test_that("pk.calc.dn", { # Ensure correct calculation expect_equal(pk.calc.dn(1, 5), 0.2) expect_equal(pk.calc.dn(NA, 5), NA_real_) expect_equal(pk.calc.dn(1, NA), NA_real_) }) test_that("pk.calc.cmax", { # Ensure that the formalsmap functionality works within pk.nca source("generate.data.R") tmpconc <- generate.conc(2, 2, 0:24) tmpdose <- generate.dose(tmpconc) tmpconc <- merge(tmpconc, tmpdose[,c("ID", "treatment", "dose")]) myconc <- PKNCAconc(tmpconc, conc~time|treatment+dose+ID) mydose <- PKNCAdose(tmpdose, dose~time|treatment+ID) mydata <- PKNCAdata(myconc, mydose, intervals=data.frame(start=0, end=24, auclast.dn=TRUE)) myres <- pk.nca(mydata) expect_equal(myres$result$PPORRES[myres$result$PPTESTCD %in% "auclast"]/ myres$result$PPORRES[myres$result$PPTESTCD %in% "auclast.dn"], myres$result$dose[myres$result$PPTESTCD %in% "auclast"], info="Dose normalization works when requested as a parameter in pk.nca") })