test_that("input validation", { skip_on_cran() cdm <- mockDrugUtilisation(con = connection(), writeSchema = schema()) expect_no_error( requirePriorDrugWashout( cohort = cdm$cohort1, days = 90 ) ) expect_no_error( requirePriorDrugWashout( cohort = cdm$cohort1, days = Inf ) ) expect_no_error( requirePriorDrugWashout( cohort = cdm$cohort1, days = Inf, name = "cohort2" ) ) expect_message( requirePriorDrugWashout( cohort = cdm$cohort1, days = Inf, cohortId = c(1, 3), name = "cohort2" ) ) expect_error( requirePriorDrugWashout( cohort = cdm$cohort1, days = -90 ) ) expect_error( requirePriorDrugWashout( cohort = cdm$cohort1, days = Inf, cohortId = c(1, 3, 4), name = "cohort2" ) ) expect_error( requirePriorDrugWashout( cohort = cdm$cohort1, days = Inf, cohortId = "1", name = "cohort2" ) ) expect_error( requirePriorDrugWashout( cohort = cdm, days = 90 ) ) expect_error( requirePriorDrugWashout( cohort = "cohort1", days = 90 ) ) expect_error( requirePriorDrugWashout( cohort = cdm$cohort1, days = "90" ) ) expect_error( requirePriorDrugWashout( cohort = cdm$cohort1, days = 90, name = cohort2 ) ) expect_error( cdm$cohort3 <- requirePriorDrugWashout( cohort = cdm$cohort1, days = 90, name = "cohort2" ) ) expect_no_error( requirePriorDrugWashout( cohort = cdm$cohort1, days = 0 ) ) cohort1 <- dplyr::tibble( cohort_definition_id = as.integer(c()), subject_id = as.integer(c()), cohort_start_date = as.Date(c( )), cohort_end_date = as.Date(c( )) ) observationPeriod <- dplyr::tibble( observation_period_id = c(1, 2, 3), person_id = c(1, 2, 3), observation_period_start_date = as.Date(c( "2015-01-01", "2016-05-15", "2012-12-30" )), observation_period_end_date = as.Date(c( "2025-01-01", "2026-05-15", "2030-12-30" )), period_type_concept_id = 44814724 ) cdm <- mockDrugUtilisation( con = connection(), writeSchema = schema(), cohort1 = cohort1, observation_period = observationPeriod ) expect_no_error( requirePriorDrugWashout(cohort = cdm$cohort1, days = 90, name = "cohort2") ) mockDisconnect(cdm = cdm) }) test_that("requirePrioUseWashout example", { skip_on_cran() cohort1 <- dplyr::tibble( cohort_definition_id = c(1, 1, 1, 1), subject_id = c(1, 1, 2, 2), cohort_start_date = as.Date(c( "2020-01-01", "2020-06-01", "2020-01-02", "2020-01-01" )), cohort_end_date = as.Date(c( "2020-04-01", "2020-08-01", "2020-02-02", "2020-01-01" )) ) observationPeriod <- dplyr::tibble( observation_period_id = c(1, 2, 3), person_id = c(1, 2, 3), observation_period_start_date = as.Date(c( "2015-01-01", "2016-05-15", "2012-12-30" )), observation_period_end_date = as.Date(c( "2025-01-01", "2026-05-15", "2030-12-30" )), period_type_concept_id = 44814724 ) cdm <- mockDrugUtilisation( con = connection(), writeSchema = schema(), cohort1 = cohort1, observation_period = observationPeriod ) cdm$cohort2 <- requirePriorDrugWashout(cohort = cdm$cohort1, days = 90, name = "cohort2") expect_true((cdm$cohort1 |> dplyr::tally() |> dplyr::pull("n") |> as.numeric()) != (cdm$cohort2 |> dplyr::tally() |> dplyr::pull("n") |> as.numeric()) ) expect_equal( (cdm$cohort2 |> dplyr::tally() |> dplyr::pull("n") |> as.numeric()), 2 ) cdm$cohort2 <- requirePriorDrugWashout(cohort = cdm$cohort1, days = 10, name = "cohort2") expect_equal( (cdm$cohort2 |> dplyr::tally() |> dplyr::pull("n") |> as.numeric()), 3 ) cdm$cohort2 <- requirePriorDrugWashout(cohort = cdm$cohort1, days = Inf, name = "cohort2") expect_equal( (cdm$cohort2 |> dplyr::tally() |> dplyr::pull("n") |> as.numeric()), 2 ) cohort1 <- dplyr::tibble( cohort_definition_id = c(1, 1, 2, 2), subject_id = c(1, 1, 2, 2), cohort_start_date = as.Date(c( "2020-01-01", "2020-06-01", "2020-01-02", "2020-01-01" )), cohort_end_date = as.Date(c( "2020-04-01", "2020-08-01", "2020-02-02", "2020-01-01" )) ) observationPeriod <- dplyr::tibble( observation_period_id = c(1, 2, 3), person_id = c(1, 2, 3), observation_period_start_date = as.Date(c( "2015-01-01", "2016-05-15", "2012-12-30" )), observation_period_end_date = as.Date(c( "2025-01-01", "2026-05-15", "2030-12-30" )), period_type_concept_id = 44814724 ) cdm <- mockDrugUtilisation( cohort1 = cohort1, observation_period = observationPeriod ) cdm$cohort3 <- requirePriorDrugWashout(cohort = cdm$cohort1, days = 90, name = "cohort3") expect_equal( (cdm$cohort3 |> dplyr::tally() |> dplyr::pull("n") |> as.numeric()), 2 ) cdm$cohort3 <- requirePriorDrugWashout(cohort = cdm$cohort1, days = 0, name = "cohort3") expect_equal( cdm$cohort3 |> dplyr::tally() |> dplyr::pull("n") |> as.numeric(), 4 ) cdm$cohort3 <- cdm$cohort1 |> requirePriorDrugWashout( days = 90, cohortId = 1, name = "cohort3") expect_equal( cdm$cohort3 |> dplyr::tally() |> dplyr::pull("n") |> as.numeric(), 3 ) cdm$cohort3 <- requirePriorDrugWashout(cohort = cdm$cohort1, days = 90, cohortId = 2, name = "cohort3") expect_equal( (cdm$cohort3 |> dplyr::tally() |> dplyr::pull("n") |> as.numeric()), 3 ) cdm$cohort3 <- requirePriorDrugWashout(cohort = cdm$cohort1, days = 90, cohortId = c(1,2), name = "cohort3") expect_equal( (cdm$cohort3 |> dplyr::tally() |> dplyr::pull("n") |> as.numeric()), 2 ) mockDisconnect(cdm = cdm) }) test_that("test cohortId, example 2", { skip_on_cran() cohort1 <- dplyr::tibble( cohort_definition_id = c(1, 2, 1, 2), subject_id = c(1, 1, 2, 2), cohort_start_date = as.Date(c( "2020-01-01", "2020-06-01", "2020-01-02", "2020-01-01" )), cohort_end_date = as.Date(c( "2020-04-01", "2020-08-01", "2020-02-02", "2020-01-01" )) ) observationPeriod <- dplyr::tibble( observation_period_id = c(1, 2, 3), person_id = c(1, 2, 3), observation_period_start_date = as.Date(c( "2015-01-01", "2016-05-15", "2012-12-30" )), observation_period_end_date = as.Date(c( "2025-01-01", "2026-05-15", "2030-12-30" )), period_type_concept_id = 44814724 ) cdm <- mockDrugUtilisation( con = connection(), writeSchema = schema(), cohort1 = cohort1, observation_period = observationPeriod ) cdm$cohort3 <- requirePriorDrugWashout(cohort = cdm$cohort1, days = 90, name = "cohort3") expect_equal( (cdm$cohort3 |> dplyr::tally() |> dplyr::pull("n") |> as.numeric()), 4 ) cdm$cohort3 <- requirePriorDrugWashout(cohort = cdm$cohort1, days = 0, name = "cohort3") expect_equal( (cdm$cohort3 |> dplyr::tally() |> dplyr::pull("n") |> as.numeric()), 4 ) cdm$cohort3 <- requirePriorDrugWashout(cohort = cdm$cohort1, days = 90, cohortId = 1, name = "cohort3") expect_equal( (cdm$cohort3 |> dplyr::tally() |> dplyr::pull("n") |> as.numeric()), 4 ) cdm$cohort3 <- requirePriorDrugWashout(cohort = cdm$cohort1, days = 90, cohortId = 2, name = "cohort3") expect_equal( (cdm$cohort3 |> dplyr::tally() |> dplyr::pull("n") |> as.numeric()), 4 ) cdm$cohort3 <- requirePriorDrugWashout(cohort = cdm$cohort1, days = 90, cohortId = c(1,2), name = "cohort3") expect_equal( (cdm$cohort3 |> dplyr::tally() |> dplyr::pull("n") |> as.numeric()), 4 ) mockDisconnect(cdm = cdm) }) test_that("requireDrugInDateRange", { skip_on_cran() cdm <- mockDrugUtilisation( con = connection(), writeSchema = schema(), cohort1 = dplyr::tibble( cohort_definition_id = c(1, 3, 2, 1, 3, 3, 1, 3, 2, 1) |> as.integer(), subject_id = c(1, 2, 3, 4, 5, 6, 7, 8, 9, 10) |> as.integer(), cohort_start_date = as.Date(c( "2020-09-20", "2022-05-21", "2010-02-10", "2022-01-26", "2019-07-17", "1991-05-25", "2015-09-10", "2012-02-04", "2022-10-05", "1997-11-07" )), cohort_end_date = as.Date(c( "2021-03-18", "2022-06-05", "2010-07-21", "2022-04-28", "2019-12-26", "1992-04-18", "2018-05-02", "2012-02-15", "2022-11-12", "2003-08-04" )) ) ) cdm$cohort3 <- requireDrugInDateRange( cohort = cdm$cohort1, dateRange = as.Date(c("2020-01-01", "2020-12-12")), indexDate = "cohort_start_date", cohortId = NULL, name = "cohort3" ) expect_true(nrow(cdm$cohort3 |> dplyr::collect()) == 1) expect_true(cdm$cohort3 |> dplyr::pull("subject_id") == 1) expect_true(all(attrition(cdm$cohort3)$reason == c( 'Initial qualifying events', 'require cohort_start_date between 2020-01-01 to 2020-12-12', 'Initial qualifying events', 'require cohort_start_date between 2020-01-01 to 2020-12-12', 'Initial qualifying events', 'require cohort_start_date between 2020-01-01 to 2020-12-12' ))) cdm$cohort4 <- requireDrugInDateRange( cohort = cdm$cohort1, dateRange = as.Date(c("2020-01-01", "2020-12-12")), indexDate = "cohort_start_date", cohortId = 2:3, name = "cohort4" ) expect_true(nrow(cdm$cohort4 |> dplyr::collect()) == 4) expect_true(cdm$cohort4 |> dplyr::pull("cohort_definition_id") |> unique() == 1) expect_true(all(attrition(cdm$cohort4)$reason == c( 'Initial qualifying events', 'Initial qualifying events', 'require cohort_start_date between 2020-01-01 to 2020-12-12', 'Initial qualifying events', 'require cohort_start_date between 2020-01-01 to 2020-12-12' ))) cdm$cohort5 <- requireDrugInDateRange( cohort = cdm$cohort1, dateRange = as.Date(c(NA, "2000-01-01")), indexDate = "cohort_start_date", name = "cohort5" ) expect_true(nrow(cdm$cohort5 |> dplyr::collect()) == 2) expect_true(all(cdm$cohort5 |> dplyr::pull("cohort_definition_id") |> unique() |> sort() == c(1, 3))) expect_true(all(attrition(cdm$cohort5)$reason == c( 'Initial qualifying events', 'require cohort_start_date before 2000-01-01', 'Initial qualifying events', 'require cohort_start_date before 2000-01-01', 'Initial qualifying events', 'require cohort_start_date before 2000-01-01' ))) cdm$cohort6 <- requireDrugInDateRange( cohort = cdm$cohort1, dateRange = as.Date(c("2020-01-01", NA)), indexDate = "cohort_end_date", name = "cohort6" ) expect_true(nrow(cdm$cohort6 |> dplyr::collect()) == 4) expect_true(all(cdm$cohort6 |> dplyr::pull("cohort_definition_id") |> sort() == c(1, 1, 2, 3))) expect_true(all(cdm$cohort6 |> dplyr::pull("subject_id") |> unique() |> sort() == c(1, 2, 4, 9))) expect_true(all(attrition(cdm$cohort6)$reason == c( 'Initial qualifying events', 'require cohort_end_date after 2020-01-01', 'Initial qualifying events', 'require cohort_end_date after 2020-01-01', 'Initial qualifying events', 'require cohort_end_date after 2020-01-01' ))) cohort1 <- cdm$cohort1 |> collectCohort() cdm$cohort1 <- requireDrugInDateRange( cohort = cdm$cohort1, dateRange = as.Date(c(NA, NA)), indexDate = "cohort_end_date" ) expect_true(all(attrition(cdm$cohort1)$reason == c( 'Initial qualifying events', 'No date restrictions to cohort_end_date', 'Initial qualifying events', 'No date restrictions to cohort_end_date', 'Initial qualifying events', 'No date restrictions to cohort_end_date' ))) expect_equal(cohort1, cdm$cohort1 |> collectCohort()) mockDisconnect(cdm = cdm) }) test_that("requireObservationBeforeDrug", { skip_on_cran() cdm <- mockDrugUtilisation( con = connection(), writeSchema = schema(), cohort1 = dplyr::tibble( cohort_definition_id = c(1, 3, 2, 1, 3, 3, 1, 3, 2, 1) |> as.integer(), subject_id = c(1, 2, 3, 4, 5, 6, 7, 8, 9, 10) |> as.integer(), cohort_start_date = as.Date(c( "2020-09-20", "2022-05-21", "2010-02-10", "2022-01-26", "2019-07-17", "1991-05-25", "2015-09-10", "2012-02-04", "2022-10-05", "1997-11-07" )), cohort_end_date = as.Date(c( "2021-03-18", "2022-06-05", "2010-07-21", "2022-04-28", "2019-12-26", "1992-04-18", "2018-05-02", "2012-02-15", "2022-11-12", "2003-08-04" )) ), observation_period = dplyr::tibble( observation_period_id = 1:10 |> as.integer(), person_id = 1:10 |> as.integer(), observation_period_start_date = as.Date(c( '2020-04-01', '2022-05-21', '1983-08-02', '2020-12-16', '2013-01-18', '1989-05-25', '2015-03-10', '2012-01-29', '2022-06-01', '1990-02-25' )), observation_period_end_date = as.Date(c( '2021-04-25', '2022-06-13', '2010-08-27', '2022-05-25', '2020-05-30', '1992-04-27', '2019-02-02', '2012-02-19', '2022-12-23', '2006-03-14' )), period_type_concept_id = 44814724L ) ) cdm$cohort3 <- requireObservationBeforeDrug( cohort = cdm$cohort1, days = 0, cohortId = NULL, name = "cohort3" ) expect_equal(cdm$cohort1 |> collectCohort(), cdm$cohort3 |> collectCohort()) expect_true(all(attrition(cdm$cohort3)$reason == c( 'Initial qualifying events', 'require prior observation of 0 days', 'Initial qualifying events', 'require prior observation of 0 days', 'Initial qualifying events', 'require prior observation of 0 days' ))) cdm$cohort4 <- requireObservationBeforeDrug( cohort = cdm$cohort1, days = 999999, cohortId = 1, name = "cohort4" ) expect_false(1 %in% (cdm$cohort4 |> dplyr::pull("cohort_definition_id"))) expect_equal(cdm$cohort1 |> collectCohort(2:3), cdm$cohort4 |> collectCohort(2:3)) expect_true(all(attrition(cdm$cohort4)$reason == c( 'Initial qualifying events', 'require prior observation of 999999 days', 'Initial qualifying events', 'Initial qualifying events' ))) cohort <- requireObservationBeforeDrug( cohort = cdm$cohort1, days = 200 ) expect_true(omopgenerics::tableName(cohort) == "cohort1") expect_true(all(cohort |> dplyr::pull("cohort_definition_id") |> sort() == c(1, 1, 2, 3, 3))) expect_true(all(cohort |> dplyr::pull("subject_id") |> sort() == c(3, 4, 5, 6, 10))) expect_true(all(cohort |> dplyr::pull("cohort_start_date") |> sort() == c("1991-05-25", "1997-11-07", "2010-02-10", "2019-07-17", "2022-01-26"))) mockDisconnect(cdm = cdm) }) test_that("requireIsFirstDrugEntry", { skip_on_cran() cdm <- mockDrugUtilisation( con = connection(), writeSchema = schema(), cohort = dplyr::tibble( cohort_definition_id = c(1, 1, 1, 1, 1, 1, 2, 2, 2, 2, 2, 2), subject_id = c(1, 1, 1, 2, 3, 3, 3, 3, 1, 1, 2, 3), cohort_start_date = as.Date(c( "2020-04-01", "2020-05-01", "2020-06-01", "2022-05-21", "1983-08-02", "1983-12-02", "1993-08-02", "2005-08-02", "2020-04-01", "2020-05-01", "2022-05-30", "2000-08-02" )), cohort_end_date = as.Date(c( "2020-04-01", "2020-05-01", "2020-06-01", "2022-05-21", "1983-08-02", "1983-12-02", "1993-08-02", "2005-08-02", "2020-04-01", "2020-05-01", "2022-05-30", "2000-08-02" )) ) ) cdm$cohort3 <- requireIsFirstDrugEntry( cohort = cdm$cohort, cohortId = NULL, name = "cohort3" ) expect_true(all(attrition(cdm$cohort3)$reason == c( "Initial qualifying events", "require is the first entry", "Initial qualifying events", "require is the first entry" ))) expect_true(all(cdm$cohort3 |> dplyr::pull("cohort_start_date") |> sort() == c( "1983-08-02", "1993-08-02", "2020-04-01", "2020-04-01", "2022-05-21", "2022-05-30" ))) expect_true(all(cdm$cohort3 |> dplyr::pull("cohort_definition_id") |> sort() == c( 1, 1, 1, 2, 2, 2 ))) expect_true(all(cdm$cohort3 |> dplyr::pull("subject_id") |> sort() == c( 1, 1, 2, 2, 3, 3 ))) cohort <- requireIsFirstDrugEntry( cohort = cdm$cohort, cohortId = 1 ) expect_true(all(attrition(cohort)$reason == c( "Initial qualifying events", "require is the first entry", "Initial qualifying events" ))) expect_true(all(cohort |> dplyr::pull("cohort_start_date") |> sort() == c( "1983-08-02", "1993-08-02", "2000-08-02", "2005-08-02", "2020-04-01", "2020-04-01", "2020-05-01", "2022-05-21", "2022-05-30" ))) expect_true(all(cohort |> dplyr::pull("cohort_definition_id") |> sort() == c( 1, 1, 1, 2, 2, 2, 2, 2, 2 ))) expect_true(all(cohort |> dplyr::pull("subject_id") |> sort() == c( 1, 1, 1, 2, 2, 3, 3, 3, 3 ))) mockDisconnect(cdm = cdm) })