R Under development (unstable) (2024-08-21 r87038 ucrt) -- "Unsuffered Consequences"
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> require("DoseFinding")
Loading required package: DoseFinding
> ########################################################################
> ## test Bayesian fitting
> ## compare bFitMod on example data set with jags
> 
> data(biom)
> 
> ## (i) fit biom data
> ## data to fit
> model <- "sigEmax"
> anMod <- lm(resp~factor(dose)-1, data=biom)
> drFit <- coef(anMod);y <- drFit
> vCov <- vcov(anMod)
> Omega <- solve(vCov)#+diag(5)*1000
> dose <- sort(unique(biom$dose))
> nD <- length(dose)
> prior <- list(t = c(0, sqrt(2), 3), norm = c(0, sqrt(2)),
+               beta=c(0,1,1,1), lnorm=c(0, sqrt(0.5)))
> res <- bFitMod(dose, drFit, vCov, model = "sigEmax", prior=prior, nSim = 100)
> 
> ## ## jags code (commented out, only for "manual" testing)
> ## library(rjags)
> ## path <- "~/Projekte/DoseFindingPackage/"
> ## modelstr <- "
> ## model{
> ##   y[] ~ dmnorm(mu[], Omega[,])
> ##   for(i in 1:nD){
> ##     mu[i] <- E0 + (Emax*dose[i]^h)/(dose[i]^h+ED50^h)
> ##   }
> ##   E0 ~ dt(0, 0.5, 3)
> ##   Emax ~ dnorm(0, 0.5)
> ##   ED50 ~ dunif(0,1)
> ##   h ~ dlnorm(0, 2)
> ## }
> ## "
> ## file <- paste(path, "mod.txt", sep="")
> ## cat(modelstr, file = file)
> 
> ## ## data
> ## jags.data <- list(y=y, nD=nD, dose=dose, Omega=Omega)
> ## jags.inits <-  list("E0"=0,"Emax"=0,"ED50"=0.5,"h"=1)
> ## mod <- jags.model(file, jags.data, jags.inits, n.chains = 3)
> ## samp <- jags.samples(mod, c("E0","Emax","ED50", "h"), 100000)
> 
> ## quantile(samp$E0, c(0.05,0.25,0.5,0.75,0.95))
> ## quantile(res$samples[,1], c(0.05,0.25,0.5,0.75,0.95))
> ## quantile(samp$Emax, c(0.05,0.25,0.5,0.75,0.95))
> ## quantile(res$samples[,2], c(0.05,0.25,0.5,0.75,0.95))
> ## quantile(samp$ED50, c(0.05,0.25,0.5,0.75,0.95))
> ## quantile(res$samples[,3], c(0.05,0.25,0.5,0.75,0.95))
> ## quantile(samp$h, c(0.05,0.25,0.5,0.75,0.95))
> ## quantile(res$samples[,4], c(0.05,0.25,0.5,0.75,0.95))
> 
> ## cor(cbind(as.numeric(samp$E0[,,]),
> ##           as.numeric(samp$Emax[,,]),
> ##           as.numeric(samp$ED50[,,]),
> ##           as.numeric(samp$h[,,])))
> ## cor(res$samples)
> 
> ## (ii) now run with inflated variance (essentially sample prior)
> vCov <- vcov(anMod)*100000
> Omega <- solve(vCov)#+diag(5)*1000
> res <- bFitMod(dose, drFit, vCov, model = "sigEmax", prior=prior, nSim = 100)
> 
> ## ## jags code (commented out, only for "manual" testing)
> ## jags.data <- list(y=y, nD=nD, dose=dose, Omega=Omega)
> ## mod <- jags.model(file, jags.data, jags.inits, n.chains = 3)
> ## samp <- jags.samples(mod, c("E0","Emax","ED50", "h"), 100000)
> 
> ## quantile(samp$E0, c(0.05,0.25,0.5,0.75,0.95))
> ## quantile(res$samples[,1], c(0.05,0.25,0.5,0.75,0.95))
> ## quantile(samp$Emax, c(0.05,0.25,0.5,0.75,0.95))
> ## quantile(res$samples[,2], c(0.05,0.25,0.5,0.75,0.95))
> ## quantile(samp$ED50, c(0.05,0.25,0.5,0.75,0.95))
> ## quantile(res$samples[,3], c(0.05,0.25,0.5,0.75,0.95))
> ## quantile(samp$h, c(0.05,0.25,0.5,0.75,0.95))
> ## quantile(res$samples[,4], c(0.05,0.25,0.5,0.75,0.95))
> 
> ## cor(cbind(as.numeric(samp$E0[,,]),
> ##           as.numeric(samp$Emax[,,]),
> ##           as.numeric(samp$ED50[,,]),
> ##           as.numeric(samp$h[,,])))
> ## cor(res$samples)
> 
> ########################################################################
> ## test bootstrap fitting
> 
> vCov <- vcov(anMod)
> bnds <- matrix(c(0.001, 0.5, 1.5, 10), 2, 2)
> res <- bFitMod(dose, drFit, vCov, model = "sigEmax", nSim = 100, bnds=bnds,
+                type = "bootstrap")
> dd <- dose[-1];resp <- drFit[2:5]-drFit[1]
> vc <- cbind(-1,diag(4))%*%vCov%*%t(cbind(-1,diag(4)))
> res <- bFitMod(dd, resp, vc, model = "linear", nSim = 100, bnds=bnds,
+                placAdj = TRUE, type = "bootstrap")
> 
> ########################################################################
> ## test dose calculations, when model = "linInt" and placAdj=TRUE
> 
> data(IBScovars)
> anovaMod <- lm(resp~factor(dose)+gender, data=IBScovars)
> drFit <- coef(anovaMod)[2:5] # placebo adjusted estimates at doses
> vCov <- vcov(anovaMod)[2:5,2:5]
> dose <- sort(unique(IBScovars$dose))[-1]
> fm <- fitMod(dose, drFit, S=vCov, model = "linInt", type = "general", placAdj=TRUE)
> ED(fm, 0.25)
[1] 0.3076509
> ED(fm, 0.5)
[1] 0.6153019
> ED(fm, 0.75)
[1] 0.9229528
> ED(fm, 0.95)
[1] 2.673503
> TD(fm, 0.2)
[1] 0.7028559
> TD(fm, 0.3)
[1] 2.064397
> TD(fm, 0.4)
[1] NA
> 
> prior <- list(norm = c(0,1000), norm = c(0,1000),
+               norm = c(0,1000), norm = c(0,1000))
> gsample <- bFitMod(dose, drFit, vCov, model = "linInt", placAdj=TRUE,
+                    start = c(1, 1, 1, 1), nSim = 1000, prior = prior)
> td1 <- TD(gsample, 0.3)
> td2 <- TD(gsample, 0.3, TDtype="d", doses = seq(0,4,length=101))
> ed1 <- ED(gsample, 0.8)
> ed2 <- ED(gsample, 0.8, EDtype="d", doses = seq(0,4,length=101))
> 
> 
> proc.time()
   user  system elapsed 
   2.39    0.25    2.57