context("GroupSequentialDesign") test_that("Group-sequential design constructor works", { order <- 5L design <- GroupSequentialDesign(25, 0.0, 2.0, 40.0, 1.96, order) # check if functions are defined correctly expect_equal( n2(design, 1.0), 40.0, tolerance = sqrt(.Machine$double.eps), scale = 1) expect_equal( c2(design, 1.0), 1.96, tolerance = sqrt(.Machine$double.eps), scale = 1) # check if length does fit expect_true( length(tunable_parameters(design)) == order + 4) # check if key figures can be computed null <- PointMassPrior(.0, 1) alternative <- PointMassPrior(.4, 1) dist <- Normal(two_armed = FALSE) ess <- ExpectedSampleSize(dist, alternative) pow <- Power(dist, alternative) toer <- Power(dist, null) expect_equal( evaluate(ess, design), 44.1, tolerance = 1e-1, scale = 1) expect_equal( evaluate(pow, design), 0.842, tolerance = 1e-3, scale = 1) expect_equal( evaluate(toer, design), 0.035, tolerance = 1e-3, scale = 1) }) # end 'group-sequential design constructor works' test_that("GS survival design works", { order <- 5L design <- GroupSequentialDesign(25, 0.0, 2.0, 40.0, 1.96, order, 0.6) # check if functions are defined correctly expect_equal( n2(design, 1.0), 40.0, tolerance = sqrt(.Machine$double.eps), scale = 1) expect_equal( c2(design, 1.0), 1.96, tolerance = sqrt(.Machine$double.eps), scale = 1) # check if length does fit expect_true( length(tunable_parameters(design)) == order + 4) # check if key figures can be computed null <- PointMassPrior(1.0, 1) alternative <- PointMassPrior(1.4, 1) dist <- Survival(0.6,two_armed = FALSE) ess <- ExpectedSampleSize(dist, alternative) pow <- Power(dist, alternative) toer <- Power(dist, null) expect_equal( evaluate(ess, design), 48.13485, tolerance = 1e-1, scale = 1) expect_equal( evaluate(pow, design), 0.703, tolerance = 1e-3, scale = 1) expect_equal( evaluate(toer, design), 0.03468, tolerance = 1e-3, scale = 1) })# end 'GS survival design works' test_that("GSDesign can be converted to TwoStageDesign", { design1 <- GroupSequentialDesign(50, 0, 2, 50, rep(2, 5)) design2 <- TwoStageDesign(design1) pow <- Power(Normal(), PointMassPrior(.3, 1)) ess <- ExpectedSampleSize(Normal(), PointMassPrior(.3, 1)) expect_equal( evaluate(pow, design1), evaluate(pow, design2), tolerance = 1e-3, scale = 1) expect_equal( evaluate(ess, design1), evaluate(ess, design2), tolerance = 1e-3, scale = 1) }) # end 'GSDesign can be converted to TwoStageDesign' test_that("GSDesign Survival can be converted to TSDesign Survival",{ design <- GroupSequentialDesign(50, 0, 2, 50, rep(2, 5)) design1 <- GroupSequentialDesign(50, 0, 2, 50, rep(2, 5), event_rate = 0.7) expect_equal( SurvivalDesign(design,0.7), design1 ) expect_equal( GroupSequentialDesign(design,0.7), design1 ) expect_equal( GroupSequentialDesign(design), design ) design2 <- TwoStageDesign(design1) design3 <- TwoStageDesign(design, event_rate=0.7) expect_equal( design2, design3 ) pow <- Power(Normal(), PointMassPrior(1.4, 1)) ess <- ExpectedSampleSize(Normal(), PointMassPrior(1.4, 1)) expect_equal( evaluate(pow, design1), evaluate(pow, design2), tolerance = 1e-3, scale = 1) expect_equal( evaluate(ess, design1), evaluate(ess, design2), tolerance = 1e-3, scale = 1) }) # end 'GSDesign can be converted to TwoStageDesign' test_that("Rounding works", { expect_equal( n2(GroupSequentialDesign(50, 0, 2, 50.2, rep(2, 5)), 1), 50.0, tolerance = 1e-6, scale = 1 ) }) test_that("show method", { expect_equal( paste0(capture.output(show(GroupSequentialDesign(25, 0.0, 2.0, 40.0, 1.96, 5L))), collapse = "\n\r"), "GroupSequentialDesign " ) expect_equal( paste0(capture.output(show(GroupSequentialDesign(25, 0.0, 2.0, 40.0, 1.96, 5L, 0.7))), collapse = "\n\r"), "GroupSequentialDesignSurvival " ) })