context("tunable parameters") # preliminaries n1 <- 25 c1f <- .0 c1e <- 2.0 order <- 5L n2_piv <- 40.0 c2_piv <- 1.96 initial_design <- TwoStageDesign(n1, c1f, c1e, n2_piv, c2_piv, order) dist <- Normal(two_armed = FALSE) null <- PointMassPrior(.0, 1) alternative <- PointMassPrior(.4, 1) ess <- ExpectedSampleSize(dist, alternative) pow <- Power(dist, alternative) toer <- Power(dist, null) test_that("boundary designs respect tunable", { n2 <- seq(100, 40, length.out = order) c2 <- seq(2.0, 0.0, length.out = order) d <- TwoStageDesign(n1, c1f, c1e, n2, c2, order) d <- make_fixed(d, n1) d_lb <- get_lower_boundary_design(d) d_ub <- get_upper_boundary_design(d) expect_true(all( d@tunable == d_lb@tunable)) expect_true(all( d@tunable == d_ub@tunable)) }) # end 'boundary designs respect tunable' test_that("fixing parameters works", { # can change tunability of relevant parameters tmp <<- make_fixed(initial_design, n1, c1f, c1e, n2_pivots, c2_pivots) for (name in c("n1", "c1f", "c1e", "n2_pivots", "c2_pivots")) { expect_true( !tmp@tunable[name]) } # did not affect other fields for (name in c("x1_norm_pivots", "weights")) { expect_true( tmp@tunable[name] == initial_design@tunable[name]) } }) test_that("fixed params can be made tunable again",{ # can we make params 'tunable' again? tmp <<- make_tunable(initial_design, n1, c2_pivots) for (name in c("n1", "c1f", "c1e")) { expect_true( tmp@tunable[name]) } }) # end 'make_tunable works as desired' test_that("two stage design can be optimized with fixed first stage", { initial_design <- make_fixed(initial_design, n1, c1f, c1e) res <- suppressWarnings( minimize( ess, subject_to( pow >= 0.8, toer <= .05 ), initial_design, opts = list( xtol_abs = 1e-5, algorithm = "NLOPT_LN_COBYLA", maxiter = 10 # we do not need convergence, # only see if it works technically! ) ) ) # check that fixed params did not change expect_equal( res$design@n1, initial_design@n1, tolerance = sqrt(.Machine$double.eps), scale = 1) expect_equal( res$design@c1f, initial_design@c1f, tolerance = sqrt(.Machine$double.eps), scale = 1) expect_equal( res$design@c1e, initial_design@c1e, tolerance = sqrt(.Machine$double.eps), scale = 1) }) test_that("two stage design can be optimized with fixed sample sizes", { initial_design <- make_fixed(initial_design, n1, n2_pivots) res <- suppressWarnings( minimize( ess, subject_to( pow >= 0.8, toer <= .05 ), initial_design, opts = list( xtol_abs = 1e-5, algorithm = "NLOPT_LN_COBYLA", maxiter = 10 # we do not need convergence, # only see if it works technically! ) ) ) # check that fixed params did not change expect_equal( res$design@n1, initial_design@n1, tolerance = sqrt(.Machine$double.eps), scale = 1) expect_equal( res$design@n2_pivots, initial_design@n2_pivots, tolerance = sqrt(.Machine$double.eps), scale = 1) }) # end 'two-stage design can be optimized with fixed sample sizes' test_that("group-sequential design can be optimized with fixed sample sizes", { initial_gs_design <- make_fixed( GroupSequentialDesign(25, .0, 2.0, 50.0, 2.0, order), n1, n2_pivots) res <- suppressWarnings( minimize( ess, subject_to( pow >= 0.8, toer <= .05 ), initial_gs_design, opts = list( algorithm = "NLOPT_LN_COBYLA", xtol_abs = 1e-5, maxiter = 10 ) ) ) # check that fixed params did not change expect_equal( res$design@n1, initial_gs_design@n1, tolerance = sqrt(.Machine$double.eps), scale = 1) expect_equal( res$design@n2_pivots, initial_gs_design@n2_pivots, tolerance = sqrt(.Machine$double.eps), scale = 1) }) # end 'group-sequential design can be optimized with fixed sample sizes' test_that("one-stage design can be optimized with fixed sample sizes", { initial_os_design <- make_fixed(OneStageDesign(60.0, 2.0), c1f) res <- minimize( ess, subject_to( pow >= 0.8, toer <= 0.025 ), initial_os_design ) # check that fixed params did not change expect_equal( res$design@c1f, initial_os_design@c1f, tolerance = sqrt(.Machine$double.eps), scale = 1) }) # end 'one-stage design can be optimized with fixed sample sizes'