test_that("mock db: check output format", { cdm <- mockIncidencePrevalenceRef() cdm <- generateDenominatorCohortSet(cdm = cdm, name = "denominator") inc <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "months" ) # check estimates tibble expect_true(all(c( "analysis_id", "n_persons", "person_days", "person_years", "n_events", "incidence_100000_pys", "incidence_100000_pys_95CI_lower", "incidence_100000_pys_95CI_upper", "incidence_start_date", "incidence_end_date", "cohort_obscured", "result_obscured", "analysis_outcome_washout", "analysis_repeated_events", "analysis_interval", "analysis_complete_database_intervals", "analysis_min_cell_count", "outcome_cohort_id", "outcome_cohort_name", "denominator_cohort_id", "denominator_age_group", "denominator_sex", "denominator_days_prior_observation", "denominator_start_date", "denominator_end_date", "denominator_target_cohort_definition_id", "denominator_target_cohort_name", "cdm_name" ) %in% names(inc))) expect_true(all(c( "analysis_id", "number_records", "number_subjects", "reason_id", "reason", "excluded_records", "excluded_subjects", "analysis_outcome_washout", "analysis_repeated_events", "analysis_interval", "analysis_complete_database_intervals", "analysis_min_cell_count", "outcome_cohort_id", "outcome_cohort_name", "denominator_cohort_id", "denominator_age_group", "denominator_sex", "denominator_days_prior_observation", "denominator_start_date", "denominator_end_date", "denominator_target_cohort_definition_id", "denominator_target_cohort_name", "cdm_name" ) %in% names(attrition(inc)))) expect_equal(suppressWarnings(incidenceAttrition(inc)), attrition(inc)) my_settings <- settings(inc) expect_true(nrow(my_settings) > 0) expect_equal(settings(inc), suppressWarnings(incidenceSet(inc))) # do not return participants as default expect_true(is.null(participants(inc, 1))) CDMConnector::cdm_disconnect(cdm) cdm <- mockIncidencePrevalenceRef() cdm <- generateDenominatorCohortSet(cdm = cdm, name = "denominator") inc <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "months", returnParticipants = TRUE ) expect_true(tibble::is_tibble(participants(inc, 1) %>% dplyr::collect())) expect_true(participants(inc, 1) %>% dplyr::collect() %>% dplyr::select("subject_id") %>% dplyr::pull() == 1) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: checks on working example", { personTable <- tibble::tibble( person_id = "1", gender_concept_id = "8507", year_of_birth = 2000, month_of_birth = 01, day_of_birth = 01 ) observationPeriodTable <- tibble::tibble( observation_period_id = "1", person_id = "1", observation_period_start_date = as.Date("2000-01-01"), observation_period_end_date = as.Date("2012-06-01") ) outcomeTable <- tibble::tibble( cohort_definition_id = 1, subject_id = "1", cohort_start_date = c( as.Date("2008-02-05"), as.Date("2010-02-08"), as.Date("2010-02-20") ), cohort_end_date = c( as.Date("2008-02-05"), as.Date("2010-02-08"), as.Date("2010-02-20") ) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet(cdm = cdm, name = "denominator") inc <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = c("years", "overall") ) expect_true(nrow(inc) >= 1) # reconnect cdmReconn <- CDMConnector::cdm_from_con( con = attr(attr(cdm, "cdm_source"), "dbcon"), cohort_tables = c("denominator", "outcome"), write_schema = "main", cdm_schema = "main", cdm_name = "mock" ) inc_recon <- estimateIncidence( cdm = cdmReconn, denominatorTable = "denominator", outcomeTable = "outcome", interval = c("years", "overall") ) expect_equal(inc, inc_recon) expect_equal(attrition(inc), attrition(inc_recon)) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: check working example 2", { skip_on_cran() personTable <- tibble::tibble( person_id = "1", gender_concept_id = "8507", year_of_birth = 2000, month_of_birth = 01, day_of_birth = 01 ) observationPeriodTable <- tibble::tibble( observation_period_id = "1", person_id = "1", observation_period_start_date = as.Date("2010-01-01"), observation_period_end_date = as.Date("2012-06-01") ) outcomeTable <- tibble::tibble( cohort_definition_id = 1, subject_id = "1", cohort_start_date = c( as.Date("2010-02-05"), as.Date("2010-02-08"), as.Date("2010-02-20") ), cohort_end_date = c( as.Date("2010-02-05"), as.Date("2010-02-08"), as.Date("2010-02-20") ) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet(cdm = cdm, name = "denominator") inc <- estimateIncidence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", repeatedEvents = FALSE, outcomeWashout = 0, minCellCount = 0, completeDatabaseIntervals = FALSE ) expect_true(sum(inc$n_events) == 1) inc <- estimateIncidence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", repeatedEvents = TRUE, outcomeWashout = 2, minCellCount = 0, completeDatabaseIntervals = FALSE ) expect_true(sum(inc$n_events) == 3) inc <- estimateIncidence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", repeatedEvents = TRUE, outcomeWashout = 10, minCellCount = 0, completeDatabaseIntervals = FALSE ) expect_true(sum(inc$n_events) == 2) # even if repeatedEvents = TRUE, # if outcomeWashout=NULL (all of history) # then it won´t be possible to have any recurrent events inc <- estimateIncidence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", repeatedEvents = TRUE, outcomeWashout = Inf, minCellCount = 0, completeDatabaseIntervals = FALSE ) expect_true(sum(inc$n_events) == 1) inc <- estimateIncidence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", repeatedEvents = TRUE, outcomeWashout = Inf, minCellCount = 0, interval = "weeks", completeDatabaseIntervals = FALSE ) expect_true(sum(inc$n_events) == 1) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: check study periods", { skip_on_cran() personTable <- tibble::tibble( person_id = "1", gender_concept_id = "8507", year_of_birth = 2000, month_of_birth = 01, day_of_birth = 01 ) observationPeriodTable <- tibble::tibble( observation_period_id = "1", person_id = "1", observation_period_start_date = as.Date("2010-01-15"), observation_period_end_date = as.Date("2010-12-15") ) outcomeTable <- tibble::tibble( cohort_definition_id = 1, subject_id = "1", cohort_start_date = c( as.Date("2010-02-05"), as.Date("2010-02-08"), as.Date("2010-02-20") ), cohort_end_date = c( as.Date("2010-02-05"), as.Date("2010-02-08"), as.Date("2010-02-20") ) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet(cdm = cdm, name = "denominator") inc <- estimateIncidence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "months", outcomeWashout = 0, repeatedEvents = TRUE, minCellCount = 0, completeDatabaseIntervals = FALSE ) # we expect 12 months of which the last in december # the last month should also be included # as the person goes up to the last day of the month expect_true(nrow(inc) == 12) inc <- estimateIncidence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", outcomeWashout = 0, interval = "months", repeatedEvents = TRUE, minCellCount = 0, completeDatabaseIntervals = TRUE ) # now with completeDatabaseIntervals is TRUE # we expect 10 months of which the last in november expect_true(nrow(inc) == 10) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: check overall", { skip_on_cran() personTable <- tibble::tibble( person_id = c("1", "2"), gender_concept_id = "8507", year_of_birth = 2000, month_of_birth = 01, day_of_birth = 01 ) observationPeriodTable <- tibble::tibble( observation_period_id = c("1", "2"), person_id = c("1", "2"), observation_period_start_date = c( as.Date("2005-01-15"), as.Date("2005-01-15") ), observation_period_end_date = c( as.Date("2007-05-01"), as.Date("2011-06-15") ) ) outcomeTable <- tibble::tibble( cohort_definition_id = 1, subject_id = c("1", "2", "2"), cohort_start_date = c( as.Date("2006-02-05"), as.Date("2006-02-05"), as.Date("2010-02-05") ), cohort_end_date = c( as.Date("2006-02-05"), as.Date("2006-02-05"), as.Date("2010-02-05") ) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet( cdm = cdm, name = "denominator", cohortDateRange = c(as.Date("2007-01-01"), as.Date(NA)) ) inc <- estimateIncidence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "overall", repeatedEvents = FALSE, outcomeWashout = 0, minCellCount = 0, completeDatabaseIntervals = FALSE ) # we expect one row with the overall results # with two people # one person had the event before the study period # (but washout was 0 so was included) # one person had the event during the study period expect_true(nrow(inc) == 1) expect_true(inc$n_persons == 2) expect_true(inc$incidence_start_date == as.Date("2007-01-01")) expect_true(inc$incidence_end_date == as.Date("2010-02-05")) # date of first event inc <- estimateIncidence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "overall", repeatedEvents = TRUE, outcomeWashout = 0, minCellCount = 0, completeDatabaseIntervals = FALSE ) expect_true(nrow(inc) == 1) expect_true(inc$incidence_start_date == as.Date("2007-01-01")) expect_true(inc$incidence_end_date == as.Date("2011-06-15")) # date of end of obs CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: check person days", { skip_on_cran() personTable <- tibble::tibble( person_id = c("1", "2"), gender_concept_id = c("8507", "8532"), year_of_birth = c(2000, 1999), month_of_birth = c(07, 07), day_of_birth = c(01, 01) ) observationPeriodTable <- tibble::tibble( observation_period_id = c("1", "2"), person_id = c("1", "2"), observation_period_start_date = c( as.Date("2007-01-01"), as.Date("2007-01-01") ), observation_period_end_date = c( as.Date("2022-12-31"), as.Date("2022-10-05") ) ) outcomeTable <- tibble::tibble( cohort_definition_id = 1, subject_id = "1", cohort_start_date = c(as.Date("2021-06-27")), cohort_end_date = c(as.Date("2021-06-27")) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet( cdm = cdm, name = "denominator", ageGroup = list(c(20, 30)) ) inc <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", repeatedEvents = FALSE, interval = c("Years"), minCellCount = 0, completeDatabaseIntervals = FALSE ) # in 2019 we expect person 2 to contribute from 1st july to end of December expect_true(inc$person_days[1] == as.numeric(difftime( as.Date("2019-12-31"), as.Date("2019-07-01") )) + 1) # in 2020 we expect person 2 to contribute all year # and person 1 from 1st January to end of December expect_true(inc$person_days[2] == (as.numeric(difftime( as.Date("2020-12-31"), as.Date("2020-07-01") )) + 1) + (as.numeric(difftime( as.Date("2020-12-31"), as.Date("2020-01-01") ) + 1))) # in 2021 we expect person 2 to contribute all year # and person 1 from 1st January up to 27th june (date of their outcome) expect_true(inc$person_days[3] == (as.numeric(difftime( as.Date("2021-12-31"), as.Date("2021-01-01") )) + 1) + (as.numeric(difftime( as.Date("2021-06-27"), as.Date("2021-01-01") ) + 1))) # in 2022 we expect person 2 to contribute all year # (person 1 is out- they have had an event) expect_true(inc$person_days[4] == (as.numeric(difftime( as.Date("2021-10-05"), as.Date("2021-01-01") )) + 1)) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: check periods follow calendar dates", { skip_on_cran() # check that even if startDate as during a period # periods still follow calendar dates personTable <- tibble::tibble( person_id = "1", gender_concept_id = "8507", year_of_birth = 2000, month_of_birth = 01, day_of_birth = 01 ) observationPeriodTable <- tibble::tibble( observation_period_id = "1", person_id = "1", observation_period_start_date = as.Date("2010-01-01"), observation_period_end_date = as.Date("2012-12-31") ) outcomeTable <- tibble::tibble( cohort_definition_id = 1, subject_id = "1", cohort_start_date = c( as.Date("2010-03-01"), as.Date("2011-01-31"), as.Date("2011-02-01"), as.Date("2011-03-01") ), cohort_end_date = c( as.Date("2010-03-01"), as.Date("2011-01-31"), as.Date("2011-02-01"), as.Date("2011-03-01") ) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) # startDate during a year (with year as interval) cdm <- generateDenominatorCohortSet( cdm = cdm, name = "denominator", cohortDateRange = c(as.Date("2010-02-01"), as.Date(NA)) ) inc <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", repeatedEvents = TRUE, outcomeWashout = 0, interval = c("Years"), minCellCount = 0, completeDatabaseIntervals = FALSE ) expect_true(inc$n_events[1] == 1) expect_true(inc$n_events[2] == 3) # startDate during a month (with month as interval) cdm <- generateDenominatorCohortSet( cdm = cdm, name = "denominator", cohortDateRange = c(as.Date("2011-01-15"), as.Date(NA)) ) inc <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", repeatedEvents = TRUE, outcomeWashout = 0, interval = c("months"), minCellCount = 0, completeDatabaseIntervals = FALSE ) expect_true(inc$n_events[1] == 1) expect_true(inc$n_events[2] == 1) expect_true(inc$n_events[3] == 1) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: check washout windows", { skip_on_cran() personTable <- tibble::tibble( person_id = "1", gender_concept_id = "8507", year_of_birth = 2000, month_of_birth = 01, day_of_birth = 01 ) observationPeriodTable <- tibble::tibble( observation_period_id = "1", person_id = "1", observation_period_start_date = as.Date("2010-01-01"), observation_period_end_date = as.Date("2012-12-31") ) outcomeTable <- tibble::tibble( cohort_definition_id = 1, subject_id = "1", cohort_start_date = c( as.Date("2010-06-01"), # more than six months since the last event as.Date("2011-01-13"), # two days since the end of the last event as.Date("2011-01-16"), # one day since the end of the last event as.Date("2011-01-18") ), cohort_end_date = c( as.Date("2010-06-02"), as.Date("2011-01-14"), as.Date("2011-01-17"), as.Date("2011-01-19") ) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet(cdm = cdm, name = "denominator") incW0 <- estimateIncidence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", repeatedEvents = TRUE, outcomeWashout = 0, completeDatabaseIntervals = FALSE, minCellCount = 0 ) # expect all events if we have zero days washout expect_true(sum(incW0$n_events) == 4) incW1 <- estimateIncidence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", repeatedEvents = TRUE, outcomeWashout = 1, completeDatabaseIntervals = FALSE, minCellCount = 0 ) # expect three events if we have one days washout expect_true(sum(incW1$n_events) == 3) incW2 <- estimateIncidence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", repeatedEvents = TRUE, outcomeWashout = 2, completeDatabaseIntervals = FALSE, minCellCount = 0 ) # expect two events if we have two days washout expect_true(sum(incW2$n_events) == 2) incW365 <- estimateIncidence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", repeatedEvents = TRUE, outcomeWashout = 365, completeDatabaseIntervals = FALSE, minCellCount = 0 ) # expect one event if we have 365 days washout expect_true(sum(incW365$n_events) == 1) incNull <- estimateIncidence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", repeatedEvents = TRUE, outcomeWashout = Inf, completeDatabaseIntervals = FALSE, minCellCount = 0 ) # expect one event if we have NULL (all history washout) expect_true(sum(incNull$n_events) == 1) # but, we will have move days when using the 365 day washout # as the person came back to contribute more time at risk expect_true(sum(incNull$person_days) < sum(incW365$person_days)) CDMConnector::cdm_disconnect(cdm) # never satisfy criteria in study period personTable <- tibble::tibble( person_id = "1", gender_concept_id = "8507", year_of_birth = 2000, month_of_birth = 01, day_of_birth = 01 ) observationPeriodTable <- tibble::tibble( observation_period_id = "1", person_id = "1", observation_period_start_date = as.Date("2009-01-01"), observation_period_end_date = as.Date("2012-12-31") ) outcomeTable <- tibble::tibble( cohort_definition_id = 1, subject_id = "1", cohort_start_date = c( as.Date("2009-12-31") ), cohort_end_date = c( as.Date("2010-06-02") ) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet(cdm = cdm, name = "denominator", cohortDateRange = as.Date(c("2010-01-01", NA))) incW365 <- estimateIncidence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", repeatedEvents = TRUE, outcomeWashout = 36500, completeDatabaseIntervals = FALSE, minCellCount = 0 ) expect_true(nrow(incW365) == 0) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: check events overlapping with start of a period", { skip_on_cran() personTable <- tibble::tibble( person_id = c("1", "2"), gender_concept_id = c("8507", "8532"), year_of_birth = c(2000, 1999), month_of_birth = c(07, 07), day_of_birth = c(01, 01) ) observationPeriodTable <- tibble::tibble( observation_period_id = c("1", "2"), person_id = c("1", "2"), observation_period_start_date = c( as.Date("2000-01-21"), as.Date("2007-01-01") ), observation_period_end_date = c( as.Date("2022-12-31"), as.Date("2022-12-31") ) ) outcomeTable <- tibble::tibble( cohort_definition_id = 1, subject_id = "1", cohort_start_date = c(as.Date("2020-06-27")), cohort_end_date = c(as.Date("2020-07-19")) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet( cdm = cdm, name = "denominator", ageGroup = list(c(20, 30)) ) inc <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", outcomeWashout = Inf, repeatedEvents = TRUE, interval = c("Years"), minCellCount = 0 ) expect_true(all(inc$n_persons == 1)) CDMConnector::cdm_disconnect(cdm) # another example personTable <- tibble::tibble( person_id = c("1", "2"), gender_concept_id = c("8507", "8532"), year_of_birth = c(2000, 1999), month_of_birth = c(07, 07), day_of_birth = c(01, 01) ) observationPeriodTable <- tibble::tibble( observation_period_id = c("1", "2"), person_id = c("1", "2"), observation_period_start_date = c( as.Date("2000-01-21"), as.Date("2007-01-01") ), observation_period_end_date = c( as.Date("2022-12-31"), as.Date("2022-12-31") ) ) outcomeTable <- tibble::tibble( cohort_definition_id = c(1, 1), subject_id = c("1", "1"), cohort_start_date = c(as.Date("2020-06-27"), as.Date("2020-07-30")), cohort_end_date = c(as.Date("2020-07-19"), as.Date("2020-08-20")) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet( cdm = cdm, name = "denominator", ageGroup = list(c(20, 30)) ) inc2 <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", outcomeWashout = Inf, repeatedEvents = TRUE, interval = c("Years"), minCellCount = 0 ) expect_true(all(inc2$n_persons == 1)) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: compare results from months and years", { skip_on_cran() personTable <- tibble::tibble( person_id = c("1", "2"), gender_concept_id = rep("8507", 2), year_of_birth = rep(2000, 2), month_of_birth = rep(01, 2), day_of_birth = rep(01, 2) ) observationPeriodTable <- tibble::tibble( observation_period_id = c("1", "2"), person_id = c("1", "2"), observation_period_start_date = c( as.Date("2010-01-01"), as.Date("2010-01-01") ), observation_period_end_date = c( as.Date("2012-01-01"), as.Date("2012-01-01") ) ) outcomeTable <- tibble::tibble( cohort_definition_id = 1, subject_id = "1", cohort_start_date = c( as.Date("2011-07-01") ), cohort_end_date = c( as.Date("2011-07-01") ) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet( cdm = cdm, name = "denominator", cohortDateRange = c(as.Date("2010-01-01"), as.Date("2011-12-31")) ) incMonths <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = c("months"), minCellCount = 0 ) incYears <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = c("years"), minCellCount = 0 ) # consistent results for months and years expect_true(sum(incMonths$n_events) == sum(incYears$n_events)) expect_equal( sum(incMonths$person_days), sum(incYears$person_days) ) expect_equal( sum(incMonths$person_years), sum(incYears$person_years) ) CDMConnector::cdm_disconnect(cdm) cdm <- mockIncidencePrevalenceRef(sampleSize = 1000) cdm <- generateDenominatorCohortSet( cdm = cdm, name = "denominator", cohortDateRange = c(as.Date("2010-01-01"), as.Date("2011-12-31")) ) incWeeks <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = c("weeks"), completeDatabaseIntervals = FALSE, minCellCount = 0 ) incQuarters <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = c("quarters"), completeDatabaseIntervals = FALSE, minCellCount = 0 ) incMonths <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = c("months"), completeDatabaseIntervals = FALSE, minCellCount = 0 ) incYears <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = c("years"), completeDatabaseIntervals = FALSE, minCellCount = 0 ) # consistent results for months and years expect_true(sum(incWeeks$n_events) == sum(incYears$n_events)) expect_true(sum(incQuarters$n_events) == sum(incYears$n_events)) expect_true(sum(incMonths$n_events) == sum(incYears$n_events)) expect_equal( sum(incWeeks$person_days), sum(incYears$person_days) ) expect_equal( sum(incQuarters$person_days), sum(incYears$person_days) ) expect_equal( sum(incMonths$person_days), sum(incYears$person_days) ) expect_equal( sum(incWeeks$person_years), sum(incYears$person_years) ) expect_equal( sum(incQuarters$person_years), sum(incYears$person_years) ) expect_equal( sum(incMonths$person_years), sum(incYears$person_years) ) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: check entry and event on same day", { skip_on_cran() personTable <- tibble::tibble( person_id = "1", gender_concept_id = "8507", year_of_birth = 2000, month_of_birth = 01, day_of_birth = 01 ) observationPeriodTable <- tibble::tibble( observation_period_id = "1", person_id = "1", observation_period_start_date = as.Date("2010-01-28"), observation_period_end_date = as.Date("2012-12-31") ) outcomeTable <- tibble::tibble( cohort_definition_id = 1, subject_id = "1", cohort_start_date = c( as.Date("2010-01-28") ), cohort_end_date = c( as.Date("2010-01-28") ) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet(cdm = cdm, name = "denominator") incWithoutRep <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", repeatedEvents = FALSE, outcomeWashout = Inf, interval = "years", minCellCount = 0, completeDatabaseIntervals = FALSE ) expect_true(sum(incWithoutRep$n_events) == 1) incWithRep <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", repeatedEvents = TRUE, outcomeWashout = Inf, interval = "years", minCellCount = 0, completeDatabaseIntervals = FALSE ) expect_true(sum(incWithRep$n_events) == 1) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: cohort start overlaps with the outcome", { skip_on_cran() personTable <- tibble::tibble( person_id = c("1", "2"), gender_concept_id = c("8507", "8532"), year_of_birth = c(1995, 1995), month_of_birth = c(07, 07), day_of_birth = c(01, 01) ) observationPeriodTable <- tibble::tibble( observation_period_id = c("1", "2"), person_id = c("1", "2"), observation_period_start_date = c( as.Date("2019-05-09"), as.Date("2019-01-01") ), observation_period_end_date = c( as.Date("2022-05-19"), as.Date("2021-12-31") ) ) outcomeTable <- tibble::tibble( cohort_definition_id = 1, subject_id = c("1"), cohort_start_date = c(as.Date("2019-05-09")), cohort_end_date = c(as.Date("2022-05-19")) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet( cdm = cdm, name = "denominator", cohortDateRange = as.Date(c("2021-01-01", "2021-12-31")) ) inc <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", outcomeWashout = 180, repeatedEvents = TRUE, interval = c("Years"), minCellCount = 0 ) expect_true(all(inc$n_persons == c(1))) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: check outcome in previous obeservation period", { skip_on_cran() # 1) with outcome starting and ending before observation period start personTable <- tibble::tibble( person_id = c("1", "2"), gender_concept_id = c("8507", "8532"), year_of_birth = c(1995, 1995), month_of_birth = c(07, 07), day_of_birth = c(01, 01) ) observationPeriodTable <- tibble::tibble( observation_period_id = c("1", "2" ,"3"), person_id = c("1", "1", "2"), observation_period_start_date = c( as.Date("2000-01-01"), as.Date("2010-01-01"), as.Date("2000-01-01") ), observation_period_end_date = c( as.Date("2005-12-31"), as.Date("2020-12-31"), as.Date("2020-12-31") ) ) outcomeTable <- tibble::tibble( cohort_definition_id = c(1, 1), subject_id = c("1", "1"), cohort_start_date = as.Date(c("2000-01-01", "2018-01-01")), cohort_end_date = as.Date(c("2005-12-31", "2019-01-01")) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet( cdm = cdm, name = "denominator", cohortDateRange = c(as.Date("2011-01-01"), as.Date("2020-01-01")) ) # with rep events - should have both people incRep <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", outcomeWashout = 0, repeatedEvents = TRUE, interval = c("Years"), minCellCount = 0 ) expect_true(all(incRep$n_persons == 2)) # with inf wash out- should only have 1 person incNoRep <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", outcomeWashout = Inf, repeatedEvents = TRUE, interval = c("Years"), minCellCount = 0 ) expect_true(all(incNoRep$n_persons == 1)) # with 5 year wash out- should have 2 people at the start of the study period incNoRep2 <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", outcomeWashout = 1825, repeatedEvents = TRUE, interval = c("Years"), minCellCount = 0 ) expect_true(max(incNoRep2$n_persons) == 2) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: check minimum counts", { skip_on_cran() # 20 people personTable <- tibble::tibble( person_id = as.character(c(1:20)), gender_concept_id = rep("8507", 20), year_of_birth = rep(2000, 20), month_of_birth = rep(01, 20), day_of_birth = rep(01, 20) ) observationPeriodTable <- tibble::tibble( observation_period_id = as.character(c(1:20)), person_id = as.character(c(1:20)), observation_period_start_date = rep(as.Date("2000-01-01"), 20), observation_period_end_date = rep(as.Date("2012-06-01"), 20) ) outcomeTable <- dplyr::bind_rows( # 17 in first period tibble::tibble( cohort_definition_id = rep("1", 17), subject_id = as.character(c(1:17)), cohort_start_date = rep( as.Date("2000-01-02"), 17 ), cohort_end_date = rep( as.Date("2000-01-03"), 17 ) ), # three in second tibble::tibble( cohort_definition_id = rep("1", 3), subject_id = as.character(c(18:20)), cohort_start_date = rep( as.Date("2000-02-02"), 3 ), cohort_end_date = rep( as.Date("2000-02-03"), 3 ) ) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet(cdm = cdm, name = "denominator") inc <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "months", repeatedEvents = FALSE, minCellCount = 0, completeDatabaseIntervals = FALSE ) expect_true(inc$n_persons[1] == 20) expect_true(inc$n_persons[2] == 3) expect_true(!is.na(inc$person_days[1])) expect_true(!is.na(inc$person_days[2])) expect_true(!is.na(inc$person_years[1])) expect_true(!is.na(inc$person_years[2])) expect_true(inc$n_events[1] == 17) expect_true(inc$n_events[2] == 3) expect_true(!is.na(inc$incidence_100000_pys[1])) expect_true(!is.na(inc$incidence_100000_pys[2])) expect_true(!is.na(inc$incidence_100000_pys_95CI_lower[1])) expect_true(!is.na(inc$incidence_100000_pys_95CI_lower[2])) expect_true(!is.na(inc$incidence_100000_pys_95CI_upper[1])) expect_true(!is.na(inc$incidence_100000_pys_95CI_upper[2])) inc <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "months", repeatedEvents = FALSE, minCellCount = 5, completeDatabaseIntervals = FALSE ) expect_true(inc$n_persons[1] == 20) expect_true(is.na(inc$n_persons[2])) expect_true(!is.na(inc$person_days[1])) expect_true(is.na(inc$person_days[2])) expect_true(!is.na(inc$person_years[1])) expect_true(is.na(inc$person_years[2])) expect_true(inc$n_events[1] == 17) expect_true(is.na(inc$n_events[2])) expect_true(!is.na(inc$incidence_100000_pys[1])) expect_true(is.na(inc$incidence_100000_pys[2])) expect_true(!is.na(inc$incidence_100000_pys_95CI_lower[1])) expect_true(is.na(inc$incidence_100000_pys_95CI_lower[2])) expect_true(!is.na(inc$incidence_100000_pys_95CI_upper[1])) expect_true(is.na(inc$incidence_100000_pys_95CI_upper[2])) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: multiple overlapping outcomes", { skip_on_cran() # two personTable <- tibble::tibble( person_id = c("1", "2"), gender_concept_id = c("8507", "8532"), year_of_birth = c(1995, 1995), month_of_birth = c(07, 07), day_of_birth = c(01, 01) ) observationPeriodTable <- tibble::tibble( observation_period_id = c("1", "2"), person_id = c("1", "2"), observation_period_start_date = c( as.Date("2020-04-29"), as.Date("2019-01-01") ), observation_period_end_date = c( as.Date("2020-12-31"), as.Date("2021-12-31") ) ) outcomeTable <- tibble::tibble( cohort_definition_id = c(1, 1), subject_id = c("1", "1"), cohort_start_date = c(as.Date("2020-04-29"), as.Date("2020-11-10")), cohort_end_date = c(as.Date("2020-05-17"), as.Date("2020-12-17")) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet(cdm = cdm, name = "denominator") inc <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", outcomeWashout = 180, repeatedEvents = TRUE, interval = c("Years"), minCellCount = 0 ) expect_true(all(inc$n_persons) == 1) CDMConnector::cdm_disconnect(cdm) # three personTable <- tibble::tibble( person_id = c("1", "2"), gender_concept_id = c("8507", "8532"), year_of_birth = c(1995, 1995), month_of_birth = c(07, 07), day_of_birth = c(01, 01) ) observationPeriodTable <- tibble::tibble( observation_period_id = c("1", "2"), person_id = c("1", "2"), observation_period_start_date = c( as.Date("2020-04-29"), as.Date("2019-01-01") ), observation_period_end_date = c( as.Date("2020-12-31"), as.Date("2021-12-31") ) ) outcomeTable <- tibble::tibble( cohort_definition_id = c(1, 1, 1), subject_id = c("1", "1", "1"), cohort_start_date = c( as.Date("2020-04-29"), as.Date("2020-11-08"), as.Date("2020-11-10") ), cohort_end_date = c( as.Date("2020-05-17"), as.Date("2020-11-09"), as.Date("2020-12-17") ) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet(cdm = cdm, name = "denominator") inc <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", outcomeWashout = 180, repeatedEvents = TRUE, interval = c("Years"), minCellCount = 0 ) expect_true(all(inc$n_persons) == 1) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: cohort before period start ending after period", { skip_on_cran() personTable <- tibble::tibble( person_id = c("1", "2"), gender_concept_id = c("8507", "8532"), year_of_birth = c(1990, 1990), month_of_birth = c(01, 01), day_of_birth = c(01, 01) ) observationPeriodTable <- tibble::tibble( observation_period_id = c("1", "2"), person_id = c("1", "2"), observation_period_start_date = c( as.Date("2000-07-31"), as.Date("2000-07-31") ), observation_period_end_date = c( as.Date("2020-01-01"), as.Date("2010-01-01") ) ) outcomeTable <- tibble::tibble( cohort_definition_id = c(1, 1), subject_id = c("1", "2"), cohort_start_date = c( as.Date("2000-08-02"), as.Date("2001-06-01") ), cohort_end_date = c( as.Date("2020-01-01"), as.Date("2001-07-01") ) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet( cdm = cdm, name = "denominator", cohortDateRange = c(as.Date("2001-01-01"), as.Date("2001-12-31")) ) # regardless of washout we expect one event # with only one participant # person 1s outcome starts before period and ends after # no washout inc <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", outcomeWashout = 0, repeatedEvents = FALSE, interval = c("Years"), completeDatabaseIntervals = FALSE, minCellCount = 0 ) expect_true(all(inc$n_events == c(1))) # washout inc <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", outcomeWashout = Inf, repeatedEvents = FALSE, interval = c("Years"), completeDatabaseIntervals = FALSE, minCellCount = 0 ) expect_true(all(inc$n_events == c(1))) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: check full period requirement - year", { skip_on_cran() personTable <- tibble::tibble( person_id = c("1", "2"), gender_concept_id = c("8507", "8532"), year_of_birth = c(1995, 1995), month_of_birth = c(07, 07), day_of_birth = c(01, 01) ) observationPeriodTable <- tibble::tibble( observation_period_id = c("1", "2"), person_id = c("1", "2"), observation_period_start_date = c( as.Date("2020-05-09"), as.Date("2020-03-01") ), observation_period_end_date = c( as.Date("2020-06-06"), as.Date("2021-06-06") ) ) outcomeTable <- tibble::tibble( cohort_definition_id = 1, subject_id = c("1"), cohort_start_date = c(as.Date("2020-05-28")), cohort_end_date = c(as.Date("2020-05-29")) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet( cdm = cdm, name = "denominator", ageGroup = list(c(20, 30)) ) inc <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", outcomeWashout = Inf, repeatedEvents = TRUE, completeDatabaseIntervals = TRUE, interval = c("Years"), minCellCount = 0 ) expect_true(nrow(inc) == 0) CDMConnector::cdm_disconnect(cdm) # edge case first day to last of the year # still expect this to work personTable <- tibble::tibble( person_id = c("1", "2"), gender_concept_id = c("8507", "8532"), year_of_birth = c(1995, 1995), month_of_birth = c(07, 07), day_of_birth = c(01, 01) ) observationPeriodTable <- tibble::tibble( observation_period_id = c("1", "2"), person_id = c("1", "2"), observation_period_start_date = c( as.Date("2020-05-09"), as.Date("2020-01-01") ), observation_period_end_date = c( as.Date("2020-12-31"), as.Date("2020-12-31") ) ) outcomeTable <- tibble::tibble( cohort_definition_id = 1, subject_id = c("1"), cohort_start_date = c(as.Date("2020-05-29")), cohort_end_date = c(as.Date("2020-05-29")) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet( cdm = cdm, name = "denominator", ageGroup = list(c(20, 30)) ) inc <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", outcomeWashout = Inf, repeatedEvents = TRUE, interval = c("Years"), minCellCount = 0 ) expect_true(nrow(inc) == 1) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: check full period requirement - month", { skip_on_cran() # expected to work personTable <- tibble::tibble( person_id = c("1", "2"), gender_concept_id = c("8507", "8532"), year_of_birth = c(1995, 1995), month_of_birth = c(07, 07), day_of_birth = c(01, 01) ) observationPeriodTable <- tibble::tibble( observation_period_id = c("1", "2"), person_id = c("1", "2"), observation_period_start_date = c( as.Date("2020-04-28"), as.Date("2020-01-01") ), observation_period_end_date = c( as.Date("2020-06-06"), as.Date("2020-06-06") ) ) outcomeTable <- tibble::tibble( cohort_definition_id = 1, subject_id = c("1"), cohort_start_date = c(as.Date("2020-04-28")), cohort_end_date = c(as.Date("2020-05-19")) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet( cdm = cdm, name = "denominator", ageGroup = list(c(20, 30)) ) inc <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", outcomeWashout = Inf, repeatedEvents = TRUE, interval = c("Months"), minCellCount = 0 ) expect_true(nrow(inc) >= 1) CDMConnector::cdm_disconnect(cdm) # edge case first day to last of the month # still expect this to work personTable <- tibble::tibble( person_id = c("1", "2"), gender_concept_id = c("8507", "8532"), year_of_birth = c(1995, 1995), month_of_birth = c(07, 07), day_of_birth = c(01, 01) ) observationPeriodTable <- tibble::tibble( observation_period_id = c("1", "2"), person_id = c("1", "2"), observation_period_start_date = c( as.Date("2020-04-28"), as.Date("2020-01-01") ), observation_period_end_date = c( as.Date("2020-04-29"), as.Date("2020-01-31") ) ) outcomeTable <- tibble::tibble( cohort_definition_id = 1, subject_id = c("1"), cohort_start_date = c(as.Date("2020-04-28")), cohort_end_date = c(as.Date("2020-04-28")) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet( cdm = cdm, name = "denominator", ageGroup = list(c(20, 30)) ) inc <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", outcomeWashout = Inf, repeatedEvents = TRUE, interval = c("Months"), minCellCount = 0 ) expect_true(inc$n_persons == 1) expect_true(nrow(inc) >= 1) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: check completeDatabaseIntervals", { skip_on_cran() personTable <- tibble::tibble( person_id = c("1", "2"), gender_concept_id = c("8507", "8532"), year_of_birth = c(1995, 1995), month_of_birth = c(07, 07), day_of_birth = c(01, 01) ) observationPeriodTable <- tibble::tibble( observation_period_id = c("1", "2"), person_id = c("1", "2"), observation_period_start_date = c( as.Date("2019-05-09"), as.Date("2019-02-02") ), observation_period_end_date = c( as.Date("2022-06-01"), as.Date("2021-06-06") ) ) outcomeTable <- tibble::tibble( cohort_definition_id = 1, subject_id = c("1"), cohort_start_date = c(as.Date("2020-04-28")), cohort_end_date = c(as.Date("2020-05-19")) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet( cdm = cdm, name = "denominator" ) # full periods required TRUE # repetitive events TRUE # - we expect to start in 2020 (both start during 2019) # - we expect to go up to 2021 (id 2 end date is in 2022) inc <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = c("Years"), outcomeWashout = 0, repeatedEvents = TRUE, completeDatabaseIntervals = TRUE, minCellCount = 0 ) expect_true(nrow(inc) == 2) expect_true(lubridate::year(inc$incidence_start_date[1]) == "2020") expect_true(lubridate::year(inc$incidence_start_date[2]) == "2021") # repetitive events FALSE # - now we expect only to use 2020 (id 2 obs end is in 21) inc <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = c("Years"), repeatedEvents = FALSE, completeDatabaseIntervals = TRUE, minCellCount = 0 ) expect_true(nrow(inc) == 1) expect_true(lubridate::year(inc$incidence_start_date[1]) == "2020") # full periods required FALSE # repetitive events TRUE # - we expect to start in 2019 # - we expect to go up to 2022 inc <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", outcomeWashout = 0, interval = c("Years"), repeatedEvents = TRUE, completeDatabaseIntervals = FALSE, minCellCount = 0 ) expect_true(nrow(inc) == 4) expect_true(lubridate::year(inc$incidence_start_date[1]) == "2019") expect_true(lubridate::year(inc$incidence_start_date[2]) == "2020") expect_true(lubridate::year(inc$incidence_start_date[3]) == "2021") expect_true(lubridate::year(inc$incidence_start_date[4]) == "2022") # repetitive events FALSE inc <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = c("Years"), repeatedEvents = FALSE, completeDatabaseIntervals = FALSE, minCellCount = 0 ) expect_true(nrow(inc) == 3) expect_true(lubridate::year(inc$incidence_start_date[1]) == "2019") expect_true(lubridate::year(inc$incidence_start_date[2]) == "2020") expect_true(lubridate::year(inc$incidence_start_date[3]) == "2021") CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: check insufficient study days", { skip_on_cran() personTable <- tibble::tibble( person_id = c("1", "2"), gender_concept_id = c("8507", "8532"), year_of_birth = c(1995, 1995), month_of_birth = c(07, 07), day_of_birth = c(01, 01) ) observationPeriodTable <- tibble::tibble( observation_period_id = c("1", "2"), person_id = c("1", "2"), observation_period_start_date = c( as.Date("2019-05-09"), as.Date("2019-02-02") ), observation_period_end_date = c( as.Date("2019-06-01"), as.Date("2019-06-06") ) ) outcomeTable <- tibble::tibble( cohort_definition_id = 1, subject_id = c("1"), cohort_start_date = c(as.Date("2019-06-01")), cohort_end_date = c(as.Date("2019-06-01")) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet( cdm = cdm, name = "denominator" ) # we have less than a year of follow up # so we should return an empty tibble if full periods are required # and we´re looking for yearly incidence inc <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = c("Years"), repeatedEvents = TRUE, completeDatabaseIntervals = TRUE, minCellCount = 0 ) expect_true(nrow(inc) == 0) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: check with and without study start and end date", { skip_on_cran() personTable <- tibble::tibble( person_id = c("1", "2", "3", "4", "5", "6"), gender_concept_id = "8507", year_of_birth = 2000, month_of_birth = 07, day_of_birth = 01 ) # one person leaving before 2010 observationPeriodTable <- tibble::tibble( observation_period_id = c("1", "2", "3", "4", "5", "6"), person_id = c("1", "2", "3", "4", "5", "6"), observation_period_start_date = c( rep(as.Date("2007-01-01"), 5), as.Date("2010-06-01") ), observation_period_end_date = c( rep(as.Date("2022-12-31"), 4), as.Date("2009-06-01"), as.Date("2010-11-01") ) ) outcomeTable <- dplyr::bind_rows( # 1 event before obs start ending after obs end tibble::tibble( cohort_definition_id = 1, subject_id = "1", cohort_start_date = c(as.Date("2007-01-01")), cohort_end_date = c(as.Date("2022-12-31")) ), # 2 multiple events tibble::tibble( cohort_definition_id = 1, subject_id = "2", cohort_start_date = c(as.Date("2008-06-01")), cohort_end_date = c(as.Date("2008-10-01")) ), tibble::tibble( cohort_definition_id = 1, subject_id = "2", cohort_start_date = c(as.Date("2008-11-01")), cohort_end_date = c(as.Date("2010-10-14")) ), tibble::tibble( cohort_definition_id = 1, subject_id = "2", cohort_start_date = c(as.Date("2010-12-01")), cohort_end_date = c(as.Date("2011-06-18")) ), tibble::tibble( cohort_definition_id = 1, subject_id = "2", cohort_start_date = c(as.Date("2011-06-19")), cohort_end_date = c(as.Date("2012-12-31")) ), # 3 multiple events into the period tibble::tibble( cohort_definition_id = 1, subject_id = "3", cohort_start_date = c(as.Date("2009-06-01")), cohort_end_date = c(as.Date("2010-02-01")) ), tibble::tibble( cohort_definition_id = 1, subject_id = "3", cohort_start_date = c(as.Date("2010-06-01")), cohort_end_date = c(as.Date("2022-12-31")) ) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) # no study period required cdm <- generateDenominatorCohortSet(cdm = cdm, name = "denominator1") # study period cdm <- generateDenominatorCohortSet( cdm = cdm, name = "denominator2", cohortDateRange = c(as.Date("2009-01-01"), as.Date("2011-01-01")) ) # no washout, repetitive events inc1A <- estimateIncidence(cdm, denominatorTable = "denominator1", outcomeTable = "outcome", interval = "years", repeatedEvents = TRUE, outcomeWashout = 0, minCellCount = 0, completeDatabaseIntervals = FALSE ) inc2A <- estimateIncidence(cdm, denominatorTable = "denominator2", outcomeTable = "outcome", interval = "years", repeatedEvents = TRUE, outcomeWashout = 0, minCellCount = 0, completeDatabaseIntervals = FALSE ) # given the settings above we would expect the same results for 2010 expect_true(inc1A %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("n_persons") %>% dplyr::pull() == inc2A %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("n_persons") %>% dplyr::pull()) expect_true(inc1A %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("person_days") %>% dplyr::pull() == inc2A %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("person_days") %>% dplyr::pull()) expect_true(inc1A %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("n_events") %>% dplyr::pull() == inc2A %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("n_events") %>% dplyr::pull()) # 365 washout, repetitive events inc1B <- estimateIncidence(cdm, denominatorTable = "denominator1", outcomeTable = "outcome", interval = "years", repeatedEvents = TRUE, outcomeWashout = 365, minCellCount = 0, completeDatabaseIntervals = FALSE ) inc2B <- estimateIncidence(cdm, denominatorTable = "denominator2", outcomeTable = "outcome", interval = "years", repeatedEvents = TRUE, outcomeWashout = 365, minCellCount = 0, completeDatabaseIntervals = FALSE ) # given the settings above we would expect the same results for 2010 expect_true(inc1B %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("n_persons") %>% dplyr::pull() == inc2B %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("n_persons") %>% dplyr::pull()) expect_true(inc1B %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("person_days") %>% dplyr::pull() == inc2B %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("person_days") %>% dplyr::pull()) expect_true(inc1B %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("n_events") %>% dplyr::pull() == inc2B %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("n_events") %>% dplyr::pull()) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: check study start and end date 1000", { skip_on_cran() # with one outcome per person cdm <- mockIncidencePrevalenceRef( sampleSize = 1000 ) # no study period required cdm <- generateDenominatorCohortSet(cdm = cdm, name = "denominator1") # study period cdm <- generateDenominatorCohortSet( cdm = cdm, name = "denominator2", cohortDateRange = c(as.Date("2009-01-01"), as.Date("2011-01-01")) ) # no washout, repetitive events inc1A <- estimateIncidence(cdm, denominatorTable = "denominator1", outcomeTable = "outcome", interval = "years", repeatedEvents = TRUE, outcomeWashout = 0, minCellCount = 0, completeDatabaseIntervals = FALSE ) inc2A <- estimateIncidence(cdm, denominatorTable = "denominator2", outcomeTable = "outcome", interval = "years", repeatedEvents = TRUE, outcomeWashout = 0, minCellCount = 0, completeDatabaseIntervals = FALSE ) expect_true(inc1A %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("n_persons") %>% dplyr::pull() == inc2A %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("n_persons") %>% dplyr::pull()) expect_true(inc1A %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("person_days") %>% dplyr::pull() == inc2A %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("person_days") %>% dplyr::pull()) expect_true(inc1A %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("n_events") %>% dplyr::pull() == inc2A %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("n_events") %>% dplyr::pull()) expect_true(inc1A %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("incidence_100000_pys") %>% dplyr::pull() == inc2A %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("incidence_100000_pys") %>% dplyr::pull()) # 365 washout, repetitive events inc1B <- estimateIncidence(cdm, denominatorTable = "denominator1", outcomeTable = "outcome", interval = "years", repeatedEvents = TRUE, outcomeWashout = 365, minCellCount = 0, completeDatabaseIntervals = FALSE ) inc2B <- estimateIncidence(cdm, denominatorTable = "denominator2", outcomeTable = "outcome", interval = "years", repeatedEvents = TRUE, outcomeWashout = 365, minCellCount = 0, completeDatabaseIntervals = FALSE ) expect_true(inc1B %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("n_persons") %>% dplyr::pull() == inc2B %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("n_persons") %>% dplyr::pull()) expect_true(inc1B %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("person_days") %>% dplyr::pull() == inc2B %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("person_days") %>% dplyr::pull()) expect_true(inc1B %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("n_events") %>% dplyr::pull() == inc2B %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("n_events") %>% dplyr::pull()) expect_true(inc1B %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("incidence_100000_pys") %>% dplyr::pull() == inc1B %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("incidence_100000_pys") %>% dplyr::pull()) CDMConnector::cdm_disconnect(cdm) # with multiple outcomes per person cdm <- mockIncidencePrevalenceRef( sampleSize = 1000 ) # no study period required cdm <- generateDenominatorCohortSet( cdm = cdm, name = "denominator1" ) # study period cdm <- generateDenominatorCohortSet( cdm = cdm, name = "denominator2", cohortDateRange = c(as.Date("2009-01-01"), as.Date("2011-01-01")) ) # no washout, repetitive events inc1A <- estimateIncidence(cdm, denominatorTable = "denominator1", outcomeTable = "outcome", interval = "years", repeatedEvents = TRUE, outcomeWashout = 0, minCellCount = 0, completeDatabaseIntervals = FALSE ) inc2A <- estimateIncidence(cdm, denominatorTable = "denominator2", outcomeTable = "outcome", interval = "years", repeatedEvents = TRUE, outcomeWashout = 0, minCellCount = 0, completeDatabaseIntervals = FALSE ) expect_true(inc1A %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("n_persons") %>% dplyr::pull() == inc2A %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("n_persons") %>% dplyr::pull()) expect_true(inc1A %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("person_days") %>% dplyr::pull() == inc2A %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("person_days") %>% dplyr::pull()) expect_true(inc1A %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("n_events") %>% dplyr::pull() == inc2A %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("n_events") %>% dplyr::pull()) expect_true(inc1A %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("incidence_100000_pys") %>% dplyr::pull() == inc2A %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("incidence_100000_pys") %>% dplyr::pull()) # 365 washout, repetitive events inc1B <- estimateIncidence(cdm, denominatorTable = "denominator1", outcomeTable = "outcome", interval = "years", repeatedEvents = TRUE, outcomeWashout = 365, minCellCount = 0, completeDatabaseIntervals = FALSE ) inc2B <- estimateIncidence(cdm, denominatorTable = "denominator2", outcomeTable = "outcome", interval = "years", repeatedEvents = TRUE, outcomeWashout = 365, minCellCount = 0, completeDatabaseIntervals = FALSE ) expect_true(inc1B %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("n_persons") %>% dplyr::pull() == inc2B %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("n_persons") %>% dplyr::pull()) expect_true(inc1B %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("person_days") %>% dplyr::pull() == inc2B %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("person_days") %>% dplyr::pull()) expect_true(inc1B %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("n_events") %>% dplyr::pull() == inc2B %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("n_events") %>% dplyr::pull()) expect_true(inc1B %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("incidence_100000_pys") %>% dplyr::pull() == inc2B %>% dplyr::filter(lubridate::year(incidence_start_date) == 2010) %>% dplyr::select("incidence_100000_pys") %>% dplyr::pull()) CDMConnector::cdm_disconnect(cdm) }) test_that("expected errors with mock", { skip_on_cran() personTable <- tibble::tibble( person_id = "1", gender_concept_id = "8507", year_of_birth = 2000, month_of_birth = 01, day_of_birth = 01 ) observationPeriodTable <- tibble::tibble( observation_period_id = "1", person_id = "1", observation_period_start_date = as.Date("2010-01-01"), observation_period_end_date = as.Date("2012-06-01") ) outcomeTable <- tibble::tibble( cohort_definition_id = 1, subject_id = "1", cohort_start_date = c( as.Date("2010-02-05"), as.Date("2010-02-08"), as.Date("2010-02-20") ), cohort_end_date = c( as.Date("2010-02-05"), as.Date("2010-02-08"), as.Date("2010-02-20") ) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet(cdm = cdm, name = "denominator") # not a cdm reference expect_error(estimateIncidence( cdm = "a", denominatorTable = "denominator", outcomeTable = "outcome" )) # wrong type expect_error(estimateIncidence( cdm = cdm, denominatorTable = "denominator", denominatorCohortId = "1", outcomeTable = "outcome", outcomeCohortId = "1" )) # no study pop expect_error(estimateIncidence(cdm, outcomeTable = "outcome", interval = c("months"), denominatorTable = "denominator1" )) expect_error(estimateIncidence(cdm, outcomeTable = "outcome", interval = c("months"), denominatorTable = "denominator", denominatorCohortId = 999 )) # outcome definition id doesn't exist in cohort set expect_error(estimateIncidence(cdm, outcomeTable = "outcome", interval = c("months"), denominatorTable = "denominator", outcomeCohortId = 11 )) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: multiple observation periods", { skip_on_cran() # create data for hypothetical people to test personTable <- tibble::tibble( person_id = c("1", "2"), gender_concept_id = c("8507", "8507"), year_of_birth = c(1998, 1976), month_of_birth = c(02, 06), day_of_birth = c(12, 01) ) observationPeriodTable <- tibble::tibble( observation_period_id = c("1", "2", "3"), person_id = c("1", "1", "2"), observation_period_start_date = c( as.Date("2005-04-01"), as.Date("2009-04-10"), as.Date("2010-12-11") ), observation_period_end_date = c( as.Date("2005-11-29"), as.Date("2016-01-02"), as.Date("2015-06-01") ) ) conditionX <- tibble::tibble( cohort_definition_id = c(1, 1), subject_id = c("1", "2"), cohort_start_date = c( as.Date("2005-07-19"), as.Date("2010-12-11") ), cohort_end_date = c( as.Date("2005-07-19"), as.Date("2015-06-01") ) ) outcomeTable <- tibble::tibble( cohort_definition_id = c(1, 1, 1, 1), subject_id = c("1", "1", "2", "2"), cohort_start_date = c( as.Date("2005-08-09"), as.Date("2010-01-11"), as.Date("2010-12-21"), as.Date("2014-04-04") ), cohort_end_date = c( as.Date("2005-08-09"), as.Date("2010-01-11"), as.Date("2010-12-21"), as.Date("2014-04-04") ) ) # should only pick up one of the four observation periods, # as the inclusion of the cohorts is only well defined for one # (entry event in the observation period) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, targetCohortTable = conditionX, outcomeTable = outcomeTable ) cdm <- generateTargetDenominatorCohortSet( cdm = cdm, name = "denominator", targetCohortTable = "target", targetCohortId = 1 ) incW0 <- estimateIncidence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", repeatedEvents = TRUE, outcomeWashout = 0, completeDatabaseIntervals = FALSE, minCellCount = 0 ) # expect all events if we have zero days washout expect_true(sum(incW0$n_events) == 2) CDMConnector::cdm_disconnect(cdm) # Change the inclusion so that both patients have valid observation periods. Now 1 should have two, and 2 one. # Should capture the final part of the first observation period, and the initial part of the second for person 1 conditionX <- tibble::tibble( cohort_definition_id = c(1, 1, 1), subject_id = c("1", "1", "2"), cohort_start_date = c( as.Date("2005-07-19"), as.Date("2009-04-10"), as.Date("2010-12-11") ), cohort_end_date = c( as.Date("2005-08-11"), as.Date("2015-01-02"), as.Date("2011-12-11") ) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, targetCohortTable = conditionX, outcomeTable = outcomeTable ) cdm <- generateTargetDenominatorCohortSet( cdm = cdm, name = "denominator", targetCohortTable = "target", targetCohortId = 1 ) incW10 <- estimateIncidence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", repeatedEvents = TRUE, outcomeWashout = 10, completeDatabaseIntervals = FALSE, minCellCount = 0 ) # expect all events if we have ten days washout expect_true(sum(incW10$n_events) == 3) CDMConnector::cdm_disconnect(cdm) # try event not counted for outcome but counted for washout as denominator (before observ period) outcomeTable <- tibble::tibble( cohort_definition_id = c(1, 1, 1, 1, 1), subject_id = c("1", "1", "1", "2", "2"), cohort_start_date = c( as.Date("2005-07-11"), as.Date("2005-08-09"), as.Date("2010-01-11"), as.Date("2010-12-21"), as.Date("2014-04-04") ), cohort_end_date = c( as.Date("2005-07-11"), as.Date("2005-08-09"), as.Date("2010-01-11"), as.Date("2010-12-21"), as.Date("2014-04-04") ) ) # now we would expect same number of events, but three less days in the denominator cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, targetCohortTable = conditionX, outcomeTable = outcomeTable ) cdm <- generateTargetDenominatorCohortSet( cdm = cdm, name = "denominator", targetCohortTable = "target", targetCohortId = 1 ) inc_PreWashout <- estimateIncidence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", repeatedEvents = TRUE, outcomeWashout = 10, completeDatabaseIntervals = FALSE, minCellCount = 0 ) expect_true(sum(inc_PreWashout$n_events) == 3) expect_true(inc_PreWashout %>% dplyr::select(person_days) %>% sum() == as.numeric(difftime(as.Date("2005-08-11"), as.Date("2005-07-19"))) + 1 - 2 + as.numeric(difftime(as.Date("2015-01-02"), as.Date("2009-04-10"))) + 1 - 10 + as.numeric(difftime(as.Date("2011-12-11"), as.Date("2010-12-11"))) + 1 - 10 - 3) CDMConnector::cdm_disconnect(cdm) # multiple events in one of the observation periods of person 1 conditionX <- tibble::tibble( cohort_definition_id = c(1, 1, 1), subject_id = c("1", "1", "2"), cohort_start_date = c( as.Date("2005-06-19"), as.Date("2009-04-10"), as.Date("2010-12-11") ), cohort_end_date = c( as.Date("2005-08-11"), as.Date("2015-01-02"), as.Date("2011-12-11") ) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, targetCohortTable = conditionX, outcomeTable = outcomeTable ) cdm <- generateTargetDenominatorCohortSet( cdm = cdm, name = "denominator", targetCohortTable = "target", targetCohortId = 1 ) inc_Mult1_W0 <- estimateIncidence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", repeatedEvents = TRUE, outcomeWashout = 0, completeDatabaseIntervals = FALSE, minCellCount = 0 ) inc_Mult1_W30 <- estimateIncidence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", repeatedEvents = TRUE, outcomeWashout = 30, completeDatabaseIntervals = FALSE, minCellCount = 0 ) # we should have 4 events with washout 0, but 3 events with washout 30 expect_true(sum(inc_Mult1_W0$n_events) == 4) expect_true(sum(inc_Mult1_W30$n_events) == 3) expect_true(inc_Mult1_W0 %>% dplyr::select(person_days) %>% sum() == as.numeric(difftime(as.Date("2005-08-11"), as.Date("2005-06-19"))) + 1 + as.numeric(difftime(as.Date("2015-01-02"), as.Date("2009-04-10"))) + 1 + as.numeric(difftime(as.Date("2011-12-11"), as.Date("2010-12-11"))) + 1) expect_true(inc_Mult1_W30 %>% dplyr::select(person_days) %>% sum() == as.numeric(difftime(as.Date("2005-08-11"), as.Date("2005-06-19"))) - 30 + as.numeric(difftime(as.Date("2015-01-02"), as.Date("2009-04-10"))) + 1 - 30 + as.numeric(difftime(as.Date("2011-12-11"), as.Date("2010-12-11"))) + 1 - 30) CDMConnector::cdm_disconnect(cdm) # The first event of person 1 will not be included in the observation period # but should also influence the second event with the washout conditionX <- tibble::tibble( cohort_definition_id = c(1, 1, 1), subject_id = c("1", "1", "2"), cohort_start_date = c( as.Date("2005-07-19"), as.Date("2009-04-10"), as.Date("2010-12-11") ), cohort_end_date = c( as.Date("2005-08-11"), as.Date("2015-01-02"), as.Date("2011-12-11") ) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, targetCohortTable = conditionX, outcomeTable = outcomeTable ) cdm <- generateTargetDenominatorCohortSet( cdm = cdm, name = "denominator", targetCohortTable = "target", targetCohortId = 1 ) inc_PreWashEv <- estimateIncidence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", repeatedEvents = TRUE, outcomeWashout = 30, completeDatabaseIntervals = FALSE, minCellCount = 0 ) # we should have 2 events with washout 30 expect_true(sum(inc_PreWashEv$n_events) == 2) expect_true(inc_PreWashEv %>% dplyr::select(person_days) %>% sum() == as.numeric(difftime(as.Date("2005-08-11"), as.Date("2005-07-19"))) - 30 + 7 + as.numeric(difftime(as.Date("2015-01-02"), as.Date("2009-04-10"))) + 1 - 30 + as.numeric(difftime(as.Date("2011-12-11"), as.Date("2010-12-11"))) + 1 - 30) CDMConnector::cdm_disconnect(cdm) # three observation periods for 1 person and a # couple of consecutive events lost to washout observationPeriodTable <- tibble::tibble( observation_period_id = c("1", "2", "3", "4"), person_id = c("1", "1", "1", "2"), observation_period_start_date = c( as.Date("2005-04-01"), as.Date("2009-04-10"), as.Date("2010-08-20"), as.Date("2010-01-01") ), observation_period_end_date = c( as.Date("2005-11-29"), as.Date("2010-01-02"), as.Date("2011-12-11"), as.Date("2015-06-01") ) ) conditionX <- tibble::tibble( cohort_definition_id = c(1, 1, 1, 1), subject_id = c("1", "1", "1", "2"), cohort_start_date = c( as.Date("2005-04-01"), as.Date("2009-06-10"), as.Date("2010-08-20"), as.Date("2010-01-01") ), cohort_end_date = c( as.Date("2005-11-29"), as.Date("2010-01-02"), as.Date("2011-10-11"), as.Date("2015-06-01") ) ) outcomeTable <- tibble::tibble( cohort_definition_id = c(1, 1, 1, 1, 1, 1, 1), subject_id = c("1", "1", "1", "1", "1", "1", "2"), cohort_start_date = c( as.Date("2005-08-09"), as.Date("2005-08-10"), as.Date("2005-08-11"), as.Date("2009-11-11"), as.Date("2009-11-21"), as.Date("2010-12-21"), as.Date("2014-04-04") ), cohort_end_date = c( as.Date("2005-08-09"), as.Date("2005-08-10"), as.Date("2005-08-11"), as.Date("2009-11-11"), as.Date("2009-11-21"), as.Date("2010-12-21"), as.Date("2014-04-04") ) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, targetCohortTable = conditionX, outcomeTable = outcomeTable ) cdm <- generateTargetDenominatorCohortSet( cdm = cdm, name = "denominator", targetCohortTable = "target", targetCohortId = 1 ) inc_3op <- estimateIncidence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", repeatedEvents = TRUE, outcomeWashout = 1, completeDatabaseIntervals = FALSE, minCellCount = 0 ) # we should have 5 events with washout 1 expect_true(sum(inc_3op$n_events) == 5) # try repeated events FALSE. inc_repev <- estimateIncidence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", repeatedEvents = FALSE, outcomeWashout = 1, completeDatabaseIntervals = FALSE, minCellCount = 0 ) # we should have 1 event, expect_true(sum(inc_repev$n_events) == 2) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: check confidence intervals", { skip_on_cran() cdm <- mockIncidencePrevalenceRef( sampleSize = 1000 ) cdm <- generateDenominatorCohortSet( cdm = cdm, name = "denominator", cohortDateRange = c(as.Date("2008-01-01"), as.Date("2011-01-01")) ) inc <- estimateIncidence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "years", repeatedEvents = TRUE, outcomeWashout = 0, minCellCount = 0, completeDatabaseIntervals = TRUE ) expect_equal(inc$incidence_100000_pys_95CI_lower, epitools::pois.exact(inc$n_events, inc$person_years)$lower * 100000, tolerance = 1e-2 ) expect_equal(inc$incidence_100000_pys_95CI_upper, epitools::pois.exact(inc$n_events, inc$person_years)$upper * 100000, tolerance = 1e-2 ) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: check attrition", { skip_on_cran() cdm <- mockIncidencePrevalenceRef(sampleSize = 1000) cdm <- generateDenominatorCohortSet( cdm = cdm, name = "denominator", sex = c("Male", "Female") ) inc <- estimateIncidence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "years" ) # for female cohort we should have a row for those excluded for not being male expect_true(any("Not Female" == attrition(inc) %>% dplyr::filter(denominator_sex == "Female") %>% dplyr::pull(.data$reason))) # for male, the opposite expect_true(any("Not Male" == attrition(inc) %>% dplyr::filter(denominator_sex == "Male") %>% dplyr::pull(.data$reason))) # check we can pick out specific analysis attrition expect_true(nrow(attrition(inc) %>% dplyr::filter(analysis_id == 1)) > 1) expect_true(nrow(attrition(inc) %>% dplyr::filter(analysis_id == 2)) > 1) CDMConnector::cdm_disconnect(cdm) # check obscuring counts cdm <- mockIncidencePrevalenceRef(sampleSize = 4) cdm <- generateDenominatorCohortSet( cdm = cdm, name = "denominator", sex = c("Male", "Female") ) inc <- estimateIncidence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "years" ) expect_true(attrition(inc) %>% dplyr::filter(reason == "Not Male") %>% dplyr::pull("excluded_subjects") == "<5") CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: check attrition with complete database intervals", { skip_on_cran() personTable <- tibble::tibble( person_id = c("1", "2"), gender_concept_id = "8507", year_of_birth = 2000, month_of_birth = 01, day_of_birth = 01 ) observationPeriodTable <- tibble::tibble( observation_period_id = c("1", "2"), person_id = c("1", "2"), observation_period_start_date = c( as.Date("2000-06-01"), as.Date("2000-06-01") ), observation_period_end_date = c( as.Date("2011-07-01"), as.Date("2000-07-01") ) ) outcomeTable <- tibble::tibble( cohort_definition_id = 1, subject_id = "1", cohort_start_date = c( as.Date("2008-02-05"), as.Date("2010-02-08"), as.Date("2010-02-20") ), cohort_end_date = c( as.Date("2008-02-05"), as.Date("2010-02-08"), as.Date("2010-02-20") ) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet(cdm = cdm, name = "denominator") inc <- estimateIncidence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "years", minCellCount = 0 ) expect_true(attrition(inc) %>% dplyr::filter(reason == "Not observed during the complete database interval") %>% dplyr::pull(excluded_subjects) == 1) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: check compute permanent", { skip_on_cran() # using temp cdm <- mockIncidencePrevalenceRef(sampleSize = 1000) attr(cdm, "write_schema") <- "main" cdm <- generateDenominatorCohortSet(cdm = cdm, name = "denominator") inc <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "overall" ) # if using temp tables # we have temp tables created by dbplyr # expect_true(any(stringr::str_starts( # CDMConnector::listTables(attr(attr(cdm, "cdm_source"), "dbcon")), # "dbplyr_" # ))) CDMConnector::cdm_disconnect(cdm) # using permanent cdm <- mockIncidencePrevalenceRef(sampleSize = 1000) cdm <- generateDenominatorCohortSet(cdm = cdm, name = "denominator") inc <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "overall" ) # no temp tables created by dbplyr expect_false(any(stringr::str_starts( CDMConnector::listTables(attr(attr(cdm, "cdm_source"), "dbcon")), "dbplyr_" ))) inc <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "overall", returnParticipants = TRUE ) expect_true(any(stringr::str_detect( CDMConnector::listTables(attr(attr(cdm, "cdm_source"), "dbcon"), schema = attr(cdm, "write_schema") ), "inc_participants" ))) expect_false(any(stringr::str_starts( CDMConnector::listTables(attr(attr(cdm, "cdm_source"), "dbcon")), "dbplyr_" ))) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: check participants", { skip_on_cran() cdm <- mockIncidencePrevalenceRef(sampleSize = 10) cdm$outcome2 <- cdm$outcome %>% dplyr::mutate(cohort_definition_id = subject_id) %>% dplyr::compute(name = "outcome2") cdm <- omopgenerics::insertTable(cdm = cdm, table = cdm$outcome2 %>% dplyr::collect(), name = "outcome2") cdm$outcome2 <- cdm$outcome2 %>% omopgenerics::newCohortTable() cdm <- generateDenominatorCohortSet( cdm = cdm, name = "dpop", ageGroup = list( c(0, 50), c(51, 100) ) ) start_tables <- CDMConnector::listTables(attr(attr(cdm, "cdm_source"), "dbcon"), schema = attr(attr(cdm, "cdm_source"), "write_schema")) inc <- estimateIncidence( cdm = cdm, denominatorTable = "dpop", outcomeTable = "outcome2", interval = "overall", returnParticipants = TRUE ) end_tables <- CDMConnector::listTables(attr(attr(cdm, "cdm_source"), "dbcon"), schema = attr(attr(cdm, "cdm_source"), "write_schema")) new_tables <- setdiff(end_tables, start_tables) # we should have cleaned up all the intermediate tables expect_equal( names(participants(inc, 1) %>% head(1) %>% dplyr::collect()), c( "subject_id", "cohort_start_date", "cohort_end_date", "outcome_start_date" ) ) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: overwriting participants", { skip_on_cran() cdm <- mockIncidencePrevalenceRef(sampleSize = 1000) attr(cdm, "write_schema") <- c(schema = "main", prefix = "test_") cdm <- generateDenominatorCohortSet( cdm = cdm, name = "dpop", ageGroup = list( c(0, 50), c(51, 100) ) ) inc1 <- estimateIncidence( cdm = cdm, denominatorTable = "dpop", denominatorCohortId = 1, outcomeTable = "outcome", returnParticipants = TRUE ) inc1_count <- nrow(participants(inc1, 1) %>% dplyr::collect()) inc2 <- estimateIncidence( cdm = cdm, denominatorTable = "dpop", denominatorCohortId = 2, outcomeTable = "outcome", returnParticipants = TRUE ) # participants from prev1 should still be the same # (ie no interference from having rerun the function) expect_true(nrow(participants(inc1, 1) %>% dplyr::collect()) == inc1_count) # # we should have two tables with participants # # one for each function call # expect_true(length(stringr::str_subset( # CDMConnector::listTables(attr(attr(cdm, "cdm_source"), "dbcon"), # schema = attr(cdm, "write_schema") # ), # "participants" # )) == 2) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: if missing cohort attributes", { # missing cohort_set cdm <- mockIncidencePrevalenceRef() cdm <- generateDenominatorCohortSet(cdm = cdm, name = "denominator") attr(cdm$outcome, "cohort_set") <- NULL expect_error(estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "overall" )) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: empty outcome cohort", { cdm <- mockIncidencePrevalenceRef(sampleSize = 200) cdm <- generateDenominatorCohortSet(cdm = cdm, name = "denominator") cdm$outcome <- cdm$outcome %>% dplyr::filter(cohort_definition_id == 99) expect_no_error(inc <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "months" )) expect_true(sum(inc$n_events)==0) # make sure we also have a confidence interval even in the case of an empty outcome cohort expect_true(all(inc$incidence_100000_pys == 0)) expect_true(all(inc$incidence_100000_pys_95CI_lower == 0)) expect_true(all(inc$incidence_100000_pys_95CI_upper > 0)) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: incidence using strata vars", { cdm <- mockIncidencePrevalenceRef(sampleSize = 2000, outPre = 0.2) cdm <- generateDenominatorCohortSet(cdm = cdm, name = "denominator", cohortDateRange = as.Date( c("1993-01-01", "1998-01-01") )) inc_orig <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "months" ) cdm$denominator <- cdm$denominator %>% dplyr::mutate(my_strata = dplyr::if_else(year(cohort_start_date) < 1995, "first", "second")) %>% dplyr::compute() inc <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "months", strata = list(c("my_strata")) ) expect_true(all(c("strata_name", "strata_level") %in% colnames(inc))) expect_true(all(c("Overall", "my_strata") %in% unique(inc %>% dplyr::pull("strata_name")))) expect_true(all(c("Overall", "first", "second") %in% unique(inc %>% dplyr::pull("strata_level")))) # original without strata should be the same as "Overall" strata expect_equal(inc_orig, inc %>% dplyr::filter(strata_name == "Overall") %>% dplyr::select(!c("strata_name", "strata_level"))) cdm$denominator <- cdm$denominator %>% dplyr::mutate(my_strata2 = dplyr::if_else(month(cohort_start_date)<7, "a", "b")) %>% dplyr::compute() inc2 <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "months", strata = list(c("my_strata","my_strata2")) ) expect_true(all(c("strata_name", "strata_level") %in% colnames(inc2))) expect_true(all(c("Overall", "my_strata and my_strata2") %in% unique(inc2 %>% dplyr::pull("strata_name")))) expect_true(all(c("Overall", "first and a", "first and b", "second and a", "second and b") %in% unique(inc2 %>% dplyr::pull("strata_level")))) inc3 <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "months", strata = list(c("my_strata"), c("my_strata2"), c("my_strata", "my_strata2"))) expect_true(all(c("strata_name", "strata_level") %in% colnames(inc3))) expect_true(all(c("Overall", "my_strata", "my_strata2", "my_strata and my_strata2") %in% unique(inc3 %>% dplyr::pull("strata_name")))) expect_true(all(c("Overall", "first", "second", "a", "b", "first and a", "first and b", "second and a", "second and b") %in% unique(inc3 %>% dplyr::pull("strata_level")))) # without overall strata inc4 <- estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "months", strata = list(c("my_strata"), c("my_strata2"), c("my_strata", "my_strata2")), includeOverallStrata = FALSE) expect_false("Overall" %in% unique(inc4 %>% dplyr::pull("strata_name"))) expect_true(all(c("my_strata", "my_strata2", "my_strata and my_strata2") %in% unique(inc4 %>% dplyr::pull("strata_name")))) expect_false("Overall" %in% unique(inc4 %>% dplyr::pull("strata_level"))) expect_true(all(c("first", "second", "a", "b", "first and a", "first and b", "second and a", "second and b") %in% unique(inc4 %>% dplyr::pull("strata_level")))) expect_error(estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "months", strata = list(c("not_a_col")))) expect_error(estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "months", strata = list(c("my_strata", "not_a_col")))) expect_error(estimateIncidence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "months", strata = list(c("my_strata"), c("not_a_col")))) CDMConnector::cdm_disconnect(cdm) })