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Type 'q()' to quit R. > library(testthat) > library(babelmixr2) Loading required package: nlmixr2 Loading required package: nlmixr2data > > test_check("babelmixr2") i parameter labels from comments will be replaced by 'label()' i mu2 item: Rx_pow_di(WT, 2) i writing monolix files i done i run Monolix manually and rerun nlmixr() i mu2 item: Rx_pow_di(WT, 2) i leaving alone monolix files because 'monolixTest-monolix.txt' is present > loading into symengine environment... > pruning branches (`if`/`else`) of full model... v done > loading into symengine environment... > pruning branches (`if`/`else`) of full model... v done > finding duplicate expressions in EBE model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in EBE model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > compiling EBE model... using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2_model_shared.h:3, from rx_28de19f5b7138969f6c61fd05f7b1dd4_x64.c:119: D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition v done > Calculating residuals/tables v done > compress origData in nlmixr2 object, save 1336 > compress parHistData in nlmixr2 object, save 1624 Error : nonmem minimization not successful > loading into symengine environment... > pruning branches (`if`/`else`) of full model... v done > calculate jacobian > calculate sensitivities > calculate d(f)/d(eta) > finding duplicate expressions in inner model... > optimizing duplicate expressions in inner model... > finding duplicate expressions in EBE model... > optimizing duplicate expressions in EBE model... > compiling inner model... using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2_model_shared.h:3, from rx_c7d339ddc1f4d92786064331afa6d47a_x64.c:156: D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition v done > finding duplicate expressions in FD model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > optimizing duplicate expressions in FD model... [====|====|====|====|====|====|====|====|====|====] 0:00:00 > compiling EBE model... using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2_model_shared.h:3, from rx_fad6f2daa2de01a2bfe485e3531a0896_x64.c:124: D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition v done > compiling events FD model... using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2_model_shared.h:3, from rx_9f5891b0f7770e576385e514229f92e5_x64.c:124: D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition v done [====|====|====|====|====|====|====|====|====|====] 0:00:15 > compress origData in nlmixr2 object, save 27560 Updated original fit object f warning: eig_sym(): given matrix is not symmetric > loading into symengine environment... > pruning branches (`if`/`else`) of full model... v done i writing nonmem files i done > loading into symengine environment... > pruning branches (`if`/`else`) of full model... v done > loading into symengine environment... > pruning branches (`if`/`else`) of full model... v done > loading into symengine environment... > pruning branches (`if`/`else`) of full model... v done i mu2 item: Rx_pow_di(WT, 2) > loading into symengine environment... > pruning branches (`if`/`else`) of full model... v done i writing nonmem files i done i only exported NONMEM control stream/data i mu2 item: Rx_pow_di(WT, 2) > loading into symengine environment... > pruning branches (`if`/`else`) of full model... v done i only exported NONMEM control stream/data Error in bblDatToPknca(model = env$ui, data = rawData, rxControl = rxControl) : no dosing rows (EVID = 1 or 4) detected Error : no rows in event table or input data Error in nlmixr2Est(env, ...) : Could not detect DV assignment for unit conversion using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2_model_shared.h:3, from rx_de2e4b916f9f2d059c51365b84479e98_x64.c:119: D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2_model_shared.h:3, from rx_0589c33dc6a68c0404ce82518b8d5c62_x64.c:119: D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2_model_shared.h:3, from rx_5d1b06d5d324c438f7339a75cac1568b_x64.c:119: D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition i Ds-optimality important parameters: tcl, tv i Ds-optimality unimportant parameters: eta.cl, eta.v, add.err i Ds-optimality important parameters: tcl, tv, eta.cl i Ds-optimality unimportant parameters: eta.v, add.err i Ds-optimality important parameters: tv i Ds-optimality unimportant parameters: tcl, eta.cl, eta.v, add.err i Ds-optimality important parameters: tcl, tv i Ds-optimality unimportant parameters: eta.cl, eta.v, add.err i Ds-optimality important parameters: tcl, tv i Ds-optimality unimportant parameters: eta.cl, eta.v, add.err using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2_model_shared.h:3, from rx_437e5fb466e561c71086247133b572e6_x64.c:119: D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2_model_shared.h:3, from rx_825e1234d7dbd56c682b271775f42d1c_x64.c:119: D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition i groupsize should be specified; but for now assuming 20 using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2_model_shared.h:3, from rx_e0b2f35f995e3599c92661430440e212_x64.c:119: D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2_model_shared.h:3, from rx_d9305ed2babcb3e48180b8f831bb0376_x64.c:119: D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition i groupsize should be specified; but for now assuming 20 i assuming group size m=2 using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2_model_shared.h:3, from rx_965bf17e081b2f8cdb47dffe3c73ca9e_x64.c:120: D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition using C compiler: 'gcc.exe (GCC) 13.2.0' In file included from D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2_model_shared.h:3, from rx_368cf9e5528896759d3da739d7a2f10f_x64.c:120: D:\RCompile\CRANincoming\R-devel\lib\rxode2\include/rxode2.h:3: warning: "STRICT_R_HEADERS" redefined 3 | #define STRICT_R_HEADERS | : note: this is the location of the previous definition [ FAIL 0 | WARN 7 | SKIP 5 | PASS 353 ] ══ Skipped tests (5) ═══════════════════════════════════════════════════════════ • On CRAN (5): 'test-as-nlmixr2.R:8:3', 'test-as-nlmixr2.R:66:3', 'test-bioavil-works.R:2:3', 'test-poped.R:228:7', 'test-poped.R:287:9' [ FAIL 0 | WARN 7 | SKIP 5 | PASS 353 ] > > proc.time() user system elapsed 340.51 37.31 445.87