test_that("mock db: check output format", { cdm <- mockIncidencePrevalenceRef() %>% generateDenominatorCohortSet(name = "denominator") prev <- estimatePrevalence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "years" ) # check estimates tibble expect_true(all(c( "analysis_id", "n_cases", "n_population", "prevalence", "prevalence_95CI_lower", "prevalence_95CI_upper", "prevalence_start_date", "prevalence_end_date", "population_obscured", "cases_obscured", "result_obscured", "outcome_cohort_id", "outcome_cohort_name", "analysis_type", "analysis_time_point", "analysis_interval", "analysis_full_contribution", "analysis_complete_database_intervals", "analysis_min_cell_count", "denominator_cohort_id", "denominator_age_group", "denominator_sex", "denominator_days_prior_observation", "denominator_start_date", "denominator_end_date", "denominator_target_cohort_definition_id", "denominator_target_cohort_name", "cdm_name" ) %in% names(prev))) expect_true(all(c( "analysis_id", "number_records", "number_subjects", "reason_id", "reason", "excluded_records", "excluded_subjects", "outcome_cohort_id", "outcome_cohort_name", "analysis_type", "analysis_time_point", "analysis_interval", "analysis_full_contribution", "analysis_complete_database_intervals", "analysis_min_cell_count", "denominator_cohort_id", "denominator_age_group", "denominator_sex", "denominator_days_prior_observation", "denominator_start_date", "denominator_end_date", "denominator_target_cohort_definition_id", "denominator_target_cohort_name", "cdm_name" ) %in% names(attrition(prev)))) expect_equal(prevalenceAttrition(prev), attrition(prev)) my_settings <- prevalenceSet(prev) expect_true(nrow(my_settings) > 0) expect_equal(settings(prev), prevalenceSet(prev)) # by default we donĀ“t return the participants expect_true(is.null(participants(prev, analysisId = 1))) CDMConnector::cdm_disconnect(cdm) cdm <- mockIncidencePrevalenceRef() cdm <- generateDenominatorCohortSet(cdm = cdm, name = "denominator") prev <- estimatePrevalence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "years", returnParticipants = TRUE ) # now we do return the participants expect_true(is.list(participants(prev, 1))) # list of references to participants expect_true(tibble::is_tibble(participants(prev, 1) %>% dplyr::collect())) expect_true(participants(prev, 1) %>% dplyr::collect() %>% dplyr::select("subject_id") %>% dplyr::pull() == 1) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: checks on working example", { personTable <- tibble::tibble( person_id = "1", gender_concept_id = "8507", year_of_birth = 2000, month_of_birth = 01, day_of_birth = 01 ) observationPeriodTable <- tibble::tibble( observation_period_id = "1", person_id = "1", observation_period_start_date = as.Date("2000-01-01"), observation_period_end_date = as.Date("2012-06-01") ) outcomeTable <- tibble::tibble( cohort_definition_id = 1, subject_id = "1", cohort_start_date = c( as.Date("2008-02-05"), as.Date("2010-02-08"), as.Date("2010-02-20") ), cohort_end_date = c( as.Date("2008-02-05"), as.Date("2010-02-08"), as.Date("2010-02-20") ) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet(cdm = cdm, name = "denominator") prev <- estimatePrevalence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = c("months", "years"), minCellCount = 0 ) expect_true(nrow(prev) >= 1) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: working examples 2", { skip_on_cran() personTable <- tibble::tibble( person_id = "1", gender_concept_id = "8507", year_of_birth = 2000, month_of_birth = 01, day_of_birth = 01 ) observationPeriodTable <- tibble::tibble( observation_period_id = "1", person_id = "1", observation_period_start_date = as.Date("2010-01-01"), observation_period_end_date = as.Date("2012-06-01") ) outcomeTable <- tibble::tibble( cohort_definition_id = 1, subject_id = "1", cohort_start_date = c( as.Date("2010-02-05"), as.Date("2010-02-08"), as.Date("2010-02-20") ), cohort_end_date = c( as.Date("2010-02-05"), as.Date("2010-02-08"), as.Date("2010-02-20") ) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet( cdm = cdm, name = "denominator" ) prev <- estimatePrevalence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", type = "point", interval = c("months", "years") ) expect_true(nrow(prev) >= 1) prev <- estimatePrevalence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", type = "point", interval = c("months", "years") ) expect_true(nrow(prev) >= 1) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: check minimum counts", { skip_on_cran() # 20 people personTable <- tibble::tibble( person_id = as.character(c(1:20)), gender_concept_id = rep("8507", 20), year_of_birth = rep(2000, 20), month_of_birth = rep(01, 20), day_of_birth = rep(01, 20) ) observationPeriodTable <- dplyr::bind_rows( tibble::tibble( observation_period_id = as.character(c(1:17)), person_id = as.character(c(1:17)), observation_period_start_date = rep(as.Date("2000-01-01"), 17), observation_period_end_date = rep(as.Date("2000-01-31"), 17) ), tibble::tibble( observation_period_id = as.character(c(18:20)), person_id = as.character(c(18:20)), observation_period_start_date = rep(as.Date("2000-01-01"), 3), observation_period_end_date = rep(as.Date("2012-06-01"), 3) ) ) outcomeTable <- dplyr::bind_rows( # 17 in first period tibble::tibble( cohort_definition_id = rep(1, 17), subject_id = as.character(c(1:17)), cohort_start_date = rep( as.Date("2000-01-02"), 17 ), cohort_end_date = rep( as.Date("2000-01-03"), 17 ) ), # three in second tibble::tibble( cohort_definition_id = rep(1, 3), subject_id = as.character(c(18:20)), cohort_start_date = rep( as.Date("2000-02-02"), 3 ), cohort_end_date = rep( as.Date("2000-02-03"), 3 ) ) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet(cdm = cdm, name = "denominator") prev <- estimatePrevalence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", minCellCount = 0, type = "period", interval = "months" ) expect_true(prev$n_cases[1] == 17) expect_true(prev$n_cases[2] == 3) expect_true(prev$n_cases[3] == 0) expect_true(prev$n_population[1] == 20) expect_true(prev$n_population[2] == 3) expect_true(prev$n_population[3] == 3) expect_true(!is.na(prev$prevalence[1])) expect_true(!is.na(prev$prevalence[2])) expect_true(!is.na(prev$prevalence[3])) expect_true(!is.na(prev$prevalence_95CI_lower[1])) expect_true(!is.na(prev$prevalence_95CI_upper[1])) prev <- estimatePrevalence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", minCellCount = 5, type = "period", interval = "months" ) expect_true(prev$n_cases[1] == 17) expect_true(is.na(prev$n_cases[2])) expect_true(!is.na(prev$n_cases[3])) # don't suppress zero expect_true(prev$n_population[1] == 20) expect_true(is.na(prev$n_population[2])) expect_true(is.na(prev$n_population[3])) expect_true(!is.na(prev$prevalence[1])) expect_true(is.na(prev$prevalence[2])) expect_true(is.na(prev$prevalence[3])) expect_true(!is.na(prev$prevalence_95CI_lower[1])) expect_true(is.na(prev$prevalence_95CI_lower[2])) expect_true(is.na(prev$prevalence_95CI_lower[3])) expect_true(!is.na(prev$prevalence_95CI_upper[1])) expect_true(is.na(prev$prevalence_95CI_upper[2])) expect_true(is.na(prev$prevalence_95CI_upper[3])) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: check study time periods", { skip_on_cran() personTable <- tibble::tibble( person_id = "1", gender_concept_id = "8507", year_of_birth = 2000, month_of_birth = 01, day_of_birth = 01 ) observationPeriodTable <- tibble::tibble( observation_period_id = "1", person_id = "1", observation_period_start_date = as.Date("2010-01-01"), observation_period_end_date = as.Date("2010-12-31") ) outcomeTable <- tibble::tibble( cohort_definition_id = 1, subject_id = "1", cohort_start_date = c( as.Date("2010-02-05"), as.Date("2010-02-08"), as.Date("2010-02-20") ), cohort_end_date = c( as.Date("2010-02-05"), as.Date("2010-02-08"), as.Date("2010-02-20") ) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet(cdm = cdm, name = "denominator") prev <- estimatePrevalence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", type = "point", interval = "months" ) # we expect 12 months of which the last in December # the last month should also be included # as the person goes up to the last day of the month expect_true(nrow(prev) == 12) # overall period prev <- estimatePrevalence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", type = "period", interval = "overall" ) # just one row expect_true(nrow(prev) == 1) CDMConnector::cdm_disconnect(cdm) # should return empty if no study days personTable <- tibble::tibble( person_id = "1", gender_concept_id = "8507", year_of_birth = 2000, month_of_birth = 01, day_of_birth = 01 ) observationPeriodTable <- tibble::tibble( observation_period_id = "1", person_id = "1", observation_period_start_date = as.Date("2010-01-01"), observation_period_end_date = as.Date("2010-11-15") ) outcomeTable <- tibble::tibble( cohort_definition_id = 1, subject_id = "1", cohort_start_date = c( as.Date("2010-02-05"), as.Date("2010-02-08"), as.Date("2010-02-20") ), cohort_end_date = c( as.Date("2010-02-05"), as.Date("2010-02-08"), as.Date("2010-02-20") ) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet(cdm = cdm, name = "denominator") prev <- estimatePrevalence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", type = "period", fullContribution = TRUE, interval = "weeks" ) expect_true(nrow(prev) == 45) prev <- estimatePrevalence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", type = "period", fullContribution = TRUE, interval = "months" ) expect_true(nrow(prev) == 10) prev <- estimatePrevalence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", type = "period", fullContribution = TRUE, interval = "years" ) expect_true(nrow(prev) == 0) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: check fullContribution requirement", { skip_on_cran() personTable <- tibble::tibble( person_id = c("1", "2", "3"), gender_concept_id = "8507", year_of_birth = 2000, month_of_birth = 01, day_of_birth = 01 ) observationPeriodTable <- tibble::tibble( observation_period_id = c("1", "2", "3"), person_id = c("1", "2", "3"), observation_period_start_date = c( as.Date("2010-01-01"), as.Date("2010-01-01"), as.Date("2012-04-01") ), observation_period_end_date = c( as.Date("2011-06-01"), as.Date("2012-06-01"), as.Date("2012-06-01") ) ) outcomeTable <- tibble::tibble( cohort_definition_id = 1, subject_id = "1", cohort_start_date = c( as.Date("2010-02-05"), as.Date("2010-02-08"), as.Date("2010-02-20") ), cohort_end_date = c( as.Date("2010-02-05"), as.Date("2010-02-08"), as.Date("2010-02-20") ) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet( cdm = cdm, name = "denominator" ) prev <- estimatePrevalence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", type = "period", interval = "years", fullContribution = FALSE, completeDatabaseIntervals = FALSE, minCellCount = 0 ) expect_true(all(prev$n_population == 2)) prev <- estimatePrevalence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", type = "period", interval = "years", fullContribution = TRUE, completeDatabaseIntervals = FALSE, minCellCount = 0 ) expect_true(all(prev$n_population == c(2, 1, 1))) expect_true(attrition(prev) %>% dplyr::filter(reason == "Do not satisfy full contribution requirement for an interval") %>% dplyr::pull("excluded_subjects") == 1) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: check periods follow calendar dates", { skip_on_cran() # check that even if study_start_date is during a period # periods still follow calendar dates personTable <- tibble::tibble( person_id = "1", gender_concept_id = "8507", year_of_birth = 2000, month_of_birth = 01, day_of_birth = 01 ) observationPeriodTable <- tibble::tibble( observation_period_id = "1", person_id = "1", observation_period_start_date = as.Date("2010-06-05"), observation_period_end_date = as.Date("2013-06-15") ) outcomeTable <- tibble::tibble( cohort_definition_id = 1, subject_id = "1", cohort_start_date = c( as.Date("2011-01-31"), as.Date("2011-02-01"), as.Date("2011-03-01") ), cohort_end_date = c( as.Date("2011-01-31"), as.Date("2011-02-01"), as.Date("2011-03-01") ) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) # if completeDatabaseIntervals is TRUE we should go from 2010 to 2013 # but if FALSE we should go from 2011 to 2012 # for yearly incidence cdm <- generateDenominatorCohortSet( cdm = cdm, name = "denominator" ) prev1 <- estimatePrevalence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", type = "period", interval = "years", minCellCount = 0, fullContribution = FALSE, completeDatabaseIntervals = FALSE ) expect_true(nrow(prev1) == 4) expect_true(all(lubridate::year(prev1$prevalence_start_date) == c("2010", "2011", "2012", "2013"))) prev2 <- estimatePrevalence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", type = "period", interval = "years", minCellCount = 0, fullContribution = FALSE, completeDatabaseIntervals = TRUE ) expect_true(nrow(prev2) == 2) expect_true(all(lubridate::year(prev2$prevalence_start_date) == c("2011", "2012"))) # for months cdm <- generateDenominatorCohortSet( cdm = cdm, name = "denominator", cohortDateRange = c(as.Date("2011-01-15"), as.Date(NA)) ) # where we expect the study to start on 2011-01-15 prev <- estimatePrevalence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", type = "period", interval = "months", minCellCount = 0, fullContribution = FALSE, completeDatabaseIntervals = FALSE ) expect_true(prev$prevalence_start_date[1] == as.Date("2011-01-15")) # where we expect the study to start the next month prev <- estimatePrevalence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", type = "period", interval = "months", minCellCount = 0, fullContribution = FALSE, completeDatabaseIntervals = TRUE ) expect_true(prev$prevalence_start_date[1] == as.Date("2011-02-01")) # for overall prev <- estimatePrevalence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", type = "period", interval = "overall", minCellCount = 0, fullContribution = FALSE, completeDatabaseIntervals = FALSE ) expect_true(prev$prevalence_start_date[1] == as.Date("2011-01-15")) expect_true(prev$prevalence_end_date[1] == as.Date("2013-06-15")) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: check multiple outcome ids", { skip_on_cran() personTable <- tibble::tibble( person_id = c("1", "2"), gender_concept_id = "8507", year_of_birth = 2000, month_of_birth = 01, day_of_birth = 01 ) observationPeriodTable <- tibble::tibble( observation_period_id = c("1", "2"), person_id = c("1", "2"), observation_period_start_date = as.Date("2011-01-01"), observation_period_end_date = as.Date("2012-06-01") ) outcomeTable <- tibble::tibble( cohort_definition_id = c(1, 2), # two different outcome ids subject_id = c("1", "2"), cohort_start_date = c( as.Date("2011-02-05") ), cohort_end_date = c( as.Date("2011-02-05") ) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet( cdm = cdm, name = "denominator" ) prev <- estimatePrevalence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", type = "period", interval = "years", minCellCount = 0 ) expect_true(all(prev[["n_cases"]] == 1)) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: some empty result sets", { skip_on_cran() personTable <- tibble::tibble( person_id = c("1", "2"), gender_concept_id = "8507", year_of_birth = 2000, month_of_birth = 01, day_of_birth = 01 ) observationPeriodTable <- tibble::tibble( observation_period_id = c("1", "2"), person_id = c("1", "2"), observation_period_start_date = as.Date("2012-02-01"), observation_period_end_date = as.Date("2012-06-01") ) outcomeTable <- tibble::tibble( cohort_definition_id = c(1, 2), # two different outcome ids subject_id = c("1", "2"), cohort_start_date = c( as.Date("2012-02-05") ), cohort_end_date = c( as.Date("2012-02-05") ) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet( cdm = cdm, name = "denominator" ) prev <- estimatePrevalence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", type = "period", interval = "years", minCellCount = 0 ) expect_true(nrow(prev) == 0) prev <- estimatePrevalence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", type = "period", interval = c("months", "years"), minCellCount = 0 ) expect_true(nrow(prev) > 0) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: check expected errors", { skip_on_cran() personTable <- tibble::tibble( person_id = "1", gender_concept_id = "8507", year_of_birth = 2000, month_of_birth = 01, day_of_birth = 01 ) observationPeriodTable <- tibble::tibble( observation_period_id = "1", person_id = "1", observation_period_start_date = as.Date("2010-01-01"), observation_period_end_date = as.Date("2012-06-01") ) outcomeTable <- tibble::tibble( cohort_definition_id = 1, subject_id = "1", cohort_start_date = c( as.Date("2010-02-05"), as.Date("2010-02-08"), as.Date("2010-02-20") ), cohort_end_date = c( as.Date("2010-02-05"), as.Date("2010-02-08"), as.Date("2010-02-20") ) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet(cdm = cdm, name = "denominator") expect_error(estimatePrevalence( cdm = "a", denominatorTable = "denominator", outcomeTable = "outcome", outcomeCohortId = 1, denominatorCohortId = 1 )) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: check user point prevalence function", { skip_on_cran() cdm <- mockIncidencePrevalenceRef() cdm <- generateDenominatorCohortSet(cdm = cdm, name = "denominator") prev <- estimatePrevalence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome" ) prev_point <- estimatePointPrevalence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome" ) expect_true(all(names(prev) == names(prev_point))) expect_true(all(names(prev) == names(prev_point))) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: check user period prevalence function", { skip_on_cran() cdm <- mockIncidencePrevalenceRef() cdm <- generateDenominatorCohortSet(cdm = cdm, name = "denominator") prev <- estimatePrevalence( cdm = cdm, type = "period", denominatorTable = "denominator", outcomeTable = "outcome" ) prev_period <- estimatePeriodPrevalence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome" ) expect_true(all(names(prev) == names(prev_period))) expect_true(all(names(prev) == names(prev_period))) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: multiple observation periods", { skip_on_cran() # create data for hypothetical people to test personTable <- tibble::tibble( person_id = c("1", "2"), gender_concept_id = c("8507", "8507"), year_of_birth = c(1998, 1976), month_of_birth = c(02, 06), day_of_birth = c(12, 01) ) # three observation periods for 1 person # and a couple of consecutive events lost to washout observationPeriodTable <- tibble::tibble( observation_period_id = c("1", "2", "3", "4"), person_id = c("1", "1", "1", "2"), observation_period_start_date = c( as.Date("2005-04-01"), as.Date("2009-04-10"), as.Date("2010-08-20"), as.Date("2012-01-01") ), observation_period_end_date = c( as.Date("2005-11-29"), as.Date("2010-01-02"), as.Date("2011-12-11"), as.Date("2015-06-01") ) ) conditionX <- tibble::tibble( cohort_definition_id = c( 1, 1, 1), subject_id = c("1", "1", "2"), cohort_start_date = c( as.Date("2005-04-01"), as.Date("2009-06-10"), as.Date("2013-01-01") ), cohort_end_date = c( as.Date("2005-11-29"), as.Date("2010-01-02"), as.Date("2015-01-01") ) ) outcomeTable <- tibble::tibble( cohort_definition_id = c(1, 1, 1, 1, 1, 1, 1), subject_id = c("1", "1", "1", "1", "1", "1", "2"), cohort_start_date = c( as.Date("2005-08-09"), as.Date("2005-08-10"), as.Date("2005-08-11"), as.Date("2009-11-11"), as.Date("2009-11-21"), as.Date("2010-12-21"), as.Date("2014-04-04") ), cohort_end_date = c( as.Date("2005-08-09"), as.Date("2005-08-10"), as.Date("2005-08-11"), as.Date("2009-11-11"), as.Date("2009-11-21"), as.Date("2010-12-21"), as.Date("2014-04-04") ) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, targetCohortTable = conditionX, outcomeTable = outcomeTable ) cdm <- generateTargetDenominatorCohortSet( cdm = cdm, name = "denominator", targetCohortTable = "target", targetCohortId = 1 ) ppe <- estimatePeriodPrevalence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "years", fullContribution = FALSE, completeDatabaseIntervals = FALSE, minCellCount = 0 ) # nobody should appear in 2006 expect_true(ppe %>% dplyr::filter(prevalence_start_date == "2006-01-01") %>% dplyr::pull("n_population") == 0) expect_true(ppe %>% dplyr::filter(prevalence_start_date == "2006-01-01") %>% dplyr::pull("n_cases") == 0) # one person with an event in 2005 expect_true(ppe %>% dplyr::filter(lubridate::year(prevalence_start_date) == "2005") %>% dplyr::pull("n_population") == 1) expect_true(ppe %>% dplyr::filter(lubridate::year(prevalence_start_date) == "2005") %>% dplyr::pull("n_cases") == 1) # as for point prevalence, we would expect no positive n_cases at default ppo <- estimatePointPrevalence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "months", minCellCount = 0 ) expect_true(sum(ppo$n_cases) == 0) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: check confidence intervals", { skip_on_cran() cdm <- mockIncidencePrevalenceRef(sampleSize = 1000) cdm <- generateDenominatorCohortSet( cdm = cdm, name = "denominator" ) prev <- estimatePrevalence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", type = "point", interval = "years", minCellCount = 0 ) %>% dplyr::filter(n_population > 1) # compare our wilson CIs with those from Hmisc hmisc_ci <- Hmisc::binconf(prev$n_cases, prev$n_population, alpha = 0.05, method = c("wilson"), return.df = TRUE ) expect_equal(prev$prevalence_95CI_lower, hmisc_ci$Lower, tolerance = 1e-2 ) expect_equal(prev$prevalence_95CI_upper, hmisc_ci$Upper, tolerance = 1e-2 ) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: check attrition", { skip_on_cran() cdm <- mockIncidencePrevalenceRef(sampleSize = 1000) cdm <- generateDenominatorCohortSet( cdm = cdm, name = "denominator", sex = c("Male", "Female") ) prev <- estimatePrevalence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", type = "point", interval = "years", minCellCount = 0 ) # for female cohort we should have a row for those excluded for not being male expect_true(any("Not Female" == attrition(prev) %>% dplyr::filter(denominator_sex == "Female") %>% dplyr::pull(.data$reason))) # for male, the opposite expect_true(any("Not Male" == attrition(prev) %>% dplyr::filter(denominator_sex == "Male") %>% dplyr::pull(.data$reason))) # check we can pick out specific analysis attrition expect_true(nrow(attrition(prev) %>% dplyr::filter(analysis_id == 1)) > 1) expect_true(nrow(attrition(prev) %>% dplyr::filter(analysis_id == 2)) > 1) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: check attrition with complete database intervals", { skip_on_cran() personTable <- tibble::tibble( person_id = c("1", "2", "3"), gender_concept_id = "8507", year_of_birth = 2000, month_of_birth = 01, day_of_birth = 01 ) observationPeriodTable <- tibble::tibble( observation_period_id = c("1", "2", "3"), person_id = c("1", "2", "3"), observation_period_start_date = c( as.Date("2000-06-01"), as.Date("2000-06-01"), as.Date("2000-06-01") ), observation_period_end_date = c( as.Date("2011-07-01"), as.Date("2012-06-01"), as.Date("2000-06-15") ) ) outcomeTable <- tibble::tibble( cohort_definition_id = 1, subject_id = "1", cohort_start_date = c( as.Date("2008-02-05"), as.Date("2010-02-08"), as.Date("2010-02-20") ), cohort_end_date = c( as.Date("2008-02-05"), as.Date("2010-02-08"), as.Date("2010-02-20") ) ) cdm <- mockIncidencePrevalenceRef( personTable = personTable, observationPeriodTable = observationPeriodTable, outcomeTable = outcomeTable ) cdm <- generateDenominatorCohortSet( cdm = cdm, name = "denominator" ) prev <- estimatePrevalence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", type = "point", interval = "years", completeDatabaseIntervals = TRUE, minCellCount = 0 ) expect_true(attrition(prev) %>% dplyr::filter(reason == "Not observed during the complete database interval") %>% dplyr::pull("excluded_subjects") == 1) # check min cell suppression prev2 <- estimatePrevalence(cdm, denominatorTable = "denominator", outcomeTable = "outcome", type = "point", interval = "years", completeDatabaseIntervals = TRUE, minCellCount = 5 ) expect_true(attrition(prev2) %>% dplyr::filter(reason == "Not observed during the complete database interval") %>% dplyr::pull("excluded_subjects") == "<5") CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: check compute permanent", { skip_on_cran() # using permanent (no prefix) cdm <- mockIncidencePrevalenceRef(sampleSize = 1000) attr(attr(cdm, "cdm_source"), "write_schema") <- "main" cdm <- generateDenominatorCohortSet( cdm = cdm, name = "dpop" ) prev <- estimatePrevalence( cdm = cdm, denominatorTable = "dpop", outcomeTable = "outcome", interval = "years" ) # no temp tables created by dbplyr expect_false(any(stringr::str_starts( CDMConnector::listTables(attr(attr(cdm, "cdm_source"), "dbcon"), schema = attr(attr(cdm, "cdm_source"), "write_schema") ), "dbplyr_" ))) prev <- estimatePrevalence( cdm = cdm, denominatorTable = "dpop", outcomeTable = "outcome", interval = "years", type = "point", returnParticipants = TRUE ) expect_true(any(stringr::str_detect( CDMConnector::listTables(attr(attr(cdm, "cdm_source"), "dbcon"), schema = attr(attr(cdm, "cdm_source"), "write_schema") ), "point_prev_participants1" ))) prev <- estimatePrevalence( cdm = cdm, denominatorTable = "dpop", outcomeTable = "outcome", interval = "years", type = "period", returnParticipants = TRUE ) expect_true(any(stringr::str_detect( CDMConnector::listTables(attr(attr(cdm, "cdm_source"), "dbcon"), schema = attr(attr(cdm, "cdm_source"), "write_schema") ), "period_prev_participants1" ))) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: check participants", { skip_on_cran() cdm <- mockIncidencePrevalenceRef(sampleSize = 100) cdm <- generateDenominatorCohortSet( cdm = cdm, name = "dpop", sex = c("Male", "Female", "Both"), ageGroup = list( c(0, 50), c(51, 100) ) ) start_tables <- CDMConnector::listTables(attr(attr(cdm, "cdm_source"), "dbcon"), schema = attr(attr(cdm, "cdm_source"), "write_schema")) prev <- estimatePrevalence( cdm = cdm, denominatorTable = "dpop", outcomeTable = "outcome", returnParticipants = TRUE ) end_tables <- CDMConnector::listTables(attr(attr(cdm, "cdm_source"), "dbcon"), schema = attr(attr(cdm, "cdm_source"), "write_schema")) new_tables <- setdiff(end_tables, start_tables) # we should have one new database table with our participants # everything else should have been cleaned up along the way expect_true(length(new_tables) == 1) prev_participants <- participants(prev, 1) %>% dplyr::collect() expect_equal(names(prev_participants), c("subject_id", "cohort_start_date", "cohort_end_date", "outcome_start_date")) expect_true(nrow(prev_participants %>% dplyr::filter(is.na(cohort_start_date))) == 0) prev2 <- estimatePrevalence( cdm = cdm, denominatorTable = "dpop", interval = "months", outcomeTable = "outcome", returnParticipants = TRUE ) end_tables2 <- CDMConnector::listTables(attr(attr(cdm, "cdm_source"), "dbcon"), schema = attr(attr(cdm, "cdm_source"), "write_schema")) new_tables2 <- setdiff(end_tables2, start_tables) # we should have another new database table with our participants from the # 2nd analysis expect_true(length(new_tables2) == 2) # with participants from first analysis unchanged expect_equal(prev_participants, participants(prev, 1) %>% dplyr::collect()) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: overwriting participants", { skip_on_cran() cdm <- mockIncidencePrevalenceRef(sampleSize = 1000) cdm <- generateDenominatorCohortSet( cdm = cdm, name = "dpop", ageGroup = list( c(0, 50), c(51, 100) ) ) prev1 <- estimatePrevalence( cdm = cdm, denominatorTable = "dpop", denominatorCohortId = 1, outcomeTable = "outcome", returnParticipants = TRUE ) prev1_count <- nrow(participants(prev1, 1) %>% dplyr::collect()) prev2 <- estimatePrevalence( cdm = cdm, denominatorTable = "dpop", denominatorCohortId = 2, outcomeTable = "outcome", returnParticipants = TRUE ) # participants from prev1 should still be the same # (ie no interference from having rerun the function) expect_true(nrow(participants(prev1, 1) %>% dplyr::collect()) == prev1_count) # we should have two tables with participants # one for each function call expect_true(length(stringr::str_subset( CDMConnector::listTables(attr(attr(cdm, "cdm_source"), "dbcon"), schema = attr(attr(cdm, "cdm_source"), "write_schema") ), "participants" )) == 2) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: if missing cohort attributes", { # missing cohort_set cdm <- mockIncidencePrevalenceRef() cdm <- generateDenominatorCohortSet(cdm = cdm, name = "denominator") attr(cdm$outcome, "cohort_set") <- NULL expect_error(estimatePrevalence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "years" )) CDMConnector::cdm_disconnect(cdm) # missing cohort_count cdm <- mockIncidencePrevalenceRef() cdm <- generateDenominatorCohortSet(cdm = cdm, name = "denominator") attr(cdm$outcome, "cohort_attrition") <- NULL expect_error(estimatePrevalence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "years" )) CDMConnector::cdm_disconnect(cdm) }) test_that("mock db: test empty outcome table works", { skip_on_cran() cdm <- mockIncidencePrevalenceRef(sampleSize = 1000) cdm[["outcome"]] <- cdm[["outcome"]] %>% dplyr::filter(cohort_definition_id == 33) cdm <- generateDenominatorCohortSet(cdm = cdm, name = "denominator") expect_no_error(estimatePrevalence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "years" )) }) test_that("mock db: prevalence using strata vars", { cdm <- mockIncidencePrevalenceRef(sampleSize = 1000, outPre = 0.7) cdm <- generateDenominatorCohortSet(cdm = cdm, name = "denominator") prev_orig <- estimatePrevalence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "years" ) cdm$denominator <- cdm$denominator %>% dplyr::mutate(my_strata = dplyr::if_else(year(cohort_start_date) < 1990, "first", "second")) %>% dplyr::compute() prev <- estimatePrevalence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "years", strata = list(c("my_strata")) ) expect_true(all(c("strata_name", "strata_level") %in% colnames(prev))) expect_true(all(c("Overall", "my_strata") %in% unique(prev %>% dplyr::pull("strata_name")))) expect_true(all(c("Overall", "first", "second") %in% unique(prev %>% dplyr::pull("strata_level")))) # original without strata should be the same as "Overall" strata expect_equal(prev_orig, prev %>% dplyr::filter(strata_name == "Overall") %>% dplyr::select(!c("strata_name", "strata_level"))) cdm$denominator <- cdm$denominator %>% dplyr::mutate(my_strata2 = dplyr::if_else(month(cohort_start_date)<7, "a", "b")) %>% dplyr::compute() prev2 <- estimatePrevalence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "years", strata = list(c("my_strata","my_strata2")) ) expect_true(all(c("strata_name", "strata_level") %in% colnames(prev2))) expect_true(all(c("Overall", "my_strata and my_strata2") %in% unique(prev2 %>% dplyr::pull("strata_name")))) expect_true(all(c("Overall", "first and a", "first and b", "second and a", "second and b") %in% unique(prev2 %>% dplyr::pull("strata_level")))) prev3 <- estimatePrevalence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "years", strata = list(c("my_strata"), c("my_strata2"), c("my_strata", "my_strata2"))) expect_true(all(c("strata_name", "strata_level") %in% colnames(prev3))) expect_true(all(c("Overall", "my_strata", "my_strata2", "my_strata and my_strata2") %in% unique(prev3 %>% dplyr::pull("strata_name")))) expect_true(all(c("Overall", "first", "second", "a", "b", "first and a", "first and b", "second and a", "second and b") %in% unique(prev3 %>% dplyr::pull("strata_level")))) # without overall strata prev4 <- estimatePrevalence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "years", strata = list(c("my_strata"), c("my_strata2"), c("my_strata", "my_strata2")), includeOverallStrata = FALSE) expect_false("Overall" %in% unique(prev4 %>% dplyr::pull("strata_name"))) expect_true(all(c("my_strata", "my_strata2", "my_strata and my_strata2") %in% unique(prev4 %>% dplyr::pull("strata_name")))) expect_false("Overall" %in% unique(prev4 %>% dplyr::pull("strata_level"))) expect_true(all(c("first", "second", "a", "b", "first and a", "first and b", "second and a", "second and b") %in% unique(prev4 %>% dplyr::pull("strata_level")))) expect_error(estimatePrevalence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "years", strata = list(c("not_a_col")))) expect_error(estimatePrevalence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "years", strata = list(c("my_strata", "not_a_col")))) expect_error(estimatePrevalence( cdm = cdm, denominatorTable = "denominator", outcomeTable = "outcome", interval = "years", strata = list(c("my_strata"), c("not_a_col")))) CDMConnector::cdm_disconnect(cdm) })