]$obs == dat.calib.blr.w.manual[["plotdata"]][[1]]$obs)) ### ### Calculate observed event probabilities with w.function, where calc_weights_manual = calc_weights (exactly same as internal procedure) calc_weights_manual <- calc_weights dat.calib.blr.w.function <- calib_msm(data.ms = msebmtcal, data.raw = ebmtcal, j=1, s=0, t = 1826, tp.pred = tp.pred, calib.type = 'blr', curve.type = "rcs", rcs.nk = 3, w.function = calc_weights_manual, w.covs = c("year", "agecl", "proph", "match")) expect_type(dat.calib.blr.w.function, "list") expect_equal(class(dat.calib.blr.w.function), c("calib_blr", "calib_msm")) expect_length(dat.calib.blr.w.function[["mean"]], 6) expect_length(dat.calib.blr.w.function[["plotdata"]], 6) expect_length(dat.calib.blr.w.function[["plotdata"]][[1]]$id, 1778) expect_length(dat.calib.blr.w.function[["plotdata"]][[6]]$id, 1778) expect_false(dat.calib.blr.w.function[["metadata"]]$CI) ## Check answer is same whether w.function used or not expect_equal(dat.calib.blr[["plotdata"]][[1]], dat.calib.blr.w.function[["plotdata"]][[1]]) expect_equal(dat.calib.blr[["plotdata"]][[6]], dat.calib.blr.w.function[["plotdata"]][[6]]) ### ### Redefine calc_weights, but change order of all the input arguments (this shouldn't make a difference) calc_weights_manual <- function(stabilised = FALSE, max.follow = NULL, data.ms, covs = NULL, landmark.type = "state", j = NULL, t, s, max.weight = 10, data.raw){ ### Modify everybody to be censored after time t, if a max.follow has been specified if(!is.null(max.follow)){ if (max.follow == "t"){ data.raw <- dplyr::mutate(data.raw, dtcens.s = dplyr::case_when(dtcens < t + 2 ~ dtcens.s, dtcens >= t + 2 ~ 0), dtcens = dplyr::case_when(dtcens < t + 2 ~ dtcens, dtcens >= t + 2 ~ t + 2)) } else { data.raw <- dplyr::mutate(data.raw, dtcens.s = dplyr::case_when(dtcens < max.follow + 2 ~ dtcens.s, dtcens >= max.follow + 2 ~ 0), dtcens = dplyr::case_when(dtcens < max.follow + 2 ~ dtcens, dtcens >= max.follow + 2 ~ max.follow + 2)) } } ### Create a new outcome, which is the time until censored from s data.raw$dtcens.modified <- data.raw$dtcens - s ### Save a copy of data.raw data.raw.save <- data.raw ### If landmark.type = "state", calculate weights only in individuals in state j at time s ### If landmark.type = "all", calculate weights in all uncensored individuals at time s (note that this excludes individuals ### who have reached absorbing states, who have been 'censored' from the survival distribution is censoring) if (landmark.type == "state"){ ### Identify individuals who are uncensored in state j at time s ids.uncens <- base::subset(data.ms, from == j & Tstart <= s & s < Tstop) |> dplyr::select(id) |> dplyr::distinct(id) |> dplyr::pull(id) } else if (landmark.type == "all"){ ### Identify individuals who are uncensored time s ids.uncens <- base::subset(data.ms, Tstart <= s & s < Tstop) |> dplyr::select(id) |> dplyr::distinct(id) |> dplyr::pull(id) } ### Subset data.ms and data.raw to these individuals data.ms <- data.ms |> base::subset(id %in% ids.uncens) data.raw <- data.raw |> base::subset(id %in% ids.uncens) ### ### Create models for censoring in order to calculate the IPCW weights ### Seperate models for estimating the weights, and stabilising the weights (intercept only model) ### if (!is.null(covs)){ ### A model where we adjust for predictor variables cens.model <- survival::coxph(stats::as.formula(paste("survival::Surv(dtcens.modified, dtcens.s) ~ ", paste(covs, collapse = "+"), sep = "")), data = data.raw) ### Intercept only model (numerator for stabilised weights) cens.model.int <- survival::coxph(stats::as.formula(paste("survival::Surv(dtcens.modified, dtcens.s) ~ 1", sep = "")), data = data.raw) } else if (is.null(covs)){ ### If user has not input any predictors for estimating weights, the model for estimating the weights is the intercept only model (i.e. Kaplan Meier estimator) ### Intercept only model (numerator for stabilised weights) cens.model.int <- survival::coxph(stats::as.formula(paste("survival::Surv(dtcens.modified, dtcens.s) ~ 1", sep = "")), data = data.raw) ### Assign cens.model to be the same cens.model <- cens.model.int } ### Calculate a data frame containing probability of censored and uncenosred at each time point ### The weights will be the probability of being uncensored, at the time of the event for each individual ## Extract baseline hazard data.weights <- survival::basehaz(cens.model, centered = FALSE) ## Add lp to data.raw.save data.raw.save$lp <- stats::predict(cens.model, newdata = data.raw.save, type = "lp", reference = "zero") ### Create weights for the cohort at time t - s ### Note for individuals who reached an absorbing state, we take the probability of them being uncensored at the time of reached the ### abosrbing state. For individuals still alive, we take the probability of being uncensored at time t - s. ### Get location of individuals who entered absorbing states or were censored prior to evaluation time obs.absorbed.prior <- which(data.raw.save$dtcens <= t & data.raw.save$dtcens.s == 0) obs.censored.prior <- which(data.raw.save$dtcens <= t & data.raw.save$dtcens.s == 1) ### ### Now create unstabilised probability of (un)censoring weights ### Note that weights are the probability of being uncensored, so if an individual has low probability of being uncesored, ### the inervse of this will be big, weighting them strongly ### ### First assign all individuals a weight of the probability of being uncensored at time t ### This is the linear predictor times the cumulative hazard at time t, and appropriate transformation to get a risk data.raw.save$pcw <- as.numeric(exp(-exp(data.raw.save$lp)*data.weights$hazard[max(which(data.weights$time <= t - s))])) ## Write a function which will extract the uncensored probability for an individual with linear predictor lp at a given time t prob.uncens.func <- function(input){ ## Assign t and person_id t <- input[1] lp <- input[2] if (t <= 0){ return(NA) } else if (t > 0){ ## Get hazard at appropriate time if (t < min(data.weights$time)){ bhaz.t <- 0 } else if (t >= min(data.weights$time)){ bhaz.t <- data.weights$hazard[max(which(data.weights$time <= t))] } ## Return risk return(exp(-exp(lp)*bhaz.t)) } } ### Apply this function to all the times at which individuals have entered an absorbing state prior to censoring data.raw.save$pcw[obs.absorbed.prior] <- apply(data.raw.save[obs.absorbed.prior, c("dtcens.modified", "lp")], 1, FUN = prob.uncens.func) ### For individuals who were censored prior to t, assign the weight as NA data.raw.save$pcw[obs.censored.prior] <- NA ### Invert these data.raw.save$ipcw <- 1/data.raw.save$pcw ### ### Stabilise these weights dependent on user-input ### if (stabilised == TRUE){ ## Extract baseline hazard data.weights.numer <- survival::basehaz(cens.model.int, centered = TRUE) ### Assign all individuals a weight of the probability of being uncesored at time t data.raw.save$pcw.numer <- as.numeric(exp(-data.weights.numer$hazard[max(which(data.weights.numer$time <= t - s))])) ### Create stabilised weight data.raw.save$ipcw.stab <- data.raw.save$pcw.numer*data.raw.save$ipcw } ### Finally cap these at 10 and create output object ### Create output object if (stabilised == FALSE){ data.raw.save$ipcw <- pmin(data.raw.save$ipcw, max.weight) output.weights <- data.frame("id" = data.raw.save$id, "ipcw" = data.raw.save$ipcw, "pcw" = data.raw.save$pcw) } else if (stabilised == TRUE){ data.raw.save$ipcw <- pmin(data.raw.save$ipcw, max.weight) data.raw.save$ipcw.stab <- pmin(data.raw.save$ipcw.stab, max.weight) output.weights <- data.frame("id" = data.raw.save$id, "ipcw" = data.raw.save$ipcw, "ipcw.stab" = data.raw.save$ipcw.stab, "pcw" = data.raw.save$pcw) } return(output.weights) } ### Calculate observed event probabilities with new w.function dat.calib.blr.w.function <- calib_msm(data.ms = msebmtcal, data.raw = ebmtcal, j=1, s=0, t = 1826, tp.pred = tp.pred, calib.type = 'blr', curve.type = "rcs", rcs.nk = 3, w.function = calc_weights_manual, w.covs = c("year", "agecl", "proph", "match")) expect_type(dat.calib.blr.w.function, "list") expect_equal(class(dat.calib.blr.w.function), c("calib_blr", "calib_msm")) expect_length(dat.calib.blr.w.function[["mean"]], 6) expect_length(dat.calib.blr.w.function[["plotdata"]], 6) expect_length(dat.calib.blr.w.function[["plotdata"]][[1]]$id, 1778) expect_length(dat.calib.blr.w.function[["plotdata"]][[6]]$id, 1778) expect_false(dat.calib.blr.w.function[["metadata"]]$CI) ## Check answer is same whether w.function used or not expect_equal(dat.calib.blr[["plotdata"]][[1]], dat.calib.blr.w.function[["plotdata"]][[1]]) expect_equal(dat.calib.blr[["plotdata"]][[6]], dat.calib.blr.w.function[["plotdata"]][[6]]) ### ### Repeat this process (manual definition of calc_weights), again arguments are in different order, but this time an extra argument is added, which adds 10 to every weight. ### This extra arguments is something that could be inputted by user, and want to check it does actually change the answer. It should no longer agree with dat.calb.blr. calc_weights_manual <- function(stabilised = FALSE, max.follow = NULL, data.ms, covs = NULL, landmark.type = "state", j = NULL, t, s, max.weight = 10, data.raw, extra.arg = NULL){ ### Modify everybody to be censored after time t, if a max.follow has been specified if(!is.null(max.follow)){ if (max.follow == "t"){ data.raw <- dplyr::mutate(data.raw, dtcens.s = dplyr::case_when(dtcens < t + 2 ~ dtcens.s, dtcens >= t + 2 ~ 0), dtcens = dplyr::case_when(dtcens < t + 2 ~ dtcens, dtcens >= t + 2 ~ t + 2)) } else { data.raw <- dplyr::mutate(data.raw, dtcens.s = dplyr::case_when(dtcens < max.follow + 2 ~ dtcens.s, dtcens >= max.follow + 2 ~ 0), dtcens = dplyr::case_when(dtcens < max.follow + 2 ~ dtcens, dtcens >= max.follow + 2 ~ max.follow + 2)) } } ### Create a new outcome, which is the time until censored from s data.raw$dtcens.modified <- data.raw$dtcens - s ### Save a copy of data.raw data.raw.save <- data.raw ### If landmark.type = "state", calculate weights only in individuals in state j at time s ### If landmark.type = "all", calculate weights in all uncensored individuals at time s (note that this excludes individuals ### who have reached absorbing states, who have been 'censored' from the survival distribution is censoring) if (landmark.type == "state"){ ### Identify individuals who are uncensored in state j at time s ids.uncens <- base::subset(data.ms, from == j & Tstart <= s & s < Tstop) |> dplyr::select(id) |> dplyr::distinct(id) |> dplyr::pull(id) } else if (landmark.type == "all"){ ### Identify individuals who are uncensored time s ids.uncens <- base::subset(data.ms, Tstart <= s & s < Tstop) |> dplyr::select(id) |> dplyr::distinct(id) |> dplyr::pull(id) } ### Subset data.ms and data.raw to these individuals data.ms <- data.ms |> base::subset(id %in% ids.uncens) data.raw <- data.raw |> base::subset(id %in% ids.uncens) ### ### Create models for censoring in order to calculate the IPCW weights ### Seperate models for estimating the weights, and stabilising the weights (intercept only model) ### if (!is.null(covs)){ ### A model where we adjust for predictor variables cens.model <- survival::coxph(stats::as.formula(paste("survival::Surv(dtcens.modified, dtcens.s) ~ ", paste(covs, collapse = "+"), sep = "")), data = data.raw) ### Intercept only model (numerator for stabilised weights) cens.model.int <- survival::coxph(stats::as.formula(paste("survival::Surv(dtcens.modified, dtcens.s) ~ 1", sep = "")), data = data.raw) } else if (is.null(covs)){ ### If user has not input any predictors for estimating weights, the model for estimating the weights is the intercept only model (i.e. Kaplan Meier estimator) ### Intercept only model (numerator for stabilised weights) cens.model.int <- survival::coxph(stats::as.formula(paste("survival::Surv(dtcens.modified, dtcens.s) ~ 1", sep = "")), data = data.raw) ### Assign cens.model to be the same cens.model <- cens.model.int } ### Calculate a data frame containing probability of censored and uncenosred at each time point ### The weights will be the probability of being uncensored, at the time of the event for each individual ## Extract baseline hazard data.weights <- survival::basehaz(cens.model, centered = FALSE) ## Add lp to data.raw.save data.raw.save$lp <- stats::predict(cens.model, newdata = data.raw.save, type = "lp", reference = "zero") ### Create weights for the cohort at time t - s ### Note for individuals who reached an absorbing state, we take the probability of them being uncensored at the time of reached the ### abosrbing state. For individuals still alive, we take the probability of being uncensored at time t - s. ### Get location of individuals who entered absorbing states or were censored prior to evaluation time obs.absorbed.prior <- which(data.raw.save$dtcens <= t & data.raw.save$dtcens.s == 0) obs.censored.prior <- which(data.raw.save$dtcens <= t & data.raw.save$dtcens.s == 1) ### ### Now create unstabilised probability of (un)censoring weights ### Note that weights are the probability of being uncensored, so if an individual has low probability of being uncesored, ### the inervse of this will be big, weighting them strongly ### ### First assign all individuals a weight of the probability of being uncensored at time t ### This is the linear predictor times the cumulative hazard at time t, and appropriate transformation to get a risk data.raw.save$pcw <- as.numeric(exp(-exp(data.raw.save$lp)*data.weights$hazard[max(which(data.weights$time <= t - s))])) ## Write a function which will extract the uncensored probability for an individual with linear predictor lp at a given time t prob.uncens.func <- function(input){ ## Assign t and person_id t <- input[1] lp <- input[2] if (t <= 0){ return(NA) } else if (t > 0){ ## Get hazard at appropriate time if (t < min(data.weights$time)){ bhaz.t <- 0 } else if (t >= min(data.weights$time)){ bhaz.t <- data.weights$hazard[max(which(data.weights$time <= t))] } ## Return risk return(exp(-exp(lp)*bhaz.t)) } } ### Apply this function to all the times at which individuals have entered an absorbing state prior to censoring data.raw.save$pcw[obs.absorbed.prior] <- apply(data.raw.save[obs.absorbed.prior, c("dtcens.modified", "lp")], 1, FUN = prob.uncens.func) ### For individuals who were censored prior to t, assign the weight as NA data.raw.save$pcw[obs.censored.prior] <- NA ### Invert these data.raw.save$ipcw <- 1/data.raw.save$pcw ### ### Stabilise these weights dependent on user-input ### if (stabilised == TRUE){ ## Extract baseline hazard data.weights.numer <- survival::basehaz(cens.model.int, centered = TRUE) ### Assign all individuals a weight of the probability of being uncesored at time t data.raw.save$pcw.numer <- as.numeric(exp(-data.weights.numer$hazard[max(which(data.weights.numer$time <= t - s))])) ### Create stabilised weight data.raw.save$ipcw.stab <- data.raw.save$pcw.numer*data.raw.save$ipcw } ### Finally cap these at 10 and create output object ### Create output object if (stabilised == FALSE){ data.raw.save$ipcw <- pmin(data.raw.save$ipcw, max.weight) output.weights <- data.frame("id" = data.raw.save$id, "ipcw" = data.raw.save$ipcw, "pcw" = data.raw.save$pcw) } else if (stabilised == TRUE){ data.raw.save$ipcw <- pmin(data.raw.save$ipcw, max.weight) data.raw.save$ipcw.stab <- pmin(data.raw.save$ipcw.stab, max.weight) output.weights <- data.frame("id" = data.raw.save$id, "ipcw" = data.raw.save$ipcw, "ipcw.stab" = data.raw.save$ipcw.stab, "pcw" = data.raw.save$pcw) } ### Add this extra argument to the weights, to check it does something output.weights$ipcw <- output.weights$ipcw + extra.arg return(output.weights) } ### Calculate observed event probabilities with new w.function dat.calib.blr.w.function <- calib_msm(data.ms = msebmtcal, data.raw = ebmtcal, j=1, s=0, t = 1826, tp.pred = tp.pred, calib.type = 'blr', curve.type = "rcs", rcs.nk = 3, w.function = calc_weights_manual, w.covs = c("year", "agecl", "proph", "match"), extra.arg = 10) expect_type(dat.calib.blr.w.function, "list") expect_equal(class(dat.calib.blr.w.function), c("calib_blr", "calib_msm")) expect_length(dat.calib.blr.w.function[["mean"]], 6) expect_length(dat.calib.blr.w.function[["plotdata"]], 6) expect_length(dat.calib.blr.w.function[["plotdata"]][[1]]$id, 1778) expect_length(dat.calib.blr.w.function[["plotdata"]][[6]]$id, 1778) expect_false(dat.calib.blr.w.function[["metadata"]]$CI) ## Check answer is same whether w.function used or not expect_false(any(dat.calib.blr[["plotdata"]][[1]]$obs == dat.calib.blr.w.function[["plotdata"]][[1]]$obs)) }) test_that("test warnings and errors", { ## Extract relevant predicted risks from tps0 tp.pred <- dplyr::select(dplyr::filter(tps0, j == 3), any_of(paste("pstate", 1:6, sep = ""))) ## Calculate observed event probabilities expect_error( calib_msm(data.ms = msebmtcal, data.raw = ebmtcal, j=1, s=0, t = 1826, tp.pred = tp.pred, calib.type = 'blr', curve.type = "rcs", rcs.nk = 3, w.covs = c("year", "agecl", "proph", "match"), transitions.out = c(1,2,3,4)) ) ## Calculate observed event probabilities weights.manual <- calc_weights(data.ms = msebmtcal, data.raw = ebmtcal, t = 1826, s = 0, landmark.type = "state", j = 1, max.weight = 10, stabilised = FALSE)$ipcw[-1] expect_error( calib_msm(data.ms = msebmtcal, data.raw = ebmtcal, j=1, s=0, t = 1826, tp.pred = tp.pred, calib.type = 'blr', curve.type = "rcs", rcs.nk = 3, weights = weights.manual) ) ## Write a weights function with the wrong variable names calc_weights_error <- function(data.ms, data.raw, covs = NULL, t, s, j = NULL, max.weight = 10, stabilised = FALSE, max.follow = NULL){ return(data.ms) } expect_error( calib_msm(data.ms = msebmtcal, data.raw = ebmtcal, j=1, s=0, t = 1826, tp.pred = tp.pred, calib.type = 'blr', curve.type = "rcs", rcs.nk = 3, w.function = calc_weights_error, w.covs = c("year", "agecl", "proph", "match")) ) ### check warnings when there are zero predicted probabilities for valid transitions ## Extract relevant predicted risks from tps0 tp.pred <- dplyr::select(dplyr::filter(tps100, j == 1), dplyr::any_of(paste("pstate", 1:6, sep = ""))) tp.pred[,1] <- rep(0, nrow(tp.pred)) ### ### Calculate observed event probabilities expect_error(calib_msm(data.ms = msebmtcal, data.raw = ebmtcal, j=1, s=100, t = 1826, tp.pred = tp.pred, calib.type = 'blr', curve.type = "loess", rcs.nk = 3, w.covs = c("year", "agecl", "proph", "match"))) ### check error when there are non-zero predicted probabilities for transitions which do not happen ## Extract relevant predicted risks from tps0 tp.pred <- dplyr::select(dplyr::filter(tps100, j == 1), dplyr::any_of(paste("pstate", 1:6, sep = ""))) tp.pred[,3] <- runif(nrow(tp.pred), 0, 1) ### ### Calculate observed event probabilities expect_error(calib_msm(data.ms = msebmtcal, data.raw = ebmtcal, j=1, s=100, t = 1826, tp.pred = tp.pred, calib.type = 'blr', curve.type = "loess", rcs.nk = 3, w.covs = c("year", "agecl", "proph", "match"))) ## Extract relevant predicted risks from tps0 tp.pred <- dplyr::select(dplyr::filter(tps100, j == 3), dplyr::any_of(paste("pstate", 1:6, sep = ""))) tp.pred[,1] <- runif(nrow(tp.pred), 0, 1) ### ### Calculate observed event probabilities expect_error(calib_msm(data.ms = msebmtcal, data.raw = ebmtcal, j=3, s=100, t = 1826, tp.pred = tp.pred, calib.type = 'blr', curve.type = "loess", rcs.nk = 3, w.covs = c("year", "agecl", "proph", "match"))) ### check error when there are zero predicted probabilities for transitions which do happen in dataset ## Extract relevant predicted risks from tps0 tp.pred <- dplyr::select(dplyr::filter(tps100, j == 3), dplyr::any_of(paste("pstate", 1:6, sep = ""))) tp.pred[,3] <- rep(0, nrow(tp.pred)) ### ### Calculate observed event probabilities expect_error(calib_msm(data.ms = msebmtcal, data.raw = ebmtcal, j=3, s=100, t = 1826, tp.pred = tp.pred, calib.type = 'blr', curve.type = "loess", rcs.nk = 3, w.covs = c("year", "agecl", "proph", "match"))) ## Extract relevant predicted risks from tps0 tp.pred <- dplyr::select(dplyr::filter(tps100, j == 3), dplyr::any_of(paste("pstate", 1:6, sep = ""))) tp.pred[,1] <- rep(0, nrow(tp.pred)) })