# Function to access private variables and functions get_private <- function(x) { x[['.__enclos_env__']]$private } test_that("get_parameterValues()",{ # Test error when rootData is not instance of combiStructureGenerator infoStr <- data.frame(n = c(100, 100, 100), globalState= c("M", "U", "M")) output <- get_parameterValues() output$alpha_pI <- 0.5 wrongRootData <- simulate_initialData(infoStr = infoStr, params = output) expect_error(get_parameterValues(rootData = wrongRootData), info = "fails to throw error when argument is not combiStructureInstance") # Test return default parameter values output <- get_parameterValues() expect_true(is.data.frame(output), info = "fails to output dataframe") # Test return rootData parameter values infoStr <- data.frame(n = c(100, 100, 100), globalState= c("M", "U", "M")) output$alpha_pI <- 0.5 rootData <- simulate_initialData(infoStr = infoStr, params = output)$data output <- get_parameterValues(rootData = rootData) expect_equal(output$alpha_pI, 0.5, info ="fails to return rootData parameters when given") }) test_that("simulate_initialData",{ # Test errors for incorrect input ## a) Incomplete infoStr argument infoStr <- data.frame(n = c(100, 100, 100)) expect_error(simulate_initialData(infoStr = infoStr), info ="fails to throw error 'infoStr should be a dataframe with columns: 'n', 'globalState''") ## b) infoStr with eqFreqs: incorrect values infoStr <- data.frame(n = c(100, 100, 100), globalState = c("M", "U", "M"), u_eqFreq = c(0.1, 0.8, 0.1), p_eqFreq = c(NA, 0.1, 0.1), m_eqFreq = c(0.8, 0.1, 0.8)) expect_error(simulate_initialData(infoStr = infoStr), info = "fails to throw error when given eqFreqs in infoStr have missing values") infoStr <- data.frame(n = c(100, 100, 100), globalState = c("M", "U", "M"), u_eqFreq = c(0.1, 0.8, 0.1), p_eqFreq = c(0, 0.1, 0.1), m_eqFreq = c(0.8, 0.1, 0.8)) expect_error(simulate_initialData(infoStr = infoStr), info = "fails to throw error when given eqFreqs in infoStr are incorrect") ## c) incorrect customized params infoStr <- data.frame(n = c(100, 100, 100), globalState = c("M", "U", "M")) custom_params <- matrix(1:11, ncol = 11) colnames(custom_params) <- c("alpha_pI", "beta_pI", "alpha_mI", "beta_mI", "alpha_pNI", "beta_pNI", "alpha_mNI", "beta_mNI", "mu", "alpha_Ri", "iota") expect_error(simulate_initialData(infoStr = infoStr, params = custom_params), info ="fails to throw error when given params is not data frame") custom_params <- get_parameterValues() custom_params <- custom_params[,-1] expect_error(simulate_initialData(infoStr = infoStr, params = custom_params), info ="fails to throw error when given params dataframe is not complete") # Test output is correctly generated for correct input ## a) For input without customized eqFreqs or params infoStr <- data.frame(n = c(100, 100, 100), globalState= c("M", "U", "M")) output <- simulate_initialData(infoStr = infoStr) expect_equal(class(output$data)[1], "combiStructureGenerator", info ="does not generate correct output$data class for correct input") expect_true(all(output$params == get_parameterValues()), info ="does not return default parameter values when not given a)") ## b) For input with customized eqFreqs infoStr <- data.frame(n = c(100, 100, 100), globalState = c("M", "U", "M"), u_eqFreq = c(0.1, 0.8, 0.1), p_eqFreq = c(0.1, 0.1, 0.1), m_eqFreq = c(0.8, 0.1, 0.8)) output <- simulate_initialData(infoStr = infoStr) expect_equal(class(output$data)[1], "combiStructureGenerator", info ="does not generate correct output$data class for correct input") expect_true(all(output$params == get_parameterValues()), info ="does not return default parameter values when not given b)") ## c) For input with customized params infoStr <- data.frame(n = c(100, 100, 100), globalState = c("M", "U", "M"), u_eqFreq = c(0.1, 0.8, 0.1), p_eqFreq = c(0.1, 0.1, 0.1), m_eqFreq = c(0.8, 0.1, 0.8)) custom_params <- get_parameterValues() custom_params$iota <- 0.5 output <- simulate_initialData(infoStr = infoStr, params = custom_params) expect_equal(class(output$data)[1], "combiStructureGenerator", info ="does not generate correct output$data class for correct input") expect_true(all(output$params == custom_params), info ="does not return customized params when given") }) test_that("simulate_evolData input control",{ # Test errors for incorrect input ## a) Missing tree or infoStr infoStr <- data.frame(n = c(100, 100, 100), globalState= c("M", "U", "M")) tree <- "(a:1, c:2, (d:3.7, e:4):5);" expect_error(simulate_evolData(infoStr = infoStr), info='fails to throw error when tree argument is missing') expect_error(simulate_evolData(tree = tree), info='fails to throw error when neither infoStr nor rootData are given') ## b) infoStr with eqFreqs: incorrect values infoStr <- data.frame(n = c(100, 100, 100), globalState = c("M", "U", "M"), u_eqFreq = c(0.1, 0.8, 0.1), p_eqFreq = c(NA, 0.1, 0.1), m_eqFreq = c(0.8, 0.1, 0.8)) expect_error(simulate_evolData(infoStr = infoStr, tree = tree), info = "fails to throw error when given eqFreqs in infoStr have missing values") infoStr <- data.frame(n = c(100, 100, 100), globalState = c("M", "U", "M"), u_eqFreq = c(0.1, 0.8, 0.1), p_eqFreq = c(0, 0.1, 0.1), m_eqFreq = c(0.8, 0.1, 0.8)) expect_error(simulate_evolData(infoStr = infoStr, tree = tree), info = "fails to throw error when given eqFreqs in infoStr are incorrect") ## c) incorrect customized params infoStr <- data.frame(n = c(100, 100, 100), globalState = c("M", "U", "M")) custom_params <- matrix(1:11, ncol = 11) colnames(custom_params) <- c("alpha_pI", "beta_pI", "alpha_mI", "beta_mI", "alpha_pNI", "beta_pNI", "alpha_mNI", "beta_mNI", "mu", "alpha_Ri", "iota") expect_error(simulate_evolData(infoStr = infoStr, tree = tree, params = custom_params), info ="fails to throw error when given params is not data frame") custom_params <- get_parameterValues() custom_params <- custom_params[,-1] expect_error(simulate_evolData(infoStr = infoStr, tree = tree, params = custom_params), info ="fails to throw error when given params dataframe is not complete") ## d) params given when rootData is given (if rootData is given, its parameter values are used) params <- get_parameterValues() infoStr <- data.frame(n = c(100, 100, 100), globalState= c("M", "U", "M")) rootData <- simulate_initialData(infoStr = infoStr)$data expect_error(simulate_evolData(rootData = rootData, tree = tree, params = params), info = "fails to throw error when rootData is given and params not NULL") }) test_that("simulate_evolData output",{ # Test output is correctly generated for correct input ## a.1) For input without customized eqFreqs or params: input infoStr infoStr <- data.frame(n = c(100, 100, 100), globalState= c("M", "U", "M")) tree <- "(a:1, c:2, (d:3.7, e:4):5);" silence <- capture.output({ output <- simulate_evolData(infoStr = infoStr, tree = tree) }) expect_equal(class(output$data), "list", info ="does not generate correct output$data list (a1)") print <- sub("\\[\\d+\\] \"(.+):.*\"$", "\\1", silence[2]) expect_print <- "Simulating data at root and letting it evolve along given tree: (a:1, c:2, (d:3.7, e:4)" expect_equal(print, expect_print, info = "Not simulating initial data when infoStr is given") expect_true(all(output$params == get_parameterValues()), info = "fails to return default params when not given") expect_equal(output$tree, tree, info ="returns different tree from given one (a1)") ## a.2) For input without customized eqFreqs or params: input rootData rootData <- simulate_initialData(infoStr = infoStr)$data silence <- capture.output({ output <- simulate_evolData(rootData = rootData, tree = tree) }) expect_equal(class(output$data), "list", info ="does not generate correct output$data list (a2)") print <- sub("\\[\\d+\\] \"(.+):.*\"$", "\\1", silence[2]) expect_print <- "Simulating evolution of given data at root along given tree: (a:1, c:2, (d:3.7, e:4)" expect_equal(print, expect_print, info = "Not initiating evolution of given data when rootData is given") expect_true(all(output$params == get_parameterValues()), info = "fails to return default params when not given") expect_equal(output$tree, tree, info ="returns different tree from given one (a2)") ## b) For input with customized eqFreqs infoStr <- data.frame(n = c(100, 100, 100), globalState = c("M", "U", "M"), u_eqFreq = c(0.1, 0.8, 0.1), p_eqFreq = c(0.1, 0.1, 0.1), m_eqFreq = c(0.8, 0.1, 0.8)) silence <- capture.output({ output <- simulate_evolData(infoStr = infoStr, tree = tree) }) expect_equal(class(output$data), "list", info ="does not generate correct output$data list (b)") print <- sub("\\[\\d+\\] \"(.+):.*\"$", "\\1", silence[2]) expect_print <- "Simulating data at root and letting it evolve along given tree: (a:1, c:2, (d:3.7, e:4)" expect_equal(print, expect_print, info = "Not simulating initial data when infoStr is given (b)") expect_true(all(output$params == get_parameterValues()), info ="does not return default parameter values when not given b)") expect_equal(output$tree, tree, info ="returns different tree from given one (b)") ## c) For input with customized params: input infoStr and params infoStr <- data.frame(n = c(100, 100, 100), globalState = c("M", "U", "M"), u_eqFreq = c(0.1, 0.8, 0.1), p_eqFreq = c(0.1, 0.1, 0.1), m_eqFreq = c(0.8, 0.1, 0.8)) custom_params <- get_parameterValues() custom_params$iota <- 0.5 silence <- capture.output({ output <- simulate_evolData(infoStr = infoStr, tree = tree, params = custom_params) }) expect_equal(class(output$data), "list", info ="does not generate correct output$data list (c)") print <- sub("\\[\\d+\\] \"(.+):.*\"$", "\\1", silence[1]) expect_print <- "Simulating data at root and letting it evolve along given tree: (a:1, c:2, (d:3.7, e:4)" expect_equal(print, expect_print, info = "Not simulating initial data when infoStr is given c)") expect_true(all(output$params == custom_params), info ="does not return customized params when given") expect_equal(output$tree, tree, info ="returns different tree from given one (c)") ## d) For input with customized params: input rootData custom_params <- get_parameterValues() custom_params$alpha_mNI <- 0.5 infoStr <- data.frame(n = c(100, 100, 100), globalState= c("M", "U", "M")) rootData <- simulate_initialData(infoStr = infoStr, params = custom_params)$data silence <- capture.output({ output <- simulate_evolData(rootData = rootData, tree = tree) }) expect_equal(class(output$data), "list", info ="does not generate correct output$data list (d)") print <- sub("\\[\\d+\\] \"(.*)\"", "\\1", silence[1]) expect_print <- "Parameter values set as in given rootData" expect_equal(print, expect_print, info = "Fails to inform that parameter values are set as in given rootData d)") expect_equal(output$params$alpha_mNI, 0.5, info = "does not return params as in given rootData") }) test_that("simulate_evolData output$data",{ infoStr <- data.frame(n = c(100, 100, 100), globalState= c("M", "U", "M")) tree <- "(a:1, c:2, (d:3.7, e:4):5);" replicate_number <- 3 # Case only_tip = TRUE silence <- capture.output({ output <- simulate_evolData(infoStr = infoStr, tree = tree, n_rep = replicate_number, only_tip = TRUE) }) expect_equal(length(output$data), replicate_number, info = "$data output length not equal to number of replicates") expect_equal(length(output$data[[1]]), 4, info = "replicate output lenght different from number of tree tips when only_tip = TRUE") expect_equal(names(output$data[[1]][[1]]), c("name", "seq"), info = "tip information does not include 'name' and 'seq'") expect_equal(output$data[[1]][[1]]$name, "a", info = "returns incorrect tip name") expect_equal(output$data[[1]][[2]]$name, "c", info = "returns incorrect tip name") expect_equal(output$data[[1]][[3]]$name, "d", info = "returns incorrect tip name") expect_equal(output$data[[1]][[4]]$name, "e", info = "returns incorrect tip name") expect_equal(length(output$data[[1]][[1]]$seq), dim(infoStr)[1], info = "returns incorrect number of $seq vectors") expect_equal(class(output$data[[1]][[1]]$seq[[1]]), "numeric", info = "fails to return numeric vector with methylation encoding per structure") # Case only_tip = FALSE silence <- capture.output({ output <- simulate_evolData(infoStr = infoStr, tree = tree, n_rep = 3, only_tip = FALSE) }) expect_true("sim_data" %in% names(output$data), info = "$data output does not contain simulated data") expect_true("branchInTree" %in% names(output$data), info = "$data output does not contain info on relationship between tree branches") expect_equal(length(output$data$sim_data), replicate_number, info = "$data output length not equal to number of replicates") expect_equal(length(output$data$sim_data[[1]]), 6, info = "replicate output lenght different from number of tree branches when only_tip = FALSE") expect_equal(names(output$data$sim_data[[1]][[1]]), c("name", "IWE", "seq", "eqFreqs"), info = " incomplete branch information") expect_null(output$data$sim_data[[1]][[1]]$name, info = "returns incorrect branch name") expect_equal(output$data$sim_data[[1]][[2]]$name, "a", info = "returns incorrect branch name") expect_equal(output$data$sim_data[[1]][[3]]$name, "c", info = "returns incorrect branch name") expect_null(output$data$sim_data[[1]][[4]]$name, info = "returns incorrect branch name") expect_equal(output$data$sim_data[[1]][[5]]$name, "d", info = "returns incorrect branch name") expect_equal(output$data$sim_data[[1]][[6]]$name, "e", info = "returns incorrect branch name") expect_equal(length(output$data$sim_data[[1]][[1]]$seq), dim(infoStr)[1], info = "returns incorrect number of $seq vectors") expect_equal(class(output$data$sim_data[[1]][[1]]$seq[[1]]), "numeric", info = "fails to return numeric vector with methylation encoding per structure") expect_null(output$data$sim_data[[1]][[1]]$IWE, info = "returns not NULL $IWE information for tree root") for (i in 2:length(output$data$sim_data[[1]])){ IWE <- output$data$sim_data[[1]][[i]]$IWE if (is.logical(IWE)) { # If IWE is a logical value (FALSE), assert that it is FALSE expect_false(IWE, info = paste("IWE for i =", i, "is not FALSE")) } else { # If IWE is a list, assert that it contains names "island" and "times" expect_true("islands" %in% names(IWE), info = paste("island missing for i =", i)) expect_true("times" %in% names(IWE), info = paste("times missing for i =", i)) } } expect_equal(length(output$data$sim_data[[1]][[1]]$eqFreqs), dim(infoStr)[1], info = "returns incorrect number of $eqFreqs vectors") expect_equal(class(output$data$sim_data[[1]][[1]]$eqFreqs[[1]]), "numeric", info = "fails to return numeric vector with methylation equilibrium frequencies") expect_null(output$data$branchInTree[[1]]$parent_index, info = "tree root does not have NULL parent_index") expect_equal(output$data$branchInTree[[1]]$offspring_index, c(2,3,4)) expect_equal(output$data$branchInTree[[2]]$parent_index, 1) expect_equal(output$data$branchInTree[[3]]$parent_index, 1) expect_equal(output$data$branchInTree[[4]]$parent_index, 1) expect_null(output$data$branchInTree[[2]]$offspring_index) expect_null(output$data$branchInTree[[3]]$offspring_index) expect_equal(output$data$branchInTree[[4]]$offspring_index, c(5,6)) expect_equal(output$data$branchInTree[[5]]$parent_index, 4) expect_equal(output$data$branchInTree[[6]]$parent_index, 4) expect_null(output$data$branchInTree[[5]]$offspring_index) expect_null(output$data$branchInTree[[6]]$offspring_index) })